Skip to main content

Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy.

Publication ,  Journal Article
Blazkova, J; Gao, F; Marichannegowda, MH; Justement, JS; Shi, V; Whitehead, EJ; Schneck, RF; Huiting, ED; Gittens, K; Cottrell, M; Benko, E ...
Published in: Nat Med
November 2021

Certain infected individuals suppress human immunodeficiency virus (HIV) in the absence of anti-retroviral therapy (ART). Elucidating the underlying mechanism(s) is of high interest. Here we present two contrasting case reports of HIV-infected individuals who controlled plasma viremia for extended periods after undergoing analytical treatment interruption (ATI). In Participant 04, who experienced viral blips and initiated undisclosed self-administration of suboptimal ART detected shortly before day 1,250, phylogenetic analyses of plasma HIV env sequences suggested continuous viral evolution and/or reactivation of pre-existing viral reservoirs over time. Antiviral CD8+ T cell activities were higher in Participant 04 than in Participant 30. In contrast, Participant 30 exhibited potent plasma-IgG-mediated neutralization activity against autologous virus that became ineffective when he experienced sudden plasma viral rebound 1,434 d after ATI due to HIV superinfection. Our data provide insight into distinct mechanisms of post-treatment interruption control and highlight the importance of frequent monitoring of undisclosed use of ART and superinfection during the ATI phase.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

November 2021

Volume

27

Issue

11

Start / End Page

1893 / 1898

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virus Activation
  • Viremia
  • Viral Load
  • Patient Compliance
  • Middle Aged
  • Male
  • Immunology
  • Immunoglobulin G
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Blazkova, J., Gao, F., Marichannegowda, M. H., Justement, J. S., Shi, V., Whitehead, E. J., … Chun, T.-W. (2021). Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy. Nat Med, 27(11), 1893–1898. https://doi.org/10.1038/s41591-021-01503-6
Blazkova, Jana, Feng Gao, Manukumar Honnayakanahalli Marichannegowda, J Shawn Justement, Victoria Shi, Emily J. Whitehead, Rachel F. Schneck, et al. “Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy.Nat Med 27, no. 11 (November 2021): 1893–98. https://doi.org/10.1038/s41591-021-01503-6.
Blazkova J, Gao F, Marichannegowda MH, Justement JS, Shi V, Whitehead EJ, et al. Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy. Nat Med. 2021 Nov;27(11):1893–8.
Blazkova, Jana, et al. “Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy.Nat Med, vol. 27, no. 11, Nov. 2021, pp. 1893–98. Pubmed, doi:10.1038/s41591-021-01503-6.
Blazkova J, Gao F, Marichannegowda MH, Justement JS, Shi V, Whitehead EJ, Schneck RF, Huiting ED, Gittens K, Cottrell M, Benko E, Kovacs C, Lack J, Sneller MC, Moir S, Fauci AS, Chun T-W. Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy. Nat Med. 2021 Nov;27(11):1893–1898.

Published In

Nat Med

DOI

EISSN

1546-170X

Publication Date

November 2021

Volume

27

Issue

11

Start / End Page

1893 / 1898

Location

United States

Related Subject Headings

  • env Gene Products, Human Immunodeficiency Virus
  • Virus Activation
  • Viremia
  • Viral Load
  • Patient Compliance
  • Middle Aged
  • Male
  • Immunology
  • Immunoglobulin G
  • Humans