Ziqiang Guan | Scholars@Duke

Ziqiang Guan
Research Professor in Biochemistry

We develop and apply mass spectrometry techniques to address biochemical and biomedical questions that are lipid-related. Research projects include:

1) Structural lipidomics

o Develop and apply high resolution tandem mass spectrometry-based lipidomics for the discovery, structural elucidation and functional study of novel lipids.

2) Elucidation of novel pathways/enzymes of lipid biosynthesis and metabolism

o Genetic, biochemical and MS approaches are employed to identify the substrates and pathways involved in lipid biosynthesis and metabolism

3) Identification of lipid biomarkers of genetic diseases and cancers

o Provide molecular insights into the disease mechanisms, as well as to serve as the diagnostic and prognostic tools of diseases.

Current Appointments & Affiliations

Research Professor in Biochemistry, Biochemistry, Basic Science Departments 2017

Contact Information

240 Nanaline H Duke, Durham, NC 27710
Duke Box 3711, Durham, NC 27710
zguan@biochem.duke.edu (919) 684-3005

Background
Education, Training, & Certifications
- Research Associate, Chemistry, Cornell University 1994 - 1997
- Ph.D., University of Texas at Austin 1994
Duke Appointment History
- Associate Research Professor in Biochemistry, Biochemistry, Basic Science Departments 2004 - 2017
- Instructor, Temporary in the Department of Biochemistry, Biochemistry, Basic Science Departments 2004
Recognition
In the News
- OCT 8, 2013
  
