Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection.

Journal Article (Journal Article)

During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus (ZIKV) infection during human pregnancy and fetal microcephaly and other anomalies suggests that ZIKV may bypass the placenta to reach the fetus. This led us to investigate ZIKV infection of primary human trophoblasts (PHTs), which are the barrier cells of the placenta. We discovered that PHT cells from full-term placentas are refractory to ZIKV infection. In addition, medium from uninfected PHT cells protects non-placental cells from ZIKV infection. PHT cells constitutively release the type III interferon (IFN) IFNλ1, which functions in both a paracrine and autocrine manner to protect trophoblast and non-trophoblast cells from ZIKV infection. Our data suggest that for ZIKV to access the fetal compartment, it must evade restriction by trophoblast-derived IFNλ1 and other trophoblast-specific antiviral factors and/or use alternative strategies to cross the placental barrier.

Full Text

Duke Authors

Cited Authors

  • Bayer, A; Lennemann, NJ; Ouyang, Y; Bramley, JC; Morosky, S; Marques, ETDA; Cherry, S; Sadovsky, Y; Coyne, CB

Published Date

  • May 11, 2016

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 705 - 712

PubMed ID

  • 27066743

Pubmed Central ID

  • 27066743

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2016.03.008

Language

  • eng

Conference Location

  • United States