Steven Malcolmson
Associate Professor of Chemistry
The discovery of catalysts is of great importance to the practice of modern synthetic chemistry, both to improve upon the existing catalog of chemical transformations and to generate new modes of reactivity. Research in the Malcolmson lab focuses on the discovery of novel methods
for the efficient and selective synthesis of small molecule scaffolds through the design and development of new catalysts
. In these transformations, we seek to realize new synthetic bond disconnections while also controlling some aspect of selectivity (e.g., enantio-, and/or site selectivity). The catalysts and methods developed in the group are being applied to the synthesis of biologically active molecules
to drive the development of new chemistry as well as help to address problems in human health.
Current Appointments & Affiliations
- Associate Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2020
Contact Information
- 1103 French Science Center, Durham, NC 27708
- Box 90346, Durham, NC 27708-0346
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steven.malcolmson@duke.edu
(919) 660-1575
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Malcolmson Research Group
- Background
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Education, Training, & Certifications
- Postdoctoral Fellow, Prof. Christopher Walsh, Harvard Medical School 2010 - 2013
- Ph.D., Boston College 2010
- B.A., Boston University 2004
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Previous Appointments & Affiliations
- Assistant Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013 - 2020
- Scholar In Residence in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2013
- Recognition
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In the News
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SEP 21, 2021 Office of Faculty Advancement -
MAR 23, 2016
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- Research
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Selected Grants
- Strategies for the Catalytic Synthesis of Nitrogen-Containing Molecules awarded by National Institutes of Health 2022 - 2027
- Developing Next-Generation Hyperpolarization Methods for Chemical Analysis awarded by National Science Foundation 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- A Reverse Polarity Stereoselective C-C Bond-Forming Strategy for Preparing Chiral Amines awarded by National Institutes of Health 2017 - 2023
- Development of Catalytic Enantioselective Intermolecular Diene Hydrofunctionalization Reactions awarded by National Science Foundation 2018 - 2022
- Improving Understanding, Utility and Generality of Hyperpolarized, Long-lived Spin States in Magnetic Resonance awarded by National Science Foundation 2017 - 2021
- Probing Hyperpolarized 15N2-diazirine as A Universal Molecular Tag in MRI awarded by National Institutes of Health 2018 - 2021
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- GAANN - Department of Chemistry awarded by Department of Education 2015 - 2019
- A Reverse Polarity Approach to Preparing Chiral Amines Through Stereoselective C-C Bond Assembly awarded by American Chemical Society 2016 - 2018
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
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External Relationships
- XiMo AG, wholly-owned subsidiary of Verbio AG
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Zhou, Pengfei, Xinxin Shao, and Steven J. Malcolmson. “A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines.” Journal of the American Chemical Society 143, no. 34 (September 2021): 13999–8. https://doi.org/10.1021/jacs.1c07707.Full Text
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Zhou, Pengfei, Xinxin Shao, and Steven Malcolmson. “A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines that Furnish Allylic Amines,” July 26, 2021. https://doi.org/10.33774/chemrxiv-2021-zvdcz-v2.Full Text
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Malcolmson, Steven J. “Racing against unwanted isomerization.” Science (New York, N.Y.) 371, no. 6527 (January 2021): 345–46. https://doi.org/10.1126/science.abf8851.Full Text
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Zhou, Pengfei, Xinxin Shao, and Steven Malcolmson. “A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines that Furnish Allylic Amines,” 2021. https://doi.org/10.26434/chemrxiv.14347661.v1.Full Text
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Onyeagusi, Chibueze I., and Steven J. Malcolmson. “Strategies for the Catalytic Enantioselective Synthesis of α-Trifluoromethyl Amines.” Acs Catalysis 10, no. 21 (November 2020): 12507–36. https://doi.org/10.1021/acscatal.0c03569.Full Text
