Zachary James Reitman
Assistant Professor of Radiation Oncology
Dr. Reitman’s clinical interests include radiotherapy for primary and metastatic tumors of the brain and spine. He is also interested in basic and translational research studies to develop new treatment approaches for pediatric and adult brain tumors. He uses genomic analysis, radiation biology studies, and genetically engineered animal models of cancer to carry out this research
Current Research Interests
The goal of the Reitman Lab is to make discoveries that guide the design of improved treatment strategies for children and adults with brain tumors. The Reitman Lab is based in the Department of Radiation Oncology and the team works closely with the faculty and staff in the Preston Robert Tisch Brain Tumor Center at Duke, the Department of Neurosurgery and the Duke Cancer Institute.
Current Appointments & Affiliations
- Assistant Professor of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2021
- Assistant Professor of Pathology, Pathology, Clinical Science Departments 2022
- Assistant Professor in Neurosurgery, Neurosurgery, Neurosurgery 2022
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019
Contact Information
- 30 Duke Medicine Circle, Box 3085, Durham, NC 27710
- 30 Duke Medicine Circle, Box 3085, Durham, NC 27710
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(919) 668-7336
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Reitman Lab website
- Background
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Education, Training, & Certifications
- Resident, Radiation Oncology, Massachusetts General Hospital 2015 - 2019
- Internship, Internal Medicine, Union Memorial Hospital 2014 - 2015
- M.D., Duke University School of Medicine 2014
- Ph.D., Duke University School of Medicine 2012
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Medical Licensure
- Board Certified in Radiation Oncology, American Board of Radiology. North Carolina. 2021
- 0101269602. Virginia. 2020
- 201900924. North Carolina. 2019
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Previous Appointments & Affiliations
- Medical Instructor in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2019 - 2021
- Expertise
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Subject Headings
- Research
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Selected Grants
- Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM awarded by National Institutes of Health 2022 - 2027
- Dissecting mechanisms of radioresistance associated with p53 mutations in DIPG awarded by Chadtough Defeat DIPG Foundation 2022 - 2024
- Identifying brainstem glioma subtypes that can be radiosensitized by ATM inhibition awarded by Pediatric Brain Tumor Foundation 2019 - 2023
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Enhancing the efficacy of radiation therapy for brainstem gliomas awarded by St. Baldrick's Foundation 2020 - 2022
- Enhancing the efficacy of radiation therapy for DIPG awarded by Michael Mosier Defeat DIPG Foundation 2020 - 2021
- Prioritizing PPM1D mutations as a target for new DIPG therapies awarded by Michael Mosier Defeat DIPG Foundation 2019
- Generation of a genetically-modified microorganism for adipic acid production awarded by North Carolina Biotechnology Center 2014 - 2015
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External Relationships
- Eisai Pharmaceuticals
- Genetron Health
- Oakstone Publishing CME
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Vaios, Eugene J., Sebastian F. Winter, Helen A. Shih, Jorg Dietrich, Katherine B. Peters, Scott R. Floyd, John P. Kirkpatrick, and Zachary J. Reitman. “Novel Mechanisms and Future Opportunities for the Management of Radiation Necrosis in Patients Treated for Brain Metastases in the Era of Immunotherapy.” Cancers (Basel) 15, no. 9 (April 24, 2023). https://doi.org/10.3390/cancers15092432.Full Text Link to Item
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Regal, Joshua A., María E. Guerra García, Vaibhav Jain, Vidyalakshmi Chandramohan, David M. Ashley, Simon G. Gregory, Eric M. Thompson, Giselle Y. López, and Zachary J. Reitman. “Ganglioglioma deep transcriptomics reveals primitive neuroectoderm neural precursor-like population.” Acta Neuropathol Commun 11, no. 1 (March 25, 2023): 50. https://doi.org/10.1186/s40478-023-01548-3.Full Text Link to Item
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Weidenhammer, Loren B., Harrison Q. Liu, Lixia Luo, Nerissa T. Williams, Katherine Deland, David G. Kirsch, and Zachary J. Reitman. “Inducing primary brainstem gliomas in genetically engineered mice using RCAS/TVA retroviruses and Cre/loxP recombination.” Star Protoc 4, no. 1 (February 13, 2023): 102094. https://doi.org/10.1016/j.xpro.2023.102094.Full Text Link to Item
