Ziqiang Guan | Scholars@Duke

Ziqiang Guan
Research Professor in Biochemistry

We develop and apply mass spectrometry techniques to address biochemical and biomedical questions that are lipid-related. Research projects include:

1) Structural lipidomics

o Develop and apply high resolution tandem mass spectrometry-based lipidomics for the discovery, structural elucidation and functional study of novel lipids.

2) Elucidation of novel pathways/enzymes of lipid biosynthesis and metabolism

o Genetic, biochemical and MS approaches are employed to identify the substrates and pathways involved in lipid biosynthesis and metabolism

3) Identification of lipid biomarkers of genetic diseases and cancers

o Provide molecular insights into the disease mechanisms, as well as to serve as the diagnostic and prognostic tools of diseases.

Current Appointments & Affiliations

Research Professor in Biochemistry, Biochemistry, Basic Science Departments 2017

Contact Information

240 Nanaline H Duke, Durham, NC 27710
Duke Box 3711, Durham, NC 27710
zguan@biochem.duke.edu (919) 684-3005

Background
Education, Training, & Certifications
- Research Associate, Chemistry, Cornell University 1994 - 1997
- Ph.D., University of Texas at Austin 1994
Duke Appointment History
- Associate Research Professor in Biochemistry, Biochemistry, Basic Science Departments 2004 - 2017
- Instructor, Temporary in the Department of Biochemistry, Biochemistry, Basic Science Departments 2004
Recognition
In the News
- OCT 8, 2013
  
