Teresa Kathleen Tarrant | Scholars@Duke

Teresa Kathleen Tarrant
Associate Professor of Medicine

I first became interested in clinical immunology as a medical student studying autoimmune inflammatory eye disease at the National Institutes of Health. Since then, I have been inspired to understand what causes autoimmunity and immune deficiency disorders in order to improve the quality of life for my patients. I see patients with multiple complex immune disorders with particular expertise in autoimmune and Rheumatoid arthritis, primary Sjogren's syndrome, and Common Variable Immunodeficiency (CVID). My research investigates immune targets that may impact either the development of immune disease or identify new therapies for patients. The goal is to help us understand why and how immunologic diseases develop so that we may better treat them.

Current Appointments & Affiliations

Associate Professor of Medicine, Medicine, Rheumatology and Immunology, Medicine 2018

Contact Information

200 Trent Dr., DUMC 3874, Durham, NC 27710
234 Crooked Creek Pkwy, Ste. 400, Duke Rheumatology Clinic at South Durham, Durham, NC 27713
teresa.tarrant@duke.edu (919) 684-6797

Background
Education, Training, & Certifications
- Immunology Postdoctoral Fellowship, Thurston Arthritis Research Center, University of North Carolina - Chapel Hill 2004 - 2005
- Allergy and Immunology Fellowship, Medicine, Duke University School of Medicine 2002 - 2005
- Rheumatology Fellowship, Medicine, Duke University School of Medicine 2001 - 2005
- Internal Medicine Residency, Clinical Investigator Pathway, Duke University School of Medicine 1999 - 2001
- M.D., University of Florida, College of Medicine 1999
Previous Appointments & Affiliations
- Instructor in the Department of Medicine, Medicine, Rheumatology and Immunology, Medicine 2016 - 2018
Recognition
In the News
- DEC 8, 2020 Innovation and Entrepreneurship
  
