Josh Huang | Scholars@Duke

Josh Huang
Duke School of Medicine Distinguished Professor in Neuroscience

We study the development and function of cortical circuits underlying motor control and cognitive processing. Our research program integrates multi-faceted approaches from genetic engineering to single-cell genomics, developmental neurobiology, imaging, electrophysiology, and behavioral analyses, and aims to link fundamental neuroscience to the understanding and treatment of neuropsychiatric disorders.

Current Appointments & Affiliations

Duke School of Medicine Distinguished Professor in Neuroscience, Neurobiology, Basic Science Departments 2022
Professor of Neurobiology, Neurobiology, Basic Science Departments 2021
Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2021

Contact Information

311 Research Drive, Box 3209, Durham, NC 27710
311 Research Drive, Box 3209, Durham, NC 27710
josh.huang@duke.edu (919) 613-1573
Huang Lab

Background
Education, Training, & Certifications
- Ph.D., Brandeis University 1995
Previous Appointments & Affiliations
- Instructor in the Department of Neurobiology, Neurobiology, Basic Science Departments 2020 - 2021
Recognition
In the News
- MAY 18, 2022
  
  University Awards 24 New Distinguished Professorships
- APR 28, 2022
  
  Four Faculty Elected to American Academy of Arts & Sciences
- OCT 6, 2021
  
  Duke Neuroscientist Co-Leads Massive Effort to Map Brain
Awards & Honors
- Elected Member. American Academy of Arts & Sciences. 2022
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- RNA-programmable cell-type targeting, editing, and therapy awarded by National Institutes of Health 2021 - 2026
- RNA-programmable cell type targeting and manipulation across vertebrate nervous systems awarded by National Institutes of Health 2021 - 2024
- Neurobiology Training Program awarded by National Institutes of Health 2019 - 2024
- Discovering the molecular genetic principles of cell type organization through neurobiology-guided computational analysis of single cell multi-omics data sets awarded by National Institutes of Health 2021 - 2024
- Large scale discovery and validation of brain cell type enhancers for viral targeting and circuit manipulation awarded by National Institutes of Health 2020 - 2023
- Activity dependent integration of chandelier cells during cortical circuit assembly awarded by National Institutes of Health 2021 - 2023
- Transcriptome-based systematic discovery of GABAergic neurons in the neocortex awarded by National Institutes of Health 2020 - 2022
- A Comprehensive Center for Mouse Brain Cell Atlas - Project 2: Anatomy awarded by Cold Spring Harbor Laboratory 2021 - 2022
- A Comprehensive Center for Mouse Brain Cell Atlas P1: Molecular Signatures awarded by Cold Spring Harbor Laboratory 2021 - 2022
- A Comprehensive Center for Mouse Brain Cell Atlas P3: Cell Specific Targeting Approaches and Tools awarded by Cold Spring Harbor Laboratory 2021 - 2022
- Revealing the transcriptomic basis of neuronal identity through functional meta-analysis awarded by Cold Spring Harbor Laboratory 2020 - 2021
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Deng, Hanfei, Xiong Xiao, Tao Yang, Kimberly Ritola, Adam Hantman, Yulong Li, Z Josh Huang, and Bo Li. “A genetically defined insula-brainstem circuit selectively controls motivational vigor.” Cell 184, no. 26 (December 22, 2021): 6344-6360.e18. https://doi.org/10.1016/j.cell.2021.11.019.
    Full Text Link to Item
  - Dudok, Barna, Miklos Szoboszlay, Anirban Paul, Peter M. Klein, Zhenrui Liao, Ernie Hwaun, Gergely G. Szabo, et al. “Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.” Neuron 109, no. 23 (December 1, 2021): 3838-3850.e8. https://doi.org/10.1016/j.neuron.2021.09.033.
    Full Text Link to Item
