Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.
Publication
, Journal Article
Otsuki, K; Zhang, M; Kikuchi, T; Tsuji, M; Tejima, M; Bai, Z-S; Zhou, D; Huang, L; Chen, C-H; Lee, K-H; Li, N; Koike, K; Li, W
Published in: J Nat Med
September 2021
Macrocyclic daphnane orthoesters (MDOs) have attracted significant research interest for the drug discovery to cure HIV infection based on the "Shock and Kill" strategy. In the present study, the first chemical study on Wikstroemia ligustrina (Thymelaeaceae) was carried out by LC-MS analysis and phytochemical investigation. Nine daphnane diterpenoids (1-9) including seven MDOs were detected by LC-MS analysis. Further phytochemical investigation resulted in the isolation and structural elucidation of five daphnanes (1, 2, 5, 8, and 9) with potent anti-HIV activity. Taking the isolated MDO (1) as a model compound, the MS/MS fragmentation pathway was also elucidated.
Duke Scholars
Published In
J Nat Med
DOI
EISSN
1861-0293
Publication Date
September 2021
Volume
75
Issue
4
Start / End Page
1058 / 1066
Location
Japan
Related Subject Headings
- Wikstroemia
- Tandem Mass Spectrometry
- Phytochemicals
- Medicinal & Biomolecular Chemistry
- Humans
- HIV Infections
- Diterpenes
- Chromatography, Liquid
- 4208 Traditional, complementary and integrative medicine
Citation
APA
Chicago
ICMJE
MLA
NLM
Otsuki, K., Zhang, M., Kikuchi, T., Tsuji, M., Tejima, M., Bai, Z.-S., … Li, W. (2021). Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation. J Nat Med, 75(4), 1058–1066. https://doi.org/10.1007/s11418-021-01551-9
Otsuki, Kouharu, Mi Zhang, Takashi Kikuchi, Minami Tsuji, Miyuko Tejima, Zi-Song Bai, Di Zhou, et al. “Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.” J Nat Med 75, no. 4 (September 2021): 1058–66. https://doi.org/10.1007/s11418-021-01551-9.
Otsuki K, Zhang M, Kikuchi T, Tsuji M, Tejima M, Bai Z-S, et al. Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation. J Nat Med. 2021 Sep;75(4):1058–66.
Otsuki, Kouharu, et al. “Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation.” J Nat Med, vol. 75, no. 4, Sept. 2021, pp. 1058–66. Pubmed, doi:10.1007/s11418-021-01551-9.
Otsuki K, Zhang M, Kikuchi T, Tsuji M, Tejima M, Bai Z-S, Zhou D, Huang L, Chen C-H, Lee K-H, Li N, Koike K, Li W. Identification of anti-HIV macrocyclic daphnane orthoesters from Wikstroemia ligustrina by LC-MS analysis and phytochemical investigation. J Nat Med. 2021 Sep;75(4):1058–1066.
Published In
J Nat Med
DOI
EISSN
1861-0293
Publication Date
September 2021
Volume
75
Issue
4
Start / End Page
1058 / 1066
Location
Japan
Related Subject Headings
- Wikstroemia
- Tandem Mass Spectrometry
- Phytochemicals
- Medicinal & Biomolecular Chemistry
- Humans
- HIV Infections
- Diterpenes
- Chromatography, Liquid
- 4208 Traditional, complementary and integrative medicine