Personalized Radiation Attenuating Materials for Gastrointestinal Mucosal Protection.

Journal Article (Journal Article)

Cancer patients undergoing therapeutic radiation routinely develop injury of the adjacent gastrointestinal (GI) tract mucosa due to treatment. To reduce radiation dose to critical GI structures including the rectum and oral mucosa, 3D-printed GI radioprotective devices composed of high-Z materials are generated from patient CT scans. In a radiation proctitis rat model, a significant reduction in crypt injury is demonstrated with the device compared to without (p < 0.0087). Optimal device placement for radiation attenuation is further confirmed in a swine model. Dosimetric modeling in oral cavity cancer patients demonstrates a 30% radiation dose reduction to the normal buccal mucosa and a 15.2% dose reduction in the rectum for prostate cancer patients with the radioprotectant material in place compared to without. Finally, it is found that the rectal radioprotectant device is more cost-effective compared to a hydrogel rectal spacer. Taken together, these data suggest that personalized radioprotectant devices may be used to reduce GI tissue injury in cancer patients undergoing therapeutic radiation.

Full Text

Duke Authors

Cited Authors

  • Byrne, JD; Young, CC; Chu, JN; Pursley, J; Chen, MX; Wentworth, AJ; Feng, A; Kirtane, AR; Remillard, KA; Hancox, CI; Bhagwat, MS; Machado, N; Hua, T; Tamang, SM; Collins, JE; Ishida, K; Hayward, A; Becker, SL; Edgington, SK; Schoenfeld, JD; Jeck, WR; Hur, C; Traverso, G

Published Date

  • June 2021

Published In

Volume / Issue

  • 8 / 12

Start / End Page

  • 2100510 -

PubMed ID

  • 34194950

Pubmed Central ID

  • PMC8224439

Electronic International Standard Serial Number (EISSN)

  • 2198-3844

Digital Object Identifier (DOI)

  • 10.1002/advs.202100510

Language

  • eng

Conference Location

  • Germany