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Immune responses at the maternal-fetal interface.

Publication ,  Journal Article
Ander, SE; Diamond, MS; Coyne, CB
Published in: Sci Immunol
January 11, 2019

Pregnancy poses an immunological challenge because a genetically distinct (nonself) fetus must be supported within the pregnant female for the required gestational period. Placentation, or the establishment of the fetally derived placenta, is a common strategy used by eutherian mammals to protect the fetus and promote its growth. However, the substantial morphological differences of the placental architecture among species suggest that the process of placentation results from convergent evolution. Although there are considerable similarities in placental function across placental mammals, there are important differences that arise owing to species-specific immunological (and other biological) constraints. This Review focuses on the immunological similarities and differences that occur at the maternal-fetal interface in the context of human and mouse pregnancies. We discuss how the decidua and placenta of these different species form key immunological barriers that sustain maternal tolerance yet generate innate immune responses that prevent microbial infections.

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Published In

Sci Immunol

DOI

EISSN

2470-9468

Publication Date

January 11, 2019

Volume

4

Issue

31

Location

United States

Related Subject Headings

  • Pregnancy
  • Placenta
  • Leukocytes
  • Infections
  • Immune Tolerance
  • Humans
  • Female
  • Decidua
  • Animals
  • 3204 Immunology
 

Citation

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Ander, S. E., Diamond, M. S., & Coyne, C. B. (2019). Immune responses at the maternal-fetal interface. Sci Immunol, 4(31). https://doi.org/10.1126/sciimmunol.aat6114
Ander, Stephanie E., Michael S. Diamond, and Carolyn B. Coyne. “Immune responses at the maternal-fetal interface.Sci Immunol 4, no. 31 (January 11, 2019). https://doi.org/10.1126/sciimmunol.aat6114.
Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019 Jan 11;4(31).
Ander, Stephanie E., et al. “Immune responses at the maternal-fetal interface.Sci Immunol, vol. 4, no. 31, Jan. 2019. Pubmed, doi:10.1126/sciimmunol.aat6114.
Ander SE, Diamond MS, Coyne CB. Immune responses at the maternal-fetal interface. Sci Immunol. 2019 Jan 11;4(31).

Published In

Sci Immunol

DOI

EISSN

2470-9468

Publication Date

January 11, 2019

Volume

4

Issue

31

Location

United States

Related Subject Headings

  • Pregnancy
  • Placenta
  • Leukocytes
  • Infections
  • Immune Tolerance
  • Humans
  • Female
  • Decidua
  • Animals
  • 3204 Immunology