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Colell, Johannes F. P., Angus W. J. Logan, Zijian Zhou, Jacob R. Lindale, Raul Laasner, Roman V. Shchepin, Eduard Y. Chekmenev, et al. “Rational ligand choice extends the SABRE substrate scope.” Chemical Communications (Cambridge, England) 56, no. 65 (August 2020): 9336–39. https://doi.org/10.1039/d0cc01330g.Full Text
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Adamson, Nathan J., Sangjune Park, Pengfei Zhou, Andrew L. Nguyen, and Steven J. Malcolmson. “Enantioselective Construction of Quaternary Stereogenic Centers by the Addition of an Acyl Anion Equivalent to 1,3-Dienes.” Organic Letters 22, no. 5 (March 2020): 2032–37. https://doi.org/10.1021/acs.orglett.0c00412.Full Text
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Onyeagusi, Chibueze I., Xinxin Shao, and Steven J. Malcolmson. “Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes.” Organic Letters 22, no. 4 (February 2020): 1681–85. https://doi.org/10.1021/acs.orglett.0c00342.Full Text
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Adamson, N. J., and S. J. Malcolmson. “Catalytic Enantio- And Regioselective Addition of Nucleophiles in the Intermolecular Hydrofunctionalization of 1,3-Dienes.” Acs Catalysis 10, no. 2 (January 17, 2020): 1060–76. https://doi.org/10.1021/acscatal.9b04712.Full Text
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Onyeagusi, Chibueze, Xinxin Shao, and Steven Malcolmson. “Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes,” 2020. https://doi.org/10.26434/chemrxiv.11653143.v1.Full Text
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Shao, Xinxin, and Steven J. Malcolmson. “Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers.” Organic Letters 21, no. 18 (September 2019): 7380–85. https://doi.org/10.1021/acs.orglett.9b02692.Full Text
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Malcolmson, Steven J., Kangnan Li, and Xinxin Shao. “2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines.” Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry 30, no. 11 (July 2019): 1253–68. https://doi.org/10.1055/s-0037-1611770.Full Text
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Park, Sangjune, Nathan J. Adamson, and Steven J. Malcolmson. “Brønsted acid and Pd-PHOX dual-catalysed enantioselective addition of activated C-pronucleophiles to internal dienes.” Chemical Science 10, no. 19 (May 2019): 5176–82. https://doi.org/10.1039/c9sc00633h.Full Text
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Adamson, Nathan J., Haleh Jeddi, and Steven J. Malcolmson. “Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design.” Journal of the American Chemical Society 141, no. 21 (May 2019): 8574–83. https://doi.org/10.1021/jacs.9b02637.Full Text
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Daniel, Paige E., Chibueze I. Onyeagusi, Anthony A. Ribeiro, Kangnan Li, and Steven J. Malcolmson. “Palladium-Catalyzed Synthesis of α-Trifluoromethyl Benzylic Amines via Fluoroarylation of gem-Difluoro-2-azadienes Enabled by Phosphine-Catalyzed Formation of an Azaallyl-Silver Intermediate.” Acs Catalysis 9, no. 1 (January 2019): 205–10. https://doi.org/10.1021/acscatal.8b03999.Full Text
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Park, S., and S. J. Malcolmson. “Development and Mechanistic Investigations of Enantioselective Pd-Catalyzed Intermolecular Hydroaminations of Internal Dienes.” Acs Catalysis 8, no. 9 (September 7, 2018): 8468–76. https://doi.org/10.1021/acscatal.8b01914.Full Text
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Shao, Xinxin, Kangnan Li, and Steven J. Malcolmson. “Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines.” Journal of the American Chemical Society 140, no. 23 (June 2018): 7083–87. https://doi.org/10.1021/jacs.8b04750.Full Text
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Adamson, Nathan J., Katherine C. E. Wilbur, and Steven J. Malcolmson. “Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles.” Journal of the American Chemical Society 140, no. 8 (February 2018): 2761–64. https://doi.org/10.1021/jacs.7b13300.Full Text
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Li, Kangnan, Xinxin Shao, Luke Tseng, and Steven J. Malcolmson. “2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones.” Journal of the American Chemical Society 140, no. 2 (January 2018): 598–601. https://doi.org/10.1021/jacs.7b12213.Full Text
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Shen, Kun, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long‐Lived SABRE‐Induced Hyperpolarization.” Angewandte Chemie 129, no. 40 (September 25, 2017): 12280–84. https://doi.org/10.1002/ange.201704970.Full Text
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Shen, Kun, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang. “Titelbild: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization (Angew. Chem. 40/2017).” Angewandte Chemie 129, no. 40 (September 25, 2017): 12179–12179. https://doi.org/10.1002/ange.201707296.Full Text
