Josh Huang | Scholars@Duke

Josh Huang
Professor of Neurobiology

Current Appointments & Affiliations

Professor of Neurobiology, Neurobiology, Basic Science Departments 2021

Contact Information

311 Research Drive, Box 3209, Durham, NC 27710
311 Research Drive, Box 3209, Durham, NC 27710
josh.huang@duke.edu (919) 613-1573

Background
Education, Training, & Certifications
- Ph.D., Brandeis University 1995
Previous Appointments & Affiliations
- Instructor in the Department of Neurobiology, Neurobiology, Basic Science Departments 2020 - 2021
Recognition
In the News
- OCT 6, 2021
  
  Duke Neuroscientist Co-Leads Massive Effort to Map Brain
Research
Selected Grants
- RNA-programmable cell-type targeting, editing, and therapy awarded by National Institutes of Health 2021 - 2026
- RNA-programmable cell type targeting and manipulation across vertebrate nervous systems awarded by National Institutes of Health 2021 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Discovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets awarded by National Institutes of Health 2021 - 2024
- Large scale discovery and validation of brain cell type enhancers for viral targeting and circuit manipulation awarded by National Institutes of Health 2020 - 2023
- Activity dependent integration of chandelier cells during cortical circuit assembly awarded by National Institutes of Health 2021 - 2023
- A Comprehensive Center for Mouse Brain Cell Atlas - Project 2: Anatomy awarded by Cold Spring Harbor Laboratory 2021 - 2022
- A Comprehensive Center for Mouse Brain Cell Atlas P1: Molecular Signatures awarded by Cold Spring Harbor Laboratory 2021 - 2022
- A Comprehensive Center for Mouse Brain Cell Atlas P3: Cell Specific Targeting Approaches and Tools awarded by Cold Spring Harbor Laboratory 2021 - 2022
- Revealing the transcriptomic basis of neuronal identity through functional meta-analysis awarded by Cold Spring Harbor Laboratory 2020 - 2021
- Transcriptome-based systematic discovery of GABAergic neurons in the neocortex awarded by National Institutes of Health 2020 - 2021
External Relationships
- I serve on the Scientific Advisory Board of Tsinghua IDG/McGovern Institute for Brain Research, Tsinghua University, China.
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Matho, Katherine S., Dhananjay Huilgol, William Galbavy, Miao He, Gukhan Kim, Xu An, Jiangteng Lu, et al. “Genetic dissection of the glutamatergic neuron system in cerebral cortex.” Nature 598, no. 7879 (October 2021): 182–87. https://doi.org/10.1038/s41586-021-03955-9.
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  - Peng, Hanchuan, Peng Xie, Lijuan Liu, Xiuli Kuang, Yimin Wang, Lei Qu, Hui Gong, et al. “Morphological diversity of single neurons in molecularly defined cell types.” Nature 598, no. 7879 (October 2021): 174–81. https://doi.org/10.1038/s41586-021-03941-1.
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  - Yao, Zizhen, Hanqing Liu, Fangming Xie, Stephan Fischer, Ricky S. Adkins, Andrew I. Aldridge, Seth A. Ament, et al. “A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex.” Nature 598, no. 7879 (October 2021): 103–10. https://doi.org/10.1038/s41586-021-03500-8.
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  - Wang, Bor-Shuen, Maria Sol Bernardez Sarria, Xu An, Miao He, Nazia M. Alam, Glen T. Prusky, Michael C. Crair, and Z Josh Huang. “Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex.” Neuron 109, no. 3 (February 3, 2021): 502-515.e7. https://doi.org/10.1016/j.neuron.2020.11.004.
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  - Huang, Z Josh, and Anirban Paul. “The diversity of GABAergic neurons and neural communication elements.” Nat Rev Neurosci 20, no. 9 (September 2019): 563–72. https://doi.org/10.1038/s41583-019-0195-4.
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  - Lu, Jiangteng, Jason Tucciarone, Nancy Padilla-Coreano, Miao He, Joshua A. Gordon, and Z Josh Huang. “Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells.” Nat Neurosci 20, no. 10 (October 2017): 1377–83. https://doi.org/10.1038/nn.4624.
