Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes
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, Journal Article
Onyeagusi, C; Shao, X; Malcolmson, S
2020
We describe a strategy for the enantio- and diastereoselective synthesis of homoallylic α-trifluoromethyl amines by the catalytic hydroalkylation of terminal dienes. Trifluoromethylsubstituted isatin-derived azadienolate nucleophiles undergo γ-selective alkylation with a Pd–DTBM-SEGPHOS catalyst, which additionally promotes regioselective addition to the diene and delivers products in up to 86% yield, 10:1 dr, and 97.5:2.5 er.
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Onyeagusi, C., Shao, X., & Malcolmson, S. (2020). Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes. https://doi.org/10.26434/chemrxiv.11653143.v1
Onyeagusi, Chibueze, Xinxin Shao, and Steven Malcolmson. “Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes,” 2020. https://doi.org/10.26434/chemrxiv.11653143.v1.
Onyeagusi C, Shao X, Malcolmson S. Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes. 2020;
Onyeagusi, Chibueze, et al. Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes. 2020. Epmc, doi:10.26434/chemrxiv.11653143.v1.
Onyeagusi C, Shao X, Malcolmson S. Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes. 2020;