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Shen, Kun, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang. “Cover Picture: Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization (Angew. Chem. Int. Ed. 40/2017).” Angewandte Chemie International Edition 56, no. 40 (September 25, 2017): 12015–12015. https://doi.org/10.1002/anie.201707296.Full Text
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Shen, Kun, Angus W. J. Logan, Johannes F. P. Colell, Junu Bae, Gerardo X. Ortiz, Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization.” Angewandte Chemie (International Ed. in English) 56, no. 40 (September 2017): 12112–16. https://doi.org/10.1002/anie.201704970.Full Text
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Li, Kangnan, Alexandria E. Weber, Luke Tseng, and Steven J. Malcolmson. “Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines.” Organic Letters 19, no. 16 (August 2017): 4239–42. https://doi.org/10.1021/acs.orglett.7b01886.Full Text
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Daniel, Paige E., Alexandria E. Weber, and Steven J. Malcolmson. “Umpolung Synthesis of 1,3-Amino Alcohols: Stereoselective Addition of 2-Azaallyl Anions to Epoxides.” Organic Letters 19, no. 13 (July 2017): 3490–93. https://doi.org/10.1021/acs.orglett.7b01471.Full Text
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Colell, Johannes F. P., Meike Emondts, Angus W. J. Logan, Kun Shen, Junu Bae, Roman V. Shchepin, Gerardo X. Ortiz, et al. “Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.” Journal of the American Chemical Society 139, no. 23 (June 2017): 7761–67. https://doi.org/10.1021/jacs.7b00569.Full Text
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Adamson, Nathan J., Ethan Hull, and Steven J. Malcolmson. “Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd-PHOX Catalyst.” Journal of the American Chemical Society 139, no. 21 (May 2017): 7180–83. https://doi.org/10.1021/jacs.7b03480.Full Text
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Colell, Johannes F. P., Angus W. J. Logan, Zijian Zhou, Roman V. Shchepin, Danila A. Barskiy, Gerardo X. Ortiz, Qiu Wang, et al. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange.” The Journal of Physical Chemistry. C, Nanomaterials and Interfaces 121, no. 12 (March 2017): 6626–34. https://doi.org/10.1021/acs.jpcc.6b12097.Full Text
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Logan, Angus W. J., Thomas Theis, Johannes F. P. Colell, Warren S. Warren, and Steven J. Malcolmson. “Hyperpolarization of Nitrogen-15 Schiff Bases by Reversible Exchange Catalysis with para-Hydrogen.” Chemistry (Weinheim an Der Bergstrasse, Germany) 22, no. 31 (July 2016): 10777–81. https://doi.org/10.1002/chem.201602393.Full Text
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Theis, T., G. X. Ortiz, A. W. J. Logan, K. E. Claytor, Y. Feng, W. P. Huhn, V. Blum, et al. “Direct and cost-efficient hyperpolarization of long-lived nuclear spin states on universal 15N2-diazirine molecular tags.” Science Advances 2, no. 3 (March 25, 2016). https://doi.org/10.1126/sciadv.1501438.Full Text Open Access Copy Link to Item
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Malcolmson, Steven J., Travis S. Young, J Graham Ruby, Peter Skewes-Cox, and Christopher T. Walsh. “The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.” Proceedings of the National Academy of Sciences of the United States of America 110, no. 21 (May 2013): 8483–88. https://doi.org/10.1073/pnas.1307111110.Full Text
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Lichtscheidl, Alejandro G., Victor W. L. Ng, Peter Müller, Michael K. Takase, Richard R. Schrock, Steven J. Malcolmson, Simon J. Meek, Bo Li, Elizabeth T. Kiesewetter, and Amir H. Hoveyda. “Bipyridine Adducts of Molybdenum Imido Alkylidene and Imido Alkylidyne Complexes.” Organometallics 31, no. 12 (June 2012): 4558–64. https://doi.org/10.1021/om300353e.Full Text
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Walsh, Christopher T., Steven J. Malcolmson, and Travis S. Young. “Three ring posttranslational circuses: insertion of oxazoles, thiazoles, and pyridines into protein-derived frameworks.” Acs Chemical Biology 7, no. 3 (March 2012): 429–42. https://doi.org/10.1021/cb200518n.Full Text
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Crawford, Jason M., Sarah A. Mahlstedt, Steven J. Malcolmson, Jon Clardy, and Christopher T. Walsh. “Dihydrophenylalanine: a prephenate-derived Photorhabdus luminescens antibiotic and intermediate in dihydrostilbene biosynthesis.” Chemistry & Biology 18, no. 9 (September 2011): 1102–12. https://doi.org/10.1016/j.chembiol.2011.07.009.Full Text
