Teresa Kathleen Tarrant
Associate Professor of Medicine
I first became interested in clinical immunology as a medical student studying autoimmune inflammatory eye disease at the National Institutes of Health. Since then, I have been inspired to understand what causes autoimmunity and immune deficiency disorders in order to improve the quality of life for my patients. I see patients with multiple complex immune disorders with particular expertise in autoimmune and Rheumatoid arthritis, primary Sjogren's syndrome, and the immunodeficiency disorders Common Variable Immunodeficiency (CVID), Adenosine Deaminase Deficiency (ADA) disorders, and WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis). My research investigates immune targets that may impact either the development of immune disease or identify new therapies for patients. The goal is to help us understand why and how immunologic diseases develop so that we may better treat them.
Current Research Interests
1. Discovering new therapies for immune mediated diseases such as Sjogren's syndrome and WHIM; we are actively enrolling patients in clinical trials
2. Investigating the pathogenesis of Adenosine Deaminase Deficiency (ADA) disorders
3. Characterizing novel genetic variants of WHIM syndrome and ADA deficiency disorders
Current Appointments & Affiliations
- Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2018
Contact Information
- 200 Trent Dr., DUMC 3874, Durham, NC 27710
- 235 Sands Resarch Bldg, 303 Research Dr., Durham, NC 27710
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teresa.tarrant@duke.edu
(919) 684-4499
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Google Scholar
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LinkedIn
- Background
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Education, Training, & Certifications
- Immunology Postdoctoral Fellowship, Thurston Arthritis Research Center, University of North Carolina - Chapel Hill 2004 - 2005
- Allergy and Immunology Fellowship, Medicine, Duke University School of Medicine 2002 - 2005
- Rheumatology Fellowship, Medicine, Duke University School of Medicine 2001 - 2005
- Internal Medicine Residency, Clinical Investigator Pathway, Duke University School of Medicine 1999 - 2001
- M.D., University of Florida, College of Medicine 1999
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Medical Licensure
- 20001305. North Carolina. 2023
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Previous Appointments & Affiliations
- Instructor in the Department of Medicine, Medicine, Rheumatology and Immunology, Medicine 2016 - 2018
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Leadership & Clinical Positions at Duke
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Director, Clinical Immunology Laboratory, Duke University Health System
Vice Chief, Translational Research for Rheumatology
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Director, Clinical Immunology Laboratory, Duke University Health System
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Academic Positions Outside Duke
- Associate Professor in the Department of Medicine with tenure, Rheumatology and Allergy Immunology, University of North Carolina. 2015 - 2016
- Assistant Professor in the Department of Microbiology and Immunology, University of North Carolina. 2011 - 2016
- Assistant Professor in the Department of Medicine, Rheumatology and Allergy Immunology, University of North Carolina. 2006 - 2015
- Recognition
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In the News
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NOV 30, 2022 Biospace -
DEC 8, 2020 Innovation and Entrepreneurship -
JUL 14, 2020 -
APR 27, 2020 -
DEC 3, 2019 -
SEP 10, 2019
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Awards & Honors
- Academic Leadership, Innovation, and Collaborative Engagement Program. Office for Faculty, Duke University. 2022
- Chancellor's Faculty Entrepreneurship Workshop. University of North Carolina. 2016
- Disease Targeted Research Innovative Grant. Rheumatology Research Foundation. 2016
- Academic Career Leadership Academy in Medicine (ACCLAIM). University of North Carolina. 2014
- Expertise
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Subject Headings
- Research
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Selected Grants
- Non-Registry Agreement Clinical Trial awarded by Chiesi USA, Inc 2022 - 2025
- CD40L antagonism in RA- ITN FY22ITN566 awarded by Benaroya Research Institute at Virginia Mason 2022 - 2023
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Mavorixafor in Patients with WHIM Syndrome with Open-Label Extension awarded by X4 Pharmaceuticals 2020 - 2022
- Reprogramming Inflammatory Cells with Mesenchymal Stromal Cell RNA Granules awarded by Cord Blood Association Foundation 2019 - 2022
- Rheumatoid Arthritis ABBV-3373 awarded by AbbVie Inc. 2019 - 2020
- Medical and Graduate Student Preceptorship awarded by Rheumatology Research Foundation 2019 - 2020
- Light-mediated delivery of therapeutics for Rheumatoid Arthritis awarded by Rheumatology Research Foundation 2016 - 2018
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External Relationships
- AbbVie Pharmaceuticals
- Chiesi USA
- Department of Justice
- Pfizer Inc.