  New Urine Test Could Diagnose Eye Disease
Expertise
Subject Headings
Global Scholarship
- Expertise
  - United States of America (Country)
Research
Selected Grants
- Structural and Mechanistic Characterization of MraY Catalysis and Inhibition awarded by National Institutes of Health 2017 - 2020
- Adaptive alterations of lipids in the cellular envelop of Streptococcus mitis 2019 - 2020
- Biochemistry and Structure of Lipid A Enzymes awarded by National Institutes of Health 2016 - 2020
- DHDDS and retinal degeneration awarded by University of Miami 2014 - 2019
- Platelet AADACL1 in thrombosis, lipidomics and signaling awarded by University of North Carolina - Chapel Hill 2018 - 2019
- Human Stringent Response as Novel Therapeutic Approaches for Breast Cancers awarded by Department of Defense 2015 - 2018
- Targeting the synthetic essential kinases of breast cancers awarded by Department of Defense 2015 - 2018
- Biosynthesis And Function Of Lipopolysaccharides awarded by National Institutes of Health 1994 - 2015
- NQO1: Linking Oxidant Stress to Inflammation in Airway Epithelial Cells awarded by National Institutes of Health 2010 - 2014
- Lipid A Modification Systems in Gram-Negative Bacteria awarded by National Institutes of Health 1995 - 2013
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Entova, Sonya, Ziqiang Guan, and Barbara Imperiali. “Investigation of the conserved reentrant membrane helix in the monotopic phosphoglycosyl transferase superfamily supports key molecular interactions with polyprenol phosphate substrates..” Arch Biochem Biophys 675 (September 26, 2019). https://doi.org/10.1016/j.abb.2019.108111.
    Full Text Link to Item
  - Joyce, Luke R., Ziqiang Guan, and Kelli L. Palmer. “Phosphatidylcholine biosynthesis in Mitis group streptococci via host metabolite scavenging..” J Bacteriol, September 9, 2019. https://doi.org/10.1128/JB.00495-19.
    Full Text Open Access Copy Link to Item
  - Guan, Ziqiang, Teresa A. Garrett, and Howard Goldfine. “Lipidomic Analysis of Clostridium cadaveris and Clostridium fallax..” Lipids 54, no. 8 (August 2019): 423–31. https://doi.org/10.1002/lipd.12181.
    Full Text Link to Item
  - Zhao, Jinshi, Jinsu An, Dohyeon Hwang, Qinglin Wu, Su Wang, Robert A. Gillespie, Eun Gyeong Yang, Ziqiang Guan, Pei Zhou, and Hak Suk Chung. “The Lipid A 1-Phosphatase, LpxE, Functionally Connects Multiple Layers of Bacterial Envelope Biogenesis..” Mbio 10, no. 3 (June 18, 2019). https://doi.org/10.1128/mBio.00886-19.
    Full Text Open Access Copy Link to Item
  - Kuk, Alvin C. Y., Aili Hao, Ziqiang Guan, and Seok-Yong Lee. “Visualizing conformation transitions of the Lipid II flippase MurJ..” Nat Commun 10, no. 1 (April 15, 2019). https://doi.org/10.1038/s41467-019-09658-0.
    Full Text Link to Item
  - Brown, Hannah E., Kyla S. Ost, Shannon K. Esher, Kaila M. Pianalto, Joseph W. Saelens, Ziqiang Guan, and J. Andrew Alspaugh. “Identifying a novel connection between the fungal plasma membrane and pH-sensing..” Mol Microbiol 109, no. 4 (August 2018): 474–93. https://doi.org/10.1111/mmi.13998.
    Full Text Open Access Copy Link to Item
  - Kimchi, Adva, Samer Khateb, Rong Wen, Ziqiang Guan, Alexey Obolensky, Avigail Beryozkin, Shoshi Kurtzman, et al. “Nonsyndromic Retinitis Pigmentosa in the Ashkenazi Jewish Population: Genetic and Clinical Aspects..” Ophthalmology 125, no. 5 (May 2018): 725–34. https://doi.org/10.1016/j.ophtha.2017.11.014.
    Full Text Link to Item
  - Lin, Yibin, Mikhail Bogdanov, Shuo Lu, Ziqiang Guan, William Margolin, Jerrold Weiss, and Lei Zheng. “The phospholipid-repair system LplT/Aas in Gram-negative bacteria protects the bacterial membrane envelope from host phospholipase A2 attack..” J Biol Chem 293, no. 9 (March 2, 2018): 3386–98. https://doi.org/10.1074/jbc.RA117.001231.
    Full Text Open Access Copy Link to Item
  - Bhardwaj, Pooja, Amrita Hans, Kinnari Ruikar, Ziqiang Guan, and Kelli L. Palmer. “Reduced Chlorhexidine and Daptomycin Susceptibility in Vancomycin-Resistant Enterococcus faecium after Serial Chlorhexidine Exposure..” Antimicrob Agents Chemother 62, no. 1 (January 2018). https://doi.org/10.1128/AAC.01235-17.
    Full Text Link to Item
  - Guan, Ziqiang, Antonia Delago, Phillip Nußbaum, Benjamin H. Meyer, Sonja-Verena Albers, and Jerry Eichler. “Gene deletions leading to a reduction in the number of cyclopentane rings in Sulfolobus acidocaldarius tetraether lipids..” Fems Microbiol Lett 365, no. 1 (January 1, 2018). https://doi.org/10.1093/femsle/fnx250.
    Full Text Open Access Copy Link to Item
  - Hoffmann, Reuben, Kariona Grabińska, Ziqiang Guan, William C. Sessa, and Aaron M. Neiman. “Long-Chain Polyprenols Promote Spore Wall Formation in Saccharomyces cerevisiae..” Genetics 207, no. 4 (December 2017): 1371–86. https://doi.org/10.1534/genetics.117.300322.
    Full Text Link to Item
  - Tang, Shuang, Yi Fang, Gang Huang, Xiaojiang Xu, Elizabeth Padilla-Banks, Wei Fan, Qing Xu, et al. “Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development..” Embo J 36, no. 21 (November 2, 2017): 3175–93. https://doi.org/10.15252/embj.201796708.
    Full Text Link to Item
  - Sandoval-Calderón, Mario, Ziqiang Guan, and Christian Sohlenkamp. “Knowns and unknowns of membrane lipid synthesis in streptomycetes..” Biochimie 141 (October 2017): 21–29. https://doi.org/10.1016/j.biochi.2017.05.008.
    Full Text Link to Item
  - Elharar, Yifat, Ananda Rao Podilapu, Ziqiang Guan, Suvarn S. Kulkarni, and Jerry Eichler. “Assembling Glycan-Charged Dolichol Phosphates: Chemoenzymatic Synthesis of a Haloferax volcanii N-Glycosylation Pathway Intermediate..” Bioconjug Chem 28, no. 9 (September 20, 2017): 2461–70. https://doi.org/10.1021/acs.bioconjchem.7b00436.
    Full Text Link to Item
  - Eichler, Jerry, and Ziqiang Guan. “Lipid sugar carriers at the extremes: The phosphodolichols Archaea use in N-glycosylation..” Biochim Biophys Acta Mol Cell Biol Lipids 1862, no. 6 (June 2017): 589–99. https://doi.org/10.1016/j.bbalip.2017.03.005.
    Full Text Link to Item
  - Adams, Hannah M., Luke R. Joyce, Ziqiang Guan, Ronda L. Akins, and Kelli L. Palmer. “Streptococcus mitis and S. oralis Lack a Requirement for CdsA, the Enzyme Required for Synthesis of Major Membrane Phospholipids in Bacteria..” Antimicrob Agents Chemother 61, no. 5 (May 2017). https://doi.org/10.1128/AAC.02552-16.
    Full Text Open Access Copy Link to Item
  - Goldfine, Howard, and Ziqiang Guan. “Editorial for Special Issue on lipid methodology..” Anal Biochem 524 (May 1, 2017): 1–2. https://doi.org/10.1016/j.ab.2017.02.008.
    Full Text Link to Item
  - Vences-Guzmán, Miguel Ángel, M. Paula Goetting-Minesky, Ziqiang Guan, Santiago Castillo-Ramirez, Luz América Córdoba-Castro, Isabel M. López-Lara, Otto Geiger, Christian Sohlenkamp, and J. Christopher Fenno. “1,2-Diacylglycerol choline phosphotransferase catalyzes the final step in the unique Treponema denticola phosphatidylcholine biosynthesis pathway..” Mol Microbiol 103, no. 5 (March 2017): 896–912. https://doi.org/10.1111/mmi.13596.
    Full Text Open Access Copy Link to Item
  - Li, Chijun, Brandon K. Tan, Jinshi Zhao, and Ziqiang Guan. “In Vivo and in Vitro Synthesis of Phosphatidylglycerol by an Escherichia coli Cardiolipin Synthase..” J Biol Chem 291, no. 48 (November 25, 2016): 25144–53. https://doi.org/10.1074/jbc.M116.762070.
    Full Text Open Access Copy Link to Item
  - Guan, Ziqiang, Antonia Delago, Phillip Nußbaum, Benjamin Meyer, Sonja-Verena Albers, and Jerry Eichler. “N-glycosylation in the thermoacidophilic archaeon Sulfolobus acidocaldarius involves a short dolichol pyrophosphate carrier..” Febs Lett 590, no. 18 (September 2016): 3168–78. https://doi.org/10.1002/1873-3468.12341.
    Full Text Open Access Copy Link to Item
  - Guan, Ziqiang, Lingli Chen, Jacoline Gerritsen, Hauke Smidt, and Howard Goldfine. “The cellular lipids of Romboutsia..” Biochim Biophys Acta 1861, no. 9 Pt A (September 2016): 1076–82. https://doi.org/10.1016/j.bbalip.2016.06.006.
