Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.
Publication
, Journal Article
Liu, S; Yang, W; Shen, L; Turner, JR; Coyne, CB; Wang, T
Published in: J Virol
February 2009
A tight junction (TJ) protein, claudin-1 (CLDN1), was identified recently as a key factor for hepatitis C virus (HCV) entry. Here, we show that another TJ protein, occludin, is also required for HCV entry. Mutational study of CLDN1 revealed that its tight junctional distribution plays an important role in mediating viral entry. Together, these data support the model in which HCV enters liver cells from the TJ. Interestingly, HCV infection of Huh-7 hepatoma cells downregulated the expression of CLDN1 and occludin, preventing superinfection. The altered TJ protein expression may contribute to the morphological and functional changes observed in HCV-infected hepatocytes.
Duke Scholars
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Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
February 2009
Volume
83
Issue
4
Start / End Page
2011 / 2014
Location
United States
Related Subject Headings
- Virus Internalization
- Virology
- Tight Junctions
- Occludin
- Membrane Proteins
- Humans
- Hepatocytes
- Hepacivirus
- Down-Regulation
- Claudin-1
Citation
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Chicago
ICMJE
MLA
NLM
Liu, S., Yang, W., Shen, L., Turner, J. R., Coyne, C. B., & Wang, T. (2009). Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol, 83(4), 2011–2014. https://doi.org/10.1128/JVI.01888-08
Liu, Shufeng, Wei Yang, Le Shen, Jerrold R. Turner, Carolyn B. Coyne, and Tianyi Wang. “Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.” J Virol 83, no. 4 (February 2009): 2011–14. https://doi.org/10.1128/JVI.01888-08.
Liu S, Yang W, Shen L, Turner JR, Coyne CB, Wang T. Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol. 2009 Feb;83(4):2011–4.
Liu, Shufeng, et al. “Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection.” J Virol, vol. 83, no. 4, Feb. 2009, pp. 2011–14. Pubmed, doi:10.1128/JVI.01888-08.
Liu S, Yang W, Shen L, Turner JR, Coyne CB, Wang T. Tight junction proteins claudin-1 and occludin control hepatitis C virus entry and are downregulated during infection to prevent superinfection. J Virol. 2009 Feb;83(4):2011–2014.
Published In
J Virol
DOI
EISSN
1098-5514
Publication Date
February 2009
Volume
83
Issue
4
Start / End Page
2011 / 2014
Location
United States
Related Subject Headings
- Virus Internalization
- Virology
- Tight Junctions
- Occludin
- Membrane Proteins
- Humans
- Hepatocytes
- Hepacivirus
- Down-Regulation
- Claudin-1