Development of GABA innervation in the cerebral and cerebellar cortices.
Journal Article (Journal Article;Review)
In many areas of the vertebrate brain, such as the cerebral and cerebellar cortices, neural circuits rely on inhibition mediated by GABA (gamma-aminobutyric acid) to shape the spatiotemporal patterns of electrical signalling. The richness and subtlety of inhibition are achieved by diverse classes of interneurons that are endowed with distinct physiological properties. In addition, the axons of interneurons display highly characteristic and class-specific geometry and innervation patterns, and thereby distribute their output to discrete spatial domains, cell types and subcellular compartments in neural networks. The cellular and molecular mechanisms that specify and modify inhibitory innervation patterns are only just beginning to be understood.
Full Text
Duke Authors
Cited Authors
- Huang, ZJ; Di Cristo, G; Ango, F
Published Date
- September 2007
Published In
Volume / Issue
- 8 / 9
Start / End Page
- 673 - 686
PubMed ID
- 17704810
International Standard Serial Number (ISSN)
- 1471-003X
Digital Object Identifier (DOI)
- 10.1038/nrn2188
Language
- eng
Conference Location
- England