15 N-Azides as practical and effective tags for developing long-lived hyperpolarized agents.

Journal Article (Journal Article)

Azide moieties, unique linear species containing three nitrogen atoms, represent an attractive class of molecular tag for hyperpolarized magnetic resonance imaging (HP-MRI). Here we demonstrate (15 N)3 -azide-containing molecules exhibit long-lasting hyperpolarization lifetimes up to 9.8 min at 1 T with remarkably high polarization levels up to 11.6% in water, thus establishing (15 N)3 -azide as a powerful spin storage for hyperpolarization. A single (15 N)-labeled azide has also been examined as an effective alternative tag with long-lived hyperpolarization. A variety of biologically important molecules are studied in this work, including choline, glucose, amino acid, and drug derivatives, demonstrating great potential of 15 N-labeled azides as universal hyperpolarized tags for nuclear magnetic resonance imaging applications.

Full Text

Duke Authors

Cited Authors

  • Bae, J; Zhang, G; Park, H; Warren, WS; Wang, Q

Published Date

  • November 2021

Published In

Volume / Issue

  • 12 / 42

Start / End Page

  • 14309 - 14315

PubMed ID

  • 34760217

Pubmed Central ID

  • PMC8565375

Electronic International Standard Serial Number (EISSN)

  • 2041-6539

International Standard Serial Number (ISSN)

  • 2041-6520

Digital Object Identifier (DOI)

  • 10.1039/d1sc04647k

Language

  • eng