ALSUntangled #64: butyrates.
Publication
, Journal Article
Sun, Y; Bedlack, R; Armon, C; Beauchamp, M; Bertorini, T; Bowser, R; Bromberg, M; Caress, J; Carter, G; Crayle, J; Cudkowicz, ME; Glass, JD ...
Published in: Amyotroph Lateral Scler Frontotemporal Degener
November 2022
ALSUntangled reviews alternative and off-label treatments for people living with amyotrophic lateral sclerosis (PALS). Here we review butyrate and its different chemical forms (butyrates). Butyrates have plausible mechanisms for slowing ALS progression and positive pre-clinical studies. One trial suggests that sodium phenylbutyrate (NaPB) in combination with Tauroursodeoxycholic acid (TUDCA) can slow ALS progression and prolong survival, but the specific contribution of NaPB toward this effect is unclear. Butyrates appear reasonably safe for use in humans. Based on the above information, we support a trial of a butyrate in PALS, but we cannot yet recommend one as a treatment.
Duke Scholars
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Published In
Amyotroph Lateral Scler Frontotemporal Degener
DOI
EISSN
2167-9223
Publication Date
November 2022
Volume
23
Issue
7-8
Start / End Page
638 / 643
Location
England
Related Subject Headings
- Humans
- Butyrates
- Amyotrophic Lateral Sclerosis
- 3209 Neurosciences
- 1109 Neurosciences
- 1103 Clinical Sciences
Citation
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Chicago
ICMJE
MLA
NLM
Sun, Y., Bedlack, R., Armon, C., Beauchamp, M., Bertorini, T., Bowser, R., … Wicks, P. (2022). ALSUntangled #64: butyrates. Amyotroph Lateral Scler Frontotemporal Degener, 23(7–8), 638–643. https://doi.org/10.1080/21678421.2022.2045323
Sun, Yuyao, Richard Bedlack, Carmel Armon, Morgan Beauchamp, Tulio Bertorini, Robert Bowser, Mark Bromberg, et al. “ALSUntangled #64: butyrates.” Amyotroph Lateral Scler Frontotemporal Degener 23, no. 7–8 (November 2022): 638–43. https://doi.org/10.1080/21678421.2022.2045323.
Sun Y, Bedlack R, Armon C, Beauchamp M, Bertorini T, Bowser R, et al. ALSUntangled #64: butyrates. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Nov;23(7–8):638–43.
Sun, Yuyao, et al. “ALSUntangled #64: butyrates.” Amyotroph Lateral Scler Frontotemporal Degener, vol. 23, no. 7–8, Nov. 2022, pp. 638–43. Pubmed, doi:10.1080/21678421.2022.2045323.
Sun Y, Bedlack R, Armon C, Beauchamp M, Bertorini T, Bowser R, Bromberg M, Caress J, Carter G, Crayle J, Cudkowicz ME, Glass JD, Jackson C, Lund I, Martin S, Paganoni S, Pattee G, Ratner D, Salmon K, Wicks P. ALSUntangled #64: butyrates. Amyotroph Lateral Scler Frontotemporal Degener. 2022 Nov;23(7–8):638–643.
Published In
Amyotroph Lateral Scler Frontotemporal Degener
DOI
EISSN
2167-9223
Publication Date
November 2022
Volume
23
Issue
7-8
Start / End Page
638 / 643
Location
England
Related Subject Headings
- Humans
- Butyrates
- Amyotrophic Lateral Sclerosis
- 3209 Neurosciences
- 1109 Neurosciences
- 1103 Clinical Sciences