Zika virus - reigniting the TORCH.

Journal Article (Journal Article;Review)

The recent association between Zika virus (ZIKV) infection during pregnancy and fetal microcephaly has led to a renewed interest in the mechanisms by which vertically transmitted microorganisms reach the fetus and cause congenital disease. In this Opinion article, we provide an overview of the structure and cellular composition of the human placenta and of the mechanisms by which traditional 'TORCH' pathogens (Toxoplasma gondii, other, rubella virus, cytomegalovirus and herpes simplex virus) access the fetal compartment. Based on our current understanding of ZIKV pathogenesis and the developmental defects that are caused by fetal ZIKV infection, ZIKV should be considered a TORCH pathogen and future research and public health measures should be planned and implemented accordingly.

Full Text

Duke Authors

Cited Authors

  • Coyne, CB; Lazear, HM

Published Date

  • November 2016

Published In

Volume / Issue

  • 14 / 11

Start / End Page

  • 707 - 715

PubMed ID

  • 27573577

Electronic International Standard Serial Number (EISSN)

  • 1740-1534

Digital Object Identifier (DOI)

  • 10.1038/nrmicro.2016.125

Language

  • eng

Conference Location

  • England