- Veila Bio
- X4 Pharmaceuticals
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Rabjohns, Emily M., Rishi R. Rampersad, Arin Ghosh, Katlyn Hurst, Amanda M. Eudy, Jaime M. Brozowski, Hyun Ho Lee, et al. “Aged G Protein-Coupled Receptor Kinase 3 (Grk3)-Deficient Mice Exhibit Enhanced Osteoclastogenesis and Develop Bone Lesions Analogous to Human Paget's Disease of Bone.” Cells 12, no. 7 (March 23, 2023). https://doi.org/10.3390/cells12070981.Full Text Link to Item
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Milne, Megan E., Jack Kimball, Teresa K. Tarrant, Rami N. Al-Rohil, and David L. Leverenz. “The Role of T Helper Type 2 (Th2) Cytokines in the Pathogenesis of Eosinophilic Granulomatosis with Polyangiitis (eGPA): an Illustrative Case and Discussion.” Curr Allergy Asthma Rep 22, no. 11 (November 2022): 141–50. https://doi.org/10.1007/s11882-022-01039-w.Full Text Link to Item
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Maheswaranathan, Mithu, Atul Kapila, Sarah Cater, and Teresa Kathleen Tarrant. “An Atypical Presentation of Abdominal Aortic Aneurysm: A Cryptogenic Case of Aortitis.” J Clin Rheumatol 28, no. 4 (June 1, 2022): e680–81. https://doi.org/10.1097/RHU.0000000000001538.Full Text Link to Item
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Otani, Iris M., Heather K. Lehman, Artemio M. Jongco, Lulu R. Tsao, Antoine E. Azar, Teresa K. Tarrant, Elissa Engel, et al. “Practical guidance for the diagnosis and management of secondary hypogammaglobulinemia: A Work Group Report of the AAAAI Primary Immunodeficiency and Altered Immune Response Committees.” J Allergy Clin Immunol 149, no. 5 (May 2022): 1525–60. https://doi.org/10.1016/j.jaci.2022.01.025.Full Text Link to Item
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Malcolm, Elizabeth J., Zachary Brandon, Lauren E. Wilson, John Paul Shoup, Heather A. King, Allison Lewinski, Melissa A. Greiner, et al. “eConsults' Impact on Care Access and Wait Times in Rheumatology.” J Clin Rheumatol 28, no. 3 (April 1, 2022): 147–54. https://doi.org/10.1097/RHU.0000000000001825.Full Text Open Access Copy Link to Item
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Tarrant, T. K., Susan J. Kelly, and Michael S. Hershfield. “Elucidating the pathogenesis of adenosine deaminase 2 deficiency: current status and unmet needs.” Expert Opinion on Orphan Drugs 9, no. 11–12 (March 28, 2022): 257–64. https://doi.org/10.1080/21678707.2021.2050367.Full Text Open Access Copy
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Brozowski, Jaime M., Roman G. Timoshchenko, D Stephen Serafin, Brittney Allyn, Jessica Koontz, Emily M. Rabjohns, Rishi R. Rampersad, et al. “G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation.” Stem Cell Res Ther 13, no. 1 (January 29, 2022): 37. https://doi.org/10.1186/s13287-022-02715-4.Full Text Open Access Copy Link to Item
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Glaser, Katharina M., Teresa K. Tarrant, and Tim Lämmermann. “Combinatorial depletions of G-protein coupled receptor kinases in immune cells identify pleiotropic and cell type-specific functions.” Front Immunol 13 (2022): 1039803. https://doi.org/10.3389/fimmu.2022.1039803.Full Text Link to Item
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Zywot, Emilia M., Natalia Orlova, Song Ding, Rishi R. Rampersad, Emily M. Rabjohns, Victoria A. Wickenheisser, Qunzhao Wang, et al. “Light-Triggered Drug Release from Red Blood Cells Suppresses Arthritic Inflammation.” Advanced Therapeutics 5, no. 1 (January 2022): 2100159. https://doi.org/10.1002/adtp.202100159.Full Text