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  - Fenno, Lief E., Joanna Mattis, Charu Ramakrishnan, Minsuk Hyun, Soo Yeun Lee, Miao He, Jason Tucciarone, et al. “Targeting cells with single vectors using multiple-feature Boolean logic.” Nat Methods 11, no. 7 (July 2014): 763–72. https://doi.org/10.1038/nmeth.2996.
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  - Fink, Andrew J. P., Katherine R. Croce, Z Josh Huang, L. F. Abbott, Thomas M. Jessell, and Eiman Azim. “Presynaptic inhibition of spinal sensory feedback ensures smooth movement.” Nature 509, no. 7498 (May 1, 2014): 43–48. https://doi.org/10.1038/nature13276.
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  - Fu, Yu, Jason M. Tucciarone, J Sebastian Espinosa, Nengyin Sheng, Daniel P. Darcy, Roger A. Nicoll, Z Josh Huang, and Michael P. Stryker. “A cortical circuit for gain control by behavioral state.” Cell 156, no. 6 (March 13, 2014): 1139–52. https://doi.org/10.1016/j.cell.2014.01.050.
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  - Huang, Z Josh, Hiroki Taniguchi, Miao He, and Sandra Kuhlman. “Genetic labeling of neurons in mouse brain.” Cold Spring Harb Protoc 2014, no. 2 (February 1, 2014): 150–60. https://doi.org/10.1101/pdb.top080374.
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  - Huang, Z Josh, Hiroki Taniguchi, Miao He, and Sandra Kuhlman. “Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain.” Cold Spring Harb Protoc 2014, no. 2 (February 1, 2014): 190–94. https://doi.org/10.1101/pdb.prot080382.
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  - Pi, Hyun-Jae, Balázs Hangya, Duda Kvitsiani, Joshua I. Sanders, Z Josh Huang, and Adam Kepecs. “Cortical interneurons that specialize in disinhibitory control.” Nature 503, no. 7477 (November 28, 2013): 521–24. https://doi.org/10.1038/nature12676.
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  - Lee, Soohyun, Illya Kruglikov, Z Josh Huang, Gord Fishell, and Bernardo Rudy. “A disinhibitory circuit mediates motor integration in the somatosensory cortex.” Nat Neurosci 16, no. 11 (November 2013): 1662–70. https://doi.org/10.1038/nn.3544.
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  - Basu, Jayeeta, Kalyan V. Srinivas, Stephanie K. Cheung, Hiroki Taniguchi, Z Josh Huang, and Steven A. Siegelbaum. “A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.” Neuron 79, no. 6 (September 18, 2013): 1208–21. https://doi.org/10.1016/j.neuron.2013.07.001.
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  - Ciceri, Gabriele, Nathalie Dehorter, Ignasi Sols, Z Josh Huang, Miguel Maravall, and Oscar Marín. “Lineage-specific laminar organization of cortical GABAergic interneurons.” Nat Neurosci 16, no. 9 (September 2013): 1199–1210. https://doi.org/10.1038/nn.3485.
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  - Pfeffer, Carsten K., Mingshan Xue, Miao He, Z Josh Huang, and Massimo Scanziani. “Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.” Nat Neurosci 16, no. 8 (August 2013): 1068–76. https://doi.org/10.1038/nn.3446.
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  - Huang, Z Josh, and Hongkui Zeng. “Genetic approaches to neural circuits in the mouse.” Annu Rev Neurosci 36 (July 8, 2013): 183–215. https://doi.org/10.1146/annurev-neuro-062012-170307.
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  - Nienborg, Hendrikje, Andrea Hasenstaub, Ian Nauhaus, Hiroki Taniguchi, Z Josh Huang, and Edward M. Callaway. “Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1.” J Neurosci 33, no. 27 (July 3, 2013): 11145–54. https://doi.org/10.1523/JNEUROSCI.5320-12.2013.
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  - Kvitsiani, D., S. Ranade, B. Hangya, H. Taniguchi, J. Z. Huang, and A. Kepecs. “Distinct behavioural and network correlates of two interneuron types in prefrontal cortex.” Nature 498, no. 7454 (June 20, 2013): 363–66. https://doi.org/10.1038/nature12176.
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  - Cioni, Jean-Michel, Ludovic Telley, Véronique Saywell, Christelle Cadilhac, Carole Jourdan, Andrea B. Huber, Josh Z. Huang, Céline Jahannault-Talignani, and Fabrice Ango. “SEMA3A signaling controls layer-specific interneuron branching in the cerebellum.” Curr Biol 23, no. 10 (May 20, 2013): 850–61. https://doi.org/10.1016/j.cub.2013.04.007.