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Carpenter, David J., Andrew T. Fairchild, Justus D. Adamson, Peter E. Fecci, John H. Sampson, James E. Herndon, Jordan A. Torok, et al. “Outcomes in Patients with Intact and Resected Brain Metastasis Treated with 5-Fraction Stereotactic Radiosurgery.” Adv Radiat Oncol 8, no. 2 (2023): 101166. https://doi.org/10.1016/j.adro.2022.101166.Full Text Link to Item
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Natesan, Divya, David J. Carpenter, Will Giles, Taofik Oyekunle, Donna Niedzwiecki, Zachary J. Reitman, John P. Kirkpatrick, and Scott R. Floyd. “Clinical Factors Associated With 30-Day Mortality Among Patients Undergoing Radiation Therapy for Brain Metastases.” Adv Radiat Oncol 8, no. 4 (2023): 101211. https://doi.org/10.1016/j.adro.2023.101211.Full Text Link to Item
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Carpenter, David J., Brahma Natarajan, Muzamil Arshad, Divya Natesan, Olivia Schultz, Michael J. Moravan, Charlotte Read, et al. “Prognostic Model for Intracranial Progression after Stereotactic Radiosurgery: A Multicenter Validation Study.” Cancers (Basel) 14, no. 21 (October 22, 2022). https://doi.org/10.3390/cancers14215186.Full Text Link to Item
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Stewart, Connor E., María E. Guerra-García, Lixia Luo, Nerissa T. Williams, Yan Ma, Joshua A. Regal, Debosir Ghosh, et al. “The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma.” Cancers (Basel) 14, no. 18 (September 17, 2022). https://doi.org/10.3390/cancers14184506.Full Text Link to Item
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Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.Full Text Link to Item
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Deland, Katherine, Joshua S. Mercer, Donna M. Crabtree, Maria E. Guerra Garcia, Michael Reinsvold, Lorraine Da Silva Campos, Nerissa T. Williams, et al. “Radiosensitizing the Vasculature of Primary Brainstem Gliomas Fails to Improve Tumor Response to Radiation Therapy.” International Journal of Radiation Oncology, Biology, Physics 112, no. 3 (March 2022): 771–79. https://doi.org/10.1016/j.ijrobp.2021.09.047.Full Text
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Khadka, Prasidda, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, et al. “PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.” Nat Commun 13, no. 1 (February 1, 2022): 604. https://doi.org/10.1038/s41467-022-28198-8.Full Text Link to Item
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García, María E Guerra, David G. Kirsch, and Zachary J. Reitman. “Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients.” Semin Radiat Oncol 32, no. 1 (January 2022): 3–14. https://doi.org/10.1016/j.semradonc.2021.09.008.Full Text Link to Item
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Yu, Shengnan, Shiyou Wei, Milan Savani, Xiang Lin, Kuang Du, Ilgen Mender, Silvia Siteni, et al. “A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.” Clin Cancer Res 27, no. 24 (December 15, 2021): 6800–6814. https://doi.org/10.1158/1078-0432.CCR-21-0374.Full Text Link to Item
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Shen, Erica, Amanda E. D. Van Swearingen, Meghan J. Price, Ketan Bulsara, Roeland G. W. Verhaak, César Baëta, Brice D. Painter, et al. “A Need for More Molecular Profiling in Brain Metastases.” Front Oncol 11 (2021): 785064. https://doi.org/10.3389/fonc.2021.785064.Full Text Link to Item
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Reitman, Zachary J., Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, et al. “Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.” Nat Commun 10, no. 1 (August 19, 2019): 3731. https://doi.org/10.1038/s41467-019-11493-2.Full Text Link to Item
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Cagney, Daniel N., Allison M. Martin, Paul J. Catalano, Zachary J. Reitman, Gabrielle A. Mezochow, Eudocia Q. Lee, Patrick Y. Wen, et al. “Impact of pemetrexed on intracranial disease control and radiation necrosis in patients with brain metastases from non-small cell lung cancer receiving stereotactic radiation.” Radiother Oncol 126, no. 3 (March 2018): 511–18. https://doi.org/10.1016/j.radonc.2018.01.005.Full Text Link to Item
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Chitneni, Satish K., Zachary J. Reitman, Rebecca Spicehandler, David M. Gooden, Hai Yan, and Michael R. Zalutsky. “Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.” Bioorg Med Chem Lett 28, no. 4 (February 15, 2018): 694–99. https://doi.org/10.1016/j.bmcl.2018.01.015.Full Text Link to Item
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Reitman, Zachary J., Frank Winkler, and Andrew E. H. Elia. “New Directions in the Treatment of Glioblastoma.” Semin Neurol 38, no. 1 (February 2018): 50–61. https://doi.org/10.1055/s-0038-1623534.Full Text Link to Item