    Full Text Open Access Copy Link to Item
  - Young, Hayley E., Jinshi Zhao, Jeffrey R. Barker, Ziqiang Guan, Raphael H. Valdivia, and Pei Zhou. “Discovery of the Elusive UDP-Diacylglucosamine Hydrolase in the Lipid A Biosynthetic Pathway in Chlamydia trachomatis..” Mbio 7, no. 2 (March 22, 2016). https://doi.org/10.1128/mBio.00090-16.
    Full Text Open Access Copy Link to Item
  - Park, Eon Joo, Kariona A. Grabińska, Ziqiang Guan, and William C. Sessa. “NgBR is essential for endothelial cell glycosylation and vascular development..” Embo Rep 17, no. 2 (February 2016): 167–77. https://doi.org/10.15252/embr.201540789.
    Full Text Open Access Copy Link to Item
  - Lin, Yibin, Mikhail Bogdanov, Shuilong Tong, Ziqiang Guan, and Lei Zheng. “Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli..” J Biol Chem 291, no. 5 (January 29, 2016): 2136–49. https://doi.org/10.1074/jbc.M115.700419.
    Full Text Link to Item
  - Ardiccioni, Chiara, Oliver B. Clarke, David Tomasek, Habon A. Issa, Desiree C. von Alpen, Heather L. Pond, Surajit Banerjee, et al. “Structure of the polyisoprenyl-phosphate glycosyltransferase GtrB and insights into the mechanism of catalysis..” Nat Commun 7 (January 5, 2016). https://doi.org/10.1038/ncomms10175.
    Full Text Open Access Copy Link to Item
  - Lukose, Vinita, Garrett Whitworth, Ziqiang Guan, and Barbara Imperiali. “Chemoenzymatic Assembly of Bacterial Glycoconjugates for Site-Specific Orthogonal Labeling..” J Am Chem Soc 137, no. 39 (October 7, 2015): 12446–49. https://doi.org/10.1021/jacs.5b07146.
    Full Text Link to Item
  - Vences-Guzmán, Miguel Ángel, Ziqiang Guan, Wendy Itzel Escobedo-Hinojosa, José Roberto Bermúdez-Barrientos, Otto Geiger, and Christian Sohlenkamp. “Discovery of a bifunctional acyltransferase responsible for ornithine lipid synthesis in Serratia proteamaculans..” Environ Microbiol 17, no. 5 (May 2015): 1487–96. https://doi.org/10.1111/1462-2920.12562.
    Full Text Link to Item
  - Gorden, D Lee, David S. Myers, Pavlina T. Ivanova, Eoin Fahy, Mano R. Maurya, Shakti Gupta, Jun Min, et al. “Biomarkers of NAFLD progression: a lipidomics approach to an epidemic..” J Lipid Res 56, no. 3 (March 2015): 722–36. https://doi.org/10.1194/jlr.P056002.
    Full Text Link to Item
  - Chang, Michelle M., Barbara Imperiali, Jerry Eichler, and Ziqiang Guan. “N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus..” Plos One 10, no. 6 (2015). https://doi.org/10.1371/journal.pone.0130482.
    Full Text Link to Item
  - Guan, Ziqiang, David Katzianer, Jun Zhu, and Howard Goldfine. “Clostridium difficile contains plasmalogen species of phospholipids and glycolipids..” Biochim Biophys Acta 1842, no. 10 (October 2014): 1353–59. https://doi.org/10.1016/j.bbalip.2014.06.011.
    Full Text Link to Item
  - Chung, Hak Suk, Eun Gyeong Yang, Dohyeon Hwang, Ji Eun Lee, Ziqiang Guan, and Christian R. H. Raetz. “Kdo hydroxylase is an inner core assembly enzyme in the Ko-containing lipopolysaccharide biosynthesis..” Biochem Biophys Res Commun 452, no. 3 (September 26, 2014): 789–94. https://doi.org/10.1016/j.bbrc.2014.08.153.
    Full Text Link to Item
  - Park, Eon Joo, Kariona A. Grabińska, Ziqiang Guan, Viktor Stránecký, Hana Hartmannová, Kateřina Hodaňová, Veronika Barešová, et al. “Mutation of Nogo-B receptor, a subunit of cis-prenyltransferase, causes a congenital disorder of glycosylation..” Cell Metab 20, no. 3 (September 2, 2014): 448–57. https://doi.org/10.1016/j.cmet.2014.06.016.
    Full Text Link to Item
  - Pride, Aaron C., Ziqiang Guan, and M Stephen Trent. “Characterization of the Vibrio cholerae VolA surface-exposed lipoprotein lysophospholipase..” J Bacteriol 196, no. 8 (April 2014): 1619–26. https://doi.org/10.1128/JB.01281-13.
    Full Text Link to Item
  - Cohen-Rosenzweig, Chen, Ziqiang Guan, Boaz Shaanan, and Jerry Eichler. “Substrate promiscuity: AglB, the archaeal oligosaccharyltransferase, can process a variety of lipid-linked glycans..” Appl Environ Microbiol 80, no. 2 (January 2014): 486–96. https://doi.org/10.1128/AEM.03191-13.
    Full Text Link to Item
  - Wen, Rong, Byron L. Lam, and Ziqiang Guan. “Aberrant dolichol chain lengths as biomarkers for retinitis pigmentosa caused by impaired dolichol biosynthesis..” J Lipid Res 54, no. 12 (December 2013): 3516–22. https://doi.org/10.1194/jlr.M043232.
    Full Text Link to Item
  - Kaminski, Lina, Ziqiang Guan, Sophie Yurist-Doutsch, and Jerry Eichler. “Two distinct N-glycosylation pathways process the Haloferax volcanii S-layer glycoprotein upon changes in environmental salinity..” Mbio 4, no. 6 (November 5, 2013): e00716–e00713. https://doi.org/10.1128/mBio.00716-13.
    Full Text Link to Item
  - Chung, Ben C., Jinshi Zhao, Robert A. Gillespie, Do-Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis..” Science 341, no. 6149 (August 30, 2013): 1012–16. https://doi.org/10.1126/science.1236501.
    Full Text Link to Item
  - Tran, Truc T., Diana Panesso, Nagendra N. Mishra, Eugenia Mileykovskaya, Ziqianq Guan, Jose M. Munita, Jinnethe Reyes, et al. “Daptomycin-resistant Enterococcus faecalis diverts the antibiotic molecule from the division septum and remodels cell membrane phospholipids..” Mbio 4, no. 4 (July 23, 2013). https://doi.org/10.1128/mBio.00281-13.
    Full Text Link to Item
  - Guan, Ziqiang, Bing Tian, Amedea Perfumo, and Howard Goldfine. “The polar lipids of Clostridium psychrophilum, an anaerobic psychrophile..” Biochimica Et Biophysica Acta 1831, no. 6 (June 2013): 1108–12. https://doi.org/10.1016/j.bbalip.2013.02.004.
    Full Text
  - Tian, Bing, Ziqiang Guan, and Howard Goldfine. “An ethanolamine-phosphate modified glycolipid in Clostridium acetobutylicum that responds to membrane stress..” Biochimica Et Biophysica Acta 1831, no. 6 (June 2013): 1185–90. https://doi.org/10.1016/j.bbalip.2013.03.005.
    Full Text
  - Pride, Aaron C., Carmen M. Herrera, Ziqiang Guan, David K. Giles, and M Stephen Trent. “The outer surface lipoprotein VolA mediates utilization of exogenous lipids by Vibrio cholerae..” Mbio 4, no. 3 (May 14, 2013): e00305–13. https://doi.org/10.1128/mBio.00305-13.
    Full Text Link to Item
  - Kandiba, Lina, Ziqiang Guan, and Jerry Eichler. “Lipid modification gives rise to two distinct Haloferax volcanii S-layer glycoprotein populations..” Biochimica Et Biophysica Acta 1828, no. 3 (March 2013): 938–43. https://doi.org/10.1016/j.bbamem.2012.11.023.
    Full Text
  - Vences-Guzmán, Miguel Ángel, Ziqiang Guan, José Roberto Bermúdez-Barrientos, Otto Geiger, and Christian Sohlenkamp. “Agrobacteria lacking ornithine lipids induce more rapid tumour formation..” Environ Microbiol 15, no. 3 (March 2013): 895–906. https://doi.org/10.1111/j.1462-2920.2012.02867.x.
    Full Text Link to Item
  - Zeng, Daina, Jinshi Zhao, Hak Suk Chung, Ziqiang Guan, Christian R. H. Raetz, and Pei Zhou. “Mutants resistant to LpxC inhibitors by rebalancing cellular homeostasis..” J Biol Chem 288, no. 8 (February 22, 2013): 5475–86. https://doi.org/10.1074/jbc.M112.447607.
    Full Text Link to Item
  - Arbiv, Adi, Sophie Yurist-Doutsch, Ziqiang Guan, and Jerry Eichler. “AglQ is a novel component of the Haloferax volcanii N-glycosylation pathway..” Plos One 8, no. 11 (2013). https://doi.org/10.1371/journal.pone.0081782.
    Full Text Link to Item
  - Chung, B. C., J. Zhao, R. A. Gillespie, D. Y. Kwon, Z. Guan, J. Hong, P. Zhou, and S. Y. Lee. “Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis.” Science 341, no. 6149 (2013): 1012–16. https://doi.org/10.1126/science.1240985.
    Full Text
  - Shin, Jinwook, Ping Zhang, Shang Wang, Jinhong Wu, Ziqiang Guan, and Xiao-Ping Zhong. “Negative control of mast cell degranulation and the anaphylactic response by the phosphatase lipin1..” Eur J Immunol 43, no. 1 (January 2013): 240–48. https://doi.org/10.1002/eji.201242571.
    Full Text Link to Item