  - BRAIN Initiative Cell Census Network (BICCN), Bryce B. “A multimodal cell census and atlas of the mammalian primary motor cortex.” Nature 598, no. 7879 (October 2021): 86–102. https://doi.org/10.1038/s41586-021-03950-0.
    Full Text Link to Item
  - Matho, Katherine S., Dhananjay Huilgol, William Galbavy, Miao He, Gukhan Kim, Xu An, Jiangteng Lu, et al. “Genetic dissection of the glutamatergic neuron system in cerebral cortex.” Nature 598, no. 7879 (October 2021): 182–87. https://doi.org/10.1038/s41586-021-03955-9.
    Full Text Link to Item
  - Peng, Hanchuan, Peng Xie, Lijuan Liu, Xiuli Kuang, Yimin Wang, Lei Qu, Hui Gong, et al. “Morphological diversity of single neurons in molecularly defined cell types.” Nature 598, no. 7879 (October 2021): 174–81. https://doi.org/10.1038/s41586-021-03941-1.
    Full Text Link to Item
  - Yao, Zizhen, Hanqing Liu, Fangming Xie, Stephan Fischer, Ricky S. Adkins, Andrew I. Aldridge, Seth A. Ament, et al. “A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex.” Nature 598, no. 7879 (October 2021): 103–10. https://doi.org/10.1038/s41586-021-03500-8.
    Full Text Link to Item
  - Wang, Bor-Shuen, Maria Sol Bernardez Sarria, Xu An, Miao He, Nazia M. Alam, Glen T. Prusky, Michael C. Crair, and Z Josh Huang. “Retinal and Callosal Activity-Dependent Chandelier Cell Elimination Shapes Binocularity in Primary Visual Cortex.” Neuron 109, no. 3 (February 3, 2021): 502-515.e7. https://doi.org/10.1016/j.neuron.2020.11.004.
    Full Text Link to Item
  - Mohan, Hemanth, Xu An, Hermione Xu, Hideki Kondo, Shengli Zhao, Katherine Matho, Simon Musall, Partha Mitra, and Josh Huang. “Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks,” 2021. https://doi.org/10.1101/2021.12.30.474537.
    Full Text
  - Xiao, Xiong, Hanfei Deng, Alessandro Furlan, Tao Yang, Xian Zhang, Ga-Ram Hwang, Jason Tucciarone, et al. “A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement.” Cell 183, no. 1 (October 1, 2020): 211-227.e20. https://doi.org/10.1016/j.cell.2020.08.032.
    Full Text Link to Item
  - BRAIN Initiative Cell Census Network (BICCN), Hong-Wei, Ricky Adkins, Andrew Aldridge, Shona Allen, Seth Ament, Xu An, Ethan Armand, et al. “A multimodal cell census and atlas of the mammalian primary motor cortex,” 2020. https://doi.org/10.1101/2020.10.19.343129.
    Full Text
  - Matho, Katherine, Dhananjay Huilgol, William Galbavy, Miao He, Gukhan Kim, Xu An, Jiangteng Lu, et al. “Genetic dissection of glutamatergic neuron subpopulations and developmental trajectories in the cerebral cortex,” 2020. https://doi.org/10.1101/2020.04.22.054064.
    Full Text
  - Muñoz-Castañeda, Rodrigo, Brian Zingg, Katherine Matho, Quanxin Wang, Xiaoyin Chen, Nicholas Foster, Arun Narasimhan, et al. “Cellular Anatomy of the Mouse Primary Motor Cortex,” 2020. https://doi.org/10.1101/2020.10.02.323154.
    Full Text
  - Chen, Xiaoyin, Yu-Chi Sun, Huiqing Zhan, Justus M. Kebschull, Stephan Fischer, Katherine Matho, Z Josh Huang, Jesse Gillis, and Anthony M. Zador. “High-Throughput Mapping of Long-Range Neuronal Projection Using In Situ Sequencing.” Cell 179, no. 3 (October 17, 2019): 772-786.e19. https://doi.org/10.1016/j.cell.2019.09.023.
    Full Text Link to Item
  - Huang, Z Josh, and Anirban Paul. “The diversity of GABAergic neurons and neural communication elements.” Nat Rev Neurosci 20, no. 9 (September 2019): 563–72. https://doi.org/10.1038/s41583-019-0195-4.
    Full Text Link to Item
  - Wang, Xiaojun, Jason Tucciarone, Siqi Jiang, Fangfang Yin, Bor-Shuen Wang, Dingkang Wang, Yao Jia, et al. “Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells.” Cell Rep 26, no. 11 (March 12, 2019): 3145-3159.e5. https://doi.org/10.1016/j.celrep.2019.02.040.
    Full Text Link to Item