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Vickerman, Brianna M., Emilia M. Zywot, Teresa K. Tarrant, and David S. Lawrence. “Taking phototherapeutics from concept to clinical launch.” Nat Rev Chem 5, no. 11 (November 2021): 816–34. https://doi.org/10.1038/s41570-021-00326-w.Full Text Link to Item
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Kienle, Korbinian, Katharina M. Glaser, Sarah Eickhoff, Michael Mihlan, Konrad Knöpper, Eduardo Reátegui, Maximilian W. Epple, et al. “Neutrophils self-limit swarming to contain bacterial growth in vivo.” Science 372, no. 6548 (June 18, 2021). https://doi.org/10.1126/science.abe7729.Full Text Link to Item
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Rabjohns, Emily M., Katlyn Hurst, Arin Ghosh, Maria C. Cuellar, Rishi R. Rampersad, and Teresa K. Tarrant. “Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.” Curr Allergy Asthma Rep 21, no. 4 (March 25, 2021): 23. https://doi.org/10.1007/s11882-021-01001-2.Full Text Link to Item
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Chu, Philip, Maria C. Cuellar, Sonali J. Bracken, and Teresa K. Tarrant. “A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.” Curr Allergy Asthma Rep 21, no. 3 (March 5, 2021): 19. https://doi.org/10.1007/s11882-021-01002-1.Full Text Open Access Copy Link to Item
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Udupa, Akrithi, David Leverenz, Stephen J. Balevic, Rebecca E. Sadun, Teresa K. Tarrant, and Jennifer L. Rogers. “Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned.” Curr Allergy Asthma Rep 21, no. 1 (January 21, 2021): 5. https://doi.org/10.1007/s11882-020-00983-9.Full Text Link to Item
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Min, Hyunjung, Li Xu, Roberta Parrott, Christopher C. Overall, Melina Lillich, Emily M. Rabjohns, Rishi R. Rampersad, et al. “Mesenchymal stromal cells reprogram monocytes and macrophages with processing bodies.” Stem Cells 39, no. 1 (January 2021): 115–28. https://doi.org/10.1002/stem.3292.Full Text Open Access Copy Link to Item
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Tarrant, T. K., S. J. Kelly, and M. S. Hershfield. “Elucidating the pathogenesis of adenosine deaminase 2 deficiency: current status and unmet needs.” Expert Opinion on Orphan Drugs 9, no. 11–12 (January 1, 2021): 257–64. https://doi.org/10.1080/21678707.2021.2050367.Full Text Open Access Copy
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Vickerman, Brianna M., Emilia M. Zywot, Teresa K. Tarrant, and David S. Lawrence. “Taking phototherapeutics from concept to clinical launch.” Nature Reviews. Chemistry 5, no. 11 (January 2021): 816–34. https://doi.org/10.1038/s41570-021-00326-w.Full Text Open Access Copy
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Leverenz, David L., and Teresa K. Tarrant. “Is the HScore useful in COVID-19?” Lancet (London, England) 395, no. 10236 (May 2020): e83. https://doi.org/10.1016/s0140-6736(20)31057-6.Full Text
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Chinn, Ivan K., Alice Y. Chan, Karin Chen, Janet Chou, Morna J. Dorsey, Joud Hajjar, Artemio M. Jongco, et al. “Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology.” J Allergy Clin Immunol 145, no. 1 (January 2020): 46–69. https://doi.org/10.1016/j.jaci.2019.09.009.Full Text Link to Item
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Marvin, Christina M., Song Ding, Rachel E. White, Natalia Orlova, Qunzhao Wang, Emilia M. Zywot, Brianna M. Vickerman, et al. “On Command Drug Delivery via Cell-Conveyed Phototherapeutics.” Small 15, no. 37 (September 2019): e1901442. https://doi.org/10.1002/smll.201901442.Full Text Link to Item