  New Urine Test Could Diagnose Eye Disease
Expertise
Subject Headings
Global Scholarship
- Expertise
  - United States of America (Country)
Research
Selected Grants
- Structural and Mechanistic Characterization of MraY Catalysis and Inhibition awarded by National Institutes of Health 2017 - 2020
- Biochemistry and Structure of Lipid A Enzymes awarded by National Institutes of Health 2016 - 2020
- Human Stringent Response as Novel Therapeutic Approaches for Breast Cancers awarded by Department of Defense 2015 - 2018
- Platelet AADACL1 in thrombosis, lipidomics and signaling awarded by University of North Carolina - Chapel Hill 2017 - 2018
- DHDDS and retinal degeneration awarded by University of Miami 2014 - 2018
- Targeting the synthetic essential kinases of breast cancers awarded by Department of Defense 2015 - 2018
- Biosynthesis And Function Of Lipopolysaccharides awarded by National Institutes of Health 1994 - 2015
- NQO1: Linking Oxidant Stress to Inflammation in Airway Epithelial Cells awarded by National Institutes of Health 2010 - 2014
- Lipid A Modification Systems in Gram-Negative Bacteria awarded by National Institutes of Health 1995 - 2013
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Chung, BC, Zhao, J, Gillespie, R, Kwon, DY, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis." January 2014. Full Text
  - Zhang, J, Guan, Z, Murphy, A, Wiley, S, Perkins, G, Worby, C, Engel, J, Raetz, CRH, Dowhan, W, and Dixon, J. "A Mitochondrial Lipid Phosphatase in Cell Metabolism and Membrane Organization." April 2012. Link to Item
  - Nobles, KN, Guan, ZQ, Xiao, KH, Oas, TG, and Lefkowitz, RJ. "Conformational changes in beta-arrestin1: The importance of beta-arrestin1's N-domain." March 6, 2006. Link to Item
  - Zhou, F, Yang, X, Xiong, C, Zhang, S, Zong, Y, Sun, L, and Guan, Z. "Application and Study of Fine-silty Sand Control Technique for Unconsolidation Quaternary Sand Gas Reservoir, Sebei Qinghai." May 12, 2004.
- Journal Articles
  - Lin, Y, Bogdanov, M, Lu, S, Guan, Z, Margolin, W, Weiss, J, and Zheng, L. "The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack." The Journal of biological chemistry 293, no. 9 (March 2018): 3386-3398. Full Text Open Access Copy
  - Bhardwaj, P, Hans, A, Ruikar, K, Guan, Z, and Palmer, KL. "Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure." Antimicrobial agents and chemotherapy 62, no. 1 (January 2018). Full Text
  - Guan, Z, Delago, A, Nußbaum, P, Meyer, BH, Albers, S-V, and Eichler, J. "Gene deletions leading to a reduction in the number of cyclopentane rings in Sulfolobus acidocaldarius tetraether lipids." FEMS microbiology letters 365, no. 1 (January 2018). Full Text Open Access Copy
  - Kimchi, A, Khateb, S, Wen, R, Guan, Z, Obolensky, A, Beryozkin, A, Kurtzman, S, Blumenfeld, A, Pras, E, Jacobson, SG, Ben-Yosef, T, Newman, H, Sharon, D, and Banin, E. "Nonsyndromic Retinitis Pigmentosa in the Ashkenazi Jewish Population: Genetic and Clinical Aspects." Ophthalmology (December 22, 2017). Full Text
  - Hoffmann, R, Grabińska, K, Guan, Z, Sessa, WC, and Neiman, AM. "Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae." Genetics 207, no. 4 (December 2017): 1371-1386. Full Text
  - Tang, S, Fang, Y, Huang, G, Xu, X, Padilla-Banks, E, Fan, W, Xu, Q, Sanderson, SM, Foley, JF, Dowdy, S, McBurney, MW, Fargo, DC, Williams, CJ, Locasale, JW, Guan, Z, and Li, X. "Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development." The EMBO journal 36, no. 21 (November 2017): 3175-3193. Full Text
  - Sandoval-Calderón, M, Guan, Z, and Sohlenkamp, C. "Knowns and unknowns of membrane lipid synthesis in streptomycetes." Biochimie 141 (October 2017): 21-29. (Review) Full Text
  - Elharar, Y, Podilapu, AR, Guan, Z, Kulkarni, SS, and Eichler, J. "Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate." Bioconjugate chemistry 28, no. 9 (September 2017): 2461-2470. Full Text
  - Eichler, J, and Guan, Z. "Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation." Biochimica et biophysica acta 1862, no. 6 (June 2017): 589-599. (Review) Full Text
  - Adams, HM, Joyce, LR, Guan, Z, Akins, RL, and Palmer, KL. "Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria." Antimicrobial agents and chemotherapy 61, no. 5 (May 2017). Full Text Open Access Copy
  - Goldfine, H, and Guan, Z. "Editorial for Special Issue on lipid methodology." Analytical biochemistry 524 (May 2017): 1-2. Full Text
  - Vences-Guzmán, MÁ, Paula Goetting-Minesky, M, Guan, Z, Castillo-Ramirez, S, Córdoba-Castro, LA, López-Lara, IM, Geiger, O, Sohlenkamp, C, and Christopher Fenno, J. "1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway." Molecular microbiology 103, no. 5 (March 2017): 896-912. Full Text Open Access Copy
  - Li, C, Tan, BK, Zhao, J, and Guan, Z. "In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase." The Journal of biological chemistry 291, no. 48 (November 2016): 25144-25153. Full Text Open Access Copy
  - Guan, Z, Chen, L, Gerritsen, J, Smidt, H, and Goldfine, H. "The cellular lipids of Romboutsia." Biochimica et biophysica acta 1861, no. 9 Pt A (September 2016): 1076-1082. Full Text Open Access Copy
  - Guan, Z, Delago, A, Nußbaum, P, Meyer, B, Albers, S-V, and Eichler, J. "N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier." FEBS letters 590, no. 18 (September 2016): 3168-3178. (Letter) Full Text Open Access Copy
  - Young, HE, Zhao, J, Barker, JR, Guan, Z, Valdivia, RH, and Zhou, P. "Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis." mBio 7, no. 2 (March 22, 2016): e00090-. Full Text Open Access Copy
  - Park, EJ, Grabińska, KA, Guan, Z, and Sessa, WC. "NgBR is essential for endothelial cell glycosylation and vascular development." EMBO reports 17, no. 2 (February 2016): 167-177. Full Text Open Access Copy