  - Lau, Billy, Keerthi Krishnan, Josh Huang, and Stephen Shea. “Maternal experience-dependent cortical plasticity in mice is circuit- and stimulus-specific and requires MECP2,” 2019. https://doi.org/10.1101/655035.
    Full Text
  - Vogt, Daniel, Kathleen K. A. Cho, Samantha M. Shelton, Anirban Paul, Z Josh Huang, Vikaas S. Sohal, and John L. R. Rubenstein. “Mouse Cntnap2 and Human CNTNAP2 ASD Alleles Cell Autonomously Regulate PV+ Cortical Interneurons.” Cereb Cortex 28, no. 11 (November 1, 2018): 3868–79. https://doi.org/10.1093/cercor/bhx248.
    Full Text Link to Item
  - Paul, Anirban, and Z Josh Huang. “Single-cell RNA Sequencing of Fluorescently Labeled Mouse Neurons Using Manual Sorting and Double In Vitro Transcription with Absolute Counts Sequencing (DIVA-Seq).” J Vis Exp, no. 140 (October 26, 2018). https://doi.org/10.3791/58690.
    Full Text Link to Item
  - Kelly, Sean M., Ricardo Raudales, Miao He, Jannifer H. Lee, Yongsoo Kim, Leif G. Gibb, Priscilla Wu, et al. “Radial Glial Lineage Progression and Differential Intermediate Progenitor Amplification Underlie Striatal Compartments and Circuit Organization.” Neuron 99, no. 2 (July 25, 2018): 345-361.e4. https://doi.org/10.1016/j.neuron.2018.06.021.
    Full Text Link to Item
  - He, Miao, and Z Josh Huang. “Genetic approaches to access cell types in mammalian nervous systems.” Curr Opin Neurobiol 50 (June 2018): 109–18. https://doi.org/10.1016/j.conb.2018.02.003.
    Full Text Link to Item
  - Crow, Megan, Anirban Paul, Sara Ballouz, Z Josh Huang, and Jesse Gillis. “Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor.” Nat Commun 9, no. 1 (February 28, 2018): 884. https://doi.org/10.1038/s41467-018-03282-0.
    Full Text Link to Item
  - Lu, Jiangteng, Jason Tucciarone, Nancy Padilla-Coreano, Miao He, Joshua A. Gordon, and Z Josh Huang. “Selective inhibitory control of pyramidal neuron ensembles and cortical subnetworks by chandelier cells.” Nat Neurosci 20, no. 10 (October 2017): 1377–83. https://doi.org/10.1038/nn.4624.
    Full Text Link to Item
  - Fenno, Lief E., Joanna Mattis, Charu Ramakrishnan, Minsuk Hyun, Soo Yeun Lee, Miao He, Jason Tucciarone, et al. “Targeting cells with single vectors using multiple-feature Boolean logic.” Nat Methods 11, no. 7 (July 2014): 763–72. https://doi.org/10.1038/nmeth.2996.
    Full Text Link to Item
  - Fink, Andrew J. P., Katherine R. Croce, Z Josh Huang, L. F. Abbott, Thomas M. Jessell, and Eiman Azim. “Presynaptic inhibition of spinal sensory feedback ensures smooth movement.” Nature 509, no. 7498 (May 1, 2014): 43–48. https://doi.org/10.1038/nature13276.
    Full Text Link to Item
  - Fu, Yu, Jason M. Tucciarone, J Sebastian Espinosa, Nengyin Sheng, Daniel P. Darcy, Roger A. Nicoll, Z Josh Huang, and Michael P. Stryker. “A cortical circuit for gain control by behavioral state.” Cell 156, no. 6 (March 13, 2014): 1139–52. https://doi.org/10.1016/j.cell.2014.01.050.
    Full Text Link to Item
  - Huang, Z Josh, Hiroki Taniguchi, Miao He, and Sandra Kuhlman. “Genetic labeling of neurons in mouse brain.” Cold Spring Harb Protoc 2014, no. 2 (February 1, 2014): 150–60. https://doi.org/10.1101/pdb.top080374.
    Full Text Link to Item
  - Huang, Z Josh, Hiroki Taniguchi, Miao He, and Sandra Kuhlman. “Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain.” Cold Spring Harb Protoc 2014, no. 2 (February 1, 2014): 190–94. https://doi.org/10.1101/pdb.prot080382.
    Full Text Link to Item
  - Pi, Hyun-Jae, Balázs Hangya, Duda Kvitsiani, Joshua I. Sanders, Z Josh Huang, and Adam Kepecs. “Cortical interneurons that specialize in disinhibitory control.” Nature 503, no. 7477 (November 28, 2013): 521–24. https://doi.org/10.1038/nature12676.
    Full Text Link to Item