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  - Chattopadhyaya, Bidisha, Elie Baho, Z Josh Huang, Melitta Schachner, and Graziella Di Cristo. “Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex.” J Neurosci 33, no. 14 (April 3, 2013): 5957–68. https://doi.org/10.1523/JNEUROSCI.1306-12.2013.
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  - DeFelipe, Javier, Pedro L. López-Cruz, Ruth Benavides-Piccione, Concha Bielza, Pedro Larrañaga, Stewart Anderson, Andreas Burkhalter, et al. “New insights into the classification and nomenclature of cortical GABAergic interneurons.” Nat Rev Neurosci 14, no. 3 (March 2013): 202–16. https://doi.org/10.1038/nrn3444.
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  - Li, Haohong, Mario A. Penzo, Hiroki Taniguchi, Charles D. Kopec, Z Josh Huang, and Bo Li. “Experience-dependent modification of a central amygdala fear circuit.” Nat Neurosci 16, no. 3 (March 2013): 332–39. https://doi.org/10.1038/nn.3322.
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  - Curley, Allison A., Stephen M. Eggan, Matt S. Lazarus, Z Josh Huang, David W. Volk, and David A. Lewis. “Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia.” Neurobiol Dis 50 (February 2013): 179–86. https://doi.org/10.1016/j.nbd.2012.10.018.
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  - Taniguchi, Hiroki, Jiangteng Lu, and Z Josh Huang. “The spatial and temporal origin of chandelier cells in mouse neocortex.” Science 339, no. 6115 (January 4, 2013): 70–74. https://doi.org/10.1126/science.1227622.
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  - Adesnik, Hillel, William Bruns, Hiroki Taniguchi, Z Josh Huang, and Massimo Scanziani. “A neural circuit for spatial summation in visual cortex.” Nature 490, no. 7419 (October 11, 2012): 226–31. https://doi.org/10.1038/nature11526.
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  - He, M., Y. Liu, X. Wang, M. Q. Zhang, G. J. Hannon, and Z. J. Huang. “Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain.” Neuron 75, no. 5 (September 6, 2012): 930–32. https://doi.org/10.1016/j.neuron.2012.08.018.
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  - Song, Juan, Chun Zhong, Michael A. Bonaguidi, Gerald J. Sun, Derek Hsu, Yan Gu, Konstantinos Meletis, et al. “Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.” Nature 489, no. 7414 (September 6, 2012): 150–54. https://doi.org/10.1038/nature11306.
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  - Lee, Seung-Hee, Alex C. Kwan, Siyu Zhang, Victoria Phoumthipphavong, John G. Flannery, Sotiris C. Masmanidis, Hiroki Taniguchi, et al. “Activation of specific interneurons improves V1 feature selectivity and visual perception.” Nature 488, no. 7411 (August 16, 2012): 379–83. https://doi.org/10.1038/nature11312.
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  - Gentet, Luc J., Yves Kremer, Hiroki Taniguchi, Z Josh Huang, Jochen F. Staiger, and Carl C. H. Petersen. “Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.” Nat Neurosci 15, no. 4 (February 26, 2012): 607–12. https://doi.org/10.1038/nn.3051.
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  - He, M., Y. Liu, X. Wang, M. Q. Zhang, G. J. Hannon, and Z. J. Huang. “Cell-type-based analysis of microRNA profiles in the mouse brain.” Neuron 73, no. 3 (February 9, 2012): 620. https://doi.org/10.1016/j.neuron.2012.01.014.
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  - Eggan, Stephen M., Matthew S. Lazarus, Samuel R. Stoyak, David W. Volk, Jill R. Glausier, Z Josh Huang, and David A. Lewis. “Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia.” Biol Psychiatry 71, no. 2 (January 15, 2012): 114–19. https://doi.org/10.1016/j.biopsych.2011.09.014.
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  - Wu, Xiaoyun, Yu Fu, Graham Knott, Jiangteng Lu, Graziella Di Cristo, and Z Josh Huang. “GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons.” J Neurosci 32, no. 1 (January 4, 2012): 331–43. https://doi.org/10.1523/JNEUROSCI.3189-11.2012.
