Daily energy expenditure through the human life course.

Journal Article (Journal Article)

Total daily energy expenditure ("total expenditure") reflects daily energy needs and is a critical variable in human health and physiology, but its trajectory over the life course is poorly studied. We analyzed a large, diverse database of total expenditure measured by the doubly labeled water method for males and females aged 8 days to 95 years. Total expenditure increased with fat-free mass in a power-law manner, with four distinct life stages. Fat-free mass-adjusted expenditure accelerates rapidly in neonates to ~50% above adult values at ~1 year; declines slowly to adult levels by ~20 years; remains stable in adulthood (20 to 60 years), even during pregnancy; then declines in older adults. These changes shed light on human development and aging and should help shape nutrition and health strategies across the life span.

Full Text

Duke Authors

Cited Authors

  • Pontzer, H; Yamada, Y; Sagayama, H; Ainslie, PN; Andersen, LF; Anderson, LJ; Arab, L; Baddou, I; Bedu-Addo, K; Blaak, EE; Blanc, S; Bonomi, AG; Bouten, CVC; Bovet, P; Buchowski, MS; Butte, NF; Camps, SG; Close, GL; Cooper, JA; Cooper, R; Das, SK; Dugas, LR; Ekelund, U; Entringer, S; Forrester, T; Fudge, BW; Goris, AH; Gurven, M; Hambly, C; El Hamdouchi, A; Hoos, MB; Hu, S; Joonas, N; Joosen, AM; Katzmarzyk, P; Kempen, KP; Kimura, M; Kraus, WE; Kushner, RF; Lambert, EV; Leonard, WR; Lessan, N; Martin, C; Medin, AC; Meijer, EP; Morehen, JC; Morton, JP; Neuhouser, ML; Nicklas, TA; Ojiambo, RM; Pietiläinen, KH; Pitsiladis, YP; Plange-Rhule, J; Plasqui, G; Prentice, RL; Rabinovich, RA; Racette, SB; Raichlen, DA; Ravussin, E; Reynolds, RM; Roberts, SB; Schuit, AJ; Sjödin, AM; Stice, E; Urlacher, SS; Valenti, G; Van Etten, LM; Van Mil, EA; Wells, JCK; Wilson, G; Wood, BM; Yanovski, J; Yoshida, T; Zhang, X; Murphy-Alford, AJ; Loechl, C; Luke, AH; Rood, J; Schoeller, DA; Westerterp, KR; Wong, WW; Speakman, JR; IAEA DLW Database Consortium,

Published Date

  • August 13, 2021

Published In

Volume / Issue

  • 373 / 6556

Start / End Page

  • 808 - 812

PubMed ID

  • 34385400

Pubmed Central ID

  • PMC8370708

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.abe5017

Language

  • eng

Conference Location

  • United States