  - Tan, Brandon K., Mikhail Bogdanov, Jinshi Zhao, William Dowhan, Christian R. H. Raetz, and Ziqiang Guan. “Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates..” Proc Natl Acad Sci U S A 109, no. 41 (October 9, 2012): 16504–9. https://doi.org/10.1073/pnas.1212797109.
    Full Text Link to Item
  - Guan, Ziqiang, Norah C. Johnston, Christian R. H. Raetz, Eric A. Johnson, and Howard Goldfine. “Lipid diversity among botulinum neurotoxin-producing clostridia..” Microbiology 158, no. Pt 10 (October 2012): 2577–84. https://doi.org/10.1099/mic.0.060707-0.
    Full Text Link to Item
  - Kaminski, Lina, Ziqiang Guan, Mehtap Abu-Qarn, Zvia Konrad, and Jerry Eichler. “AglR is required for addition of the final mannose residue of the N-linked glycan decorating the Haloferax volcanii S-layer glycoprotein..” Biochim Biophys Acta 1820, no. 10 (October 2012): 1664–70. https://doi.org/10.1016/j.bbagen.2012.06.014.
    Full Text Link to Item
  - Schumacher, Maria A., JungKi Min, Todd M. Link, Ziqiang Guan, Weijun Xu, Young-Ho Ahn, Erik J. Soderblom, et al. “Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance..” Cell Rep 2, no. 3 (September 27, 2012): 518–25. https://doi.org/10.1016/j.celrep.2012.08.013.
    Full Text Link to Item
  - Chen, Yu-Tsung, Tammy R. L. Collins, Ziqiang Guan, Vincent B. Chen, and Tao-Shih Hsieh. “Probing conformational changes in human DNA topoisomerase IIα by pulsed alkylation mass spectrometry..” J Biol Chem 287, no. 30 (July 20, 2012): 25660–68. https://doi.org/10.1074/jbc.M112.377606.
    Full Text Link to Item
  - Naparstek, Shai, Ziqiang Guan, and Jerry Eichler. “A predicted geranylgeranyl reductase reduces the ω-position isoprene of dolichol phosphate in the halophilic archaeon, Haloferax volcanii..” Biochim Biophys Acta 1821, no. 6 (June 2012): 923–33. https://doi.org/10.1016/j.bbalip.2012.03.002.
    Full Text Link to Item
  - Kandiba, Lina, Olli Aitio, Jari Helin, Ziqiang Guan, Perttu Permi, Dennis H. Bamford, Jerry Eichler, and Elina Roine. “Diversity in prokaryotic glycosylation: an archaeal-derived N-linked glycan contains legionaminic acid..” Mol Microbiol 84, no. 3 (May 2012): 578–93. https://doi.org/10.1111/j.1365-2958.2012.08045.x.
    Full Text Link to Item
  - Gründahl, J. E. H., Z. Guan, S. Rust, J. Reunert, B. Müller, I. Du Chesne, K. Zerres, et al. “Life with too much polyprenol: polyprenol reductase deficiency..” Mol Genet Metab 105, no. 4 (April 2012): 642–51. https://doi.org/10.1016/j.ymgme.2011.12.017.
    Full Text Link to Item
  - Zhang, Ji, Ziqiang Guan, Anne Murphy, Sandra Wiley, Guy Perkins, Carolyn Worby, James Engel, Christian R. H. Raetz, William Dowhan, and Jack Dixon. “A Mitochondrial Lipid Phosphatase in Cell Metabolism and Membrane Organization.” Faseb Journal 26 (April 1, 2012).
    Open Access Copy Link to Item
  - Guan, Ziqiang, Shai Naparstek, Doron Calo, and Jerry Eichler. “Protein glycosylation as an adaptive response in Archaea: growth at different salt concentrations leads to alterations in Haloferax volcanii S-layer glycoprotein N-glycosylation..” Environ Microbiol 14, no. 3 (March 2012): 743–53. https://doi.org/10.1111/j.1462-2920.2011.02625.x.
    Full Text Link to Item
  - Mishra, Nagendra N., Arnold S. Bayer, Truc T. Tran, Yousif Shamoo, Eugenia Mileykovskaya, William Dowhan, Ziqiang Guan, and Cesar A. Arias. “Daptomycin resistance in enterococci is associated with distinct alterations of cell membrane phospholipid content..” Plos One 7, no. 8 (2012). https://doi.org/10.1371/journal.pone.0043958.
    Full Text Link to Item
  - Garrett, Teresa A., Christian R. H. Raetz, Jennifer D. Son, Travis D. Richardson, Craig Bartling, and Ziqiang Guan. “Non-enzymatically derived minor lipids found in Escherichia coli lipid extracts..” Biochim Biophys Acta 1811, no. 11 (November 2011): 827–37. https://doi.org/10.1016/j.bbalip.2011.08.012.
    Full Text Link to Item
  - Guan, Ziqiang, and Jerry Eichler. “Liquid chromatography/tandem mass spectrometry of dolichols and polyprenols, lipid sugar carriers across evolution..” Biochim Biophys Acta 1811, no. 11 (November 2011): 800–806. https://doi.org/10.1016/j.bbalip.2011.04.009.
    Full Text Link to Item
  - Haig, Neil A., Ziqiang Guan, Demin Li, Andrew McMichael, Christian R. H. Raetz, and Xiao-Ning Xu. “Identification of self-lipids presented by CD1c and CD1d proteins..” J Biol Chem 286, no. 43 (October 28, 2011): 37692–701. https://doi.org/10.1074/jbc.M111.267948.
    Full Text Link to Item
  - Guan, Ziqiang, Benjamin H. Meyer, Sonja-Verena Albers, and Jerry Eichler. “The thermoacidophilic archaeon Sulfolobus acidocaldarius contains an unusually short, highly reduced dolichyl phosphate..” Biochim Biophys Acta 1811, no. 10 (October 2011): 607–16. https://doi.org/10.1016/j.bbalip.2011.06.022.
    Full Text Link to Item
  - Lin, Ren-Kuo, Nai Zhou, Yi Lisa Lyu, Yuan-Chin Tsai, Chang-Hsien Lu, John Kerrigan, Yu-tsung Chen, Ziqiang Guan, Tao-Shih Hsieh, and Leroy F. Liu. “Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα..” J Biol Chem 286, no. 38 (September 23, 2011): 33591–600. https://doi.org/10.1074/jbc.M111.258137.
    Full Text Link to Item
  - Calo, Doron, Ziqiang Guan, Shai Naparstek, and Jerry Eichler. “Different routes to the same ending: comparing the N-glycosylation processes of Haloferax volcanii and Haloarcula marismortui, two halophilic archaea from the Dead Sea..” Mol Microbiol 81, no. 5 (September 2011): 1166–77. https://doi.org/10.1111/j.1365-2958.2011.07781.x.
    Full Text Link to Item
  - Li, Chijun, Ziqiang Guan, Dan Liu, and Christian R. H. Raetz. “Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli..” Proc Natl Acad Sci U S A 108, no. 28 (July 12, 2011): 11387–92. https://doi.org/10.1073/pnas.1108840108.
    Full Text Link to Item
  - Calo, Doron, Ziqiang Guan, and Jerry Eichler. “Glyco-engineering in Archaea: differential N-glycosylation of the S-layer glycoprotein in a transformed Haloferax volcanii strain..” Microb Biotechnol 4, no. 4 (July 2011): 461–70. https://doi.org/10.1111/j.1751-7915.2011.00250.x.
    Full Text Link to Item
  - Zhang, Ji, Ziqiang Guan, Anne N. Murphy, Sandra E. Wiley, Guy A. Perkins, Carolyn A. Worby, James L. Engel, et al. “Mitochondrial phosphatase PTPMT1 is essential for cardiolipin biosynthesis..” Cell Metab 13, no. 6 (June 8, 2011): 690–700. https://doi.org/10.1016/j.cmet.2011.04.007.
    Full Text Link to Item
  - Zhang, Chaowei, John Ondeyka, Kithsiri Herath, Hiranthi Jayasuriya, Ziqiang Guan, Deborah L. Zink, Lisa Dietrich, et al. “Platensimycin and platencin congeners from Streptomyces platensis..” J Nat Prod 74, no. 3 (March 25, 2011): 329–40. https://doi.org/10.1021/np100635f.
    Full Text Link to Item
  - Guan, Ziqiang, Norah C. Johnston, Semra Aygun-Sunar, Fevzi Daldal, Christian R. H. Raetz, and Howard Goldfine. “Structural characterization of the polar lipids of Clostridium novyi NT. Further evidence for a novel anaerobic biosynthetic pathway to plasmalogens..” Biochim Biophys Acta 1811, no. 3 (March 2011): 186–93. https://doi.org/10.1016/j.bbalip.2010.12.010.
    Full Text Link to Item
  - Vences-Guzmán, Miguel Á., Ziqiang Guan, Ernesto Ormeño-Orrillo, Napoleón González-Silva, Isabel M. López-Lara, Esperanza Martínez-Romero, Otto Geiger, and Christian Sohlenkamp. “Hydroxylated ornithine lipids increase stress tolerance in Rhizobium tropici CIAT899..” Mol Microbiol 79, no. 6 (March 2011): 1496–1514. https://doi.org/10.1111/j.1365-2958.2011.07535.x.
    Full Text Link to Item
  - Lu, Yi-Hsueh, Ziqiang Guan, Jinshi Zhao, and Christian R. H. Raetz. “Three phosphatidylglycerol-phosphate phosphatases in the inner membrane of Escherichia coli..” J Biol Chem 286, no. 7 (February 18, 2011): 5506–18. https://doi.org/10.1074/jbc.M110.199265.
    Full Text Link to Item
