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Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank.

Publication ,  Journal Article
Yang, R; Lv, J; Yu, C; Guo, Y; Pei, P; Huang, N; Yang, L; Millwood, IY; Walters, RG; Chen, Y; Du, H; Tao, R; Chen, J; Chen, Z; Clarke, R ...
Published in: BMC Med
October 22, 2021

BACKGROUND: Both genetic and cardiovascular factors contribute to the risk of developing heart failure (HF), but whether idea cardiovascular health metrics (ICVHMs) offset the genetic association with incident HF remains unclear. OBJECTIVES: To investigate the genetic association with incident HF as well as the modification effect of ICVHMs on such genetic association in Chinese and British populations. METHODS: An ICVHMs based on smoking, drinking, physical activity, diets, body mass index, waist circumference, blood pressure, blood glucose, and blood lipids, and a polygenic risk score (PRS) for HF were constructed in the China Kadoorie Biobank (CKB) of 96,014 participants and UK Biobank (UKB) of 335,782 participants which were free from HF and severe chronic diseases at baseline. RESULTS: During the median follow-up of 11.38 and 8.73 years, 1451 and 3169 incident HF events were documented in CKB and UKB, respectively. HF risk increased monotonically with the increase of PRS per standard deviation (CKB: hazard ratio [HR], 1.19; 95% confidence interval [CI], 1.07, 1.32; UKB: 1.07; 1.03, 1.11; P for trend < 0.001). Each point increase in ICVHMs was associated with 15% and 20% lower risk of incident HF in CKB (0.85; 0.81, 0.90) and UKB (0.80; 0.77, 0.82), respectively. Compared with unfavorable ICVHMs, favorable ICVHMs was associated with a lower HF risk, with 0.71 (0.44, 1.15), 0.41 (0.22, 0.77), and 0.48 (0.30, 0.77) in the low, intermediate, and high genetic risk in CKB and 0.34 (0.26, 0.44), 0.32 (0.25, 0.41), and 0.37 (0.28, 0.47) in UKB (P for multiplicative interaction > 0.05). Participants with low genetic risk and favorable ICVHMs, as compared with high genetic risk and unfavorable ICVHMs, had 56~72% lower risk of HF (CKB 0.44; 0.28, 0.70; UKB 0.28; 0.22, 0.37). No additive interaction between PRS and ICVHMs was observed (relative excess risk due to interaction was 0.05 [-0.22, 0.33] in CKB and 0.04 [-0.14, 0.22] in UKB). CONCLUSIONS: In CKB and UKB, genetic risk and ICVHMs were independently associated with the risk of incident HF, which suggested that adherence to favorable cardiovascular health status was associated with a lower HF risk among participants with all gradients of genetic risk.

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Published In

BMC Med

DOI

EISSN

1741-7015

Publication Date

October 22, 2021

Volume

19

Issue

1

Start / End Page

259

Location

England

Related Subject Headings

  • United Kingdom
  • Risk Factors
  • Quality Indicators, Health Care
  • Incidence
  • Humans
  • Heart Failure
  • General & Internal Medicine
  • China
  • Biological Specimen Banks
  • 42 Health sciences
 

Citation

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Yang, R., Lv, J., Yu, C., Guo, Y., Pei, P., Huang, N., … China Kadoorie Biobank Collaborative Group, . (2021). Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank. BMC Med, 19(1), 259. https://doi.org/10.1186/s12916-021-02122-1
Yang, Ruotong, Jun Lv, Canqing Yu, Yu Guo, Pei Pei, Ninghao Huang, Ling Yang, et al. “Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank.BMC Med 19, no. 1 (October 22, 2021): 259. https://doi.org/10.1186/s12916-021-02122-1.
Yang, Ruotong, et al. “Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank.BMC Med, vol. 19, no. 1, Oct. 2021, p. 259. Pubmed, doi:10.1186/s12916-021-02122-1.
Yang R, Lv J, Yu C, Guo Y, Pei P, Huang N, Yang L, Millwood IY, Walters RG, Chen Y, Du H, Tao R, Chen J, Chen Z, Clarke R, Huang T, Li L, China Kadoorie Biobank Collaborative Group. Modification effect of ideal cardiovascular health metrics on genetic association with incident heart failure in the China Kadoorie Biobank and the UK Biobank. BMC Med. 2021 Oct 22;19(1):259.
Journal cover image

Published In

BMC Med

DOI

EISSN

1741-7015

Publication Date

October 22, 2021

Volume

19

Issue

1

Start / End Page

259

Location

England

Related Subject Headings

  • United Kingdom
  • Risk Factors
  • Quality Indicators, Health Care
  • Incidence
  • Humans
  • Heart Failure
  • General & Internal Medicine
  • China
  • Biological Specimen Banks
  • 42 Health sciences