Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Resident, Radiation Oncology, Massachusetts General Hospital 2015 - 2019
  • Internship, Internal Medicine, Union Memorial Hospital 2014 - 2015
  • M.D., Duke University School of Medicine 2014
  • Ph.D., Duke University School of Medicine 2012
• 

  Medical Licensure

  • Board Certified in Radiation Oncology, American Board of Radiology. North Carolina. 2021
  • 0101269602. Virginia. 2020
  • 201900924. North Carolina. 2019
• 

  Previous Appointments & Affiliations

  • Medical Instructor in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2019 - 2021
• Expertise
• 

  Subject Headings

  • Cancer
  • Ganglioglioma
  • Genomics
  • Glioma
  • Molecular Biology
  • Molecular radiobiology
  • Muser Mentor
  • Radiotherapy
  • Single Cell Biology
• Research
• 

  Selected Grants

  • Enhancing the efficacy of Radiation Therapy for brainstem glioma by targeting ATM awarded by National Institutes of Health 2022 - 2027
  • Dissecting mechanisms of radioresistance associated with p53 mutations in DIPG awarded by Chadtough Defeat DIPG Foundation 2022 - 2024
  • Identifying brainstem glioma subtypes that can be radiosensitized by ATM inhibition awarded by Pediatric Brain Tumor Foundation 2019 - 2023
  • Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
  • Enhancing the efficacy of radiation therapy for brainstem gliomas awarded by St. Baldrick's Foundation 2020 - 2022
  • Enhancing the efficacy of radiation therapy for DIPG awarded by Michael Mosier Defeat DIPG Foundation 2020 - 2021
  • Prioritizing PPM1D mutations as a target for new DIPG therapies awarded by Michael Mosier Defeat DIPG Foundation 2019
  • Generation of a genetically-modified microorganism for adipic acid production awarded by North Carolina Biotechnology Center 2014 - 2015
• 