  - Guan, Ziqiang, Xiaoyuan Wang, and Christian R. H. Raetz. “Identification of a chloroform-soluble membrane miniprotein in Escherichia coli and its homolog in Salmonella typhimurium..” Anal Biochem 409, no. 2 (February 15, 2011): 284–89. https://doi.org/10.1016/j.ab.2010.10.035.
    Full Text Link to Item
  - Giles, David K., Jessica V. Hankins, Ziqiang Guan, and M Stephen Trent. “Remodelling of the Vibrio cholerae membrane by incorporation of exogenous fatty acids from host and aquatic environments..” Mol Microbiol 79, no. 3 (February 2011): 716–28. https://doi.org/10.1111/j.1365-2958.2010.07476.x.
    Full Text Link to Item
  - Dennis, Edward A., Raymond A. Deems, Richard Harkewicz, Oswald Quehenberger, H Alex Brown, Stephen B. Milne, David S. Myers, et al. “A mouse macrophage lipidome..” J Biol Chem 285, no. 51 (December 17, 2010): 39976–85. https://doi.org/10.1074/jbc.M110.182915.
    Full Text Link to Item
  - Guan, Ziqiang, Shai Naparstek, Lina Kaminski, Zvia Konrad, and Jerry Eichler. “Distinct glycan-charged phosphodolichol carriers are required for the assembly of the pentasaccharide N-linked to the Haloferax volcanii S-layer glycoprotein..” Mol Microbiol 78, no. 5 (December 2010): 1294–1303. https://doi.org/10.1111/j.1365-2958.2010.07405.x.
    Full Text Link to Item
  - Rush, Jeffrey S., Sergey Matveev, Ziqiang Guan, Christian R. H. Raetz, and C. J. Waechter. “Expression of functional bacterial undecaprenyl pyrophosphate synthase in the yeast rer2{Delta} mutant and CHO cells..” Glycobiology 20, no. 12 (December 2010): 1585–93. https://doi.org/10.1093/glycob/cwq107.
    Full Text Link to Item
  - Kaminski, Lina, Mehtap Abu-Qarn, Ziqiang Guan, Shai Naparstek, Valeria V. Ventura, Christian R. H. Raetz, Paul G. Hitchen, Anne Dell, and Jerry Eichler. “AglJ adds the first sugar of the N-linked pentasaccharide decorating the Haloferax volcanii S-layer glycoprotein..” J Bacteriol 192, no. 21 (November 2010): 5572–79. https://doi.org/10.1128/JB.00705-10.
    Full Text Link to Item
  - Quehenberger, Oswald, Aaron M. Armando, Alex H. Brown, Stephen B. Milne, David S. Myers, Alfred H. Merrill, Sibali Bandyopadhyay, et al. “Lipidomics reveals a remarkable diversity of lipids in human plasma..” J Lipid Res 51, no. 11 (November 2010): 3299–3305. https://doi.org/10.1194/jlr.M009449.
    Full Text Link to Item
  - Chen, Huaiyong, Dongmei Liao, Derek Cain, Ian McLeod, Yoshihiro Ueda, Ziqiang Guan, Christian Raetz, and Garnett Kelsoe. “Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane..” Int J Exp Pathol 91, no. 5 (October 2010): 460–71. https://doi.org/10.1111/j.1365-2613.2010.00725.x.
    Full Text Link to Item
  - Andreyev, Alexander Y., Eoin Fahy, Ziqiang Guan, Samuel Kelly, Xiang Li, Jeffrey G. McDonald, Stephen Milne, et al. “Subcellular organelle lipidomics in TLR-4-activated macrophages..” J Lipid Res 51, no. 9 (September 2010): 2785–97. https://doi.org/10.1194/jlr.M008748.
    Full Text Link to Item
  - Bogdanov, Mikhail, Philip Heacock, Ziqiang Guan, and William Dowhan. “Plasticity of lipid-protein interactions in the function and topogenesis of the membrane protein lactose permease from Escherichia coli..” Proc Natl Acad Sci U S A 107, no. 34 (August 24, 2010): 15057–62. https://doi.org/10.1073/pnas.1006286107.
    Full Text Link to Item
  - Cantagrel, Vincent, Dirk J. Lefeber, Bobby G. Ng, Ziqiang Guan, Jennifer L. Silhavy, Stephanie L. Bielas, Ludwig Lehle, et al. “SRD5A3 is required for converting polyprenol to dolichol and is mutated in a congenital glycosylation disorder..” Cell 142, no. 2 (July 23, 2010): 203–17. https://doi.org/10.1016/j.cell.2010.06.001.
    Full Text Link to Item
  - Grabińska, Kariona A., Jike Cui, Aparajita Chatterjee, Ziqiang Guan, Christian R. H. Raetz, Phillips W. Robbins, and John Samuelson. “Molecular characterization of the cis-prenyltransferase of Giardia lamblia..” Glycobiology 20, no. 7 (July 2010): 824–32. https://doi.org/10.1093/glycob/cwq036.
    Full Text Link to Item
  - Johnston, Norah C., Semra Aygun-Sunar, Ziqiang Guan, Anthony A. Ribeiro, Fevzi Daldal, Christian R. H. Raetz, and Howard Goldfine. “A phosphoethanolamine-modified glycosyl diradylglycerol in the polar lipids of Clostridium tetani..” J Lipid Res 51, no. 7 (July 2010): 1953–61. https://doi.org/10.1194/jlr.M004788.
    Full Text Link to Item
  - Wang, X., Z. Guan, Y. Li, and C. R. H. Raetz. “Application of electrospray ionization mass spectrometry to characterize glycerophospholipids in Francisella tularensis subsp. novicida.” International Journal of Mass Spectrometry 293, no. 1–3 (April 27, 2010): 45–50. https://doi.org/10.1016/j.ijms.2010.03.015.
    Full Text
  - Andreyev, Alexander Y., Zhouxin Shen, Ziqiang Guan, Andrea Ryan, Eoin Fahy, Shankar Subramaniam, Christian R. H. Raetz, Steven Briggs, and Edward A. Dennis. “Application of proteomic marker ensembles to subcellular organelle identification..” Mol Cell Proteomics 9, no. 2 (February 2010): 388–402. https://doi.org/10.1074/mcp.M900432-MCP200.
    Full Text Link to Item
  - Zavaleta-Pastor, Maritza, Christian Sohlenkamp, Jun-Lian Gao, Ziqiang Guan, Rahat Zaheer, Turlough M. Finan, Christian R. H. Raetz, Isabel M. López-Lara, and Otto Geiger. “Sinorhizobium meliloti phospholipase C required for lipid remodeling during phosphorus limitation..” Proc Natl Acad Sci U S A 107, no. 1 (January 5, 2010): 302–7. https://doi.org/10.1073/pnas.0912930107.
    Full Text Link to Item
  - Zhang, Chaowei, John Ondeyka, Ziqiang Guan, Lisa Dietrich, Bruce Burgess, Jun Wang, and Sheo B. Singh. “Isolation, structure and biological activities of platensimycin B4 from Streptomyces platensis..” J Antibiot (Tokyo) 62, no. 12 (December 2009): 699–702. https://doi.org/10.1038/ja.2009.106.
    Full Text Link to Item
  - Romantsov, Tatyana, Ziqiang Guan, and Janet M. Wood. “Cardiolipin and the osmotic stress responses of bacteria..” Biochim Biophys Acta 1788, no. 10 (October 2009): 2092–2100. https://doi.org/10.1016/j.bbamem.2009.06.010.
    Full Text Link to Item
  - Guan, Ziqiang. “Discovering novel brain lipids by liquid chromatography/tandem mass spectrometry..” J Chromatogr B Analyt Technol Biomed Life Sci 877, no. 26 (September 15, 2009): 2814–21. https://doi.org/10.1016/j.jchromb.2009.03.002.
    Full Text Link to Item
  - Barb, A. W., T. M. Leavy, L. I. Robins, Z. Guan, D. A. Six, P. Zhou, M. J. Hangauer, C. R. Bertozzi, and C. Raetz. “Correction to uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC (Biochemistry (2009) 48, (3068) DOI: 10.1021/bi900167q).” Biochemistry 48, no. 32 (August 18, 2009). https://doi.org/10.1021/bi9012066.
    Full Text
  - Sandoval-Calderón, Mario, Otto Geiger, Ziqiang Guan, Francisco Barona-Gómez, and Christian Sohlenkamp. “A eukaryote-like cardiolipin synthase is present in Streptomyces coelicolor and in most actinobacteria..” J Biol Chem 284, no. 26 (June 26, 2009): 17383–90. https://doi.org/10.1074/jbc.M109.006072.
    Full Text Link to Item
  - Barb, Adam W., Tanya M. Leavy, Lori I. Robins, Ziqiang Guan, David A. Six, Pei Zhou, Matthew J. Hangauer, Carolyn R. Bertozzi, and Christian R. H. Raetz. “Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC..” Biochemistry 48, no. 14 (April 14, 2009): 3068–77. https://doi.org/10.1021/bi900167q.
    Full Text Link to Item
  - Raetz, Christian R. H., Ziqiang Guan, Brian O. Ingram, David A. Six, Feng Song, Xiaoyuan Wang, and Jinshi Zhao. “Discovery of new biosynthetic pathways: the lipid A story..” J Lipid Res 50 Suppl (April 2009): S103–8. https://doi.org/10.1194/jlr.R800060-JLR200.
    Full Text Link to Item
  - Song, Feng, Ziqiang Guan, and Christian R. H. Raetz. “Biosynthesis of undecaprenyl phosphate-galactosamine and undecaprenyl phosphate-glucose in Francisella novicida..” Biochemistry 48, no. 6 (February 17, 2009): 1173–82. https://doi.org/10.1021/bi802212t.
    Full Text Link to Item
  - Wang, Xiaoyuan, Anthony A. Ribeiro, Ziqiang Guan, and Christian R. H. Raetz. “Identification of undecaprenyl phosphate-beta-D-galactosamine in Francisella novicida and its function in lipid A modification..” Biochemistry 48, no. 6 (February 17, 2009): 1162–72. https://doi.org/10.1021/bi802211k.
