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New Directions in the Treatment of Glioblastoma.

Publication ,  Journal Article
Reitman, ZJ; Winkler, F; Elia, AEH
Published in: Semin Neurol
February 2018

Glioblastoma (GBM) is the most common primary malignant tumor of the central nervous system. The current standard of care for GBM is maximal resection followed by postoperative radiation with concomitant and adjuvant temozolomide. Despite this multimodality treatment, the median survival for GBM remains marginally better than 1 year. In the past decade, genome-wide analyses have uncovered new molecular features of GBM that have refined its classification and provided new insights into the molecular basis for GBM pathogenesis. Here, we review these molecular features and discuss major clinical trials that have recently defined the field. We describe genetic alterations in isocitrate dehydrogenase, ATRX, the telomerase promoter, and histone H3 variants that promote GBM tumorigenesis and have altered GBM categorization. We also discuss intratumoral genetic heterogeneity as one explanation for therapeutic failures and explain how ultra-long extensions of glioma cells, called tumor microtubes, mediate therapeutic resistance. These findings provide new insights into GBM biology and offer hope for the development of next-generation therapies.

Duke Scholars

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Published In

Semin Neurol

DOI

EISSN

1098-9021

Publication Date

February 2018

Volume

38

Issue

1

Start / End Page

50 / 61

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Glioblastoma
  • Brain Neoplasms
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences
 

Citation

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MLA
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Reitman, Z. J., Winkler, F., & Elia, A. E. H. (2018). New Directions in the Treatment of Glioblastoma. Semin Neurol, 38(1), 50–61. https://doi.org/10.1055/s-0038-1623534
Reitman, Zachary J., Frank Winkler, and Andrew E. H. Elia. “New Directions in the Treatment of Glioblastoma.Semin Neurol 38, no. 1 (February 2018): 50–61. https://doi.org/10.1055/s-0038-1623534.
Reitman ZJ, Winkler F, Elia AEH. New Directions in the Treatment of Glioblastoma. Semin Neurol. 2018 Feb;38(1):50–61.
Reitman, Zachary J., et al. “New Directions in the Treatment of Glioblastoma.Semin Neurol, vol. 38, no. 1, Feb. 2018, pp. 50–61. Pubmed, doi:10.1055/s-0038-1623534.
Reitman ZJ, Winkler F, Elia AEH. New Directions in the Treatment of Glioblastoma. Semin Neurol. 2018 Feb;38(1):50–61.
Journal cover image

Published In

Semin Neurol

DOI

EISSN

1098-9021

Publication Date

February 2018

Volume

38

Issue

1

Start / End Page

50 / 61

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Humans
  • Glioblastoma
  • Brain Neoplasms
  • 3209 Neurosciences
  • 3202 Clinical sciences
  • 1109 Neurosciences
  • 1103 Clinical Sciences