  External Relationships

  • Genetron Health
  • Oakstone Publishing CME
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Stewart, Connor E., María E. Guerra-García, Lixia Luo, Nerissa T. Williams, Yan Ma, Joshua A. Regal, Debosir Ghosh, et al. “The Effect of Atm Loss on Radiosensitivity of a Primary Mouse Model of Pten-Deleted Brainstem Glioma.” Cancers (Basel) 14, no. 18 (September 17, 2022). https://doi.org/10.3390/cancers14184506.
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    • Low, Justin T., Vidyalakshmi Chandramohan, Michelle L. Bowie, Michael C. Brown, Matthew S. Waitkus, Aaron Briley, Kevin Stevenson, et al. “Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.” Cancer Cell 40, no. 5 (May 9, 2022): 439–40. https://doi.org/10.1016/j.ccell.2022.04.009.
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    • Deland, Katherine, Joshua S. Mercer, Donna M. Crabtree, Maria E. Guerra Garcia, Michael Reinsvold, Lorraine Da Silva Campos, Nerissa T. Williams, et al. “Radiosensitizing the Vasculature of Primary Brainstem Gliomas Fails to Improve Tumor Response to Radiation Therapy.” Int J Radiat Oncol Biol Phys 112, no. 3 (March 1, 2022): 771–79. https://doi.org/10.1016/j.ijrobp.2021.09.047.
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    • Khadka, Prasidda, Zachary J. Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M. Carvalho, et al. “PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.” Nat Commun 13, no. 1 (February 1, 2022): 604. https://doi.org/10.1038/s41467-022-28198-8.
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    • García, María E Guerra, David G. Kirsch, and Zachary J. Reitman. “Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients.” Semin Radiat Oncol 32, no. 1 (January 2022): 3–14. https://doi.org/10.1016/j.semradonc.2021.09.008.
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    • Yu, Shengnan, Shiyou Wei, Milan Savani, Xiang Lin, Kuang Du, Ilgen Mender, Silvia Siteni, et al. “A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.” Clin Cancer Res 27, no. 24 (December 15, 2021): 6800–6814. https://doi.org/10.1158/1078-0432.CCR-21-0374.
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    • Shen, Erica, Amanda E. D. Van Swearingen, Meghan J. Price, Ketan Bulsara, Roeland G. W. Verhaak, César Baëta, Brice D. Painter, et al. “A Need for More Molecular Profiling in Brain Metastases.” Front Oncol 11 (2021): 785064. https://doi.org/10.3389/fonc.2021.785064.
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    • Reitman, Zachary J., Brenton R. Paolella, Guillaume Bergthold, Kristine Pelton, Sarah Becker, Robert Jones, Claire E. Sinai, et al. “Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells.” Nat Commun 10, no. 1 (August 19, 2019): 3731. https://doi.org/10.1038/s41467-019-11493-2.
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    • Cagney, Daniel N., Allison M. Martin, Paul J. Catalano, Zachary J. Reitman, Gabrielle A. Mezochow, Eudocia Q. Lee, Patrick Y. Wen, et al. “Impact of pemetrexed on intracranial disease control and radiation necrosis in patients with brain metastases from non-small cell lung cancer receiving stereotactic radiation.” Radiother Oncol 126, no. 3 (March 2018): 511–18. https://doi.org/10.1016/j.radonc.2018.01.005.
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    • Chitneni, Satish K., Zachary J. Reitman, Rebecca Spicehandler, David M. Gooden, Hai Yan, and Michael R. Zalutsky. “Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.” Bioorg Med Chem Lett 28, no. 4 (February 15, 2018): 694–99. https://doi.org/10.1016/j.bmcl.2018.01.015.
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    • Reitman, Zachary J., Frank Winkler, and Andrew E. H. Elia. “New Directions in the Treatment of Glioblastoma.” Semin Neurol 38, no. 1 (February 2018): 50–61. https://doi.org/10.1055/s-0038-1623534.
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    • Song, Zhi-Jian, Zachary J. Reitman, Zeng-Yi Ma, Jian-Hua Chen, Qi-Lin Zhang, Xue-Fei Shou, Chuan-Xin Huang, et al. “The genome-wide mutational landscape of pituitary adenomas.” Cell Res 26, no. 11 (November 2016): 1255–59. https://doi.org/10.1038/cr.2016.114.
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    • Chitneni, Satish K., Zachary J. Reitman, David M. Gooden, Hai Yan, and Michael R. Zalutsky. “Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.” Eur J Med Chem 119 (August 25, 2016): 218–30. https://doi.org/10.1016/j.ejmech.2016.04.066.
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    • Gurzadyan, V. G., H. Yan, G. Vlahovic, A. Kashin, P. Killela, Z. Reitman, S. Sargsyan, G. Yegorian, G. Milledge, and B. Vlahovic. “Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis.” R Soc Open Sci 2, no. 8 (August 2015): 150143. https://doi.org/10.1098/rsos.150143.
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    • Reitman, Zachary J., Sergey A. Sinenko, Eric P. Spana, and Hai Yan. “Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.” Blood 125, no. 2 (January 8, 2015): 336–45. https://doi.org/10.1182/blood-2014-05-577940.
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    • Reitman, Zachary J. “Smaller protein, larger therapeutic potential: PPM1D as a new therapeutic target in brainstem glioma.” Pharmacogenomics 15, no. 13 (September 2014): 1639–41. https://doi.org/10.2217/pgs.14.123.
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    • Reitman, Zachary J., Christopher G. Duncan, Ethan Poteet, Ali Winters, Liang-Jun Yan, David M. Gooden, Ivan Spasojevic, Laszlo G. Boros, Shao-Hua Yang, and Hai Yan. “Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.” J Biol Chem 289, no. 34 (August 22, 2014): 23318–28. https://doi.org/10.1074/jbc.M114.575183.
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    • Yan, H., P. J. Killela, Z. J. Reitman, Y. Jiao, C. Bettegowda, N. Agrawal, L. A. Diaz, et al. “Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Neuro Oncol 16 Suppl 3 (July 2014): iii5–6. https://doi.org/10.1093/neuonc/nou206.18.
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    • Zhang, Liwei, Lee H. Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nat Genet 46, no. 7 (July 2014): 726–30. https://doi.org/10.1038/ng.2995.
