Zachary James Reitman | Scholars@Duke

Zachary James Reitman
Medical Instructor in the Department of Radiation Oncology

Dr. Reitman’s clinical interests include radiotherapy for primary and metastatic tumors of the brain and spine. He is also interested in basic and translational research studies to develop new treatment approaches for pediatric and adult brain tumors. He uses genomic analysis, radiation biology studies, and genetically engineered animal models of cancer to carry out this research

Current Research Interests

The goal of the Reitman Lab is to make discoveries that guide the design of improved treatment strategies for children and adults with brain tumors. The Reitman Lab is based in the Department of Radiation Oncology and the team works closely with the faculty and staff in the Preston Robert Tisch Brain Tumor Center at Duke, the Department of Neurosurgery and the Duke Cancer Institute.

Current Appointments & Affiliations

Medical Instructor in the Department of Radiation Oncology, Radiation Oncology, Clinical Science Departments 2019
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2019

Contact Information

30 Duke Medicine Circle, Box 3085, Durham, NC 27710
30 Duke Medicine Circle, Box 3085, Durham, NC 27710
(919) 668-7336
Reitman Lab website

Background
Education, Training, & Certifications
- Resident, Radiation Oncology, Massachusetts General Hospital 2015 - 2019
- Internship, Internal Medicine, Union Memorial Hospital 2014 - 2015
- M.D., Duke University School of Medicine 2014
- Ph.D., Duke University School of Medicine 2012
Expertise
Subject Headings
Research
Selected Grants
- Enhancing the efficacy of radiation therapy for brainstem gliomas awarded by St. Baldrick's Foundation 2020 - 2022
- Identifying brainstem glioma subtypes that can be radiosensitized by ATM inhibition awarded by Pediatric Brain Tumor Foundation 2019 - 2022
- Enhancing the efficacy of radiation therapy for DIPG awarded by Michael Mosier Defeat DIPG Foundation 2020 - 2021
- Prioritizing PPM1D mutations as a target for new DIPG therapies awarded by Michael Mosier Defeat DIPG Foundation 2019
- Generation of a genetically-modified microorganism for adipic acid production awarded by North Carolina Biotechnology Center 2014 - 2015
External Relationships
- Genetron Health
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Chitneni, Satish K., Zachary J. Reitman, Rebecca Spicehandler, David M. Gooden, Hai Yan, and Michael R. Zalutsky. “Synthesis and evaluation of radiolabeled AGI-5198 analogues as candidate radiotracers for imaging mutant IDH1 expression in tumors.” Bioorg Med Chem Lett 28, no. 4 (February 15, 2018): 694–99. https://doi.org/10.1016/j.bmcl.2018.01.015.
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  - Song, Zhi-Jian, Zachary J. Reitman, Zeng-Yi Ma, Jian-Hua Chen, Qi-Lin Zhang, Xue-Fei Shou, Chuan-Xin Huang, et al. “The genome-wide mutational landscape of pituitary adenomas.” Cell Res 26, no. 11 (November 2016): 1255–59. https://doi.org/10.1038/cr.2016.114.
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  - Chitneni, Satish K., Zachary J. Reitman, David M. Gooden, Hai Yan, and Michael R. Zalutsky. “Radiolabeled inhibitors as probes for imaging mutant IDH1 expression in gliomas: Synthesis and preliminary evaluation of labeled butyl-phenyl sulfonamide analogs.” Eur J Med Chem 119 (August 25, 2016): 218–30. https://doi.org/10.1016/j.ejmech.2016.04.066.
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  - Gurzadyan, V. G., H. Yan, G. Vlahovic, A. Kashin, P. Killela, Z. Reitman, S. Sargsyan, G. Yegorian, G. Milledge, and B. Vlahovic. “Detecting somatic mutations in genomic sequences by means of Kolmogorov-Arnold analysis.” R Soc Open Sci 2, no. 8 (August 2015): 150143. https://doi.org/10.1098/rsos.150143.