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Zhang, Wenjun, Ioanna Ntai, Megan L. Bolla, Steven J. Malcolmson, Daniel Kahne, Neil L. Kelleher, and Christopher T. Walsh. “Nine enzymes are required for assembly of the pacidamycin group of peptidyl nucleoside antibiotics.” Journal of the American Chemical Society 133, no. 14 (April 2011): 5240–43. https://doi.org/10.1021/ja2011109.Full Text
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Hoveyda, A. H., S. J. Malcolmson, S. J. Meek, and A. R. Zhugralin. “Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis,” June 7, 2010, 343–48. https://doi.org/10.1002/9783527629626.ch12.Full Text
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Ji, J. X., A. S. C. Chan, G. Helmchen, U. Kazmaier, S. Förster, I. Ojima, J. J. Kaloko, et al. “Asymmetric Carbon-Carbon Bond-Forming Reactions,” March 26, 2010, 437–770. https://doi.org/10.1002/9780470584248.ch8.Full Text
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Hoveyda, Amir H., Steven J. Malcolmson, Simon J. Meek, and Adil R. Zhugralin. “Catalytic enantioselective olefin metathesis in natural product synthesis. Chiral metal-based complexes that deliver high enantioselectivity and more.” Angewandte Chemie (International Ed. in English) 49, no. 1 (January 2010): 34–44. https://doi.org/10.1002/anie.200904491.Full Text
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Meek, Simon J., Steven J. Malcolmson, Bo Li, Richard R. Schrock, and Amir H. Hoveyda. “The significance of degenerate processes to enantioselective olefin metathesis reactions promoted by stereogenic-at-Mo complexes.” Journal of the American Chemical Society 131, no. 45 (November 2009): 16407–9. https://doi.org/10.1021/ja907805f.Full Text
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Harvey, James Stephen, Steven J. Malcolmson, Katherine S. Dunne, Simon J. Meek, Amber L. Thompson, Richard R. Schrock, Amir H. Hoveyda, and Véronique Gouverneur. “Enantioselective synthesis of P-stereogenic phosphinates and phosphine oxides by molybdenum-catalyzed asymmetric ring-closing metathesis.” Angewandte Chemie (International Ed. in English) 48, no. 4 (January 2009): 762–66. https://doi.org/10.1002/anie.200805066.Full Text
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Sattely, Elizabeth S., Simon J. Meek, Steven J. Malcolmson, Richard R. Schrock, and Amir H. Hoveyda. “Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis.” Journal of the American Chemical Society 131, no. 3 (January 2009): 943–53. https://doi.org/10.1021/ja8084934.Full Text
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Malcolmson, Steven J., Simon J. Meek, Elizabeth S. Sattely, Richard R. Schrock, and Amir H. Hoveyda. “Highly efficient molybdenum-based catalysts for enantioselective alkene metathesis.” Nature 456, no. 7224 (December 2008): 933–37. https://doi.org/10.1038/nature07594.Full Text
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Lee, Ai-Lan, Steven J. Malcolmson, Alessandra Puglisi, Richard R. Schrock, and Amir H. Hoveyda. “Enantioselective synthesis of cyclic enol ethers and all-carbon quaternary stereogenic centers through catalytic asymmetric ring-closing metathesis.” Journal of the American Chemical Society 128, no. 15 (April 2006): 5153–57. https://doi.org/10.1021/ja058428r.Full Text
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Book Sections
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Hoveyda, A. H., R. K. M. Khan, S. Torker, and S. J. Malcolmson. “Catalyst-Controlled Stereoselective Olefin Metathesis.” In Handbook of Metathesis: Second Edition, 2–3:503–62, 2015. https://doi.org/10.1002/9783527674107.ch21.Full Text
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Preprints
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Zhou, Pengfei, Xinxin Shao, and Steven Malcolmson. “A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines that Furnish Allylic Amines.” American Chemical Society (ACS), July 26, 2021. https://doi.org/10.26434/chemrxiv-2021-zvdcz-v2.Full Text
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- Teaching & Mentoring
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Recent Courses
- CHEM 393: Research Independent Study 2023
- CHEM 394: Research Independent Study 2023
- CHEM 493: Research Independent Study 2023
- CHEM 494: Research Independent Study 2023
- CHEM 532: Organic Reactions 2023
- CHEM 538: Organometallic Chemistry and Catalysis 2023
- CHEM 393: Research Independent Study 2022
- CHEM 394: Research Independent Study 2022
- CHEM 493: Research Independent Study 2022
- CHEM 494: Research Independent Study 2022
- CHEM 538: Organometallic Chemistry and Catalysis 2022
- CHEM 202D: Organic Chemistry II 2021
- CHEM 393: Research Independent Study 2021
- CHEM 394: Research Independent Study 2021
- CHEM 493: Research Independent Study 2021
- CHEM 494: Research Independent Study 2021
- CHEM 538: Organometallic Chemistry and Catalysis 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
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