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A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen.

Publication ,  Journal Article
Murphy, JD; Olshan, AF; Lin, F-C; Troester, MA; Nichols, HB; Butt, J; Qiao, Y-L; Abnet, CC; Inoue, M; Tsugane, S; Epplein, M
Published in: Cancer Epidemiol Biomarkers Prev
April 1, 2022

BACKGROUND: Blood-based biomarkers for gastric cancer risk stratification could facilitate targeting screening to people who will benefit from it most. The ABC Method, which stratifies individuals by their Helicobacter pylori infection and serum-diagnosed chronic atrophic gastritis status, is currently used in Japan for this purpose. Most gastric cancers are caused by chronic H. pylori infection, but few studies have explored the capability of antibody response to H. pylori proteins to predict gastric cancer risk in addition to established predictors. METHODS: We used the least absolute shrinkage and selection operator (Lasso) to build a predictive model of noncardia gastric adenocarcinoma risk from serum data on pepsinogen and antibody response to 13 H. pylori antigens as well as demographic and lifestyle factors from a large international study in East Asia. RESULTS: Our best model had a significantly (P < 0.001) higher AUC of 73.79% [95% confidence interval (CI), 70.86%-76.73%] than the ABC Method (68.75%; 95% CI, 65.91%-71.58%). At 75% specificity, the new model had greater sensitivity than the ABC Method (58.67% vs. 52.68%) as well as NPV (68.24% vs. 66.29%). CONCLUSIONS: Along with serologically defined chronic atrophic gastritis, antibody response to the H. pylori proteins HP 0305, HP 1564, and UreA can improve the prediction of gastric cancer risk. IMPACT: The new risk stratification model could help target more invasive gastric screening resources to individuals at high risk.

Duke Scholars

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 1, 2022

Volume

31

Issue

4

Start / End Page

811 / 820

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Pepsinogen A
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Gastritis, Atrophic
  • Epidemiology
  • Antibody Formation
  • Adenocarcinoma
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Murphy, J. D., Olshan, A. F., Lin, F.-C., Troester, M. A., Nichols, H. B., Butt, J., … Epplein, M. (2022). A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen. Cancer Epidemiol Biomarkers Prev, 31(4), 811–820. https://doi.org/10.1158/1055-9965.EPI-21-0869
Murphy, John D., Andrew F. Olshan, Feng-Chang Lin, Melissa A. Troester, Hazel B. Nichols, Julia Butt, You-Lin Qiao, et al. “A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen.Cancer Epidemiol Biomarkers Prev 31, no. 4 (April 1, 2022): 811–20. https://doi.org/10.1158/1055-9965.EPI-21-0869.
Murphy JD, Olshan AF, Lin F-C, Troester MA, Nichols HB, Butt J, et al. A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen. Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):811–20.
Murphy, John D., et al. “A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen.Cancer Epidemiol Biomarkers Prev, vol. 31, no. 4, Apr. 2022, pp. 811–20. Pubmed, doi:10.1158/1055-9965.EPI-21-0869.
Murphy JD, Olshan AF, Lin F-C, Troester MA, Nichols HB, Butt J, Qiao Y-L, Abnet CC, Inoue M, Tsugane S, Epplein M. A Predictive Model of Noncardia Gastric Adenocarcinoma Risk Using Antibody Response to Helicobacter pylori Proteins and Pepsinogen. Cancer Epidemiol Biomarkers Prev. 2022 Apr 1;31(4):811–820.

Published In

Cancer Epidemiol Biomarkers Prev

DOI

EISSN

1538-7755

Publication Date

April 1, 2022

Volume

31

Issue

4

Start / End Page

811 / 820

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Pepsinogen A
  • Humans
  • Helicobacter pylori
  • Helicobacter Infections
  • Gastritis, Atrophic
  • Epidemiology
  • Antibody Formation
  • Adenocarcinoma