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  - Reitman, Zachary J., Sergey A. Sinenko, Eric P. Spana, and Hai Yan. “Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.” Blood 125, no. 2 (January 8, 2015): 336–45. https://doi.org/10.1182/blood-2014-05-577940.
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  - Reitman, Zachary J., Christopher G. Duncan, Ethan Poteet, Ali Winters, Liang-Jun Yan, David M. Gooden, Ivan Spasojevic, Laszlo G. Boros, Shao-Hua Yang, and Hai Yan. “Cancer-associated isocitrate dehydrogenase 1 (IDH1) R132H mutation and d-2-hydroxyglutarate stimulate glutamine metabolism under hypoxia.” J Biol Chem 289, no. 34 (August 22, 2014): 23318–28. https://doi.org/10.1074/jbc.M114.575183.
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  - Yan, H., P. J. Killela, Z. J. Reitman, Y. Jiao, C. Bettegowda, N. Agrawal, L. A. Diaz, et al. “Tert promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Neuro Oncol 16 Suppl 3 (July 2014): iii5–6. https://doi.org/10.1093/neuonc/nou206.18.
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  - Zhang, Liwei, Lee H. Chen, Hong Wan, Rui Yang, Zhaohui Wang, Jie Feng, Shaohua Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nat Genet 46, no. 7 (July 2014): 726–30. https://doi.org/10.1038/ng.2995.
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  - Killela, Patrick J., Christopher J. Pirozzi, Patrick Healy, Zachary J. Reitman, Eric Lipp, B Ahmed Rasheed, Rui Yang, et al. “Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas.” Oncotarget 5, no. 6 (March 30, 2014): 1515–25. https://doi.org/10.18632/oncotarget.1765.
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  - Killela, Patrick J., Christopher J. Pirozzi, Zachary J. Reitman, Sian Jones, B Ahmed Rasheed, Eric Lipp, Henry Friedman, et al. “The genetic landscape of anaplastic astrocytoma.” Oncotarget 5, no. 6 (March 30, 2014): 1452–57. https://doi.org/10.18632/oncotarget.1505.
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  - Zhang, L., L. H. Chen, H. Wan, R. Yang, Z. Wang, J. Feng, S. Yang, et al. “Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas.” Nature Genetics 46, no. 7 (January 1, 2014): 726–30. https://doi.org/10.1038/ng.2995.
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  - Reitman, Zachary J., Christopher J. Pirozzi, and Hai Yan. “Promoting a new brain tumor mutation: TERT promoter mutations in CNS tumors.” Acta Neuropathol 126, no. 6 (December 2013): 789–92. https://doi.org/10.1007/s00401-013-1207-5.
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  - Pirozzi, Christopher J., Zachary J. Reitman, and Hai Yan. “Releasing the block: setting differentiation free with mutant IDH inhibitors.” Cancer Cell 23, no. 5 (May 2013): 570–72. https://doi.org/10.1016/j.ccr.2013.04.024.
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  - Killela, Patrick J., Zachary J. Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A. Diaz, Allan H. Friedman, et al. “TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.” Proc Natl Acad Sci U S A 110, no. 15 (April 9, 2013): 6021–26. https://doi.org/10.1073/pnas.1303607110.
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  - Bettegowda, Chetan, Nishant Agrawal, Yuchen Jiao, Yuxuan Wang, Laura D. Wood, Fausto J. Rodriguez, Ralph H. Hruban, et al. “Exomic sequencing of four rare central nervous system tumor types.” Oncotarget 4, no. 4 (April 2013): 572–83. https://doi.org/10.18632/oncotarget.964.
