New insights into the classification and nomenclature of cortical GABAergic interneurons.
Journal Article (Review)
A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.
Full Text
Duke Authors
Cited Authors
- DeFelipe, J; López-Cruz, PL; Benavides-Piccione, R; Bielza, C; Larrañaga, P; Anderson, S; Burkhalter, A; Cauli, B; Fairén, A; Feldmeyer, D; Fishell, G; Fitzpatrick, D; Freund, TF; González-Burgos, G; Hestrin, S; Hill, S; Hof, PR; Huang, J; Jones, EG; Kawaguchi, Y; Kisvárday, Z; Kubota, Y; Lewis, DA; Marín, O; Markram, H; McBain, CJ; Meyer, HS; Monyer, H; Nelson, SB; Rockland, K; Rossier, J; Rubenstein, JLR; Rudy, B; Scanziani, M; Shepherd, GM; Sherwood, CC; Staiger, JF; Tamás, G; Thomson, A; Wang, Y; Yuste, R; Ascoli, GA
Published Date
- March 2013
Published In
Volume / Issue
- 14 / 3
Start / End Page
- 202 - 216
PubMed ID
- 23385869
Pubmed Central ID
- PMC3619199
Electronic International Standard Serial Number (EISSN)
- 1471-0048
Digital Object Identifier (DOI)
- 10.1038/nrn3444
Language
- eng
Conference Location
- England