  - Lee, Soohyun, Illya Kruglikov, Z Josh Huang, Gord Fishell, and Bernardo Rudy. “A disinhibitory circuit mediates motor integration in the somatosensory cortex.” Nat Neurosci 16, no. 11 (November 2013): 1662–70. https://doi.org/10.1038/nn.3544.
    Full Text Link to Item
  - Basu, Jayeeta, Kalyan V. Srinivas, Stephanie K. Cheung, Hiroki Taniguchi, Z Josh Huang, and Steven A. Siegelbaum. “A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.” Neuron 79, no. 6 (September 18, 2013): 1208–21. https://doi.org/10.1016/j.neuron.2013.07.001.
    Full Text Link to Item
  - Ciceri, Gabriele, Nathalie Dehorter, Ignasi Sols, Z Josh Huang, Miguel Maravall, and Oscar Marín. “Lineage-specific laminar organization of cortical GABAergic interneurons.” Nat Neurosci 16, no. 9 (September 2013): 1199–1210. https://doi.org/10.1038/nn.3485.
    Full Text Link to Item
  - Pfeffer, Carsten K., Mingshan Xue, Miao He, Z Josh Huang, and Massimo Scanziani. “Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons.” Nat Neurosci 16, no. 8 (August 2013): 1068–76. https://doi.org/10.1038/nn.3446.
    Full Text Link to Item
  - Huang, Z Josh, and Hongkui Zeng. “Genetic approaches to neural circuits in the mouse.” Annu Rev Neurosci 36 (July 8, 2013): 183–215. https://doi.org/10.1146/annurev-neuro-062012-170307.
    Full Text Link to Item
  - Nienborg, Hendrikje, Andrea Hasenstaub, Ian Nauhaus, Hiroki Taniguchi, Z Josh Huang, and Edward M. Callaway. “Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1.” J Neurosci 33, no. 27 (July 3, 2013): 11145–54. https://doi.org/10.1523/JNEUROSCI.5320-12.2013.
    Full Text Link to Item
  - Kvitsiani, D., S. Ranade, B. Hangya, H. Taniguchi, J. Z. Huang, and A. Kepecs. “Distinct behavioural and network correlates of two interneuron types in prefrontal cortex.” Nature 498, no. 7454 (June 20, 2013): 363–66. https://doi.org/10.1038/nature12176.
    Full Text Link to Item
  - Cioni, Jean-Michel, Ludovic Telley, Véronique Saywell, Christelle Cadilhac, Carole Jourdan, Andrea B. Huber, Josh Z. Huang, Céline Jahannault-Talignani, and Fabrice Ango. “SEMA3A signaling controls layer-specific interneuron branching in the cerebellum.” Curr Biol 23, no. 10 (May 20, 2013): 850–61. https://doi.org/10.1016/j.cub.2013.04.007.
    Full Text Link to Item
  - Chattopadhyaya, Bidisha, Elie Baho, Z Josh Huang, Melitta Schachner, and Graziella Di Cristo. “Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex.” J Neurosci 33, no. 14 (April 3, 2013): 5957–68. https://doi.org/10.1523/JNEUROSCI.1306-12.2013.
    Full Text Link to Item
  - DeFelipe, Javier, Pedro L. López-Cruz, Ruth Benavides-Piccione, Concha Bielza, Pedro Larrañaga, Stewart Anderson, Andreas Burkhalter, et al. “New insights into the classification and nomenclature of cortical GABAergic interneurons.” Nat Rev Neurosci 14, no. 3 (March 2013): 202–16. https://doi.org/10.1038/nrn3444.
    Full Text Link to Item
  - Li, Haohong, Mario A. Penzo, Hiroki Taniguchi, Charles D. Kopec, Z Josh Huang, and Bo Li. “Experience-dependent modification of a central amygdala fear circuit.” Nat Neurosci 16, no. 3 (March 2013): 332–39. https://doi.org/10.1038/nn.3322.
    Full Text Link to Item
  - Curley, Allison A., Stephen M. Eggan, Matt S. Lazarus, Z Josh Huang, David W. Volk, and David A. Lewis. “Role of glutamic acid decarboxylase 67 in regulating cortical parvalbumin and GABA membrane transporter 1 expression: implications for schizophrenia.” Neurobiol Dis 50 (February 2013): 179–86. https://doi.org/10.1016/j.nbd.2012.10.018.
    Full Text Link to Item
  - Taniguchi, Hiroki, Jiangteng Lu, and Z Josh Huang. “The spatial and temporal origin of chandelier cells in mouse neocortex.” Science 339, no. 6115 (January 4, 2013): 70–74. https://doi.org/10.1126/science.1227622.
    Full Text Link to Item
