How RNA modifications regulate the antiviral response.

Journal Article (Journal Article;Review)

Induction of the antiviral innate immune response is highly regulated at the RNA level, particularly by RNA modifications. Recent discoveries have revealed how RNA modifications play key roles in cellular surveillance of nucleic acids and in controlling gene expression in response to viral infection. These modifications have emerged as being essential for a functional antiviral response and maintaining cellular homeostasis. In this review, we will highlight these and other discoveries that describe how the antiviral response is controlled by modifications to both viral and cellular RNA, focusing on how mRNA cap modifications, N6-methyladenosine, and RNA editing all contribute to coordinating an efficient response that properly controls viral infection.

Full Text

Duke Authors

Cited Authors

  • Thompson, MG; Sacco, MT; Horner, SM

Published Date

  • November 2021

Published In

Volume / Issue

  • 304 / 1

Start / End Page

  • 169 - 180

PubMed ID

  • 34405413

Pubmed Central ID

  • PMC8616813

Electronic International Standard Serial Number (EISSN)

  • 1600-065X

Digital Object Identifier (DOI)

  • 10.1111/imr.13020


  • eng

Conference Location

  • England