    Full Text Link to Item
  - Grabińska, Kariona A., Sudip K. Ghosh, Ziqiang Guan, Jike Cui, Christian R. H. Raetz, Phillips W. Robbins, and John Samuelson. “Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis..” Eukaryot Cell 7, no. 8 (August 2008): 1344–51. https://doi.org/10.1128/EC.00061-08.
    Full Text Link to Item
  - Six, David A., Sherry M. Carty, Ziqiang Guan, and Christian R. H. Raetz. “Purification and mutagenesis of LpxL, the lauroyltransferase of Escherichia coli lipid A biosynthesis..” Biochemistry 47, no. 33 (August 2008): 8623–37. https://doi.org/10.1021/bi800873n.
    Full Text
  - Wu, Shilan, Mariel Birnbaumer, and Ziqiang Guan. “Phosphorylation analysis of G protein-coupled receptor by mass spectrometry: identification of a phosphorylation site in V2 vasopressin receptor..” Anal Chem 80, no. 15 (August 1, 2008): 6034–37. https://doi.org/10.1021/ac8008548.
    Full Text Link to Item
  - Gibbons, Henry S., C Michael Reynolds, Ziqiang Guan, and Christian R. H. Raetz. “An inner membrane dioxygenase that generates the 2-hydroxymyristate moiety of Salmonella lipid A..” Biochemistry 47, no. 9 (March 4, 2008): 2814–25. https://doi.org/10.1021/bi702457c.
    Full Text Link to Item
  - Yan, Aixin, Ziqiang Guan, and Christian R. H. Raetz. “An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli..” J Biol Chem 282, no. 49 (December 7, 2007): 36077–89. https://doi.org/10.1074/jbc.M706172200.
    Full Text Link to Item
  - Guan, Ziqiang, Shengrong Li, Dale C. Smith, Walter A. Shaw, and Christian R. H. Raetz. “Identification of N-acylphosphatidylserine molecules in eukaryotic cells..” Biochemistry 46, no. 50 (December 2007): 14500–513. https://doi.org/10.1021/bi701907g.
    Full Text
  - Sohlenkamp, Christian, Kanaan A. Galindo-Lagunas, Ziqiang Guan, Pablo Vinuesa, Sally Robinson, Jane Thomas-Oates, Christian R. H. Raetz, and Otto Geiger. “The lipid lysyl-phosphatidylglycerol is present in membranes of Rhizobium tropici CIAT899 and confers increased resistance to polymyxin B under acidic growth conditions..” Molecular Plant Microbe Interactions : Mpmi 20, no. 11 (November 2007): 1421–30. https://doi.org/10.1094/mpmi-20-11-1421.
    Full Text
  - Jayasuriya, Hiranthi, Ziqiang Guan, Anne W. Dombrowski, Gerald F. Bills, Jon D. Polishook, Rosalind G. Jenkins, Leslie Koch, et al. “Isolation, structure, and coccidiostat activity of coccidiostatin A..” J Nat Prod 70, no. 8 (August 2007): 1364–67. https://doi.org/10.1021/np0700523.
    Full Text Link to Item
  - Nobles, Kelly N., Ziqiang Guan, Kunhong Xiao, Terrence G. Oas, and Robert J. Lefkowitz. “The active conformation of beta-arrestin1: direct evidence for the phosphate sensor in the N-domain and conformational differences in the active states of beta-arrestins1 and -2..” J Biol Chem 282, no. 29 (July 20, 2007): 21370–81. https://doi.org/10.1074/jbc.M611483200.
    Full Text Link to Item
  - Ward, Weslyn C., Ziqiang Guan, Fabio A. Zucca, Ruggero G. Fariello, Reza Kordestani, Luigi Zecca, Christian R. H. Raetz, and John D. Simon. “Identification and quantification of dolichol and dolichoic acid in neuromelanin from substantia nigra of the human brain..” J Lipid Res 48, no. 7 (July 2007): 1457–62. https://doi.org/10.1194/jlr.C700008-JLR200.
    Full Text Link to Item
  - Wang, Xiaoyuan, Anthony A. Ribeiro, Ziqiang Guan, Soman N. Abraham, and Christian R. H. Raetz. “Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase..” Proc Natl Acad Sci U S A 104, no. 10 (March 6, 2007): 4136–41. https://doi.org/10.1073/pnas.0611606104.
    Full Text Link to Item
  - Garrett, Teresa A., Ziqiang Guan, and Christian R. H. Raetz. “Analysis of ubiquinones, dolichols, and dolichol diphosphate-oligosaccharides by liquid chromatography-electrospray ionization-mass spectrometry..” Methods in Enzymology 432 (January 2007): 117–43. https://doi.org/10.1016/s0076-6879(07)32005-3.
    Full Text
  - Okado-Matsumoto, Ayako, Ziqiang Guan, and Irwin Fridovich. “Modification of cysteine 111 in human Cu,Zn-superoxide dismutase..” Free Radic Biol Med 41, no. 12 (December 15, 2006): 1837–46. https://doi.org/10.1016/j.freeradbiomed.2006.09.011.
    Full Text Link to Item
  - Wang, Xiaoyuan, Anthony A. Ribeiro, Ziqiang Guan, Sara C. McGrath, Robert J. Cotter, and Christian R. H. Raetz. “Structure and biosynthesis of free lipid A molecules that replace lipopolysaccharide in Francisella tularensis subsp. novicida..” Biochemistry 45, no. 48 (December 5, 2006): 14427–40. https://doi.org/10.1021/bi061767s.
    Full Text Link to Item
  - Bakhtiar, Ray, and Ziqiang Guan. “Electron capture dissociation mass spectrometry in characterization of peptides and proteins..” Biotechnology Letters 28, no. 14 (July 2006): 1047–59. https://doi.org/10.1007/s10529-006-9065-z.
    Full Text
  - Kanjilal-Kolar, Suparna, Shib Sankar Basu, Margaret I. Kanipes, Ziqiang Guan, Teresa A. Garrett, and Christian R. H. Raetz. “Expression cloning of three Rhizobium leguminosarum lipopolysaccharide core galacturonosyltransferases..” J Biol Chem 281, no. 18 (May 5, 2006): 12865–78. https://doi.org/10.1074/jbc.M513864200.
    Full Text Link to Item
  - Ondeyka, John G., Anne W. Dombrowski, Jon P. Polishook, Tom Felcetto, Wesley L. Shoop, Ziqiang Guan, and Sheo B. Singh. “Isolation and insecticidal/anthelmintic activity of xanthonol, a novel bis-xanthone, from a non-sporulating fungal species..” J Antibiot (Tokyo) 59, no. 5 (May 2006): 288–92. https://doi.org/10.1038/ja.2006.40.
    Full Text Link to Item
  - Zhang, Chaowei, John G. Ondeyka, Kithsiri B. Herath, Ziqiang Guan, Javier Collado, Fernando Pelaez, Penny S. Leavitt, et al. “Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity..” J Nat Prod 69, no. 4 (April 2006): 710–12. https://doi.org/10.1021/np0505418.
    Full Text Link to Item
  - Naus, Silvia, Simone Reipschläger, Dirk Wildeboer, Stefan F. Lichtenthaler, Stefan Mitterreiter, Ziqiang Guan, Marcia L. Moss, and Jörg W. Bartsch. “Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8..” Biol Chem 387, no. 3 (March 2006): 337–46. https://doi.org/10.1515/BC.2006.045.
    Full Text Link to Item
  - McClerren, Amanda L., Stephanie Endsley, Jason L. Bowman, Niels H. Andersen, Ziqiang Guan, Johannes Rudolph, and Christian R. H. Raetz. “A slow, tight-binding inhibitor of the zinc-dependent deacetylase LpxC of lipid A biosynthesis with antibiotic activity comparable to ciprofloxacin..” Biochemistry 44, no. 50 (December 20, 2005): 16574–83. https://doi.org/10.1021/bi0518186.
    Full Text Link to Item
  - Li, Ming, Hemali P. Phatnani, Ziqiang Guan, Harvey Sage, Arno L. Greenleaf, and Pei Zhou. “Solution structure of the Set2-Rpb1 interacting domain of human Set2 and its interaction with the hyperphosphorylated C-terminal domain of Rpb1..” Proc Natl Acad Sci U S A 102, no. 49 (December 6, 2005): 17636–41. https://doi.org/10.1073/pnas.0506350102.
    Full Text Link to Item
  - Singh, Sheo B., Rosemarie Kelly, Ziqiang Guan, Jon D. Polishook, Anne W. Domrowski, Javier Collado, Antonio Gonzalez, et al. “New fungal metabolite geranylgeranyltransferase inhibitors with antifungal activity..” Natural Product Research 19, no. 8 (December 2005): 739–47. https://doi.org/10.1080/1478641042000334715.
    Full Text
  - Liu, W., Z. Guan, and S. B. Singh. “A new method for the synthesis of 1,4,5-oxadiazocines and its application in the structure modification of natural products.” Tetrahedron Letters 46, no. 46 (November 14, 2005): 8009–12. https://doi.org/10.1016/j.tetlet.2005.09.069.
    Full Text
  - Herath, Kithsiri B., Hiranthi Jayasuriya, John G. Ondeyka, Jon D. Polishook, Gerald F. Bills, Anne W. Dombrowski, Angeles Cabello, et al. “Isolation and structures of novel fungal metabolites as chemokine receptor (CCR2) antagonists..” J Antibiot (Tokyo) 58, no. 11 (November 2005): 686–94. https://doi.org/10.1038/ja.2005.94.