  - Adesnik, Hillel, William Bruns, Hiroki Taniguchi, Z Josh Huang, and Massimo Scanziani. “A neural circuit for spatial summation in visual cortex.” Nature 490, no. 7419 (October 11, 2012): 226–31. https://doi.org/10.1038/nature11526.
    Full Text Link to Item
  - He, M., Y. Liu, X. Wang, M. Q. Zhang, G. J. Hannon, and Z. J. Huang. “Cell-Type-Based Analysis of MicroRNA Profiles in the Mouse Brain.” Neuron 75, no. 5 (September 6, 2012): 930–32. https://doi.org/10.1016/j.neuron.2012.08.018.
    Full Text
  - Song, Juan, Chun Zhong, Michael A. Bonaguidi, Gerald J. Sun, Derek Hsu, Yan Gu, Konstantinos Meletis, et al. “Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision.” Nature 489, no. 7414 (September 6, 2012): 150–54. https://doi.org/10.1038/nature11306.
    Full Text Link to Item
  - Lee, Seung-Hee, Alex C. Kwan, Siyu Zhang, Victoria Phoumthipphavong, John G. Flannery, Sotiris C. Masmanidis, Hiroki Taniguchi, et al. “Activation of specific interneurons improves V1 feature selectivity and visual perception.” Nature 488, no. 7411 (August 16, 2012): 379–83. https://doi.org/10.1038/nature11312.
    Full Text Link to Item
  - Gentet, Luc J., Yves Kremer, Hiroki Taniguchi, Z Josh Huang, Jochen F. Staiger, and Carl C. H. Petersen. “Unique functional properties of somatostatin-expressing GABAergic neurons in mouse barrel cortex.” Nat Neurosci 15, no. 4 (February 26, 2012): 607–12. https://doi.org/10.1038/nn.3051.
    Full Text Link to Item
  - He, M., Y. Liu, X. Wang, M. Q. Zhang, G. J. Hannon, and Z. J. Huang. “Cell-type-based analysis of microRNA profiles in the mouse brain.” Neuron 73, no. 3 (February 9, 2012): 620. https://doi.org/10.1016/j.neuron.2012.01.014.
    Full Text
  - Eggan, Stephen M., Matthew S. Lazarus, Samuel R. Stoyak, David W. Volk, Jill R. Glausier, Z Josh Huang, and David A. Lewis. “Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia.” Biol Psychiatry 71, no. 2 (January 15, 2012): 114–19. https://doi.org/10.1016/j.biopsych.2011.09.014.
    Full Text Link to Item
  - Wu, Xiaoyun, Yu Fu, Graham Knott, Jiangteng Lu, Graziella Di Cristo, and Z Josh Huang. “GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons.” J Neurosci 32, no. 1 (January 4, 2012): 331–43. https://doi.org/10.1523/JNEUROSCI.3189-11.2012.
    Full Text Link to Item
  - Fu, Yu, Xiaoyun Wu, Jiangteng Lu, and Z Josh Huang. “Presynaptic GABA(B) Receptor Regulates Activity-Dependent Maturation and Patterning of Inhibitory Synapses through Dynamic Allocation of Synaptic Vesicles.” Front Cell Neurosci 6 (2012): 57. https://doi.org/10.3389/fncel.2012.00057.
    Full Text Link to Item
  - Paul, Anirban, Ying Cai, Gurinder S. Atwal, and Z Josh Huang. “Developmental Coordination of Gene Expression between Synaptic Partners During GABAergic Circuit Assembly in Cerebellar Cortex.” Front Neural Circuits 6 (2012): 37. https://doi.org/10.3389/fncir.2012.00037.
    Full Text Link to Item
  - Taniguchi, H., M. He, P. Wu, S. Kim, R. Paik, K. Sugino, D. Kvitsiani, et al. “A resource of cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.” Neuron 72, no. 6 (December 22, 2011): 1091. https://doi.org/10.1016/j.neuron.2011.12.010.
    Full Text
  - Mitchell, Kevin J., Z Josh Huang, Bita Moghaddam, and Akira Sawa. “Following the genes: a framework for animal modeling of psychiatric disorders.” Bmc Biol 9 (November 11, 2011): 76. https://doi.org/10.1186/1741-7007-9-76.
    Full Text Link to Item
  - Taniguchi, Hiroki, Miao He, Priscilla Wu, Sangyong Kim, Raehum Paik, Ken Sugino, Duda Kvitsiani, et al. “A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex.” Neuron 71, no. 6 (September 22, 2011): 995–1013. https://doi.org/10.1016/j.neuron.2011.07.026.
    Full Text Link to Item
  - Lazarus, Matthew S., and Z Josh Huang. “Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity.” J Neurophysiol 106, no. 2 (August 2011): 775–87. https://doi.org/10.1152/jn.00729.2010.
