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Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders

Publication ,  Journal Article
Chen, W; Huang, Q; Zuppan, CW; Rowsell, EH; Cao, JD; Weiss, LM; Wang, J
Published in: American Journal of Clinical Pathology
May 1, 2009

Posttransplant lymphoproliferative disorders (PTLDs), a heterogeneous group of monoclonal or polyclonal lesions, occur in immunosuppressed patients after solid organ or bone marrow transplantation. Although most PTLDs are Epstein-Barr virus (EBV)+ and seem to represent EBV-induced proliferations of monoclonal (or less often polyclonal) B, T, or plasma cells, a subset of PTLDs is EBV–. Because Kaposi sarcoma–associated herpesvirus/human herpesvirus 8 (KSHV/HHV-8) has been described in association with the development of hematolymphoid and nonhematolymphoid neoplasms in HIV+ patients, we investigated whether there is an association between KSHV/HHV-8 and PTLDs. Formalin-fixed, paraffin-embedded tissue from 52 confirmed PTLD cases were analyzed immunohistochemically for expression of KSHV/HHV-8 latent nuclear antigen (LNA)-1 protein and by polymerase chain reaction–hybridization analysis for the KSHV/HHV-8 genome. The PTLD subtypes included 12 with early lesions (1 plasmacytic hyperplasia and 11 infectious mononucleosis–like), 10 polymorphic, 23 monomorphic (5 Burkitt, 14 diffuse large B-cell lymphoma, 1 plasmacytoma, 1 multiple myeloma, and 2 T-cell), 1 Hodgkin lymphoma (HL), 5 HL-like lesions, and 1 unclassified or other. None of the 51 tested specimens showed expression of KSHV/HHV-8 LNA-1. Furthermore, all 46 specimens tested demonstrated complete absence of the KSHV/HHV-8 genome. Our data clearly indicated that KSHV/HHV-8 is not associated with PTLDs.

Duke Scholars

Published In

American Journal of Clinical Pathology

DOI

EISSN

1943-7722

ISSN

0002-9173

Publication Date

May 1, 2009

Volume

131

Issue

5

Start / End Page

632 / 639

Publisher

Oxford University Press (OUP)

Related Subject Headings

  • Pathology
  • 11 Medical and Health Sciences
 

Citation

APA
Chicago
ICMJE
MLA
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Chen, W., Huang, Q., Zuppan, C. W., Rowsell, E. H., Cao, J. D., Weiss, L. M., & Wang, J. (2009). Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders. American Journal of Clinical Pathology, 131(5), 632–639. https://doi.org/10.1309/ajcp2t4iiizkbhmi
Chen, Wei, Qin Huang, Craig W. Zuppan, Edward H. Rowsell, Jeffrey D. Cao, Lawrence M. Weiss, and Jun Wang. “Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders.” American Journal of Clinical Pathology 131, no. 5 (May 1, 2009): 632–39. https://doi.org/10.1309/ajcp2t4iiizkbhmi.
Chen W, Huang Q, Zuppan CW, Rowsell EH, Cao JD, Weiss LM, et al. Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders. American Journal of Clinical Pathology. 2009 May 1;131(5):632–9.
Chen, Wei, et al. “Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders.” American Journal of Clinical Pathology, vol. 131, no. 5, Oxford University Press (OUP), May 2009, pp. 632–39. Crossref, doi:10.1309/ajcp2t4iiizkbhmi.
Chen W, Huang Q, Zuppan CW, Rowsell EH, Cao JD, Weiss LM, Wang J. Complete Absence of KSHV/HHV-8 in Posttransplant Lymphoproliferative Disorders. American Journal of Clinical Pathology. Oxford University Press (OUP); 2009 May 1;131(5):632–639.
Journal cover image

Published In

American Journal of Clinical Pathology

DOI

EISSN

1943-7722

ISSN

0002-9173

Publication Date

May 1, 2009

Volume

131

Issue

5

Start / End Page

632 / 639

Publisher

Oxford University Press (OUP)

Related Subject Headings

  • Pathology
  • 11 Medical and Health Sciences