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Wickenheisser, Victoria A., Emilia Marta Zywot, Emily Mary Rabjohns, Hyun Ho Lee, David S. Lawrence, and Teresa Kathleen Tarrant. “Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.” Curr Allergy Asthma Rep 19, no. 8 (July 2, 2019): 37. https://doi.org/10.1007/s11882-019-0869-z.Full Text Link to Item
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Serafin, D Stephen, Brittney Allyn, Maria F. Sassano, Roman G. Timoshchenko, Daniel Mattox, Jaime M. Brozowski, David P. Siderovski, et al. “Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.” Mol Immunol 106 (February 2019): 12–21. https://doi.org/10.1016/j.molimm.2018.12.016.Full Text Link to Item
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Rolfes, M. C., P. Sriaroon, B. J. Dávila Saldaña, C. C. Dvorak, H. Chapdelaine, R. M. Ferdman, K. Chen, et al. “Chronic norovirus infection in primary immune deficiency disorders: an international case series.” Diagn Microbiol Infect Dis 93, no. 1 (January 2019): 69–73. https://doi.org/10.1016/j.diagmicrobio.2018.08.002.Full Text Link to Item
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Peters, Lauren A., Jacqueline Perrigoue, Arthur Mortha, Alina Iuga, Won-Min Song, Eric M. Neiman, Sean R. Llewellyn, et al. “A functional genomics predictive network model identifies regulators of inflammatory bowel disease.” Nat Genet 49, no. 10 (October 2017): 1437–49. https://doi.org/10.1038/ng.3947.Full Text Link to Item
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Schwarz, Jan, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus Brown, Ingrid de Vries, Alexander Leithner, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6.” Curr Biol 27, no. 9 (May 8, 2017): 1314–25. https://doi.org/10.1016/j.cub.2017.04.004.Full Text Link to Item
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Mainz, Emilie R., D Stephen Serafin, Tuong T. Nguyen, Teresa K. Tarrant, Christopher E. Sims, and Nancy L. Allbritton. “Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.” Anal Chem 88, no. 15 (August 2, 2016): 7786–92. https://doi.org/10.1021/acs.analchem.6b01801.Full Text Link to Item
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Yang, Luanna, Eveline Y. Wu, and Teresa K. Tarrant. “Immune Gamma Globulin Therapeutic Indications in Immune Deficiency and Autoimmunity.” Curr Allergy Asthma Rep 16, no. 8 (July 2016): 55. https://doi.org/10.1007/s11882-016-0632-7.Full Text Link to Item
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Kang, SunAh, Jennifer L. Rogers, Andrew J. Monteith, Chuancang Jiang, John Schmitz, Stephen H. Clarke, Teresa K. Tarrant, et al. “Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.” J Immunol 196, no. 10 (May 15, 2016): 4030–39. https://doi.org/10.4049/jimmunol.1500418.Full Text Link to Item
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Burbank, Allison J., Shaili N. Shah, Maureen Montgomery, David Peden, Teresa K. Tarrant, and Eric T. Weimer. “Clinically focused exome sequencing identifies an homozygous mutation that confers DOCK8 deficiency.” Pediatr Allergy Immunol 27, no. 1 (February 2016): 96–98. https://doi.org/10.1111/pai.12451.Full Text Link to Item
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Billard, Matthew J., David J. Fitzhugh, Joel S. Parker, Jaime M. Brozowski, Marcus W. McGinnis, Roman G. Timoshchenko, D Stephen Serafin, et al. “G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.” Plos One 11, no. 4 (2016): e0152856. https://doi.org/10.1371/journal.pone.0152856.Full Text Link to Item
