Teresa Kathleen Tarrant | Scholars@Duke

Teresa Kathleen Tarrant
Associate Professor of Medicine

I first became interested in clinical immunology as a medical student studying autoimmune inflammatory eye disease at the National Institutes of Health. Since then, I have been inspired to understand what causes autoimmunity and immune deficiency disorders in order to improve the quality of life for my patients. I see patients with multiple complex immune disorders with particular expertise in autoimmune and Rheumatoid arthritis, primary Sjogren's syndrome, and Common Variable Immunodeficiency (CVID). My research investigates immune targets that may impact either the development of immune disease or identify new therapies for patients. The goal is to help us understand why and how immunologic diseases develop so that we may better treat them.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2018

Contact Information

200 Trent Dr., DUMC 3874, Durham, NC 27710
234 Crooked Creek Pkwy, Ste. 400, Duke Rheumatology Clinic At South Durham, Durham, NC 27713
teresa.tarrant@duke.edu (919) 684-6797

Background
Education, Training, & Certifications
- Immunology Postdoctoral Fellowship, Thurston Arthritis Research Center, University of North Carolina at Chapel Hill 2004 - 2005
- Allergy and Immunology Fellowship, Medicine, Duke University School of Medicine 2002 - 2005
- Rheumatology Fellowship, Medicine, Duke University School of Medicine 2001 - 2005
- Internal Medicine Residency, Clinical Investigator Pathway, Duke University School of Medicine 1999 - 2001
- M.D., University of Florida College of Medicine 1999
Duke Appointment History
- Instructor in the Department of Medicine, Medicine, Rheumatology and Immunology, Medicine 2016 - 2018
Recognition
Awards & Honors
Research
Selected Grants
- Light-mediated delivery of therapeutics for Rheumatoid Arthritis awarded by Rheumatology Research Foundation 2016 - 2018
Publications & Artistic Works
Selected Publications
- Conference Papers
  - Tarrant, TK, Marvin, C, Wang, Q, Serafin, S, and Lawrence, D. "Light-Mediated Delivery of Therapeutics." American-Academy-of-Allergy-Asthma-and-Immunology / World-Allergy-Organization Joint Congress. Orlando, FL. March 2, 2018 - March 8, 2018.: MOSBY-ELSEVIER, February 1, 2018. Link to Item
  - Brozowski, JM, Timoshchenko, RG, Serafin, DS, Koontz, J, Allyn, B, Eudy, AM, Harris, T, Abraham, D, Rubin, CT, Rubin, J, Allbritton, N, Billard, MJ, and Tarrant, TK. "G Protein-Coupled Receptor Kinase 3 Modulates Mesenchymal Stem Cell Proliferation and Differentiation through Sphingosine-1-Phosphate Receptor Regulation." : WILEY, October 1, 2017. Link to Item
  - Yang, L, Shah, SN, Serafin, DS, Timoshchenko, RG, Scotland, P, Richards, K, Billard, MJ, Lugar, PL, and Tarrant, TK. "Interrogating Genetic Susceptibility Loci in CVID and Autoimmunity." February 2016. Full Text
  - Tarrant, T, Rampersad, R, Moore, C, Rothlein, L, Lefkowitz, R, Lee, D, and Patel, D. "G-Protein Receptor Kinases (grKs) Play an Important Regulatory Role in the K/BxN Serum Transfer Model of Inflammatory Arthritis." January 2007. Full Text
  - Tarrant, TK, Rampersad, RR, Moore, CG, Rothlein, LR, Lefkowitz, RM, Lee, DM, and Patel, DD. "G-protein receptor kinases (GRKs) play an important regulatory role in the K/BxN serum transfer model of inflammatory arthritis." January 2007. Full Text Link to Item
  - Tarrant, TK, Rampersad, RR, Lefkowitz, RK, Lee, DM, and Patel, DD. "Beta-arrestin2 and G-protein receptor kinases play an important regulatory role in the K/BxN serum transfer model of inflammatory arthritis." September 2005. Link to Item
- Journal Articles
  - Rolfes, MC, Sriaroon, P, Dávila Saldaña, BJ, Dvorak, CC, Chapdelaine, H, Ferdman, RM, Chen, K, Jolles, S, Patel, NC, Kim, YJ, Tarrant, TK, Martelius, T, Seppanen, M, and Joshi, AY. "Chronic norovirus infection in primary immune deficiency disorders: an international case series." Diagnostic Microbiology and Infectious Disease (August 12, 2018). Full Text
  - Mainz, ER, Serafin, DS, Nguyen, TT, Tarrant, TK, Sims, CE, and Allbritton, NL. "Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α." Analytical Chemistry 88, no. 15 (August 2016): 7786-7792. Full Text