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  - Fu, Yu, Xiaoyun Wu, Jiangteng Lu, and Z Josh Huang. “Presynaptic GABA(B) Receptor Regulates Activity-Dependent Maturation and Patterning of Inhibitory Synapses through Dynamic Allocation of Synaptic Vesicles.” Front Cell Neurosci 6 (2012): 57. https://doi.org/10.3389/fncel.2012.00057.
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  - Paul, Anirban, Ying Cai, Gurinder S. Atwal, and Z Josh Huang. “Developmental Coordination of Gene Expression between Synaptic Partners During GABAergic Circuit Assembly in Cerebellar Cortex.” Front Neural Circuits 6 (2012): 37. https://doi.org/10.3389/fncir.2012.00037.
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  - Taniguchi, H., M. He, P. Wu, S. Kim, R. Paik, K. Sugino, D. Kvitsiani, et al. “A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.” Neuron 72, no. 6 (December 22, 2011): 1091. https://doi.org/10.1016/j.neuron.2011.12.010.
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  - Mitchell, Kevin J., Z Josh Huang, Bita Moghaddam, and Akira Sawa. “Following the genes: a framework for animal modeling of psychiatric disorders.” Bmc Biol 9 (November 11, 2011): 76. https://doi.org/10.1186/1741-7007-9-76.
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  - Taniguchi, Hiroki, Miao He, Priscilla Wu, Sangyong Kim, Raehum Paik, Ken Sugino, Duda Kvitsiani, et al. “A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.” Neuron 71, no. 6 (September 22, 2011): 995–1013. https://doi.org/10.1016/j.neuron.2011.07.026.
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  - Lazarus, Matthew S., and Z Josh Huang. “Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity.” J Neurophysiol 106, no. 2 (August 2011): 775–87. https://doi.org/10.1152/jn.00729.2010.
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  - Miyamichi, Kazunari, Fernando Amat, Farshid Moussavi, Chen Wang, Ian Wickersham, Nicholas R. Wall, Hiroki Taniguchi, et al. “Cortical representations of olfactory input by trans-synaptic tracing.” Nature 472, no. 7342 (April 14, 2011): 191–96. https://doi.org/10.1038/nature09714.
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  - Fu, Yu, and Z Josh Huang. “Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses.” Proc Natl Acad Sci U S A 107, no. 52 (December 28, 2010): 22699–704. https://doi.org/10.1073/pnas.1011233108.
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  - Ma, Wen-pei, Bao-hua Liu, Ya-tang Li, Z Josh Huang, Li I. Zhang, and Huizhong W. Tao. “Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses.” J Neurosci 30, no. 43 (October 27, 2010): 14371–79. https://doi.org/10.1523/JNEUROSCI.3248-10.2010.
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  - Runyan, Caroline A., James Schummers, Audra Van Wart, Sandra J. Kuhlman, Nathan R. Wilson, Z Josh Huang, and Mriganka Sur. “Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex.” Neuron 67, no. 5 (September 9, 2010): 847–57. https://doi.org/10.1016/j.neuron.2010.08.006.
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  - Kuhlman, Sandra J., Jiangteng Lu, Matthew S. Lazarus, and Z Josh Huang. “Maturation of GABAergic inhibition promotes strengthening of temporally coherent inputs among convergent pathways.” Plos Comput Biol 6, no. 6 (June 3, 2010): e1000797. https://doi.org/10.1371/journal.pcbi.1000797.
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  - Huang, Z Josh. “Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond.” J Physiol 587, no. Pt 9 (May 1, 2009): 1881–88. https://doi.org/10.1113/jphysiol.2008.168211.
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  - Bohland, Jason W., Caizhi Wu, Helen Barbas, Hemant Bokil, Mihail Bota, Hans C. Breiter, Hollis T. Cline, et al. “A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.” Plos Comput Biol 5, no. 3 (March 2009): e1000334. https://doi.org/10.1371/journal.pcbi.1000334.
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  - Huckfeldt, Rachel M., Timm Schubert, Josh L. Morgan, Leanne Godinho, Graziella Di Cristo, Z Josh Huang, and Rachel O. L. Wong. “Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.” Nat Neurosci 12, no. 1 (January 2009): 35–43. https://doi.org/10.1038/nn.2236.