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    • Killela, Patrick J., Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B Ahmed Rasheed, Eric Lipp, Henry Friedman, et al. “The genetic landscape of anaplastic astrocytoma.” Oncotarget 5, no. 6 (March 30, 2014): 1452–57. https://doi.org/10.18632/oncotarget.1505.
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    • Killela, Patrick J., Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, B Ahmed Rasheed, Rui Yang, et al. “Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.” Oncotarget 5, no. 6 (March 30, 2014): 1515–25. https://doi.org/10.18632/oncotarget.1765.
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    • Zhang, L., L. H. Chen, H. Wan, R. Yang, Z. Wang, J. Feng, S. Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nature Genetics 46, no. 7 (January 1, 2014): 726–30. https://doi.org/10.1038/ng.2995.
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    • Reitman, Zachary J., Christopher J. Pirozzi, and Hai Yan. “Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors.” Acta Neuropathol 126, no. 6 (December 2013): 789–92. https://doi.org/10.1007/s00401-013-1207-5.
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    • Pirozzi, Christopher J., Zachary J. Reitman, and Hai Yan. “Releasing the block: setting differentiation free with mutant IDH inhibitors.” Cancer Cell 23, no. 5 (May 13, 2013): 570–72. https://doi.org/10.1016/j.ccr.2013.04.024.
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    • Killela, Patrick J., Zachary J. Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A. Diaz, Allan H. Friedman, et al. “TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 6021–26. https://doi.org/10.1073/pnas.1303607110.
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    • Bettegowda, Chetan, Nishant Agrawal, Yuchen Jiao, Yuxuan Wang, Laura D. Wood, Fausto J. Rodriguez, Ralph H. Hruban, et al. “Exomic sequencing of four rare central nervous system tumor types.” Oncotarget 4, no. 4 (April 2013): 572–83. https://doi.org/10.18632/oncotarget.964.
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    • Jin, Genglin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B Ahmed Rasheed, Rui Yang, et al. “Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.” Cancer Res 73, no. 2 (January 15, 2013): 496–501. https://doi.org/10.1158/0008-5472.CAN-12-2852.
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    • Reitman, Zachary J., Bryan D. Choi, Ivan Spasojevic, Darell D. Bigner, John H. Sampson, and Hai Yan. “Enzyme redesign guided by cancer-derived IDH1 mutations.” Nat Chem Biol 8, no. 11 (November 2012): 887–89. https://doi.org/10.1038/nchembio.1065.
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    • Jiao, Yuchen, Patrick J. Killela, Zachary J. Reitman, Ahmed B. Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, et al. “Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.” Oncotarget 3, no. 7 (July 2012): 709–22. https://doi.org/10.18632/oncotarget.588.
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    • Riggs, Kevin R., Zachary J. Reitman, Thelma J. Mielenz, and Philip C. Goodman. “Relationship Between Time of First Publication and Subsequent Publication Success Among Non-PhD Physician-Scientists.” J Grad Med Educ 4, no. 2 (June 2012): 196–201. https://doi.org/10.4300/JGME-D-11-00068.1.
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    • Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.” Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3270–75. https://doi.org/10.1073/pnas.1019393108.
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    • Jin, Genglin, Zachary J. Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D. Bigner, and Hai Yan. “2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.” Plos One 6, no. 2 (February 4, 2011): e16812. https://doi.org/10.1371/journal.pone.0016812.
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    • Lopez, Giselle Y., Zachary J. Reitman, David Solomon, Todd Waldman, Darell D. Bigner, Roger E. McLendon, Steven A. Rosenberg, Yardena Samuels, and Hai Yan. “IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.” Biochem Biophys Res Commun 398, no. 3 (July 30, 2010): 585–87. https://doi.org/10.1016/j.bbrc.2010.06.125.
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    • Reitman, Zachary J., and Hai Yan. “Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.” J Natl Cancer Inst 102, no. 13 (July 7, 2010): 932–41. https://doi.org/10.1093/jnci/djq187.
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    • Reitman, Zachary J., Natasha J. Olby, Christopher L. Mariani, Rachael Thomas, Matthew Breen, Darell D. Bigner, Roger E. McLendon, and Hai Yan. “IDH1 and IDH2 hotspot mutations are not found in canine glioma.” Int J Cancer 127, no. 1 (July 1, 2010): 245–46. https://doi.org/10.1002/ijc.25017.
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    • Reitman, Zachary J., D Williams Parsons, and Hai Yan. “IDH1 and IDH2: not your typical oncogenes.” Cancer Cell 17, no. 3 (March 16, 2010): 215–16. https://doi.org/10.1016/j.ccr.2010.02.024.
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    • Reitman, Z., and H. Yan. “The author and a colleague reply.” New England Journal of Medicine 360, no. 21 (May 21, 2009): 2249. https://doi.org/10.1056/NEJMc090391.
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    • Shen, Miaoqing, Zachary J. Reitman, Yan Zhao, Ibrahim Moustafa, Qixin Wang, Jamie J. Arnold, Harsh B. Pathak, and Craig E. Cameron. “Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex.” J Biol Chem 283, no. 2 (January 11, 2008): 875–88. https://doi.org/10.1074/jbc.M707907200.
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  • Conference Papers

    • Vaios, E. J., M. Grabowski, E. Srinivasan, D. Huie, E. Sankey, B. Otvos, M. Olufawo, et al. “Combining Laser Interstitial Thermal Therapy With SRS Improves Time to Progression for Recurrent SRS-Treated Brain Metastases.” In International Journal of Radiation Oncology, Biology, Physics, 111:e583–84, 2021. https://doi.org/10.1016/j.ijrobp.2021.07.1565.
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    • Wang, C., Y. Xie, Z. Hu, F. F. Yin, Z. Reitman, and Y. Cui. “A Dosimetric Study Comparing Two Beam Arrangement Strategies in Fractionated Thoracic Spine Stereotactic Body Radiotherapy (SBRT) Planning.” In International Journal of Radiation Oncology, Biology, Physics, 111:e557, 2021. https://doi.org/10.1016/j.ijrobp.2021.07.1510.
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