  - Ardiccioni, C, Clarke, OB, Tomasek, D, Issa, HA, von Alpen, DC, Pond, HL, Banerjee, S, Rajashankar, KR, Liu, Q, Guan, Z, Li, C, Kloss, B, Bruni, R, Kloppmann, E, Rost, B, Manzini, MC, Shapiro, L, and Mancia, F. "Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis." Nature communications 7 (January 5, 2016): 10175-. Full Text Open Access Copy
  - Lin, Y, Bogdanov, M, Tong, S, Guan, Z, and Zheng, L. "Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli." The Journal of biological chemistry 291, no. 5 (January 2016): 2136-2149. Full Text
  - Lukose, V, Whitworth, G, Guan, Z, and Imperiali, B. "Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific Orthogonal Labeling." Journal of the American Chemical Society 137, no. 39 (October 2015): 12446-12449. Full Text
  - Vences-Guzmán, MÁ, Guan, Z, Escobedo-Hinojosa, WI, Bermúdez-Barrientos, JR, Geiger, O, and Sohlenkamp, C. "Discovery of a bifunctional acyltransferase responsible for ornithine lipid synthesis in Serratia proteamaculans." Environmental microbiology 17, no. 5 (May 2015): 1487-1496. Full Text
  - Gorden, DL, Myers, DS, Ivanova, PT, Fahy, E, Maurya, MR, Gupta, S, Min, J, Spann, NJ, McDonald, JG, Kelly, SL, Duan, J, Sullards, MC, Leiker, TJ, Barkley, RM, Quehenberger, O, Armando, AM, Milne, SB, Mathews, TP, Armstrong, MD, Li, C, Melvin, WV, Clements, RH, Washington, MK, Mendonsa, AM, Witztum, JL, Guan, Z, Glass, CK, Murphy, RC, Dennis, EA, Merrill, AH, Russell, DW, Subramaniam, S, and Brown, HA. "Biomarkers of NAFLD progression: a lipidomics approach to an epidemic." Journal of lipid research 56, no. 3 (March 2015): 722-736. Full Text
  - Chang, MM, Imperiali, B, Eichler, J, and Guan, Z. "N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus." PLoS ONE 10, no. 6 (January 2015): e0130482-. Full Text
  - Vences-Guzmán, M, Guan, Z, Escobedo-Hinojosa, WI, Bermúdez-Barrientos, JR, Geiger, O, and Sohlenkamp, C. "Discovery of a bifunctional acyltransferase responsible for ornithine lipid synthesis in Serratia proteamaculans." Environmental Microbiology 17, no. 5 (2015): 1487-1496. Full Text
  - Guan, Z, Katzianer, D, Zhu, J, and Goldfine, H. "Clostridium difficile contains plasmalogen species of phospholipids and glycolipids." Biochimica et biophysica acta 1842, no. 10 (October 2014): 1353-1359. Full Text
  - Chung, HS, Yang, EG, Hwang, D, Lee, JE, Guan, Z, and Raetz, CRH. "Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis." Biochemical and biophysical research communications 452, no. 3 (September 6, 2014): 789-794. Full Text
  - Park, EJ, Grabińska, KA, Guan, Z, Stránecký, V, Hartmannová, H, Hodaňová, K, Barešová, V, Sovová, J, Jozsef, L, Ondrušková, N, Hansíková, H, Honzík, T, Zeman, J, Hůlková, H, Wen, R, Kmoch, S, and Sessa, WC. "Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation." Cell Metabolism 20, no. 3 (September 2, 2014): 448-457. Full Text
  - Park, EJ, Grabińska, KA, Guan, Z, Stránecký, V, Hartmannová, H, Hodaňová, K, Barešová, V, Sovová, J, Jozsef, L, Ondrušková, N, Hansíková, H, Honzík, T, Zeman, J, Hůlková, H, Wen, R, Kmoch, S, and Sessa, WC. "Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation." Cell metabolism 20, no. 3 (September 2014): 448-457. Full Text
  - Pride, AC, Guan, Z, and Trent, MS. "Characterization of the Vibrio cholerae VolA surface-exposed lipoprotein lysophospholipase." Journal of bacteriology 196, no. 8 (April 2014): 1619-1626. Full Text
  - Cohen-Rosenzweig, C, Guan, Z, Shaanan, B, and Eichler, J. "Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process a variety of lipid-linked glycans." Applied and environmental microbiology 80, no. 2 (January 2014): 486-496. Full Text
  - Wen, R, Lam, BL, and Guan, Z. "Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis." Journal of Lipid Research 54, no. 12 (December 1, 2013): 3516-3522. Full Text
  - Kaminski, L, Guan, Z, Yurist-Doutsch, S, and Eichler, J. "Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity." mBio 4, no. 6 (November 5, 2013): e00716-e00713. Full Text
  - Chung, BC, Zhao, J, Gillespie, RA, Kwon, D-Y, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis." Science 341, no. 6149 (August 30, 2013): 1012-1016. Full Text Link to Item
  - Tran, TT, Panesso, D, Mishra, NN, Mileykovskaya, E, Guan, Z, Munita, JM, Reyes, J, Diaz, L, Weinstock, GM, Murray, BE, Shamoo, Y, Dowhan, W, Bayer, AS, and Arias, CA. "Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids." mBio 4, no. 4 (July 23, 2013). Full Text
  - Guan, Z, Tian, B, Perfumo, A, and Goldfine, H. "The polar lipids of Clostridium psychrophilum, an anaerobic psychrophile." Biochim Biophys Acta 1831, no. 6 (June 2013): 1108-1112. Full Text Link to Item
  - Zeng, D, Zhao, J, Chung, HS, Guan, Z, Raetz, CRH, and Zhou, P. "Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis." J Biol Chem 288, no. 8 (February 22, 2013): 5475-5486. Full Text Link to Item
  - Arbiv, A, Yurist-Doutsch, S, Guan, Z, and Eichler, J. "AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway." PLoS ONE 8, no. 11 (January 2013): e81782-. Full Text
  - Chung, BC, Zhao, J, Gillespie, RA, Kwon, D-Y, Guan, Z, Hong, J, Zhou, P, and Lee, S-Y. "Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis." Science 341, no. 6149 (2013): 1012-1016. Full Text
  - Kandiba, L, Guan, Z, and Eichler, J. "Lipid modification gives rise to two distinct Haloferax volcanii S-layer glycoprotein populations." Biochimica et Biophysica Acta - Biomembranes 1828, no. 3 (2013): 938-943. Full Text
  - Pride, AC, Herrera, CM, Guan, Z, Giles, DK, and Trent, MS. "The outer surface lipoprotein VolA mediates utilization of exogenous lipids by Vibrio cholerae." mBio 4, no. 3 (2013). Full Text
  - Shin, J, Zhang, P, Wang, S, Wu, J, Guan, Z, and Zhong, X-P. "Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1." Eur J Immunol 43, no. 1 (January 2013): 240-248. Full Text Link to Item
  - Shin, J, Zhang, P, Wang, S, Wu, J, Guan, Z, and Zhong, X-P. "Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1." European Journal of Immunology 43, no. 1 (2013): 240-248. Full Text
