Cell type- and species-specific host responses to Toxoplasma gondii and its near relatives.

Journal Article (Journal Article;Review)

Toxoplasma gondii is remarkably unique in its ability to successfully infect vertebrate hosts from multiple phyla and can successfully infect most cells within these organisms. The infection outcome in each of these species is determined by the complex interaction between parasite and host genotype. As techniques to quantify global changes in cell function become more readily available and precise, new data are coming to light about how (i) different host cell types respond to parasitic infection and (ii) different parasite species impact the host. Here we focus on recent studies comparing the response to intracellular parasitism by different cell types and insights into understanding host-parasite interactions from comparative studies on T. gondii and its close extant relatives.

Full Text

Duke Authors

Cited Authors

  • Wong, ZS; Borrelli, SLS; Coyne, CC; Boyle, JP

Published Date

  • May 2020

Published In

Volume / Issue

  • 50 / 5

Start / End Page

  • 423 - 431

PubMed ID

  • 32407716

Pubmed Central ID

  • PMC8281328

Electronic International Standard Serial Number (EISSN)

  • 1879-0135

Digital Object Identifier (DOI)

  • 10.1016/j.ijpara.2020.05.001


  • eng

Conference Location

  • England