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Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.

Publication ,  Journal Article
Bozym, RA; Delorme-Axford, E; Harris, K; Morosky, S; Ikizler, M; Dermody, TS; Sarkar, SN; Coyne, CB
Published in: Cell Host Microbe
February 16, 2012

Viruses modulate the actin cytoskeleton at almost every step of their cellular journey from entry to egress. Cellular sensing of these cytoskeletal changes may function in the recognition of viral infection. Here we show that focal adhesion kinase (FAK), a focal adhesion localized tyrosine kinase that transmits signals between the extracellular matrix and the cytoplasm, serves as a RIG-I-like receptor antiviral signaling component by directing mitochondrial antiviral signaling adaptor (MAVS) activation. Cells deficient in FAK are highly susceptible to RNA virus infection and attenuated in antiviral signaling. We show that FAK interacts with MAVS at the mitochondrial membrane in a virus infection-dependent manner and potentiates MAVS-mediated signaling via a kinase-independent mechanism. A cysteine protease encoded by enteroviruses cleaves FAK to suppress its role in innate immune signaling. These findings suggest that FAK serves as a link between cytoskeletal perturbations that occur during virus infection and activation of innate immune signaling.

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Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

February 16, 2012

Volume

11

Issue

2

Start / End Page

153 / 166

Location

United States

Related Subject Headings

  • Viral Plaque Assay
  • Signal Transduction
  • RNA Viruses
  • Protein Interaction Mapping
  • Mitochondrial Membranes
  • Immunology
  • Humans
  • Focal Adhesion Protein-Tyrosine Kinases
  • Cell Line
  • Adaptor Proteins, Signal Transducing
 

Citation

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Bozym, R. A., Delorme-Axford, E., Harris, K., Morosky, S., Ikizler, M., Dermody, T. S., … Coyne, C. B. (2012). Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling. Cell Host Microbe, 11(2), 153–166. https://doi.org/10.1016/j.chom.2012.01.008
Bozym, Rebecca A., Elizabeth Delorme-Axford, Katharine Harris, Stefanie Morosky, Mine Ikizler, Terence S. Dermody, Saumendra N. Sarkar, and Carolyn B. Coyne. “Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.Cell Host Microbe 11, no. 2 (February 16, 2012): 153–66. https://doi.org/10.1016/j.chom.2012.01.008.
Bozym RA, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody TS, et al. Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling. Cell Host Microbe. 2012 Feb 16;11(2):153–66.
Bozym, Rebecca A., et al. “Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling.Cell Host Microbe, vol. 11, no. 2, Feb. 2012, pp. 153–66. Pubmed, doi:10.1016/j.chom.2012.01.008.
Bozym RA, Delorme-Axford E, Harris K, Morosky S, Ikizler M, Dermody TS, Sarkar SN, Coyne CB. Focal adhesion kinase is a component of antiviral RIG-I-like receptor signaling. Cell Host Microbe. 2012 Feb 16;11(2):153–166.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

February 16, 2012

Volume

11

Issue

2

Start / End Page

153 / 166

Location

United States

Related Subject Headings

  • Viral Plaque Assay
  • Signal Transduction
  • RNA Viruses
  • Protein Interaction Mapping
  • Mitochondrial Membranes
  • Immunology
  • Humans
  • Focal Adhesion Protein-Tyrosine Kinases
  • Cell Line
  • Adaptor Proteins, Signal Transducing