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Song, Zhi-Jian, Zachary J. Reitman, Zeng-Yi Ma, Jian-Hua Chen, Qi-Lin Zhang, Xue-Fei Shou, Chuan-Xin Huang, et al. “The genome-wide mutational landscape of pituitary adenomas.” Cell Res 26, no. 11 (November 2016): 1255–59. https://doi.org/10.1038/cr.2016.114.Full Text Link to Item
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Chitneni, Satish K., Zachary J. Reitman, David M. Gooden, Hai Yan, and Michael R. Zalutsky. “Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.” Eur J Med Chem 119 (August 25, 2016): 218–30. https://doi.org/10.1016/j.ejmech.2016.04.066.Full Text Open Access Copy Link to Item
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Gurzadyan, V. G., H. Yan, G. Vlahovic, A. Kashin, P. Killela, Z. Reitman, S. Sargsyan, G. Yegorian, G. Milledge, and B. Vlahovic. “Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis.” R Soc Open Sci 2, no. 8 (August 2015): 150143. https://doi.org/10.1098/rsos.150143.Full Text Link to Item
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Reitman, Zachary J., Sergey A. Sinenko, Eric P. Spana, and Hai Yan. “Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.” Blood 125, no. 2 (January 8, 2015): 336–45. https://doi.org/10.1182/blood-2014-05-577940.Full Text Link to Item
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Reitman, Zachary J. “Smaller protein, larger therapeutic potential: PPM1D as a new therapeutic target in brainstem glioma.” Pharmacogenomics 15, no. 13 (September 2014): 1639–41. https://doi.org/10.2217/pgs.14.123.Full Text Link to Item
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Reitman, Zachary J., Christopher G. Duncan, Ethan Poteet, Ali Winters, Liang-Jun Yan, David M. Gooden, Ivan Spasojevic, Laszlo G. Boros, Shao-Hua Yang, and Hai Yan. “Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.” J Biol Chem 289, no. 34 (August 22, 2014): 23318–28. https://doi.org/10.1074/jbc.M114.575183.Full Text Link to Item
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Yan, H., P. J. Killela, Z. J. Reitman, Y. Jiao, C. Bettegowda, N. Agrawal, L. A. Diaz, et al. “Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Neuro Oncol 16 Suppl 3 (July 2014): iii5–6. https://doi.org/10.1093/neuonc/nou206.18.Full Text Link to Item
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Zhang, Liwei, Lee H. Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nat Genet 46, no. 7 (July 2014): 726–30. https://doi.org/10.1038/ng.2995.Full Text Link to Item
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Killela, Patrick J., Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B Ahmed Rasheed, Eric Lipp, Henry Friedman, et al. “The genetic landscape of anaplastic astrocytoma.” Oncotarget 5, no. 6 (March 30, 2014): 1452–57. https://doi.org/10.18632/oncotarget.1505.Full Text Link to Item
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Killela, Patrick J., Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, B Ahmed Rasheed, Rui Yang, et al. “Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.” Oncotarget 5, no. 6 (March 30, 2014): 1515–25. https://doi.org/10.18632/oncotarget.1765.Full Text Open Access Copy Link to Item
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Zhang, L., L. H. Chen, H. Wan, R. Yang, Z. Wang, J. Feng, S. Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nature Genetics 46, no. 7 (January 1, 2014): 726–30. https://doi.org/10.1038/ng.2995.Full Text
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Reitman, Zachary J., Christopher J. Pirozzi, and Hai Yan. “Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors.” Acta Neuropathol 126, no. 6 (December 2013): 789–92. https://doi.org/10.1007/s00401-013-1207-5.Full Text Link to Item
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Pirozzi, Christopher J., Zachary J. Reitman, and Hai Yan. “Releasing the block: setting differentiation free with mutant IDH inhibitors.” Cancer Cell 23, no. 5 (May 13, 2013): 570–72. https://doi.org/10.1016/j.ccr.2013.04.024.Full Text Link to Item
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Killela, Patrick J., Zachary J. Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A. Diaz, Allan H. Friedman, et al. “TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 6021–26. https://doi.org/10.1073/pnas.1303607110.Full Text Link to Item
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Bettegowda, Chetan, Nishant Agrawal, Yuchen Jiao, Yuxuan Wang, Laura D. Wood, Fausto J. Rodriguez, Ralph H. Hruban, et al. “Exomic sequencing of four rare central nervous system tumor types.” Oncotarget 4, no. 4 (April 2013): 572–83. https://doi.org/10.18632/oncotarget.964.Full Text Link to Item