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Song, Gina, Teresa K. Tarrant, Taylor F. White, David A. Barrow, Charlene M. Santos, Roman G. Timoshchenko, Suzan K. Hanna, et al. “Roles of chemokines CCL2 and CCL5 in the pharmacokinetics of PEGylated liposomal doxorubicin in vivo and in patients with recurrent epithelial ovarian cancer.” Nanomedicine 11, no. 7 (October 2015): 1797–1807. https://doi.org/10.1016/j.nano.2015.05.007.Full Text Link to Item
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Song, Gina, David B. Darr, Charlene M. Santos, Mark Ross, Alain Valdivia, Jamie L. Jordan, Bentley R. Midkiff, et al. “Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models.” Clin Cancer Res 20, no. 23 (December 1, 2014): 6083–95. https://doi.org/10.1158/1078-0432.CCR-14-0493.Full Text Link to Item
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Shah, Shaili, Eveline Wu, V Koneti Rao, and Teresa K. Tarrant. “Autoimmune lymphoproliferative syndrome: an update and review of the literature.” Curr Allergy Asthma Rep 14, no. 9 (September 2014): 462. https://doi.org/10.1007/s11882-014-0462-4.Full Text Link to Item
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Brozowski, Jaime M., Matthew J. Billard, and Teresa K. Tarrant. “Targeting the molecular and cellular interactions of the bone marrow niche in immunologic disease.” Curr Allergy Asthma Rep 14, no. 2 (February 2014): 402. https://doi.org/10.1007/s11882-013-0402-8.Full Text Link to Item
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Rogers, Jennifer L., Teresa Tarrant, and Jason S. Kim. “Nanoparticle-based diagnostic imaging of inflammation in rheumatic disease.” Curr Rheumatol Rev 10, no. 1 (2014): 3–10. https://doi.org/10.2174/1573403x10666140914154816.Full Text Link to Item
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Tarrant, Teresa K. “Nanoscience advances in rheumatology and immunology.” Curr Rheumatol Rev 10, no. 1 (2014): 1–2. https://doi.org/10.2174/157339711001140924101042.Full Text Link to Item
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Tarrant, Teresa K., Matthew J. Billard, Roman G. Timoshchenko, Marcus W. McGinnis, D Stephen Serafin, Oded Foreman, Denise A. Esserman, et al. “G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.” J Leukoc Biol 94, no. 6 (December 2013): 1243–51. https://doi.org/10.1189/jlb.0213097.Full Text Link to Item
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Todoric, Krista, Jessica B. Koontz, Daniel Mattox, and Teresa K. Tarrant. “Autoimmunity in immunodeficiency.” Curr Allergy Asthma Rep 13, no. 4 (August 2013): 361–70. https://doi.org/10.1007/s11882-013-0350-3.Full Text Link to Item
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Giguère, Patrick M., Matthew J. Billard, Geneviève Laroche, Brian K. Buckley, Roman G. Timoshchenko, Marcus W. McGinnis, Denise Esserman, et al. “G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis.” Mol Immunol 54, no. 2 (June 2013): 193–98. https://doi.org/10.1016/j.molimm.2012.12.001.Full Text Link to Item
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Rogers, Jennifer L., Donald S. Serafin, Roman G. Timoshchenko, and Teresa K. Tarrant. “Cellular targeting in autoimmunity.” Curr Allergy Asthma Rep 12, no. 6 (December 2012): 495–510. https://doi.org/10.1007/s11882-012-0307-y.Full Text Link to Item
