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Zachary James Reitman

Assistant Professor of Radiation Oncology
Radiation Oncology
30 Duke Medicine Circle, Box 3085, Durham, NC 27710
30 Duke Medicine Circle, Box 3085, Durham, NC 27710

Overview


Dr. Reitman’s clinical interests include radiotherapy for primary and metastatic tumors of the brain and spine.  He is also interested in basic and translational research studies to develop new treatment approaches for pediatric and adult brain tumors.  He uses genomic analysis, radiation biology studies, and genetically engineered animal models of cancer to carry out this research

Current Appointments & Affiliations


Assistant Professor of Radiation Oncology · 2021 - Present Radiation Oncology, Clinical Science Departments
Assistant Professor of Pathology · 2022 - Present Pathology, Clinical Science Departments
Assistant Professor in Neurosurgery · 2022 - Present Neurosurgery, Neurosurgery
Member of the Duke Cancer Institute · 2019 - Present Duke Cancer Institute, Institutes and Centers

In the News


Published July 10, 2025
How Duke is Transforming Care for Brain and Spine Metastasis

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Recent Publications


Neurocognitive outcomes in patients with brain metastases: a systematic review.

Journal Article Lancet Oncol · December 2025 Multimodality therapy, including surgery, radiotherapy, and systemic therapy, has significantly improved overall survival for patients with brain metastases. However, treatment-related neurocognitive sequelae remain a major challenge in survivorship. Altho ... Full text Link to item Cite

Investigating the FLASH Effect in a Rat Brain Organotypic Model With a Novel High-Energy Electron Beam.

Journal Article Int J Radiat Oncol Biol Phys · October 10, 2025 PURPOSE: Ultrahigh dose rate (FLASH) radiation therapy is reported to reduce normal tissue toxicity while maintaining tumor control; however, mechanism(s) remain obscure. To study FLASH mechanisms in brain tissue, we developed a novel experimental platform ... Full text Link to item Cite
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Recent Grants


Inflammasomes - a driver of sexual dimorphism to glioma therapies

ResearchCo Investigator · Awarded by National Institutes of Health · 2025 - 2030

Role of ATRX deficiency as a determinant of topoisomerase 1 inhibitor sensitivity in high grade gliomas

ResearchCo Investigator · Awarded by American Cancer Society, Inc. · 2025 - 2028

Modulation of STING to enhance the efficacy of treatments for diffuse midline glioma

ResearchPrincipal Investigator · Awarded by Alex's Lemonade Stand · 2024 - 2028

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Education, Training & Certifications


Duke University, School of Medicine · 2014 M.D.
Duke University, School of Medicine · 2012 Ph.D.

External Links


Reitman Lab website