  - Tian, B, Guan, Z, and Goldfine, H. "An ethanolamine-phosphate modified glycolipid in Clostridium acetobutylicum that responds to membrane stress." Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1831, no. 6 (2013): 1185-1190. Full Text
  - Vences-Guzmán, MÁ, Guan, Z, Bermúdez-Barrientos, JR, Geiger, O, and Sohlenkamp, C. "Agrobacteria lacking ornithine lipids induce more rapid tumour formation." Environmental Microbiology 15, no. 3 (2013): 895-906. Full Text
  - Tan, BK, Bogdanov, M, Zhao, J, Dowhan, W, Raetz, CRH, and Guan, Z. "Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates." Proc Natl Acad Sci U S A 109, no. 41 (October 9, 2012): 16504-16509. Full Text Link to Item
  - Guan, Z, Johnston, NC, Raetz, CRH, Johnson, EA, and Goldfine, H. "Lipid diversity among botulinum neurotoxin-producing clostridia." Microbiology 158, no. Pt 10 (October 2012): 2577-2584. Full Text Link to Item
  - Schumacher, MA, Min, J, Link, TM, Guan, Z, Xu, W, Ahn, Y-H, Soderblom, EJ, Kurie, JM, Evdokimov, A, Moseley, MA, Lewis, K, and Brennan, RG. "Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance." Cell Rep 2, no. 3 (September 27, 2012): 518-525. Full Text Link to Item
  - Chen, Y-T, Collins, TRL, Guan, Z, Chen, VB, and Hsieh, T-S. "Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry." J Biol Chem 287, no. 30 (July 20, 2012): 25660-25668. Full Text Link to Item
  - Guan, Z, Naparstek, S, Calo, D, and Eichler, J. "Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation." Environ Microbiol 14, no. 3 (March 2012): 743-753. Full Text Link to Item
  - Gründahl, JEH, Guan, Z, Rust, S, Reunert, J, Müller, B, Chesne, ID, Zerres, K, Rudnik-Schöneborn, S, Ortiz-Brüchle, N, Häusler, MG, Siedlecka, J, Swiezewska, E, Raetz, CRH, and Marquardt, T. "Life with too much polyprenol: Polyprenol reductase deficiency." Molecular Genetics and Metabolism 105, no. 4 (2012): 642-651. Full Text
  - Kaminski, L, Guan, Z, Abu-Qarn, M, Konrad, Z, and Eichler, J. "AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein." Biochimica et Biophysica Acta - General Subjects 1820, no. 10 (2012): 1664-1670. Full Text
  - Kandiba, L, Aitio, O, Helin, J, Guan, Z, Permi, P, Bamford, DH, Eichler, J, and Roine, E. "Diversity in prokaryotic glycosylation: An archaeal-derived N-linked glycan contains legionaminic acid." Molecular Microbiology 84, no. 3 (2012): 578-593. Full Text
  - Mishra, NN, Bayer, AS, Tran, TT, Shamoo, Y, Mileykovskaya, E, Dowhan, W, Guan, Z, and Arias, CA. "Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content." PLoS ONE 7, no. 8 (2012). Full Text
  - Naparstek, S, Guan, Z, and Eichler, J. "A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii." Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1821, no. 6 (2012): 923-933. Full Text
  - Vences-Guzmán, MÁ, Guan, Z, Bermúdez-Barrientos, JR, Geiger, O, and Sohlenkamp, C. "Agrobacteria lacking ornithine lipids induce more rapid tumour formation." Environmental Microbiology (2012). Full Text
  - Guan, Z, and Eichler, J. "Liquid chromatography/tandem mass spectrometry of dolichols and polyprenols, lipid sugar carriers across evolution." Biochim Biophys Acta 1811, no. 11 (November 2011): 800-806. (Review) Full Text Link to Item
  - Guan, Z, Meyer, BH, Albers, S-V, and Eichler, J. "The thermoacidophilic archaeon Sulfolobus acidocaldarius contains an unusually short, highly reduced dolichyl phosphate." Biochim Biophys Acta 1811, no. 10 (October 2011): 607-616. Full Text Link to Item
  - Li, C, Guan, Z, Liu, D, and Raetz, CRH. "Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli." Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11387-11392. Full Text Link to Item
  - Guan, Z, Johnston, NC, Aygun-Sunar, S, Daldal, F, Raetz, CRH, and Goldfine, H. "Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens." Biochim Biophys Acta 1811, no. 3 (March 2011): 186-193. Full Text Link to Item
  - Lu, Y-H, Guan, Z, Zhao, J, and Raetz, CRH. "Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli." J Biol Chem 286, no. 7 (February 18, 2011): 5506-5518. Full Text Link to Item
  - Guan, Z, Wang, X, and Raetz, CRH. "Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium." Anal Biochem 409, no. 2 (February 15, 2011): 284-289. Full Text Link to Item
  - Calo, D, Guan, Z, Naparstek, S, and Eichler, J. "Different routes to the same ending: Comparing the N-glycosylation processes of Haloferax volcanii and Haloarcula marismortui, two halophilic archaea from the Dead Sea." Molecular Microbiology 81, no. 5 (2011): 1166-1177. Full Text
  - Calo, D, Guan, Z, and Eichler, J. "Glyco-engineering in Archaea: Differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain." Microbial Biotechnology 4, no. 4 (2011): 461-470. Full Text
  - Garrett, TA, Raetz, CRH, Son, JD, Richardson, TD, Bartling, C, and Guan, Z. "Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts." Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1811, no. 11 (2011): 827-837. Full Text
  - Giles, DK, Hankins, JV, Guan, Z, and Trent, MS. "Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments." Molecular Microbiology 79, no. 3 (2011): 716-728. Full Text
  - Haig, NA, Guan, Z, Li, D, McMichael, A, Raetz, CRH, and Xu, X-N. "Identification of self-lipids presented by CD1c and CD1d proteins." Journal of Biological Chemistry 286, no. 43 (2011): 37692-37701. Full Text
  - Lin, R-K, Zhou, N, Lyu, YL, Tsai, Y-C, Lu, C-H, Kerrigan, J, Chen, Y-T, Guan, Z, Hsieh, T-S, and Liu, LF. "Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα." Journal of Biological Chemistry 286, no. 38 (2011): 33591-33600. Full Text
  - Vences-Guzmán, MÁ, Guan, Z, Ormeño-Orrillo, E, González-Silva, N, López-Lara, IM, Martínez-Romero, E, Geiger, O, and Sohlenkamp, C. "Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899." Molecular Microbiology 79, no. 6 (2011): 1496-1514. Full Text
