Choroidal neovascularization in a child with infantile primary hyperoxaluria treated with bevacizumab.

Journal Article (Journal Article)

Fundus manifestations of primary hyperoxaluria include crystalline deposits, focal or diffuse macular hyperpigmentation, and subretinal fibrosis. Choroidal neovascularization has been hypothesized to underlie the pathogenesis of subretinal fibrosis, yet its manifestations are rarely observed. We report a case of infantile primary hyperoxaluria type 1 in a 17-month-old infant with macular subretinal fluid and subretinal hemorrhage that was associated with leakage on fluorescein angiography and responded to bevacizumab treatment, consistent with choroidal neovascularization. This case suggests that choroidal neovascularization may contribute to subretinal fibrosis and subsequent vision loss in infantile primary hyperoxaluria and may benefit from anti-vascular endothelial growth factor therapy.

Full Text

Duke Authors

Cited Authors

  • Michalak, SM; Bonafede, L; Kelly, MP; Cai, CX; Chen, X

Published Date

  • April 2021

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 128 - 131

PubMed ID

  • 33737053

Electronic International Standard Serial Number (EISSN)

  • 1528-3933

Digital Object Identifier (DOI)

  • 10.1016/j.jaapos.2020.12.004


  • eng

Conference Location

  • United States