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Teresa Kathleen Tarrant

Associate Professor of Medicine
Medicine, Rheumatology and Immunology
200 Trent Dr., DUMC 3874, Durham, NC 27710
235 Sands Resarch Bldg, 303 Research Dr., Durham, NC 27710

Overview


I first became interested in clinical immunology as a medical student studying autoimmune inflammatory eye disease at the National Institutes of Health.  Since then, I have been inspired to understand what causes autoimmunity and immune deficiency disorders in order to improve the quality of life for my patients.  I see patients with multiple complex immune disorders with particular expertise in autoimmune and Rheumatoid arthritis, primary Sjogren's syndrome, and the immunodeficiency disorders Common Variable Immunodeficiency (CVID), Adenosine Deaminase Deficiency (ADA) disorders, and WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis). My research investigates immune targets that may impact either the development of immune disease or identify new therapies for patients.  The goal is to help us understand why and how immunologic diseases develop so that we may better treat them.

Current Appointments & Affiliations


Associate Professor of Medicine · 2018 - Present Medicine, Rheumatology and Immunology, Medicine

In the News


Published November 30, 2022
After a Tough Summer, X4 Celebrates Phase III Win in WHIM Syndrome
Published December 8, 2020
Three I&E Incubation Awards Fund Novel Ideas to Solar Energy, IBD & Medical Laser Research
Published July 14, 2020
Accuracy in Rheumatoid Arthritis Testing Can Improve Diagnosis, Lower Costs

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Recent Publications


Early identification of delayed-onset ADA deficiency: The case for expanded first-tier newborn screening

Journal Article Journal of Human Immunity · January 5, 2026 Standard newborn screening using T cell receptor excision circles (TRECs) failed to detect delayed-onset ADA deficiency in two cases. Retrospective mass spectrometry (MS/MS) analysis showed diagnostic deoxyadenosine elevation at birth. We advocate ... Full text Cite

A Review of Adenosine Deaminase 2 (ADA2) as a Biomarker of Monocyte/Macrophage Activation.

Journal Article Curr Allergy Asthma Rep · January 3, 2026 PURPOSE OF REVIEW: Adenosine deaminase 2 (ADA2) is predominantly expressed by and secreted from activated monocytes and macrophages into plasma. This review explores the utility of ADA2 as a biomarker of monocyte/macrophage activation in a range of conditi ... Full text Link to item Cite

Diagnostic Implications and Correlates of Plasma Adenosine Deaminase 2 Activity and ADA2 Variants.

Journal Article Arthritis Rheumatol · October 28, 2025 OBJECTIVE: Deficiency of adenosine deaminase 2 (DADA2) is a monogenic autoinflammatory disease manifested as polyarteritis nodosa, stroke, and bone marrow failure. Leveraging an international cohort of 200 DADA2 cases, we aimed to characterize the diagnost ... Full text Link to item Cite
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Education, Training & Certifications


University of Florida, College of Medicine · 1999 M.D.