  Three I&E Incubation Awards Fund Novel Ideas to Solar Energy, IBD & Medical Laser Research
Awards & Honors
Research
Selected Grants
- Reprogramming Inflammatory Cells with Mesenchymal Stromal Cell RNA Granules awarded by Cord Blood Association Foundation 2019 - 2022
- A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Mavorixafor in Patients with WHIM Syndrome with Open-Label Extension awarded by X4 Pharmaceuticals 2020 - 2021
- Rheumatoid Arthritis ABBV-3373 awarded by AbbVie Inc. 2019 - 2020
- Medical and Graduate Student Preceptorship awarded by Rheumatology Research Foundation 2019 - 2020
- Light-mediated delivery of therapeutics for Rheumatoid Arthritis awarded by Rheumatology Research Foundation 2016 - 2018
External Relationships
- AbbVie Pharmaceuticals
- Department of Justice
- Thermo Fisher Scientific, Inc.
- Veila Bio
- X4 Pharmaceuticals
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Vickerman, Brianna M., Emilia M. Zywot, Teresa K. Tarrant, and David S. Lawrence. “Taking phototherapeutics from concept to clinical launch.” Nat Rev Chem, October 6, 2021, 1–19. https://doi.org/10.1038/s41570-021-00326-w.
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  - Kienle, Korbinian, Katharina M. Glaser, Sarah Eickhoff, Michael Mihlan, Konrad Knöpper, Eduardo Reátegui, Maximilian W. Epple, et al. “Neutrophils self-limit swarming to contain bacterial growth in vivo.” Science 372, no. 6548 (June 18, 2021). https://doi.org/10.1126/science.abe7729.
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  - Rabjohns, Emily M., Katlyn Hurst, Arin Ghosh, Maria C. Cuellar, Rishi R. Rampersad, and Teresa K. Tarrant. “Paget's Disease of Bone: Osteoimmunology and Osteoclast Pathology.” Current Allergy and Asthma Reports 21, no. 4 (March 25, 2021): 23. https://doi.org/10.1007/s11882-021-01001-2.
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  - Chu, Philip, Maria C. Cuellar, Sonali J. Bracken, and Teresa K. Tarrant. “A Mimic of Ankylosing Spondylitis, Ochronosis: Case Report and Review of the Literature.” Curr Allergy Asthma Rep 21, no. 3 (March 5, 2021): 19. https://doi.org/10.1007/s11882-021-01002-1.
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  - Udupa, Akrithi, David Leverenz, Stephen J. Balevic, Rebecca E. Sadun, Teresa K. Tarrant, and Jennifer L. Rogers. “Hydroxychloroquine and COVID-19: a Rheumatologist's Take on the Lessons Learned.” Curr Allergy Asthma Rep 21, no. 1 (January 21, 2021): 5. https://doi.org/10.1007/s11882-020-00983-9.
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  - Min, Hyunjung, Li Xu, Roberta Parrott, Christopher C. Overall, Melina Lillich, Emily M. Rabjohns, Rishi R. Rampersad, et al. “Mesenchymal stromal cells reprogram monocytes and macrophages with processing bodies.” Stem Cells (Dayton, Ohio) 39, no. 1 (January 2021): 115–28. https://doi.org/10.1002/stem.3292.
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  - Leverenz, David L., and Teresa K. Tarrant. “Is the HScore useful in COVID-19?” Lancet 395, no. 10236 (May 16, 2020): e83. https://doi.org/10.1016/S0140-6736(20)31057-6.
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  - Chinn, Ivan K., Alice Y. Chan, Karin Chen, Janet Chou, Morna J. Dorsey, Joud Hajjar, Artemio M. Jongco, et al. “Diagnostic interpretation of genetic studies in patients with primary immunodeficiency diseases: A working group report of the Primary Immunodeficiency Diseases Committee of the American Academy of Allergy, Asthma & Immunology.” J Allergy Clin Immunol 145, no. 1 (January 2020): 46–69. https://doi.org/10.1016/j.jaci.2019.09.009.
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  - Marvin, Christina M., Song Ding, Rachel E. White, Natalia Orlova, Qunzhao Wang, Emilia M. Zywot, Brianna M. Vickerman, et al. “On Command Drug Delivery via Cell-Conveyed Phototherapeutics.” Small 15, no. 37 (September 2019): e1901442. https://doi.org/10.1002/smll.201901442.
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  - Wickenheisser, Victoria A., Emilia Marta Zywot, Emily Mary Rabjohns, Hyun Ho Lee, David S. Lawrence, and Teresa Kathleen Tarrant. “Laser Light Therapy in Inflammatory, Musculoskeletal, and Autoimmune Disease.” Curr Allergy Asthma Rep 19, no. 8 (July 2, 2019): 37. https://doi.org/10.1007/s11882-019-0869-z.
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  - Serafin, D Stephen, Brittney Allyn, Maria F. Sassano, Roman G. Timoshchenko, Daniel Mattox, Jaime M. Brozowski, David P. Siderovski, et al. “Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages.” Mol Immunol 106 (February 2019): 12–21. https://doi.org/10.1016/j.molimm.2018.12.016.
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  - Rolfes, M. C., P. Sriaroon, B. J. Dávila Saldaña, C. C. Dvorak, H. Chapdelaine, R. M. Ferdman, K. Chen, et al. “Chronic norovirus infection in primary immune deficiency disorders: an international case series.” Diagn Microbiol Infect Dis 93, no. 1 (January 2019): 69–73. https://doi.org/10.1016/j.diagmicrobio.2018.08.002.
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  - Mainz, Emilie R., D Stephen Serafin, Tuong T. Nguyen, Teresa K. Tarrant, Christopher E. Sims, and Nancy L. Allbritton. “Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.” Anal Chem 88, no. 15 (August 2, 2016): 7786–92. https://doi.org/10.1021/acs.analchem.6b01801.
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  - Kang, SunAh, Jennifer L. Rogers, Andrew J. Monteith, Chuancang Jiang, John Schmitz, Stephen H. Clarke, Teresa K. Tarrant, et al. “Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus.” J Immunol 196, no. 10 (May 15, 2016): 4030–39. https://doi.org/10.4049/jimmunol.1500418.
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  - Billard, Matthew J., David J. Fitzhugh, Joel S. Parker, Jaime M. Brozowski, Marcus W. McGinnis, Roman G. Timoshchenko, D Stephen Serafin, et al. “G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis.” Plos One 11, no. 4 (2016): e0152856. https://doi.org/10.1371/journal.pone.0152856.
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  - Tarrant, Teresa K., Matthew J. Billard, Roman G. Timoshchenko, Marcus W. McGinnis, D Stephen Serafin, Oded Foreman, Denise A. Esserman, et al. “G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses.” J Leukoc Biol 94, no. 6 (December 2013): 1243–51. https://doi.org/10.1189/jlb.0213097.
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  - Rogers, Jennifer L., Donald S. Serafin, Roman G. Timoshchenko, and Teresa K. Tarrant. “Cellular targeting in autoimmunity.” Curr Allergy Asthma Rep 12, no. 6 (December 2012): 495–510. https://doi.org/10.1007/s11882-012-0307-y.
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  - Rothlein, Lisa R., Amy W. Shaheen, John P. Vavalle, Scott V. Smith, Jordan B. Renner, Nicholas J. