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Autoimmunity in immunodeficiency.

Publication ,  Journal Article
Todoric, K; Koontz, JB; Mattox, D; Tarrant, TK
Published in: Curr Allergy Asthma Rep
August 2013

Primary immunodeficiencies (PID) comprise a diverse group of clinical disorders with varied genetic defects. Paradoxically, a substantial proportion of PID patients develop autoimmune phenomena in addition to having increased susceptibility to infections from their impaired immunity. Although much of our understanding comes from data gathered through experimental models, there are several well-characterized PID that have improved our knowledge of the pathways that drive autoimmunity. The goals of this review will be to discuss these immunodeficiencies and to review the literature with respect to the proposed mechanisms for autoimmunity within each put forth to date.

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Published In

Curr Allergy Asthma Rep

DOI

EISSN

1534-6315

Publication Date

August 2013

Volume

13

Issue

4

Start / End Page

361 / 370

Location

United States

Related Subject Headings

  • Signal Transduction
  • Infections
  • Immunologic Deficiency Syndromes
  • Humans
  • Autoimmunity
  • Allergy
  • 3204 Immunology
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Todoric, K., Koontz, J. B., Mattox, D., & Tarrant, T. K. (2013). Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep, 13(4), 361–370. https://doi.org/10.1007/s11882-013-0350-3
Todoric, Krista, Jessica B. Koontz, Daniel Mattox, and Teresa K. Tarrant. “Autoimmunity in immunodeficiency.Curr Allergy Asthma Rep 13, no. 4 (August 2013): 361–70. https://doi.org/10.1007/s11882-013-0350-3.
Todoric K, Koontz JB, Mattox D, Tarrant TK. Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep. 2013 Aug;13(4):361–70.
Todoric, Krista, et al. “Autoimmunity in immunodeficiency.Curr Allergy Asthma Rep, vol. 13, no. 4, Aug. 2013, pp. 361–70. Pubmed, doi:10.1007/s11882-013-0350-3.
Todoric K, Koontz JB, Mattox D, Tarrant TK. Autoimmunity in immunodeficiency. Curr Allergy Asthma Rep. 2013 Aug;13(4):361–370.
Journal cover image

Published In

Curr Allergy Asthma Rep

DOI

EISSN

1534-6315

Publication Date

August 2013

Volume

13

Issue

4

Start / End Page

361 / 370

Location

United States

Related Subject Headings

  • Signal Transduction
  • Infections
  • Immunologic Deficiency Syndromes
  • Humans
  • Autoimmunity
  • Allergy
  • 3204 Immunology
  • 3201 Cardiovascular medicine and haematology