    Full Text Link to Item
  - Miyamichi, Kazunari, Fernando Amat, Farshid Moussavi, Chen Wang, Ian Wickersham, Nicholas R. Wall, Hiroki Taniguchi, et al. “Cortical representations of olfactory input by trans-synaptic tracing.” Nature 472, no. 7342 (April 14, 2011): 191–96. https://doi.org/10.1038/nature09714.
    Full Text Link to Item
  - Fu, Yu, and Z Josh Huang. “Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses.” Proc Natl Acad Sci U S A 107, no. 52 (December 28, 2010): 22699–704. https://doi.org/10.1073/pnas.1011233108.
    Full Text Link to Item
  - Ma, Wen-pei, Bao-hua Liu, Ya-tang Li, Z Josh Huang, Li I. Zhang, and Huizhong W. Tao. “Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses.” J Neurosci 30, no. 43 (October 27, 2010): 14371–79. https://doi.org/10.1523/JNEUROSCI.3248-10.2010.
    Full Text Link to Item
  - Runyan, Caroline A., James Schummers, Audra Van Wart, Sandra J. Kuhlman, Nathan R. Wilson, Z Josh Huang, and Mriganka Sur. “Response features of parvalbumin-expressing interneurons suggest precise roles for subtypes of inhibition in visual cortex.” Neuron 67, no. 5 (September 9, 2010): 847–57. https://doi.org/10.1016/j.neuron.2010.08.006.
    Full Text Link to Item
  - Kuhlman, Sandra J., Jiangteng Lu, Matthew S. Lazarus, and Z Josh Huang. “Maturation of GABAergic inhibition promotes strengthening of temporally coherent inputs among convergent pathways.” Plos Comput Biol 6, no. 6 (June 3, 2010): e1000797. https://doi.org/10.1371/journal.pcbi.1000797.
    Full Text Link to Item
  - Huang, Z Josh. “Activity-dependent development of inhibitory synapses and innervation pattern: role of GABA signalling and beyond.” J Physiol 587, no. Pt 9 (May 1, 2009): 1881–88. https://doi.org/10.1113/jphysiol.2008.168211.
    Full Text Link to Item
  - Bohland, Jason W., Caizhi Wu, Helen Barbas, Hemant Bokil, Mihail Bota, Hans C. Breiter, Hollis T. Cline, et al. “A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale.” Plos Comput Biol 5, no. 3 (March 2009): e1000334. https://doi.org/10.1371/journal.pcbi.1000334.
    Full Text Link to Item
  - Huckfeldt, Rachel M., Timm Schubert, Josh L. Morgan, Leanne Godinho, Graziella Di Cristo, Z Josh Huang, and Rachel O. L. Wong. “Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.” Nat Neurosci 12, no. 1 (January 2009): 35–43. https://doi.org/10.1038/nn.2236.
    Full Text Link to Item
  - Bartley, Aundrea F., Z Josh Huang, Kimberly M. Huber, and Jay R. Gibson. “Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits.” J Neurophysiol 100, no. 4 (October 2008): 1983–94. https://doi.org/10.1152/jn.90635.2008.
    Full Text Link to Item
  - Ango, Fabrice, Caizhi Wu, Johannes J. Van der Want, Priscilla Wu, Melitta Schachner, and Z Josh Huang. “Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites.” Plos Biol 6, no. 4 (April 29, 2008): e103. https://doi.org/10.1371/journal.pbio.0060103.
    Full Text Link to Item
  - Kuhlman, Sandra J., and Z Josh Huang. “High-resolution labeling and functional manipulation of specific neuron types in mouse brain by Cre-activated viral gene expression.” Plos One 3, no. 4 (April 16, 2008): e2005. https://doi.org/10.1371/journal.pone.0002005.
    Full Text Link to Item
  - Tan, Zhenjun, Hang Hu, Z Josh Huang, and Ariel Agmon. “Robust but delayed thalamocortical activation of dendritic-targeting inhibitory interneurons.” Proc Natl Acad Sci U S A 105, no. 6 (February 12, 2008): 2187–92. https://doi.org/10.1073/pnas.0710628105.
    Full Text Link to Item
  - Huang, Z Josh, and Peter Scheiffele. “GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development.” Curr Opin Neurobiol 18, no. 1 (February 2008): 77–83. https://doi.org/10.1016/j.conb.2008.05.008.
    Full Text Link to Item
