Immune Microenvironment Landscape in CNS Tumors and Role in Responses to Immunotherapy.

Journal Article (Journal Article;Review)

Despite the important evolution of immunotherapeutic agents, brain tumors remain, in general, refractory to immune therapeutics. Recent discoveries have revealed that the glioma microenvironment includes a wide variety of immune cells in various states that play an important role in the process of tumorigenesis. Anti-tumor immune activity may be occurring or induced in immunogenic hot spots or at the invasive edge of central nervous system (CNS) tumors. Understanding the complex heterogeneity of the immune microenvironment in gliomas will likely be the key to unlocking the full potential of immunotherapeutic strategies. An essential consideration will be the induction of immunological effector responses in the setting of the numerous aspects of immunosuppression and evasion. As such, immune therapeutic combinations are a fundamental objective for clinical studies in gliomas. Through immune profiling conducted on immune competent murine models of glioma and ex vivo human glioma tissue, we will discuss how the frequency, distribution of immune cells within the microenvironment, and immune modulatory processes, may be therapeutically modulated to lead to clinical benefits.

Full Text

Duke Authors

Cited Authors

  • Najem, H; Khasraw, M; Heimberger, AB

Published Date

  • August 9, 2021

Published In

Volume / Issue

  • 10 / 8

PubMed ID

  • 34440802

Pubmed Central ID

  • PMC8393758

Electronic International Standard Serial Number (EISSN)

  • 2073-4409

Digital Object Identifier (DOI)

  • 10.3390/cells10082032

Language

  • eng

Conference Location

  • Switzerland