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  - Bartley, Aundrea F., Z Josh Huang, Kimberly M. Huber, and Jay R. Gibson. “Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits.” J Neurophysiol 100, no. 4 (October 2008): 1983–94. https://doi.org/10.1152/jn.90635.2008.
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  - Ango, Fabrice, Caizhi Wu, Johannes J. Van der Want, Priscilla Wu, Melitta Schachner, and Z Josh Huang. “Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.” Plos Biol 6, no. 4 (April 29, 2008): e103. https://doi.org/10.1371/journal.pbio.0060103.
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  - Kuhlman, Sandra J., and Z Josh Huang. “High-resolution labeling and functional manipulation of specific neuron types in mouse brain by Cre-activated viral gene expression.” Plos One 3, no. 4 (April 16, 2008): e2005. https://doi.org/10.1371/journal.pone.0002005.
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  - Tan, Zhenjun, Hang Hu, Z Josh Huang, and Ariel Agmon. “Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons.” Proc Natl Acad Sci U S A 105, no. 6 (February 12, 2008): 2187–92. https://doi.org/10.1073/pnas.0710628105.
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  - Huang, Z Josh, and Peter Scheiffele. “GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development.” Curr Opin Neurobiol 18, no. 1 (February 2008): 77–83. https://doi.org/10.1016/j.conb.2008.05.008.
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  - Di Cristo, Graziella, Bidisha Chattopadhyaya, Sandra J. Kuhlman, Yu Fu, Marie-Claude Bélanger, Cai Zhi Wu, Urs Rutishauser, Lamberto Maffei, and Z Josh Huang. “Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity.” Nat Neurosci 10, no. 12 (December 2007): 1569–77. https://doi.org/10.1038/nn2008.
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  - Huang, Z. J., G. Di Cristo, and F. Ango. “Development of GABA innervation in the cerebral and cerebellar cortices.” Nat Rev Neurosci 8, no. 9 (September 2007): 673–86. https://doi.org/10.1038/nrn2188.
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  - Chattopadhyaya, Bidisha, Graziella Di Cristo, Cai Zhi Wu, Graham Knott, Sandra Kuhlman, Yu Fu, Richard D. Palmiter, and Z Josh Huang. “GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex.” Neuron 54, no. 6 (June 21, 2007): 889–903. https://doi.org/10.1016/j.neuron.2007.05.015.
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  - Dumitriu, Daniella, Rosa Cossart, Josh Huang, and Rafael Yuste. “Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex.” Cereb Cortex 17, no. 1 (January 2007): 81–91. https://doi.org/10.1093/cercor/bhj126.
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  - Castellano, Stefania, Francesca Macchi, Manuela Scali, Josh Z. Huang, and Yuri Bozzi. “Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice.” Brain Res 1108, no. 1 (September 7, 2006): 12–18. https://doi.org/10.1016/j.brainres.2006.06.012.
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  - Huang, Z Josh. “GABAB receptor isoforms caught in action at the scene.” Neuron 50, no. 4 (May 18, 2006): 521–24. https://doi.org/10.1016/j.neuron.2006.05.005.
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  - Huang, Z Josh. “Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules.” Nat Neurosci 9, no. 2 (February 2006): 163–66. https://doi.org/10.1038/nn1638.
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  - Sugino, Ken, Chris M. Hempel, Mark N. Miller, Alexis M. Hattox, Peter Shapiro, Caizi Wu, Z Josh Huang, and Sacha B. Nelson. “Molecular taxonomy of major neuronal classes in the adult mouse forebrain.” Nat Neurosci 9, no. 1 (January 2006): 99–107. https://doi.org/10.1038/nn1618.
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  - Jiang, Bin, Z Josh Huang, Bernardo Morales, and Alfredo Kirkwood. “Maturation of GABAergic transmission and the timing of plasticity in visual cortex.” Brain Res Brain Res Rev 50, no. 1 (December 1, 2005): 126–33. https://doi.org/10.1016/j.brainresrev.2005.05.007.
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  - Goldberg, Ethan M., Shigeo Watanabe, Su Ying Chang, Rolf H. Joho, Z Josh Huang, Christopher S. Leonard, and Bernardo Rudy. “Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse.” J Neurosci 25, no. 21 (May 25, 2005): 5230–35. https://doi.org/10.1523/JNEUROSCI.0722-05.2005.