  - Di Cristo, Graziella, Bidisha Chattopadhyaya, Sandra J. Kuhlman, Yu Fu, Marie-Claude Bélanger, Cai Zhi Wu, Urs Rutishauser, Lamberto Maffei, and Z Josh Huang. “Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity.” Nat Neurosci 10, no. 12 (December 2007): 1569–77. https://doi.org/10.1038/nn2008.
    Full Text Link to Item
  - Huang, Z. J., G. Di Cristo, and F. Ango. “Development of GABA innervation in the cerebral and cerebellar cortices.” Nat Rev Neurosci 8, no. 9 (September 2007): 673–86. https://doi.org/10.1038/nrn2188.
    Full Text Link to Item
  - Chattopadhyaya, Bidisha, Graziella Di Cristo, Cai Zhi Wu, Graham Knott, Sandra Kuhlman, Yu Fu, Richard D. Palmiter, and Z Josh Huang. “GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex.” Neuron 54, no. 6 (June 21, 2007): 889–903. https://doi.org/10.1016/j.neuron.2007.05.015.
    Full Text Link to Item
  - Dumitriu, Daniella, Rosa Cossart, Josh Huang, and Rafael Yuste. “Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex.” Cereb Cortex 17, no. 1 (January 2007): 81–91. https://doi.org/10.1093/cercor/bhj126.
    Full Text Link to Item
  - Castellano, Stefania, Francesca Macchi, Manuela Scali, Josh Z. Huang, and Yuri Bozzi. “Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice.” Brain Res 1108, no. 1 (September 7, 2006): 12–18. https://doi.org/10.1016/j.brainres.2006.06.012.
    Full Text Link to Item
  - Huang, Z Josh. “GABAB receptor isoforms caught in action at the scene.” Neuron 50, no. 4 (May 18, 2006): 521–24. https://doi.org/10.1016/j.neuron.2006.05.005.
    Full Text Link to Item
  - Huang, Z Josh. “Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules.” Nat Neurosci 9, no. 2 (February 2006): 163–66. https://doi.org/10.1038/nn1638.
    Full Text Link to Item
  - Sugino, Ken, Chris M. Hempel, Mark N. Miller, Alexis M. Hattox, Peter Shapiro, Caizi Wu, Z Josh Huang, and Sacha B. Nelson. “Molecular taxonomy of major neuronal classes in the adult mouse forebrain.” Nat Neurosci 9, no. 1 (January 2006): 99–107. https://doi.org/10.1038/nn1618.
    Full Text Link to Item
  - Jiang, Bin, Z Josh Huang, Bernardo Morales, and Alfredo Kirkwood. “Maturation of GABAergic transmission and the timing of plasticity in visual cortex.” Brain Res Brain Res Rev 50, no. 1 (December 1, 2005): 126–33. https://doi.org/10.1016/j.brainresrev.2005.05.007.
    Full Text Link to Item
  - Goldberg, Ethan M., Shigeo Watanabe, Su Ying Chang, Rolf H. Joho, Z Josh Huang, Christopher S. Leonard, and Bernardo Rudy. “Specific functions of synaptically localized potassium channels in synaptic transmission at the neocortical GABAergic fast-spiking cell synapse.” J Neurosci 25, no. 21 (May 25, 2005): 5230–35. https://doi.org/10.1523/JNEUROSCI.0722-05.2005.
    Full Text Link to Item
  - Pillai-Nair, Neeta, Anitha K. Panicker, Ramona M. Rodriguiz, Kelly L. Gilmore, Galina P. Demyanenko, Josh Z. Huang, William C. Wetsel, and Patricia F. Maness. “Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in behavior.” J Neurosci 25, no. 18 (May 4, 2005): 4659–71. https://doi.org/10.1523/JNEUROSCI.0565-05.2005.
    Full Text Link to Item
  - Di Cristo, Graziella, Caizhi Wu, Bidisha Chattopadhyaya, Fabrice Ango, Graham Knott, Egbert Welker, Karel Svoboda, and Z Josh Huang. “Subcellular domain-restricted GABAergic innervation in primary visual cortex in the absence of sensory and thalamic inputs.” Nat Neurosci 7, no. 11 (November 2004): 1184–86. https://doi.org/10.1038/nn1334.
    Full Text Link to Item
  - Chattopadhyaya, Bidisha, Graziella Di Cristo, Hiroyuki Higashiyama, Graham W. Knott, Sandra J. Kuhlman, Egbert Welker, and Z Josh Huang. “Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period.” J Neurosci 24, no. 43 (October 27, 2004): 9598–9611. https://doi.org/10.1523/JNEUROSCI.1851-04.2004.