  - Zhang, C, Ondeyka, J, Herath, K, Jayasuriya, H, Guan, Z, Zink, DL, Dietrich, L, Burgess, B, Ha, SN, Wang, J, and Singh, SB. "Platensimycin and platencin congeners from Streptomyces platensis." Journal of Natural Products 74, no. 3 (2011): 329-340. Full Text
  - Zhang, J, Guan, Z, Murphy, AN, Wiley, SE, Perkins, GA, Worby, CA, Engel, JL, Heacock, P, Nguyen, OK, Wang, JH, Raetz, CRH, Dowhan, W, and Dixon, JE. "Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis." Cell Metabolism 13, no. 6 (2011): 690-700. Full Text
  - Guan, Z, Naparstek, S, Kaminski, L, Konrad, Z, and Eichler, J. "Distinct glycan-charged phosphodolichol carriers are required for the assembly of the pentasaccharide N-linked to the Haloferax volcanii S-layer glycoprotein." Mol Microbiol 78, no. 5 (December 2010): 1294-1303. Full Text Link to Item
  - Chen, H, Liao, D, Cain, D, McLeod, I, Ueda, Y, Guan, Z, Raetz, C, and Kelsoe, G. "Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane." Int J Exp Pathol 91, no. 5 (October 2010): 460-471. Full Text Link to Item
  - Zhang, J, Guan, Z, Murphy, A, Wiley, S, Perkins, G, Worby, C, Engel, J, Raetz, CRH, Dowhan, W, and Dixon, J. "A Mitochondrial Lipid Phosphatase in Cell Metabolism and Membrane Organization." FASEB JOURNAL 24 (April 2010). Open Access Copy Link to Item
  - Andreyev, AY, Fahy, E, Guan, Z, Kelly, S, Li, X, McDonald, JG, Milne, S, Myers, D, Park, H, Ryan, A, Thompson, BM, Wang, E, Zhao, Y, Brown, HA, Merrill, AH, Raetz, CRH, Russell, DW, Subramaniam, S, and Dennis, EA. "Subcellular organelle lipidomics in TLR-4-activated macrophages." Journal of Lipid Research 51, no. 9 (2010): 2785-2797. Full Text
  - Andreyev, AY, Shen, Z, Guan, Z, Ryan, A, Fahy, E, Subramaniam, S, Raetz, CRH, Briggs, S, and Dennis, EA. "Application of proteomic marker ensembles to subcellular organelle identification." Molecular and Cellular Proteomics 9, no. 2 (2010): 388-402. Full Text
  - Bogdanov, M, Heacock, P, Guan, Z, and Dowhan, W. "Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli." Proceedings of the National Academy of Sciences of the United States of America 107, no. 34 (2010): 15057-15062. Full Text
  - Cantagrel, V, Lefeber, DJ, Ng, BG, Guan, Z, Silhavy, JL, Bielas, SL, Lehle, L, Hombauer, H, Adamowicz, M, Swiezewska, E, Brouwer, APD, Blümel, P, Sykut-Cegielska, J, Houliston, S, Swistun, D, Ali, BR, Dobyns, WB, Babovic-Vuksanovic, D, Bokhoven, HV, Wevers, RA, Raetz, CRH, Freeze, HH, Morava, É, Al-Gazali, L, and Gleeson, JG. "SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder." Cell 142, no. 2 (2010): 203-217. Full Text
  - Dennis, EA, Deems, RA, Harkewicz, R, Quehenberger, O, Brown, HA, Milne, SB, Myers, DS, Glass, CK, Hardiman, G, Reichart, D, Jr, AHM, Sullards, MC, Wang, E, Murphy, RC, Raetz, CRH, Garrett, TA, Guan, Z, Ryan, AC, Russell, DW, McDonald, JG, Thompson, BM, Shaw, WA, Sud, M, Zhao, Y, Gupta, S, Maurya, MR, Fahy, E, and Subramaniama, S. "A mouse macrophage lipidome." Journal of Biological Chemistry 285, no. 51 (2010): 39976-39985. Full Text
  - Grabińska, KA, Cui, J, Chatterjee, A, Guan, Z, Raetz, CRH, Robbins, PW, and Samuelson, J. "Molecular characterization of the cis-prenyltransferase of Giardia lamblia." Glycobiology 20, no. 7 (2010): 824-832. Full Text
  - Johnston, NC, Aygun-Sunar, S, Guan, Z, Ribeiro, AA, Daldal, F, Raetz, CRH, and Goldfine, H. "A phosphoethanolamine-modified glycosyl diradylglycerol in the polar lipids of Clostridium tetani." Journal of Lipid Research 51, no. 7 (2010): 1953-1961. Full Text
  - Kaminski, L, Abu-Qarn, M, Guan, Z, Naparstek, S, Ventura, VV, Raetz, CRH, Hitchen, PG, Dell, A, and Eichler, J. "AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein." Journal of Bacteriology 192, no. 21 (2010): 5572-5579. Full Text
  - Quehenberger, O, Armando, AM, Brown, AH, Milne, SB, Myers, DS, Merrill, AH, Bandyopadhyay, S, Jones, KN, Kelly, S, Shaner, RL, Sullards, CM, Wang, E, Murphy, RC, Barkley, RM, Leiker, TJ, Raetz, CRH, Guan, Z, Laird, GM, Six, DA, Russell, DW, McDonald, JG, Subramaniam, S, Fahy, E, and Dennis, EA. "Lipidomics reveals a remarkable diversity of lipids in human plasma1." Journal of Lipid Research 51, no. 11 (2010): 3299-3305. Full Text
  - Rush, JS, Matveev, S, Guan, Z, Raetz, CRH, and Waechter, CJ. "Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2Δ mutant and CHO cells." Glycobiology 20, no. 12 (2010): 1585-1593. Full Text
  - Wang, X, Guan, Z, Li, Y, and Raetz, CRH. "Application of electrospray ionization mass spectrometry to characterize glycerophospholipids in Francisella tularensis subsp. novicida." International Journal of Mass Spectrometry 293, no. 1-3 (2010): 45-50. Full Text
  - Zavaleta-Pastor, M, Sohlenkamp, C, Gao, J-L, Guan, Z, Zaheer, R, Finan, TM, Raetz, CRH, López-Lara, IM, and Geiger, O. "Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation." Proceedings of the National Academy of Sciences of the United States of America 107, no. 1 (2010): 302-307. Full Text
  - Guan, Z. "Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry." J Chromatogr B Analyt Technol Biomed Life Sci 877, no. 26 (September 15, 2009): 2814-2821. (Review) Full Text Link to Item
  - Barb, AW, Leavy, TM, Robins, LI, Guan, Z, Six, DA, Zhou, P, Hangauer, MJ, Bertozzi, CR, and Raetz, CRH. "Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC." Biochemistry 48, no. 14 (April 14, 2009): 3068-3077. Full Text Link to Item
  - Raetz, CRH, Guan, Z, Ingram, BO, Six, DA, Song, F, Wang, X, and Zhao, J. "Discovery of new biosynthetic pathways: the lipid A story." J Lipid Res 50 Suppl (April 2009): S103-S108. Full Text Link to Item
  - Song, F, Guan, Z, and Raetz, CRH. "Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida." Biochemistry 48, no. 6 (February 17, 2009): 1173-1182. Full Text Link to Item
