Deep learning classification of cervical dysplasia using depth-resolved angular light scattering profiles.
Journal Article (Journal Article)
We present a machine learning method for detecting and staging cervical dysplastic tissue using light scattering data based on a convolutional neural network (CNN) architecture. Depth-resolved angular scattering measurements from two clinical trials were used to generate independent training and validation sets as input of our model. We report 90.3% sensitivity, 85.7% specificity, and 87.5% accuracy in classifying cervical dysplasia, showing the uniformity of classification of a/LCI scans across different instruments. Further, our deep learning approach significantly improved processing speeds over the traditional Mie theory inverse light scattering analysis (ILSA) method, with a hundredfold reduction in processing time, offering a promising approach for a/LCI in the clinic for assessing cervical dysplasia.
Full Text
Duke Authors
Cited Authors
- Zhang, H; Kendall, WY; Jelly, ET; Wax, A
Published Date
- August 2021
Published In
Volume / Issue
- 12 / 8
Start / End Page
- 4997 - 5007
PubMed ID
- 34513238
Pubmed Central ID
- PMC8407824
Electronic International Standard Serial Number (EISSN)
- 2156-7085
International Standard Serial Number (ISSN)
- 2156-7085
Digital Object Identifier (DOI)
- 10.1364/boe.430467
Language
- eng