    Full Text Link to Item
  - Ango, Fabrice, Graziella di Cristo, Hiroyuki Higashiyama, Vann Bennett, Priscilla Wu, and Z Josh Huang. “Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment.” Cell 119, no. 2 (October 15, 2004): 257–72. https://doi.org/10.1016/j.cell.2004.10.004.
    Full Text Link to Item
  - Gianfranceschi, Laura, Rosita Siciliano, Jennifer Walls, Bernardo Morales, Alfredo Kirkwood, Z Josh Huang, Susumu Tonegawa, and Lamberto Maffei. “Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF.” Proc Natl Acad Sci U S A 100, no. 21 (October 14, 2003): 12486–91. https://doi.org/10.1073/pnas.1934836100.
    Full Text Link to Item
  - Hanover, J. L., Z. J. Huang, S. Tonegawa, and M. P. Stryker. “Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex.” J Neurosci 19, no. 22 (November 15, 1999): RC40.
    Link to Item
  - Huang, Z. J., A. Kirkwood, T. Pizzorusso, V. Porciatti, B. Morales, M. F. Bear, L. Maffei, and S. Tonegawa. “BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex.” Cell 98, no. 6 (September 17, 1999): 739–55. https://doi.org/10.1016/s0092-8674(00)81509-3.
    Full Text Link to Item
  - Huang, Z. J., K. D. Curtin, and M. Rosbash. “PER protein interactions and temperature compensation of a circadian clock in Drosophila.” Science 267, no. 5201 (February 24, 1995): 1169–72. https://doi.org/10.1126/science.7855598.
    Full Text Link to Item
  - Curtin, K. D., Z. J. Huang, and M. Rosbash. “Temporally regulated nuclear entry of the Drosophila period protein contributes to the circadian clock.” Neuron 14, no. 2 (February 1995): 365–72. https://doi.org/10.1016/0896-6273(95)90292-9.
    Full Text Link to Item
  - Huang, Z. J., I. Edery, and M. Rosbash. “PAS is a dimerization domain common to Drosophila period and several transcription factors.” Nature 364, no. 6434 (July 15, 1993): 259–62. https://doi.org/10.1038/364259a0.
    Full Text Link to Item
  - Liu, X., Q. A. Yu, Z. S. Huang, L. J. Zwiebel, J. C. Hall, and M. Rosbash. “The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression.” Neuron 6, no. 5 (May 1991): 753–66. https://doi.org/10.1016/0896-6273(91)90172-v.
    Full Text Link to Item
  - Huang, Z., and R. A. Satterlie. “Neuronal mechanisms underlying behavioral switching in a pteropod mollusc.” Journal of Comparative Physiology A 166, no. 6 (April 1, 1990): 875–87. https://doi.org/10.1007/BF00187335.
    Full Text
  - Huang, Z., and R. A. Satterlie. “Smooth muscle fiber types and a novel pattern of thick filaments in the wing of the pteropod mollusc Clione limacina.” Cell and Tissue Research 257, no. 2 (January 1, 1989): 405–14. https://doi.org/10.1007/BF00261843.
    Full Text
- Preprints
  - Huilgol, Dhananjay, Jesse Levine, William Galbavy, Bor-Shuen Wang, Miao He, Shreyas Suryanarayana, and Josh Huang. “Direct and indirect neurogenesis generate a mosaic of distinct glutamatergic projection neuron types and cortical subnetworks.” BioRxiv, 2022. https://doi.org/10.1101/2022.03.13.484161.
    Full Text
  - Mohan, Hemanth, Xu An, Hideki Kondo, Shengli Zhao, Katherine Matho, Simon Musall, Partha Mitra, and Josh Huang. “Cortical glutamatergic projection neuron types contribute to distinct functional subnetworks.” Research Square, 2022. https://doi.org/10.21203/rs.3.rs-1337382/v1.
    Full Text
  - Yao, Zizhen, Hanqing Liu, Fangming Xie, Stephan Fischer, A Sina Booeshaghi, Ricky S. Adkins, Andrew I. Aldridge, et al. “An integrated transcriptomic and epigenomic atlas of mouse primary motor cortex cell types.” Cold Spring Harbor Laboratory, March 2, 2020. https://doi.org/10.1101/2020.02.29.970558.
    Full Text
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Awards & Honors

Selected Grants

Selected Publications

Academic Articles

Preprints

Recent Courses