A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow.

Journal Article (Journal Article)

How does coordinated activity between distinct brain regions implement a set of learning rules to sculpt information processing in a given neural circuit? Using interneuron cell-type-specific optical activation and pharmacogenetic silencing in vitro, we show that temporally precise pairing of direct entorhinal perforant path (PP) and hippocampal Schaffer collateral (SC) inputs to CA1 pyramidal cells selectively suppresses SC-associated perisomatic inhibition from cholecystokinin (CCK)-expressing interneurons. The CCK interneurons provide a surprisingly strong feedforward inhibitory drive to effectively control the coincident excitation of CA1 pyramidal neurons by convergent inputs. Thus, in-phase cortico-hippocampal activity provides a powerful heterosynaptic learning rule for long-term gating of information flow through the hippocampal excitatory macrocircuit by the silencing of the CCK inhibitory microcircuit.

Full Text

Duke Authors

Cited Authors

  • Basu, J; Srinivas, KV; Cheung, SK; Taniguchi, H; Huang, ZJ; Siegelbaum, SA

Published Date

  • September 18, 2013

Published In

Volume / Issue

  • 79 / 6

Start / End Page

  • 1208 - 1221

PubMed ID

  • 24050406

Pubmed Central ID

  • PMC3836574

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

Digital Object Identifier (DOI)

  • 10.1016/j.neuron.2013.07.001

Language

  • eng

Conference Location

  • United States