Basic and Translational Research in Cardiac Repair and Regeneration: JACC State-of-the-Art Review.

Journal Article (Journal Article;Review)

This paper aims to provide an important update on the recent preclinical and clinical trials using cell therapy strategies and engineered heart tissues for the treatment of postinfarction left ventricular remodeling and heart failure. In addition to the authors' own works and opinions on the roadblocks of the field, they discuss novel approaches for cardiac remuscularization via the activation of proliferative mechanisms in resident cardiomyocytes or direct reprogramming of somatic cells into cardiomyocytes. This paper's main mindset is to present current and future strategies in light of their implications for the design of future patient trials with the ultimate objective of facilitating the translation of discoveries in regenerative myocardial therapies to the clinic.

Full Text

Duke Authors

Cited Authors

  • Zhang, J; Bolli, R; Garry, DJ; Marbán, E; Menasché, P; Zimmermann, W-H; Kamp, TJ; Wu, JC; Dzau, VJ

Published Date

  • November 23, 2021

Published In

Volume / Issue

  • 78 / 21

Start / End Page

  • 2092 - 2105

PubMed ID

  • 34794691

Pubmed Central ID

  • PMC9116459

Electronic International Standard Serial Number (EISSN)

  • 1558-3597

Digital Object Identifier (DOI)

  • 10.1016/j.jacc.2021.09.019


  • eng

Conference Location

  • United States