Remodeling Yersinia pseudotuberculosis to generate a highly immunogenic outer membrane vesicle vaccine against pneumonic plague.

Journal Article (Journal Article)

SignificanceYersinia pestis, the etiologic agent of plague, has been responsible for high mortality in several epidemics throughout human history. This plague bacillus has been used as a biological weapon during human history and is currently one of the deadliest biological threats. Currently, no licensed plague vaccines are available in the Western world. Since an array of immunogens are enclosed in outer membrane vesicles (OMVs), immune responses elicited by OMVs against a diverse range of antigens may reduce the likelihood of antigen circumvention. Therefore, self-adjuvanting OMVs from a remodeled Yersinia pseudotuberculosis strain as a type of plague vaccine could diversify prophylactic choices and solve current vaccine limitations.

Full Text

Duke Authors

Cited Authors

  • Wang, X; Li, P; Singh, AK; Zhang, X; Guan, Z; Curtiss, R; Sun, W

Published Date

  • March 15, 2022

Published In

Volume / Issue

  • 119 / 11

Start / End Page

  • e2109667119 -

PubMed ID

  • 35275791

Pubmed Central ID

  • PMC8931243

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

Digital Object Identifier (DOI)

  • 10.1073/pnas.2109667119


  • eng

Conference Location

  • United States