  - Wang, X, Ribeiro, AA, Guan, Z, and Raetz, CRH. "Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification." Biochemistry 48, no. 6 (February 17, 2009): 1162-1172. Full Text Link to Item
  - Barb, AW, Leavy, TM, Robins, LI, Guan, Z, Six, DA, Zhou, P, Hangauer, MJ, Bertozzi, CR, and Raetz, C. "Correction to uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC (Biochemistry (2009) 48, (3068) DOI: 10.1021/bi900167q)." Biochemistry 48, no. 32 (2009): 7776--. Full Text
  - Romantsov, T, Guan, Z, and Wood, JM. "Cardiolipin and the osmotic stress responses of bacteria." Biochimica et Biophysica Acta - Biomembranes 1788, no. 10 (2009): 2092-2100. Full Text
  - Sandoval-Calderón, M, Geiger, O, Guan, Z, Barona-Gómez, F, and Sohlenkamp, C. "A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria." Journal of Biological Chemistry 284, no. 26 (2009): 17383-17390. Full Text
  - Zhang, C, Ondeyka, J, Guan, Z, Dietrich, L, Burgess, B, Wang, J, and Singh, SB. "Isolation, structure and biological activities of platensimycin B 4 from Streptomyces platensis." Journal of Antibiotics 62, no. 12 (2009): 699-702. Full Text
  - Six, DA, Carty, SM, Guan, Z, and Raetz, CRH. "Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis." Biochemistry 47, no. 33 (August 19, 2008): 8623-8637. Full Text Link to Item
  - Gibbons, HS, Reynolds, CM, Guan, Z, and Raetz, CRH. "An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A." Biochemistry 47, no. 9 (March 4, 2008): 2814-2825. Full Text Link to Item
  - Grabińska, KA, Ghosh, SK, Guan, Z, Cui, J, Raetz, CRH, Robbins, PW, and Samuelson, J. "Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis." Eukaryotic Cell 7, no. 8 (2008): 1344-1351. Full Text
  - Wu, S, Birnbaumer, M, and Guan, Z. "Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: Identification of a phosphorylation site in V2 vasopressin receptor." Analytical Chemistry 80, no. 15 (2008): 6034-6037. Full Text
  - Guan, Z, Li, S, Smith, DC, Shaw, WA, and Raetz, CRH. "Identification of N-acylphosphatidylserine molecules in eukaryotic cells." Biochemistry 46, no. 50 (December 18, 2007): 14500-14513. Full Text Link to Item
  - Yan, A, Guan, Z, and Raetz, CRH. "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli." J Biol Chem 282, no. 49 (December 7, 2007): 36077-36089. Full Text Link to Item
  - Nobles, KN, Guan, Z, Xiao, K, Oas, TG, and Lefkowitz, RJ. "The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2." J Biol Chem 282, no. 29 (July 20, 2007): 21370-21381. Full Text Link to Item
  - Ward, WC, Guan, Z, Zucca, FA, Fariello, RG, Kordestani, R, Zecca, L, Raetz, CRH, and Simon, JD. "Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain." J Lipid Res 48, no. 7 (July 2007): 1457-1462. Full Text Link to Item
  - Wang, X, Ribeiro, AA, Guan, Z, Abraham, SN, and Raetz, CRH. "Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase." Proc Natl Acad Sci U S A 104, no. 10 (March 6, 2007): 4136-4141. Full Text Link to Item
  - Garrett, TA, Guan, Z, and Raetz, CRH. "Analysis of ubiquinones, dolichols, and dolichol diphosphate-oligosaccharides by liquid chromatography-electrospray ionization-mass spectrometry." Methods Enzymol 432 (2007): 117-143. Full Text Link to Item
  - Jayasuriya, H, Guan, Z, Dombrowski, AW, Bills, GF, Polishook, JD, Jenkins, RG, Koch, L, Crumley, T, Tamas, T, Dubois, M, Misura, A, Darkin-Rattray, SJ, Gregory, L, and Singh, SB. "Isolation, structure, and coccidiostat activity of coccidiostatin A." Journal of Natural Products 70, no. 8 (2007): 1364-1367. Full Text
  - Sohlenkamp, C, Galindo-Lagunas, KA, Guan, Z, Vinuesa, P, Robinson, S, Thomas-Oates, J, Raetz, CRH, and Geiger, O. "The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions." Molecular Plant-Microbe Interactions 20, no. 11 (2007): 1421-1430. Full Text
  - Okado-Matsumoto, A, Guan, Z, and Fridovich, I. "Modification of cysteine 111 in human Cu,Zn-superoxide dismutase." Free Radic Biol Med 41, no. 12 (December 15, 2006): 1837-1846. Full Text Link to Item
  - Wang, X, Ribeiro, AA, Guan, Z, McGrath, SC, Cotter, RJ, and Raetz, CRH. "Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida." Biochemistry 45, no. 48 (December 5, 2006): 14427-14440. Full Text Link to Item
  - Kanjilal-Kolar, S, Basu, SS, Kanipes, MI, Guan, Z, Garrett, TA, and Raetz, CRH. "Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases." J Biol Chem 281, no. 18 (May 5, 2006): 12865-12878. Full Text Link to Item
  - Bakhtiar, R, and Guan, Z. "Electron capture dissociation mass spectrometry in characterization of peptides and proteins." Biotechnology Letters 28, no. 14 (2006): 1047-1059. Full Text
  - Naus, S, Reipschläger, S, Wildeboer, D, Lichtenthaler, SF, Mitterreiter, S, Guan, Z, Moss, ML, and Bartsch, JW. "Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8." Biological Chemistry 387, no. 3 (2006): 337-346. Full Text
  - Ondeyka, JG, Dombrowski, AW, Polishook, JP, Felcetto, T, Shoop, WL, Guan, Z, and Singh, SB. "Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species." Journal of Antibiotics 59, no. 5 (2006): 288-292. Full Text
  - Zhang, C, Ondeyka, JG, Herath, KB, Guan, Z, Collado, J, Pelaez, F, Leavitt, PS, Gurnett, A, Nare, B, Liberator, P, and Singh, SB. "Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity." Journal of Natural Products 69, no. 4 (2006): 710-712. Full Text
  - McClerren, AL, Endsley, S, Bowman, JL, Andersen, NH, Guan, Z, Rudolph, J, and Raetz, CRH. "A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin." Biochemistry 44, no. 50 (December 20, 2005): 16574-16583. Full Text Link to Item
  - Li, M, Phatnani, HP, Guan, Z, Sage, H, Greenleaf, AL, and Zhou, P. "Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1." Proc Natl Acad Sci U S A 102, no. 49 (December 6, 2005): 17636-17641. Full Text Link to Item
  - Guan, Z, Breazeale, SD, and Raetz, CRH. "Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli." Anal Biochem 345, no. 2 (October 15, 2005): 336-339. Full Text Link to Item
