Transient neurites of retinal horizontal cells exhibit columnar tiling via homotypic interactions.

Journal Article (Journal Article)

Sensory neurons with common functions are often nonrandomly arranged and form dendritic territories that show little overlap, or tiling. Repulsive homotypic interactions underlie such patterns in cell organization in invertebrate neurons. It is unclear how dendro-dendritic repulsive interactions can produce a nonrandom distribution of cells and their spatial territories in mammalian retinal horizontal cells, as mature horizontal cell dendrites overlap substantially. By imaging developing mouse horizontal cells, we found that these cells transiently elaborate vertical neurites that form nonoverlapping columnar territories on reaching their final laminar positions. Targeted cell ablation revealed that the vertical neurites engage in homotypic interactions that result in tiling of neighboring cells before the establishment of their dendritic fields. This developmental tiling of transient neurites correlates with the emergence of a nonrandom distribution of the cells and could represent a mechanism that organizes neighbor relationships and territories of neurons before circuit assembly.

Full Text

Duke Authors

Cited Authors

  • Huckfeldt, RM; Schubert, T; Morgan, JL; Godinho, L; Di Cristo, G; Huang, ZJ; Wong, ROL

Published Date

  • January 2009

Published In

Volume / Issue

  • 12 / 1

Start / End Page

  • 35 - 43

PubMed ID

  • 19060895

Pubmed Central ID

  • PMC2743396

Electronic International Standard Serial Number (EISSN)

  • 1546-1726

Digital Object Identifier (DOI)

  • 10.1038/nn.2236

Language

  • eng

Conference Location

  • United States