    Full Text Link to Item
  - Guan, Ziqiang, Steven D. Breazeale, and Christian R. H. Raetz. “Extraction and identification by mass spectrometry of undecaprenyl diphosphate-MurNAc-pentapeptide-GlcNAc from Escherichia coli..” Analytical Biochemistry 345, no. 2 (October 2005): 336–39. https://doi.org/10.1016/j.ab.2005.07.002.
    Full Text
  - Herath, Kithsiri B., Hiranthi Jayasuriya, Ziqiang Guan, Marvin Schulman, Carolyn Ruby, Neelam Sharma, Karen MacNaul, et al. “Anthrabenzoxocinones from Streptomyces sp. as liver X receptor ligands and antibacterial agents..” Journal of Natural Products 68, no. 9 (September 2005): 1437–40. https://doi.org/10.1021/np050176k.
    Full Text
  - Ondeyka, John G., Hiranthi Jayasuriya, Kithsiri B. Herath, Ziqiang Guan, Marvin Schulman, Javier Collado, Anne W. Dombrowski, et al. “Steroidal and triterpenoidal fungal metabolites as ligands of liver X receptors..” J Antibiot (Tokyo) 58, no. 9 (September 2005): 559–65. https://doi.org/10.1038/ja.2005.76.
    Full Text Link to Item
  - Bakhtiar, Ray, and Ziqiang Guan. “Electron capture dissociation mass spectrometry in characterization of post-translational modifications..” Biochemical and Biophysical Research Communications 334, no. 1 (August 2005): 1–8. https://doi.org/10.1016/j.bbrc.2005.05.138.
    Full Text
  - Jayasuriya, Hiranthi, Kithsiri B. Herath, John G. Ondeyka, Ziqiang Guan, Robert P. Borris, Suroojnauth Tiwari, Wil de Jong, et al. “Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources..” Journal of Natural Products 68, no. 8 (August 2005): 1247–52. https://doi.org/10.1021/np050182g.
    Full Text
  - Herath, Kithsiri, Hiranthi Jayasuriya, John G. Ondeyka, Ziqiang Guan, Robert P. Borris, Eirik Stijfhoorn, Dennis Stevenson, et al. “Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand..” Journal of Natural Products 68, no. 4 (April 2005): 617–19. https://doi.org/10.1021/np050045j.
    Full Text
  - Ortlund, Eric A., Yoonkwang Lee, Isaac H. Solomon, Janet M. Hager, Rachid Safi, Yunhee Choi, Ziqiang Guan, et al. “Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP..” Nat Struct Mol Biol 12, no. 4 (April 2005): 357–63. https://doi.org/10.1038/nsmb910.
    Full Text Link to Item
  - Zhang, Chaowei, John G. Ondeyka, Kithsiri B. Herath, Ziqiang Guan, Javier Collado, Gonzalo Platas, Fernando Pelaez, et al. “Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity..” Journal of Natural Products 68, no. 4 (April 2005): 611–13. https://doi.org/10.1021/np049591n.
    Full Text
  - McClerren, Amanda L., Pei Zhou, Ziqiang Guan, Christian R. H. Raetz, and Johannes Rudolph. “Kinetic analysis of the zinc-dependent deacetylase in the lipid A biosynthetic pathway..” Biochemistry 44, no. 4 (February 1, 2005): 1106–13. https://doi.org/10.1021/bi048001h.
    Full Text Link to Item
  - Ondeykal, John G., Kithsiri B. Herath, Hiranthi Jayasuriya, Jon D. Polishook, Gerald F. Bills, Anne W. Dombrowski, Marina Mojena, et al. “Discovery of structurally diverse natural product antagonists of chemokine receptor CXCR3..” Mol Divers 9, no. 1–3 (2005): 123–29.
    Link to Item
  - Jayasuriya, Hiranthi, Kithsiri B. Herath, John G. Ondeyka, Jon D. Polishook, Gerald F. Bills, Anne W. Dombrowski, Marty S. Springer, et al. “Isolation and structure of antagonists of chemokine receptor (CCR5)..” J Nat Prod 67, no. 6 (June 2004): 1036–38. https://doi.org/10.1021/np049974l.
    Full Text Link to Item
  - Herath, Kithsiri B., Hiranthi Jayasuriya, Gerald F. Bills, Jon D. Polishook, Anne W. Dombrowski, Ziqiang Guan, Peter J. Felock, Daria J. Hazuda, and Sheo B. Singh. “Isolation, structure, absolute stereochemistry, and HIV-1 integrase inhibitory activity of integrasone, a novel fungal polyketide..” J Nat Prod 67, no. 5 (May 2004): 872–74. https://doi.org/10.1021/np0340504.
    Full Text Link to Item
  - Singh, Sheo B., Hiranthi Jayasuriya, Raymond Dewey, Jon D. Polishook, Anne W. Dombrowski, Deborah L. Zink, Ziqiang Guan, et al. “Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolites..” J Ind Microbiol Biotechnol 30, no. 12 (December 2003): 721–31. https://doi.org/10.1007/s10295-003-0101-x.
    Full Text Link to Item
  - Singh, S. B., D. L. Zink, Z. Guan, J. Collado, F. Pelaez, P. J. Felock, and D. J. Hazuda. “Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Xanthoviridicatin E and F, Two Novel Fungal Metabolites Produced by Penicillium chrysogenum.” Helvetica Chimica Acta 86, no. 10 (November 20, 2003): 3380–85. https://doi.org/10.1002/hlca.200390281.
    Full Text
  - Guan, Ziqiang, Nathan A. Yates, and Ray Bakhtiar. “Detection and characterization of methionine oxidation in peptides by collision-induced dissociation and electron capture dissociation..” J Am Soc Mass Spectrom 14, no. 6 (June 2003): 605–13. https://doi.org/10.1016/S1044-0305(03)00201-0.
    Full Text Link to Item
  - Ondeyka, J. G., A. W. Dombrowski, J. P. Polishook, T. Felcetto, W. L. Shoop, Z. Guan, and S. B. Singh. “Isolation and insecticidal activity of mellamide from Aspergillus melleus..” Journal of Industrial Microbiology & Biotechnology 30, no. 4 (April 8, 2003): 220–24. https://doi.org/10.1007/s10295-003-0048-y.
    Full Text
  - Jayasuriya, Hiranthi, Ziqiang Guan, Jon D. Polishook, Anne W. Dombrowski, Peter J. Felock, Daria J. Hazuda, and Sheo B. Singh. “Isolation, structure, and HIV-1 integrase inhibitory activity of Cytosporic acid, a fungal metabolite produced by a Cytospora sp..” J Nat Prod 66, no. 4 (April 2003): 551–53. https://doi.org/10.1021/np020533g.
    Full Text Link to Item
  - Wang, Zhen, Cornelis E. C. A. Hop, Mi-Sook Kim, Su-E W. Huskey, Thomas A. Baillie, and Ziqiang Guan. “The unanticipated loss of SO2 from sulfonamides in collision-induced dissociation..” Rapid Communications in Mass Spectrometry : Rcm 17, no. 1 (January 2003): 81–86. https://doi.org/10.1002/rcm.877.
    Full Text
  - Guan, Z., and P. R. Griffin. “Localization and characterization of peptide acylation with Ester linkage by electron capture dissociation FTICR/MS.” Proceedings 50th Asms Conference on Mass Spectrometry and Allied Topics, December 1, 2002, 857–58.
  - Guan, Ziqiang. “Identification and localization of the fatty acid modification in ghrelin by electron capture dissociation..” Journal of the American Society for Mass Spectrometry 13, no. 12 (December 2002): 1443–47. https://doi.org/10.1016/s1044-0305(02)00707-9.
    Full Text
  - Jayasuriya, Hiranthi, Russell B. Lingham, Pia Graham, Donette Quamina, Lucia Herranz, Olga Genilloud, Magda Gagliardi, et al. “Durhamycin A, a potent inhibitor of HIV Tat transactivation..” J Nat Prod 65, no. 8 (August 2002): 1091–95. https://doi.org/10.1021/np010642f.
    Full Text Link to Item
  - Singh, Sheo B., Kithsiri Herath, Ziqiang Guan, Deborah L. Zink, Anne W. Dombrowski, Jon D. Polishook, Keith C. Silverman, Russell B. Lingham, Peter J. Felock, and Daria J. Hazuda. “Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase..” Org Lett 4, no. 9 (May 2, 2002): 1431–34. https://doi.org/10.1021/ol025540a.
    Full Text Link to Item
  - Shafiee, A., A. Tsipouras, A. Bouffard, J. C. Onishi, Z. Guan, and H. Motamedi. “Enzymatic deglycosylation of enfumafungin, a triterpene glycoside natural product, and its chemically synthesized analogues.” Journal of Molecular Catalysis B Enzymatic 16, no. 1 (November 20, 2001): 27–32. https://doi.org/10.1016/S1381-1177(01)00041-8.
    Full Text
  - Guan, Z., and J. M. Liesch. “Solvation of acylium fragment ions in electrospray ionization quadrupole ion trap and Fourier transform ion cyclotron resonance mass spectrometry..” Journal of Mass Spectrometry : Jms 36, no. 3 (March 2001): 264–76. https://doi.org/10.1002/jms.124.
    Full Text
  - Wilson, K. E., N. N. Tsou, Z. Guan, C. L. Ruby, F. Pelaez, J. Gorrochategui, F. Vicente, and H. R. Onishi. “Isolation and structure elucidation of coleophomones A and B, novel inhibitors of bacterial cell wall transglycosylase.” Tetrahedron Letters 41, no. 45 (November 4, 2000): 8705–9. https://doi.org/10.1016/S0040-4039(00)01532-X.