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  - Jin, Genglin, Zachary J. Reitman, Christopher G. Duncan, Ivan Spasojevic, David M. Gooden, B Ahmed Rasheed, Rui Yang, et al. “Disruption of wild-type IDH1 suppresses D-2-hydroxyglutarate production in IDH1-mutated gliomas.” Cancer Res 73, no. 2 (January 15, 2013): 496–501. https://doi.org/10.1158/0008-5472.CAN-12-2852.
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  - Reitman, Zachary J., Bryan D. Choi, Ivan Spasojevic, Darell D. Bigner, John H. Sampson, and Hai Yan. “Enzyme redesign guided by cancer-derived IDH1 mutations.” Nat Chem Biol 8, no. 11 (November 2012): 887–89. https://doi.org/10.1038/nchembio.1065.
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  - Jiao, Yuchen, Patrick J. Killela, Zachary J. Reitman, Ahmed B. Rasheed, Christopher M. Heaphy, Roeland F. de Wilde, Fausto J. Rodriguez, et al. “Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.” Oncotarget 3, no. 7 (July 2012): 709–22. https://doi.org/10.18632/oncotarget.588.
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  - Reitman, Zachary J., Genglin Jin, Edward D. Karoly, Ivan Spasojevic, Jian Yang, Kenneth W. Kinzler, Yiping He, Darell D. Bigner, Bert Vogelstein, and Hai Yan. “Profiling the effects of isocitrate dehydrogenase 1 and 2 mutations on the cellular metabolome.” Proc Natl Acad Sci U S A 108, no. 8 (February 22, 2011): 3270–75. https://doi.org/10.1073/pnas.1019393108.
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  - Jin, Genglin, Zachary J. Reitman, Ivan Spasojevic, Ines Batinic-Haberle, Jian Yang, Oleg Schmidt-Kittler, Darell D. Bigner, and Hai Yan. “2-hydroxyglutarate production, but not dominant negative function, is conferred by glioma-derived NADP-dependent isocitrate dehydrogenase mutations.” Plos One 6, no. 2 (February 4, 2011): e16812. https://doi.org/10.1371/journal.pone.0016812.
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  - Lopez, Giselle Y., Zachary J. Reitman, David Solomon, Todd Waldman, Darell D. Bigner, Roger E. McLendon, Steven A. Rosenberg, Yardena Samuels, and Hai Yan. “IDH1(R132) mutation identified in one human melanoma metastasis, but not correlated with metastases to the brain.” Biochem Biophys Res Commun 398, no. 3 (July 30, 2010): 585–87. https://doi.org/10.1016/j.bbrc.2010.06.125.
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  - Reitman, Zachary J., and Hai Yan. “Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism.” J Natl Cancer Inst 102, no. 13 (July 7, 2010): 932–41. https://doi.org/10.1093/jnci/djq187.
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  - Reitman, Zachary J., Natasha J. Olby, Christopher L. Mariani, Rachael Thomas, Matthew Breen, Darell D. Bigner, Roger E. McLendon, and Hai Yan. “IDH1 and IDH2 hotspot mutations are not found in canine glioma.” Int J Cancer 127, no. 1 (July 1, 2010): 245–46. https://doi.org/10.1002/ijc.25017.
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  - Reitman, Zachary J., D Williams Parsons, and Hai Yan. “IDH1 and IDH2: not your typical oncogenes.” Cancer Cell 17, no. 3 (March 16, 2010): 215–16. https://doi.org/10.1016/j.ccr.2010.02.024.
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  - Reitman, Z., and H. Yan. “The author and a colleague reply.” New England Journal of Medicine 360, no. 21 (May 21, 2009): 2249. https://doi.org/10.1056/NEJMc090391.
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  - Shen, Miaoqing, Zachary J. Reitman, Yan Zhao, Ibrahim Moustafa, Qixin Wang, Jamie J. Arnold, Harsh B. Pathak, and Craig E. Cameron. “Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex.” J Biol Chem 283, no. 2 (January 11, 2008): 875–88. https://doi.org/10.1074/jbc.M707907200.
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Education, Training, & Certifications

Subject Headings

Selected Grants

External Relationships

Selected Publications

Academic Articles