Mechanisms of MAVS regulation at the mitochondrial membrane.

Journal Article (Journal Article;Review)

Mitochondria have emerged as critical platforms for antiviral innate immune signaling. This is due in large part to the mitochondrial localization of the innate immune signaling adaptor MAVS (mitochondrial antiviral signaling protein), which coordinates signals received from two independent cytosolic pathogen recognition receptors (PRRs) to induce antiviral genes. The existence of a shared adaptor for two central PRRs presents an ideal target by which the host cell can prevent cellular damage induced by uncontrolled inflammation through alteration of MAVS expression and/or signaling. In this review, we focus on the MAVS regulome and review the cellular factors that regulate MAVS by (1) protein-protein interactions, (2) alterations in mitochondrial dynamics, and/or (3) post-translational modifications.

Full Text

Duke Authors

Cited Authors

  • Jacobs, JL; Coyne, CB

Published Date

  • December 13, 2013

Published In

Volume / Issue

  • 425 / 24

Start / End Page

  • 5009 - 5019

PubMed ID

  • 24120683

Pubmed Central ID

  • PMC4562275

Electronic International Standard Serial Number (EISSN)

  • 1089-8638

Digital Object Identifier (DOI)

  • 10.1016/j.jmb.2013.10.007

Language

  • eng

Conference Location

  • Netherlands