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Jin, Genglin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B Ahmed Rasheed, Rui Yang, et al. “Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.” Cancer Res 73, no. 2 (January 15, 2013): 496–501. https://doi.org/10.1158/0008-5472.CAN-12-2852.Full Text Open Access Copy Link to Item
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Reitman, Zachary J., Bryan D. Choi, Ivan Spasojevic, Darell D. Bigner, John H. Sampson, and Hai Yan. “Enzyme redesign guided by cancer-derived IDH1 mutations.” Nat Chem Biol 8, no. 11 (November 2012): 887–89. https://doi.org/10.1038/nchembio.1065.Full Text Link to Item
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Jiao, Yuchen, Patrick J. Killela, Zachary J. Reitman, Ahmed B. Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, et al. “Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.” Oncotarget 3, no. 7 (July 2012): 709–22. https://doi.org/10.18632/oncotarget.588.Full Text Open Access Copy Link to Item
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Riggs, Kevin R., Zachary J. Reitman, Thelma J. Mielenz, and Philip C. Goodman. “Relationship Between Time of First Publication and Subsequent Publication Success Among Non-PhD Physician-Scientists.” J Grad Med Educ 4, no. 2 (June 2012): 196–201. https://doi.org/10.4300/JGME-D-11-00068.1.Full Text Link to Item
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Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.” Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3270–75. https://doi.org/10.1073/pnas.1019393108.Full Text Link to Item
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Jin, Genglin, Zachary J. Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D. Bigner, and Hai Yan. “2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.” Plos One 6, no. 2 (February 4, 2011): e16812. https://doi.org/10.1371/journal.pone.0016812.Full Text Link to Item
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Lopez, Giselle Y., Zachary J. Reitman, David Solomon, Todd Waldman, Darell D. Bigner, Roger E. McLendon, Steven A. Rosenberg, Yardena Samuels, and Hai Yan. “IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.” Biochem Biophys Res Commun 398, no. 3 (July 30, 2010): 585–87. https://doi.org/10.1016/j.bbrc.2010.06.125.Full Text Open Access Copy Link to Item
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Reitman, Zachary J., and Hai Yan. “Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.” J Natl Cancer Inst 102, no. 13 (July 7, 2010): 932–41. https://doi.org/10.1093/jnci/djq187.Full Text Link to Item
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Reitman, Zachary J., Natasha J. Olby, Christopher L. Mariani, Rachael Thomas, Matthew Breen, Darell D. Bigner, Roger E. McLendon, and Hai Yan. “IDH1 and IDH2 hotspot mutations are not found in canine glioma.” Int J Cancer 127, no. 1 (July 1, 2010): 245–46. https://doi.org/10.1002/ijc.25017.Full Text Link to Item
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Reitman, Zachary J., D Williams Parsons, and Hai Yan. “IDH1 and IDH2: not your typical oncogenes.” Cancer Cell 17, no. 3 (March 16, 2010): 215–16. https://doi.org/10.1016/j.ccr.2010.02.024.Full Text Link to Item
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Reitman, Z., and H. Yan. “The author and a colleague reply.” New England Journal of Medicine 360, no. 21 (May 21, 2009): 2249. https://doi.org/10.1056/NEJMc090391.Full Text
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Shen, Miaoqing, Zachary J. Reitman, Yan Zhao, Ibrahim Moustafa, Qixin Wang, Jamie J. Arnold, Harsh B. Pathak, and Craig E. Cameron. “Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex.” J Biol Chem 283, no. 2 (January 11, 2008): 875–88. https://doi.org/10.1074/jbc.M707907200.Full Text Link to Item
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Conference Papers
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Vaios, E. J., M. Grabowski, E. Srinivasan, D. Huie, E. Sankey, B. Otvos, M. Olufawo, et al. “Combining Laser Interstitial Thermal Therapy With SRS Improves Time to Progression for Recurrent SRS-Treated Brain Metastases.” In International Journal of Radiation Oncology, Biology, Physics, 111:e583–84, 2021. https://doi.org/10.1016/j.ijrobp.2021.07.1565.Full Text
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Wang, C., Y. Xie, Z. Hu, F. F. Yin, Z. Reitman, and Y. Cui. “A Dosimetric Study Comparing Two Beam Arrangement Strategies in Fractionated Thoracic Spine Stereotactic Body Radiotherapy (SBRT) Planning.” In International Journal of Radiation Oncology, Biology, Physics, 111:e557, 2021. https://doi.org/10.1016/j.ijrobp.2021.07.1510.Full Text
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- Teaching & Mentoring
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Recent Courses
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