  - McClerren, AL, Zhou, P, Guan, Z, Raetz, CRH, and Rudolph, J. "Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway." Biochemistry 44, no. 4 (February 1, 2005): 1106-1113. Full Text Link to Item
  - Bakhtiar, R, and Guan, Z. "Electron capture dissociation mass spectrometry in characterization of post-translational modifications." Biochemical and Biophysical Research Communications 334, no. 1 (2005): 1-8. Full Text
  - Herath, K, Jayasuriya, H, Ondeyka, JG, Guan, Z, Borris, RP, Stijfhoorn, E, Stevenson, D, Wang, J, Sharma, N, MacNaul, K, Menke, JG, Ali, A, Schulman, MJ, and Singh, SB. "Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand." Journal of Natural Products 68, no. 4 (2005): 617-619. Full Text
  - Herath, KB, Jayasuriya, H, Guan, Z, Schulman, M, Ruby, C, Sharma, N, MacNaul, K, Menke, JG, Kodali, S, Galgoci, A, Wang, J, and Singh, SB. "Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents." Journal of Natural Products 68, no. 9 (2005): 1437-1440. Full Text
  - Herath, KB, Jayasuriya, H, Ondeyka, JG, Polishook, JD, Bills, GF, Dombrowski, AW, Cabello, A, Vicario, PP, Zweerink, H, Guan, Z, and Singh, SB. "Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists." Journal of Antibiotics 58, no. 11 (2005): 686-694. Full Text
  - Jayasuriya, H, Herath, KB, Ondeyka, JG, Guan, Z, Borris, RP, Tiwari, S, Jong, WD, Chavez, F, Moss, J, Stevenson, DW, Beck, HT, Slattery, M, Zamora, N, Schulman, M, Ali, A, Sharma, N, MacNaul, K, Hayes, N, Menke, JG, and Singh, SB. "Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources." Journal of Natural Products 68, no. 8 (2005): 1247-1252. Full Text
  - Liu, W, Guan, Z, and Singh, SB. "A new method for the synthesis of 1,4,5-oxadiazocines and its application in the structure modification of natural products." Tetrahedron Letters 46, no. 46 (2005): 8009-8012. Full Text
  - Ondeyka, JG, Herath, KB, Jayasuriya, H, Polishook, JD, Bills, GF, Dombrowski, AW, Mojena, M, Koch, G, DiSalvo, J, DeMartino, J, Guan, Z, Nanakorn, W, Morenberg, CM, Balick, MJ, Stevenson, DW, Slattery, M, Borris, RP, and Singh, SB. "Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3." Molecular Diversity 9, no. 1-3 (2005): 123-129. Full Text
  - Ondeyka, JG, Jayasuriya, H, Herath, KB, Guan, Z, Schulman, M, Collado, J, Dombrowski, AW, Kwon, SS, McCallum, C, Sharma, N, MacNaul, K, Hayes, N, Menke, JG, and Singh, SB. "Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors." Journal of Antibiotics 58, no. 9 (2005): 559-565.
  - Ortlund, EA, Lee, Y, Solomon, IH, Hager, JM, Safi, R, Choi, Y, Guan, Z, Tripathy, A, Raetz, CRH, McDonnell, DP, Moore, DD, and Redinbo, MR. "Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP." Nature Structural and Molecular Biology 12, no. 4 (2005): 357-363. Full Text
  - Singh, SB, Kelly, R, Guan, Z, Polishook, JD, Dombrowski, AW, Collado, J, González, A, Pelaez, F, Register, E, Kelly, TM, Bonfiglio, C, and Williamson, JM. "New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity." Natural Product Research 19, no. 8 (2005): 739-747. Full Text
  - Zhang, C, Ondeyka, JG, Herath, KB, Guan, Z, Collado, J, Platas, G, Pelaez, F, Leavitt, PS, Gurnett, A, Nare, B, Liberator, P, and Singh, SB. "Tenellones a and B from a Diaporthe sp.: Two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity." Journal of Natural Products 68, no. 4 (2005): 611-613. Full Text
  - Herath, KB, Jayasuriya, H, Bills, GF, Polishook, JD, Dombrowski, AW, Guan, Z, Felock, PJ, Hazuda, DJ, and Singh, SB. "Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide." Journal of Natural Products 67, no. 5 (2004): 872-874. Full Text
  - Jayasuriya, H, Herath, KB, Ondeyka, JG, Polishook, JD, Bills, GF, Dombrowski, AW, Springer, MS, Siciliano, S, Malkowitz, L, Sanchez, M, Guan, Z, Tiwari, S, Stevenson, DW, Borris, RP, and Singh, SB. "Isolation and structure of antagonists of chemokine receptor (CCR5)." Journal of Natural Products 67, no. 6 (2004): 1036-1038. Full Text
  - Guan, Z, Yates, NA, and Bakhtiar, R. "Detection and characterization of methionine oxidation in peptides by collision-induced dissociation and electron capture dissociation." Journal of the American Society for Mass Spectrometry 14, no. 6 (2003): 605-613. Full Text
  - Jayasuriya, H, Guan, Z, Polishook, JD, Dombrowski, AW, Felock, PJ, Hazuda, DJ, and Singh, SB. "Isolation, structure, and HIV-1 integrase inhibitory activity of cytosporic acid, a fungal metabolite produced by a Cytospora sp." Journal of Natural Products 66, no. 4 (2003): 551-553. Full Text
  - Ondeyka, JG, Dombrowski, AW, Polishook, JP, Felcetto, T, Shoop, WL, Guan, Z, and Singh, SB. "Isolation and insecticidal activity of mellamide from Aspergillus melleus." Journal of Industrial Microbiology and Biotechnology 30, no. 4 (2003): 220-224.
  - Singh, SB, Jayasuriya, H, Dewey, R, Polishook, JD, Dombrowski, AW, Zink, DL, Guan, Z, Collado, J, Platas, G, Pelaez, F, Felock, PJ, and Hazuda, DJ. "Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites." Journal of Industrial Microbiology and Biotechnology 30, no. 12 (2003): 721-731. Full Text
  - Singh, SB, Zink, DL, Guan, Z, Collado, J, Pelaez, F, Felock, PJ, and Hazuda, DJ. "Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Xanthoviridicatin E and F, Two Novel Fungal Metabolites Produced by Penicillium chrysogenum." Helvetica Chimica Acta 86, no. 10 (2003): 3380-3385. Full Text
  - Wang, Z, Hop, CECA, Kim, M-S, Huskey, S-EW, Baillie, TA, and Guan, Z. "The unanticipated loss of SO₂ from sulfonamides in collision-induced dissociation." Rapid Communications in Mass Spectrometry 17, no. 1 (2003): 81-86. Full Text
  - Guan, Z, and Griffin, PR. "Localization and characterization of peptide acylation with Ester linkage by electron capture dissociation FTICR/MS." Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics (2002): 857-858.