    Full Text
  - McLafferty, F. W., Z. Guan, U. Haupts, T. D. Wood, and N. L. Kelleher. “Gaseous conformational structures of cytochrome c.” Journal of the American Chemical Society 120, no. 19 (May 20, 1998): 4732–40. https://doi.org/10.1021/ja9728076.
    Full Text
  - Wood, T. D., Z. Guan, C. L. Borders, L. H. Chen, G. L. Kenyon, and F. W. McLafferty. “Creatine kinase: essential arginine residues at the nucleotide binding site identified by chemical modification and high-resolution tandem mass spectrometry..” Proceedings of the National Academy of Sciences of the United States of America 95, no. 7 (March 1998): 3362–65. https://doi.org/10.1073/pnas.95.7.3362.
    Full Text
  - Aaserud, D. J., Z. Guan, D. P. Little, and F. W. McLafferty. “DNA sequencing with blackbody infrared radiative dissociation of electrosprayed ions.” International Journal of Mass Spectrometry and Ion Processes 167–168 (December 1, 1997): 705–12.
  - McLafferty, F. W., D. J. Aaserud, Z. Guan, D. P. Little, and N. L. Kelleher. “Double stranded DNA sequencing by tandem mass spectrometry.” International Journal of Mass Spectrometry and Ion Processes 165–166 (December 1, 1997): 457–66.
  - O’Connor, P. B., J. P. Speir, T. D. Wood, R. A. Chorush, Z. Guan, and F. W. McLafferty. “Broadband quadrupolar axialization of large multiply charged ions to enhance measurement and minimize conformational restrictions..” J Mass Spectrom 31, no. 5 (May 1996): 555–59. https://doi.org/10.1002/(SICI)1096-9888(199605)31:5<555::AID-JMS324>3.0.CO;2-F.
    Full Text Link to Item
  - Guan, Z., N. L. Kelleher, P. B. O’Connor, D. J. Aaserud, D. P. Little, and F. W. McLafferty. “193 nm photodissociation of larger multiply-charged biomolecules.” International Journal of Mass Spectrometry and Ion Processes 157–158 (January 1, 1996): 357–64. https://doi.org/10.1016/S0168-1176(96)04399-6.
    Full Text
  - O’Connor, P. B., J. P. Speir, T. D. Wood, R. A. Chorush, Z. Guan, and F. W. McLafferty. “Broadband quadrupolar axialization of large multiply charged ions to enhance measurement and minimize conformational restrictions.” Journal of Mass Spectrometry 31, no. 5 (1996): 555–59. https://doi.org/10.1002/(SICI)1096-9888(199605)31:5<555::AID-JMS324>3.0.CO;2-F.
    Full Text
  - Guan, Z., V. L. Campbell, J. J. Drader, C. L. Hendrickson, and D. A. Laude. “High performance detection of biomolecules using a high magnetic field electrospray ionization source/Fourier transform ion cyclotron resonance mass spectrometer.” Review of Scientific Instruments 66, no. 9 (December 1, 1995): 4507–15. https://doi.org/10.1063/1.1145350.
    Full Text
  - Guan, Z., J. J. Drader, V. L. Campbell, and D. A. Laude. “Real-time monitoring of the gas phase reactions of a single ion population using the remeasurement experiment in Fourier transform ion cyclotron resonance mass spectrometry..” Anal Chem 67, no. 8 (April 15, 1995): 1453–58. https://doi.org/10.1021/ac00104a023.
    Full Text Link to Item
  - Campbell, V. L., Z. Guan, V. H. Vartanian, and D. A. Laude. “Cell geometry considerations for the Fourier transform ion cyclotron resonance mass spectrometry remeasurement experiment..” Anal Chem 67, no. 2 (January 15, 1995): 420–25. https://doi.org/10.1021/ac00098a030.
    Full Text Link to Item
  - Campbell, V. L., Z. Guan, and D. A. Laude. “Remeasurement at high resolving power in fourier transform ion cyclotron resonance mass spectrometry.” Journal of the American Society for Mass Spectrometry 6, no. 7 (January 1, 1995): 564–70. https://doi.org/10.1016/1044-0305(95)00230-B.
    Full Text
  - Guan, Z., V. L. Campbell, and D. A. Laude. “Charge state assignment from schiff‐base adducts in low resolution electrospray mass spectra of protein mixtures and dissociation products.” Journal of Mass Spectrometry 30, no. 1 (January 1, 1995): 119–23. https://doi.org/10.1002/jms.1190300118.
    Full Text
  - Campbell, V. L., Z. Guan, and D. A. Laude. “Selective generation of charge-cependent/independent ion energy distributions from a heated capillary electrospray source.” Journal of the American Society for Mass Spectrometry 5, no. 4 (January 1, 1994): 221–29. https://doi.org/10.1016/1044-0305(94)85012-7.
    Full Text
  - Guan, Z., S. A. Hofstadler, and D. A. Laude. “Remeasurement of electrosprayed proteins in the trapped ion cell of a Fourier transform ion cyclotron resonance mass spectrometer..” Anal Chem 65, no. 11 (June 1, 1993): 1588–93. https://doi.org/10.1021/ac00059a018.
    Full Text Link to Item
  - Hofstadler, S. A., E. Schmidt, Z. Guan, and D. A. Laude. “Concentric tube vacuum chamber for high magnetic field, high-pressure ionization in a fourier transform ion cyclotron resonance mass spectrometer.” Journal of the American Society for Mass Spectrometry 4, no. 2 (January 1, 1993): 168–76. https://doi.org/10.1016/1044-0305(93)85073-7.
    Full Text
  - Zhou, F., S. L. Yau, C. Jehoulet, D. A. Laude, Z. Guan, and A. J. Bard. “Electrochemistry of C60films: Quartz crystal microbalance and mass spectrometric studies.” Journal of Physical Chemistry 96, no. 11 (December 1, 1992): 4160–62.
- Conference Papers
  - Wen, Rong, Eon Joo Park, Ziqiang Guan, Yiwen Li, Yuan Kang, Jianmin Lu, Byron L. Lam, and William Sessa. “Impaired photoreceptor functions in the NgBR(R290H/R290H) mouse.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.
    Link to Item
  - Adams, Hannah, Luke Joyce, Ziqiang Guan, Ronda Akins, and Kelli Palmer. “Streptococcus mitis and Streptococcus oralis Mutate an 'Essential'" Gene Upon Exposure to Daptomycin.” In Faseb Journal, Vol. 31. FEDERATION AMER SOC EXP BIOL, 2017.
    Link to Item
  - Li, Yiwen, Byron L. Lam, Ziqiang Guan, Zhengying Wang, Ning Wang, Yihui Chen, and Rong Wen. “Photoreceptor degeneration in the DHDDS K42EK42E mouse.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
    Link to Item
  - Wen, Rong, Byron L. Lam, Ziqiang Guan, Zhengying Wang, Ning Wang, Yihui Chen, and Yiwen Li. “Abnormal synaptic transmission between photoreceptors and bipolar cells in DHDDSK42E/K42E mice.” In Investigative Ophthalmology & Visual Science, Vol. 55. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2014.
    Link to Item
  - Chung, Ben C., Jinshi Zhao, Robert Gillespie, Do Yeon Kwon, Ziqiang Guan, Jiyong Hong, Pei Zhou, and Seok-Yong Lee. “Crystal Structure of MraY, an Essential Membrane Enzyme for Bacterial Cell Wall Synthesis.” In Biophysical Journal, 106:14a-14a. Elsevier BV, 2014. https://doi.org/10.1016/j.bpj.2013.11.131.
    Full Text
  - Zhang, Ji, Ziqiang Guan, Anne Murphy, Sandra Wiley, Guy Perkins, Carolyn Worby, James Engel, Christian R. H. Raetz, William Dowhan, and Jack Dixon. “A Mitochondrial Lipid Phosphatase in Cell Metabolism and Membrane Organization.” In Faseb Journal, Vol. 26, 2012.
    Link to Item
  - Collins, Tammy, Ziqiang Guan, Alfred Sun, Jennifer Durst, Derike Smiley, Gordon Hammes, and Tao-shih Hsieh. “Mechanistic studies of eukaryotic topoisomerase II: a cysteine footprinting and FRET approach.” In Faseb Journal, Vol. 22. FEDERATION AMER SOC EXP BIOL, 2008.
    Link to Item
  - Nobles, K. N., Z. Q. Guan, K. H. Xiao, T. G. Oas, and R. J. Lefkowitz. “Conformational changes in beta-arrestin1: The importance of beta-arrestin1's N-domain.” In Faseb Journal, 20:A114–A114. FEDERATION AMER SOC EXP BIOL, 2006.
    Link to Item
  - Zhou, F., X. Yang, C. Xiong, S. Zhang, Y. Zong, L. Sun, and Z. Guan. “Application and Study of Fine-silty Sand Control Technique for Unconsolidation Quaternary Sand Gas Reservoir, Sebei Qinghai.” In Spe International Formation Damage Control Symposium Proceedings, 2004.

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Subject Headings

Global Scholarship

Expertise

Selected Grants

Selected Publications

Academic Articles

Conference Papers