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  - Pillai-Nair, Neeta, Anitha K. Panicker, Ramona M. Rodriguiz, Kelly L. Gilmore, Galina P. Demyanenko, Josh Z. Huang, William C. Wetsel, and Patricia F. Maness. “Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior.” J Neurosci 25, no. 18 (May 4, 2005): 4659–71. https://doi.org/10.1523/JNEUROSCI.0565-05.2005.
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  - Di Cristo, Graziella, Caizhi Wu, Bidisha Chattopadhyaya, Fabrice Ango, Graham Knott, Egbert Welker, Karel Svoboda, and Z Josh Huang. “Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.” Nat Neurosci 7, no. 11 (November 2004): 1184–86. https://doi.org/10.1038/nn1334.
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  - Chattopadhyaya, Bidisha, Graziella Di Cristo, Hiroyuki Higashiyama, Graham W. Knott, Sandra J. Kuhlman, Egbert Welker, and Z Josh Huang. “Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period.” J Neurosci 24, no. 43 (October 27, 2004): 9598–9611. https://doi.org/10.1523/JNEUROSCI.1851-04.2004.
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  - Ango, Fabrice, Graziella di Cristo, Hiroyuki Higashiyama, Vann Bennett, Priscilla Wu, and Z Josh Huang. “Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.” Cell 119, no. 2 (October 15, 2004): 257–72. https://doi.org/10.1016/j.cell.2004.10.004.
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  - Gianfranceschi, Laura, Rosita Siciliano, Jennifer Walls, Bernardo Morales, Alfredo Kirkwood, Z Josh Huang, Susumu Tonegawa, and Lamberto Maffei. “Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF.” Proc Natl Acad Sci U S A 100, no. 21 (October 14, 2003): 12486–91. https://doi.org/10.1073/pnas.1934836100.
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  - Hanover, J. L., Z. J. Huang, S. Tonegawa, and M. P. Stryker. “Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex.” J Neurosci 19, no. 22 (November 15, 1999): RC40.
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  - Huang, Z. J., A. Kirkwood, T. Pizzorusso, V. Porciatti, B. Morales, M. F. Bear, L. Maffei, and S. Tonegawa. “BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.” Cell 98, no. 6 (September 17, 1999): 739–55. https://doi.org/10.1016/s0092-8674(00)81509-3.
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  - Huang, Z. J., K. D. Curtin, and M. Rosbash. “PER protein interactions and temperature compensation of a circadian clock in Drosophila.” Science 267, no. 5201 (February 24, 1995): 1169–72. https://doi.org/10.1126/science.7855598.
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  - Curtin, K. D., Z. J. Huang, and M. Rosbash. “Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock.” Neuron 14, no. 2 (February 1995): 365–72. https://doi.org/10.1016/0896-6273(95)90292-9.
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  - Huang, Z. J., I. Edery, and M. Rosbash. “PAS is a dimerization domain common to Drosophila period and several transcription factors.” Nature 364, no. 6434 (July 15, 1993): 259–62. https://doi.org/10.1038/364259a0.
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  - Liu, X., Q. A. Yu, Z. S. Huang, L. J. Zwiebel, J. C. Hall, and M. Rosbash. “The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression.” Neuron 6, no. 5 (May 1991): 753–66. https://doi.org/10.1016/0896-6273(91)90172-v.
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  - Huang, Z., and R. A. Satterlie. “Neuronal mechanisms underlying behavioral switching in a pteropod mollusc.” Journal of Comparative Physiology A 166, no. 6 (April 1, 1990): 875–87. https://doi.org/10.1007/BF00187335.
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  - Huang, Z., and R. A. Satterlie. “Smooth muscle fiber types and a novel pattern of thick filaments in the wing of the pteropod mollusc Clione limacina.” Cell and Tissue Research 257, no. 2 (January 1, 1989): 405–14. https://doi.org/10.1007/BF00261843.
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  - Lau, Billy Y. B., Keerthi Krishnan, Z Josh Huang, and Stephen D. Shea. “Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires MECP2,” n.d. https://doi.org/10.1101/655035.
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Teaching & Mentoring
Recent Courses
- NEUROBIO 393: Research Independent Study 2021
- NEUROBIO 793: Research in Neurobiology 2021

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Education, Training, & Certifications

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