Overview
We study the development and function of cortical circuits underlying motor control and cognitive processing. Our research program integrates multi-faceted approaches from genetic engineering to single-cell genomics, developmental neurobiology, imaging, electrophysiology, and behavioral analyses, and aims to link fundamental neuroscience to the understanding and treatment of neuropsychiatric disorders.
Current Appointments & Affiliations
Duke School of Medicine Distinguished Professor in Neuroscience
·
2022 - Present
Neurobiology,
Basic Science Departments
Professor of Neurobiology
·
2021 - Present
Neurobiology,
Basic Science Departments
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor of Cell Biology
·
2022 - Present
Cell Biology,
Basic Science Departments
Recent Publications
A cortical circuit for orchestrating oromanual food manipulation.
Preprint · May 20, 2025 Full text Link to item CiteOrderly specification and precise laminar deployment of mouse cortical projection neuron types through intermediate progenitors.
Journal Article Dev Cell · March 7, 2025 The cerebral cortex comprises diverse types of glutamatergic projection neurons (PNs) generated from radial glial progenitors (RGs) through either direct neurogenesis (dNG) or indirect neurogenesis (iNG) via intermediate progenitors (IPs). A foundational c ... Full text Link to item CiteCellREADR: An ADAR-based RNA sensor-actuator device.
Journal Article Methods Enzymol · 2025 RNAs are central mediators of genetic information flow and gene regulation that underlie diverse cell types and cell states across species. Thus, methods that can sense and respond to RNA profiles in living cells will have broad applications in biology and ... Full text Link to item CiteRecent Grants
RNA Programmable and Scalable Brain Cell Type Tools Across Vertebrates
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2025 - 2030Discovering the cell type basis of the IT projection system and its dysregulation after perinatal HIE
ResearchMentor · Awarded by National Institutes of Health · 2024 - 2029Neurobiology Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institute of Neurological Disorders and Stroke · 2024 - 2029View All Grants
Education, Training & Certifications
Brandeis University ·
1995
Ph.D.