Overview
The discovery of catalysts is of great importance to the practice of modern synthetic chemistry, both to improve upon the existing catalog of chemical transformations and to generate new modes of reactivity. Research in the Malcolmson lab focuses on the discovery of novel methods for the efficient and selective synthesis of small molecule scaffolds through the design and development of new catalysts. In these transformations, we seek to realize new synthetic bond disconnections while also controlling some aspect of selectivity (e.g., enantio-, and/or site selectivity). The catalysts and methods developed in the group are being applied to the synthesis of biologically active molecules to drive the development of new chemistry as well as help to address problems in human health.
Current Appointments & Affiliations
Associate Professor of Chemistry
·
2020 - Present
Chemistry,
Trinity College of Arts & Sciences
Recent Publications
Catalysis-enabled amine sorting.
Journal Article Nature chemistry · December 2024 Full text CiteShattering the mirror with copper catalysis
Journal Article Nature Synthesis · September 1, 2024 Racemic ketones are converted to stereoisomerically enriched homoallylic alcohols by copper-catalysed enantioconvergent allylation. ... Full text CiteCopper-Catalyzed Diastereo-, Enantio-, and (Z)-Selective Aminoallylation of Ketones through Reductive Couplings of Azatrienes for the Synthesis of Allylic 1,2-Amino Tertiary Alcohols.
Journal Article Journal of the American Chemical Society · July 2024 We introduce a method for the (Z)-selective aminoallylation of a range of ketones to prepare allylic 1,2-amino tertiary alcohols with excellent diastereo- and enantioselectivity. Copper-catalyzed reductive couplings of 2-azatrienes with aryl/alkyl a ... Full text CiteRecent Grants
Strategies for the Catalytic Synthesis of Nitrogen-Containing Molecules
ResearchPrincipal Investigator · Awarded by National Institute of General Medical Sciences · 2022 - 2027Developing Next-Generation Hyperpolarization Methods for Chemical Analysis
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2020 - 2025Pharmacological Sciences Training Grant
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025View All Grants
Education, Training & Certifications
Boston College ·
2010
Ph.D.
Boston University ·
2004
B.A.