New insights into the classification and nomenclature of cortical GABAergic interneurons.

Journal Article (Review)

A systematic classification and accepted nomenclature of neuron types is much needed but is currently lacking. This article describes a possible taxonomical solution for classifying GABAergic interneurons of the cerebral cortex based on a novel, web-based interactive system that allows experts to classify neurons with pre-determined criteria. Using Bayesian analysis and clustering algorithms on the resulting data, we investigated the suitability of several anatomical terms and neuron names for cortical GABAergic interneurons. Moreover, we show that supervised classification models could automatically categorize interneurons in agreement with experts' assignments. These results demonstrate a practical and objective approach to the naming, characterization and classification of neurons based on community consensus.

Full Text

Duke Authors

Cited Authors

  • DeFelipe, J; López-Cruz, PL; Benavides-Piccione, R; Bielza, C; Larrañaga, P; Anderson, S; Burkhalter, A; Cauli, B; Fairén, A; Feldmeyer, D; Fishell, G; Fitzpatrick, D; Freund, TF; González-Burgos, G; Hestrin, S; Hill, S; Hof, PR; Huang, J; Jones, EG; Kawaguchi, Y; Kisvárday, Z; Kubota, Y; Lewis, DA; Marín, O; Markram, H; McBain, CJ; Meyer, HS; Monyer, H; Nelson, SB; Rockland, K; Rossier, J; Rubenstein, JLR; Rudy, B; Scanziani, M; Shepherd, GM; Sherwood, CC; Staiger, JF; Tamás, G; Thomson, A; Wang, Y; Yuste, R; Ascoli, GA

Published Date

  • March 2013

Published In

Volume / Issue

  • 14 / 3

Start / End Page

  • 202 - 216

PubMed ID

  • 23385869

Pubmed Central ID

  • PMC3619199

Electronic International Standard Serial Number (EISSN)

  • 1471-0048

Digital Object Identifier (DOI)

  • 10.1038/nrn3444

Language

  • eng

Conference Location

  • England