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Tarrant, Teresa K., Peng Liu, Rishi R. Rampersad, Denise Esserman, Lisa R. Rothlein, Roman G. Timoshchenko, Marcus W. McGinnis, David J. Fitzhugh, Dhavalkumar D. Patel, and Alan M. Fong. “Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model.” Arthritis Rheum 64, no. 5 (May 2012): 1379–87. https://doi.org/10.1002/art.34320.Full Text Link to Item
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Elrefaei, Mohamed, Kristie Boose, Martha McGee, Teresa K. Tarrant, Feng-Chang Lin, Jason P. Fine, and John L. Schmitz. “Second generation automated anti-CCP test better predicts the clinical diagnosis of rheumatoid arthritis.” J Clin Immunol 32, no. 1 (February 2012): 131–37. https://doi.org/10.1007/s10875-011-9610-y.Full Text Link to Item
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Rampersad, Rishi R., Teresa K. Tarrant, Christopher T. Vallanat, Tatiana Quintero-Matthews, Michael F. Weeks, Denise A. Esserman, Jennifer Clark, et al. “Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis.” Plos One 6, no. 10 (2011): e25833. https://doi.org/10.1371/journal.pone.0025833.Full Text Link to Item
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Rothlein, Lisa R., Amy W. Shaheen, John P. Vavalle, Scott V. Smith, Jordan B. Renner, Nicholas J. Shaheen, and Teresa K. Tarrant. “Sclerosing mesenteritis successfully treated with a TNF antagonist.” Bmj Case Rep 2010 (December 20, 2010). https://doi.org/10.1136/bcr.07.2010.3145.Full Text Link to Item
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Jerath, Maya R., Mildred Kwan, Mily Kannarkat, Beloo Mirakhur, Lisa Carey, John Valgus, Thomas A. E. Platts-Mills, and Teresa K. Tarrant. “A desensitization protocol for the mAb cetuximab.” J Allergy Clin Immunol 123, no. 1 (January 2009): 260–62. https://doi.org/10.1016/j.jaci.2008.09.046.Full Text Link to Item
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Kim, J. S., H. An, W. J. Rieter, D. Esserman, K. M. L. Taylor-Pashow, R. B. Sartor, W. Lin, and T. K. Tarrant. “Multimodal optical and Gd-based nanoparticles for imaging in inflammatory arthritis.” Clin Exp Rheumatol 27, no. 4 (2009): 580–86.Link to Item
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Rampersad, R. R., D. Esserman, M. W. McGinnis, D. M. Lee, D. D. Patel, and T. K. Tarrant. “S100A9 is not essential for disease expression in an acute (K/BxN) or chronic (CIA) model of inflammatory arthritis.” Scand J Rheumatol 38, no. 6 (2009): 445–49. https://doi.org/10.3109/03009740902895743.Full Text Link to Item
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Tarrant, Teresa K., Rishi R. Rampersad, Denise Esserman, Lisa R. Rothlein, Peng Liu, Richard T. Premont, Robert J. Lefkowitz, David M. Lee, and Dhavalkumar D. Patel. “Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).” Clin Immunol 129, no. 1 (October 2008): 115–22. https://doi.org/10.1016/j.clim.2008.06.008.Full Text Link to Item
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Graziewicz, Maria A., Teresa K. Tarrant, Brian Buckley, Jennifer Roberts, LeShara Fulton, Henrik Hansen, Henrik Ørum, Ryszard Kole, and Peter Sazani. “An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.” Mol Ther 16, no. 7 (July 2008): 1316–22. https://doi.org/10.1038/mt.2008.85.Full Text Link to Item
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Graziewicz, Maria A., Teresa K. Tarrant, Brian Buckley, Jennifer Roberts, LeShara Fulton, Henrik Hansen, Henrik Ørum, Ryszard Kole, and Peter Sazani. “An Endogenous TNF-α Antagonist Induced by Splice-switching Oligonucleotides Reduces Inflammation in Hepatitis and Arthritis Mouse Models.” Mol Ther 16, no. 7 (July 2008): 1316–22. https://doi.org/10.1038/mt.2008.85.Full Text Link to Item