  - Kang, S, Rogers, JL, Monteith, AJ, Jiang, C, Schmitz, J, Clarke, SH, Tarrant, TK, Truong, YK, Diaz, M, Fedoriw, Y, and Vilen, BJ. "Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus." Journal of Immunology (Baltimore, Md. : 1950) 196, no. 10 (May 2016): 4030-4039. Full Text
  - Billard, MJ, Fitzhugh, DJ, Parker, JS, Brozowski, JM, McGinnis, MW, Timoshchenko, RG, Serafin, DS, Lininger, R, Klauber-Demore, N, Sahagian, G, Truong, YK, Sassano, MF, Serody, JS, and Tarrant, TK. "G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis." Plos One 11, no. 4 (January 2016): e0152856-null. Full Text
  - Tarrant, TK, Billard, MJ, Timoshchenko, RG, McGinnis, MW, Stephen Serafin, D, Foreman, O, Esserman, DA, Chao, NJ, Lento, WE, Lee, DM, Patel, D, and Siderovski, DP. "G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses." Journal of Leukocyte Biology 94, no. 6 (December 1, 2013): 1243-1251. Full Text
  - Rogers, JL, Serafin, DS, Timoshchenko, RG, and Tarrant, TK. "Cellular targeting in autoimmunity." Current Allergy and Asthma Reports 12, no. 6 (December 2012): 495-510. (Review) Full Text
  - Rothlein, LR, Shaheen, AW, Vavalle, JP, Smith, SV, Renner, JB, Shaheen, NJ, and Tarrant, TK. "Sclerosing mesenteritis successfully treated with a TNF antagonist." Case Reports 2010, no. dec17 1 (December 20, 2010): bcr0720103145-bcr0720103145. Full Text
  - Tarrant, TK, Rampersad, RR, Esserman, D, Rothlein, LR, Liu, P, Premont, RT, Lefkowitz, RJ, Lee, DM, and Patel, DD. "Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN)." Clinical Immunology (Orlando, Fla.) 129, no. 1 (October 2008): 115-122. Full Text
  - Graziewicz, MA, Tarrant, TK, Buckley, B, Roberts, J, Fulton, L, Hansen, H, Ørum, H, Kole, R, and Sazani, P. "An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models." Molecular Therapy : the Journal of the American Society of Gene Therapy 16, no. 7 (July 2008): 1316-1322. Full Text
  - Xu, H, Silver, PB, Tarrant, TK, Chan, C-C, and Caspi, RR. "Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells." Investigative Ophthalmology & Visual Science 44, no. 11 (November 2003): 4805-4812. Full Text
  - Tarrant, TK, Frazer, DH, Aya-Ay, JP, and Patel, DD. "B cell loss leading to remission in severe systemic lupus erythematosus." The Journal of rheumatology 30, no. 2 (February 2003): 412-414. (Review)
Teaching & Mentoring
Advising & Mentoring
- I enjoy working with students and fellows at all levels of training from the Department of Medicine as well as those from different disciplinary backgrounds on collaborative projects. My philosophy of teaching is to allow learners to question and to pursue investigations within a structured mentored environment. Students and fellows who work for me receive verbal and written feedback, and I similarly have found feedback from them to be invaluable to my professional growth as a researcher and educator. I have previously mentored trainees from the Departments of Medicine, Microbiology/Immunology, Pharmacy, Pharmacology, Chemistry, and Cell Biology and Physiology. I’ve also had the opportunity to directly mentor postdoctoral research fellows, undergraduates, and master’s candidates, including students who have successfully competed for K and F level federal funding. I have served on thesis committees for MD/PhD and PhD students as well as played an integral role in the Fellowship Training Programs of Allergy Immunology and Rheumatology by supervising these trainees in the clinic, participating in their education at academic conferences and journal clubs, and by serving as the dedicated supervisor of several of them in the research portions of their training.
Available to mentor:
- Post-Doc
Scholarly, Clinical, & Service Activities
Service to the Profession

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Education, Training, & Certifications

Duke Appointment History

Awards & Honors

Selected Grants

Selected Publications

Conference Papers

Journal Articles

Advising & Mentoring

Available to mentor:

Service to the Profession