GABA and neuroligin signaling: linking synaptic activity and adhesion in inhibitory synapse development.

Journal Article (Journal Article;Review)

GABA-mediated synaptic inhibition is crucial in neural circuit operations. In mammalian brains, the development of inhibitory synapses and innervation patterns is often a prolonged postnatal process, regulated by neural activity. Emerging evidence indicates that gamma-aminobutyric acid (GABA) acts beyond inhibitory transmission and regulates inhibitory synapse development. Indeed, GABA(A) receptors not only function as chloride channels that regulate membrane voltage and conductance but also play structural roles in synapse maturation and stabilization. The link from GABA(A) receptors to postsynaptic and presynaptic adhesion is probably mediated, partly by neuroligin-reurexin interactions, which are potent in promoting GABAergic synapse formation. Therefore, similar to glutamate signaling at excitatory synapse, GABA signaling may coordinate maturation of presynaptic and postsynaptic sites at inhibitory synapses. Defining the many steps from GABA signaling to receptor trafficking/stability and neuroligin function will provide further mechanistic insights into activity-dependent development and possibly plasticity of inhibitory synapses.

Full Text

Duke Authors

Cited Authors

  • Huang, ZJ; Scheiffele, P

Published Date

  • February 2008

Published In

Volume / Issue

  • 18 / 1

Start / End Page

  • 77 - 83

PubMed ID

  • 18513949

Pubmed Central ID

  • PMC3988756

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2008.05.008

Language

  • eng

Conference Location

  • England