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Rieter, William J., Jason S. Kim, Kathryn M. L. Taylor, Hongyu An, Weili Lin, Teresa Tarrant, and Wenbin Lin. “Hybrid silica nanoparticles for multimodal imaging.” Angew Chem Int Ed Engl 46, no. 20 (2007): 3680–82. https://doi.org/10.1002/anie.200604738.Full Text Link to Item
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Tarrant, Teresa K., and Dhavalkumar D. Patel. “Chemokines and leukocyte trafficking in rheumatoid arthritis.” Pathophysiology 13, no. 1 (February 21, 2006): 1–14. https://doi.org/10.1016/j.pathophys.2005.11.001.Full Text Link to Item
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Xu, Hui, Phyllis B. Silver, Teresa K. Tarrant, Chi-Chao Chan, and Rachel R. Caspi. “Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells.” Invest Ophthalmol Vis Sci 44, no. 11 (November 2003): 4805–12. https://doi.org/10.1167/iovs.02-0843.Full Text Link to Item
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Tarrant, Teresa K., D Hugh Frazer, James P. Aya-Ay, and Dhavalkumar D. Patel. “B cell loss leading to remission in severe systemic lupus erythematosus.” J Rheumatol 30, no. 2 (February 2003): 412–14.Link to Item
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Silver, P. B., T. K. Tarrant, C. C. Chan, B. Wiggert, and R. R. Caspi. “Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis.” Invest Ophthalmol Vis Sci 40, no. 6 (May 1999): 1280–84.Link to Item
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Tarrant, T. K., P. B. Silver, J. L. Wahlsten, L. V. Rizzo, C. C. Chan, B. Wiggert, and R. R. Caspi. “Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.” J Exp Med 189, no. 2 (January 18, 1999): 219–30. https://doi.org/10.1084/jem.189.2.219.Full Text Link to Item
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Tarrant, T. K., P. B. Silver, C. C. Chan, B. Wiggert, and R. R. Caspi. “Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.” J Immunol 161, no. 1 (July 1, 1998): 122–27.Link to Item
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Prendergast, R. A., C. E. Iliff, N. M. Coskuncan, R. R. Caspi, G. Sartani, T. K. Tarrant, G. A. Lutty, and D. S. McLeod. “T cell traffic and the inflammatory response in experimental autoimmune uveoretinitis.” Invest Ophthalmol Vis Sci 39, no. 5 (April 1998): 754–62.Link to Item
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Silver, P., T. Tarrant, C. C. Chan, B. Wiggert, J. Magram, and R. Caspi. “Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis.” Faseb Journal 12, no. 5 (March 20, 1998).
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Jones, L. S., L. V. Rizzo, R. K. Agarwal, T. K. Tarrant, C. C. Chan, B. Wiggert, and R. R. Caspi. “IFN-gamma-deficient mice develop experimental autoimmune uveitis in the context of a deviant effector response.” J Immunol 158, no. 12 (June 15, 1997): 5997–6005.Link to Item
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Tarrant, T., I. V. Rizzo, P. B. Silver, and R. R. Caspi. “TGF-β suppresses antigen stimulation of a uveitogenic t cell line through an effect on antigen-presenting cells.” Faseb Journal 10, no. 6 (December 1, 1996).
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Tarrant, T., L. V. Rizzo, P. B. Silver, and R. R. Caspi. “TGF-β suppresses antigen stimulation of a uveitogenic T cell line through an effect on antigen-presenting cells.” Investigative Ophthalmology and Visual Science 37, no. 3 (February 15, 1996).