  - Guan, Z. "Identification and localization of the fatty acid modification in ghrelin by electron capture dissociation." Journal of the American Society for Mass Spectrometry 13, no. 12 (2002): 1443-1447. Full Text
  - Jayasuriya, H, Lingham, RB, Graham, P, Quamina, D, Herranz, L, Genilloud, O, Gagliardi, M, Danzeisen, R, Tomassini, JE, Zink, DL, Guan, Z, and Singh, SB. "Durhamycin A, a potent inhibitor of HIV Tat transactivation." Journal of Natural Products 65, no. 8 (2002): 1091-1095. Full Text
  - Singh, SB, Herath, K, Guan, Z, Zink, DL, Dombrowski, AW, Polishook, JD, Silverman, KC, Lingham, RB, Felock, PJ, and Hazuda, DJ. "Integramides A and B, Two Novel Non-Ribosomal Linear Peptides Containing Nine C^α-Methyl Amino Acids Produced by Fungal Fermentations That are Inhibitors of HIV-1 Integrase." Organic Letters 4, no. 9 (2002): 1431-1434. Full Text
  - Guan, Z, and Liesch, JM. "Solvation of acylium fragment ions in electrospray ionization quadrupole ion trap and Fourier transform ion cyclotron resonance mass spectrometry." Journal of Mass Spectrometry 36, no. 3 (2001): 264-276. Full Text
  - Shafiee, A, Tsipouras, A, Bouffard, A, Onishi, JC, Guan, Z, and Motamedi, H. "Enzymatic deglycosylation of enfumafungin, a triterpene glycoside natural product, and its chemically synthesized analogues." Journal of Molecular Catalysis - B Enzymatic 16, no. 1 (2001): 27-32. Full Text
  - Wilson, KE, Tsou, NN, Guan, Z, Ruby, CL, Pelaez, F, Gorrochategui, J, Vicente, F, and Onishi, HR. "Isolation and structure elucidation of coleophomones A and B, novel inhibitors of bacterial cell wall transglycosylase." Tetrahedron Letters 41, no. 45 (2000): 8705-8709.
  - McLafferty, FW, Guan, Z, Haupts, U, Wood, TD, and Kelleher, NL. "Gaseous conformational structures of cytochrome c." Journal of the American Chemical Society 120, no. 19 (1998): 4732-4740. Full Text
  - Wood, TD, Guan, Z, Jr, CLB, Chen, LH, Kenyon, GL, and Mclafferty, FW. "Creatine kinase: Essential arginine residues at the nucleotide binding site identified by chemical modification and high-resolution tandem mass spectrometry." Proceedings of the National Academy of Sciences of the United States of America 95, no. 7 (1998): 3362-3365. Full Text
  - Aaserud, DJ, Guan, Z, Little, DP, and McLafferty, FW. "DNA sequencing with blackbody infrared radiative dissociation of electrosprayed ions." International Journal of Mass Spectrometry and Ion Processes 167-168 (1997): 705-712.
  - McLafferty, FW, Aaserud, DJ, Guan, Z, Little, DP, and Kelleher, NL. "Double stranded DNA sequencing by tandem mass spectrometry." International Journal of Mass Spectrometry and Ion Processes 165-166 (1997): 457-466.
  - O'Connor, PB, Speir, JP, Wood, TD, Chorush, RA, Guan, Z, and McLafferty, FW. "Broadband quadrupolar axialization of large multiply charged ions to enhance measurement and minimize conformational restrictions." Journal of mass spectrometry : JMS 31, no. 5 (May 1996): 555-559. Full Text
  - Guan, Z, Kelleher, NL, O'Connor, PB, Aaserud, DJ, Little, DP, and McLafferty, FW. "193 nm photodissociation of larger multiply-charged biomolecules." International Journal of Mass Spectrometry and Ion Processes 157-158 (1996): 357-364.
  - O'Connor, PB, Speir, JP, Wood, TD, Chorush, RA, Guan, Z, and McLafferty, FW. "Broadband quadrupolar axialization of large multiply charged ions to enhance measurement and minimize conformational restrictions." Journal of Mass Spectrometry 31, no. 5 (1996): 555-559. Full Text
  - Campbell, VL, Guan, Z, Vartanian, VH, and Laude, DA. "Cell geometry considerations for the fourier transform ion cyclotron resonance mass spectrometry remeasurement experiment." Analytical Chemistry 67, no. 2 (1995): 420-425.
  - Campbell, VL, Guan, Z, and Laude, DA. "Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry." Journal of the American Society for Mass Spectrometry 6, no. 7 (1995): 564-570. Full Text
  - Guan, Z, Campbell, VL, Drader, JJ, Hendrickson, CL, and Jr, DAL. "High performance detection of biomolecules using a high magnetic field electrospray ionization source/Fourier transform ion cyclotron resonance mass spectrometer." Review of Scientific Instruments 66, no. 9 (1995): 4507-4515. Full Text
  - Guan, Z, Campbell, VL, and Jr, DAL. "Charge state assignment from Schiff-base adducts in low resolution electrospray mass spectra of protein mixtures and dissociation products." Journal of Mass Spectrometry 30, no. 1 (1995): 119-123. Full Text
  - Guan, Z, Drader, JJ, Campbell, VL, and Laude, DA. "Real-Time Monitoring of the Gas Phase Reactions of a Single Ion Population Using the Remeasurement Experiment in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry." Analytical Chemistry 67, no. 8 (1995): 1453-1458.
  - Campbell, VL, Guan, Z, and Laude, DA. "Selective generation of charge-cependent/independent ion energy distributions from a heated capillary electrospray source." Journal of the American Society for Mass Spectrometry 5, no. 4 (1994): 221-229. Full Text
  - Guan, Z, Hofstadler, SA, and Jr, DAL. "Remeasurement of electrosprayed proteins in the trapped ion cell of a fourier transform ion cyclotron resonance mass spectrometer." Analytical Chemistry 65, no. 11 (1993): 1588-1593.
  - Hofstadler, SA, Schmidt, E, Guan, Z, and Laude, DA. "Concentric tube vacuum chamber for high magnetic field, high-pressure ionization in a fourier transform ion cyclotron resonance mass spectrometer." Journal of the American Society for Mass Spectrometry 4, no. 2 (1993): 168-176. Full Text
  - Zhou, F, Yau, S-L, Jehoulet, C, Jr, DAL, Guan, Z, and Bard, AJ. "Electrochemistry of C₆₀ films: Quartz crystal microbalance and mass spectrometric studies." Journal of Physical Chemistry 96, no. 11 (1992): 4160-4162.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Global Scholarship

Expertise

Selected Grants

Selected Publications

Conference Papers

Journal Articles