We develop and apply mass spectrometry techniques to address biochemical and biomedical questions that are lipid-related. Research projects include:
1) Structural lipidomics
o Develop and apply high resolution tandem mass spectrometry-based lipidomics for the discovery, structural elucidation and functional study of novel lipids.
2) Elucidation of novel pathways/enzymes of lipid biosynthesis and metabolism
o Genetic, biochemical and MS approaches are employed to identify the substrates and pathways involved in lipid biosynthesis and metabolism
3) Identification of lipid biomarkers of genetic diseases and cancers
o Provide molecular insights into the disease mechanisms, as well as to serve as the diagnostic and prognostic tools of diseases.