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Conference Papers
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Wickenheisser, V., E. M. Zywot, E. Rabjohns, N. Orlova, C. M. Marvin, S. Ding, D. S. Lawrence, and T. R. Tarrant. “Photo-released drugs: A targeted treatment approach for arthritis.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 11223, 2020. https://doi.org/10.1117/12.2546949.Full Text
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Malcolm, Elizabeth, Zachary Brandon, John Paul Shoup, Lauren Wilson, Heather King, Allison Lewinski, Melissa Greiner, et al. “IMPLEMENTATION AND EFFECTIVENESS OF RHEUMATOLOGY E-CONSULTS INTERVENTION TO REDUCE SPECIALIST WAIT TIMES.” In Journal of General Internal Medicine, 35:S167–S167, 2020.Link to Item
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Min, H., L. Xu, R. Parrott, E. M. Rabjohns, R. R. Rampersad, T. K. Tarrant, C. Overall, et al. “Reprogramming inflammatory macrophages with mesenchymal stromal cells.” In Cytotherapy, 22:S83–84, 2020.Link to Item
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Tarrant, Teresa K., Christina Marvin, Qunzhao Wang, Stephen Serafin, and David Lawrence. “Light-Mediated Delivery of Therapeutics.” In Journal of Allergy and Clinical Immunology, 141:AB197–AB197. Elsevier BV, 2018. https://doi.org/10.1016/j.jaci.2017.12.624.Full Text
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Yang, Luanna, Shaili N. Shah, D Stephen Serafin, Roman G. Timoshchenko, Paula Scotland, Kristy Richards, Matthew J. Billard, Patricia L. Lugar, and Teresa K. Tarrant. “Interrogating Genetic Susceptibility Loci in CVID and Autoimmunity.” In Journal of Allergy and Clinical Immunology, 137:AB179–AB179. Elsevier BV, 2016. https://doi.org/10.1016/j.jaci.2015.12.720.Full Text
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Tarrant, T. K., R. R. Rampersad, C. G. Moore, L. R. Rothlein, R. M. Lefkowitz, D. M. Lee, and D. D. Patel. “G-Protein Receptor Kinases (grKs) Play an Important Regulatory Role in the K/BxN Serum Transfer Model of Inflammatory Arthritis.” In Journal of Allergy and Clinical Immunology, 119:S234–35. Elsevier BV, 2007. https://doi.org/10.1016/j.jaci.2006.12.288.Full Text
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Tarrant, T. K., R. R. Rampersad, R. K. Lefkowitz, D. M. Lee, and D. D. Patel. “Beta-arrestin2 and G-protein receptor kinases play an important regulatory role in the K/BxN serum transfer model of inflammatory arthritis.” In Arthritis and Rheumatism, 52:S270–S270. WILEY-BLACKWELL, 2005.Link to Item
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- Teaching & Mentoring
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Advising & Mentoring
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I enjoy working with students and fellows at all levels of training from the Department of Medicine as well as those from different disciplinary backgrounds on collaborative projects. My philosophy of teaching is to allow learners to question and to pursue investigations within a structured mentored environment. Students and fellows who work for me receive verbal and written feedback, and I similarly have found feedback from them to be invaluable to my professional growth as a researcher and educator. I have previously mentored trainees from the Departments of Medicine, Microbiology/Immunology, Pharmacy, Pharmacology, Chemistry, and Cell Biology and Physiology. I’ve also had the opportunity to directly mentor postdoctoral research fellows, undergraduates, and master’s candidates, including students who have successfully competed for K and F level federal funding. I have served on thesis committees for MD/PhD and PhD students as well as played an integral role in the Fellowship Training Programs of Allergy Immunology and Rheumatology by supervising these trainees in the clinic, participating in their education at academic conferences and journal clubs, and by serving as the dedicated supervisor of several of them in the research portions of their training.
Available to mentor:
- Post-Doc
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- Scholarly, Clinical, & Service Activities
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Service to the Profession
- Board of Directors. Rheumatology Research Foundation. 2016 - 2019 2016 - 2019
- Reviewers Board. Journal of Allergy and Clinical Immunology (JACI) . 2016 2016
- Basic Science Subcommittee . ACR/ARHP Annual Meeting Planning Committee. 2015 2015
- Scientific Advisory Council. Rheumatology Research Foundation. 2013 - 2016 2013 - 2016
- Autoimmunity Section Editor. Allergy and Asthma Reports. 2012 2012
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Academic & Administrative Activities
- Preceptor for rheumatology fellows, internal medicine residents, and medical students in the Duke and Durham Veteran's Health Administration Rheumatology Clinic.
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Clinical Activities
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Attending physician at Duke University Hospital in Rheumatology and Immunology
Attending physician at the Durham Veteran's Health Administration Hospital
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Attending physician at Duke University Hospital in Rheumatology and Immunology
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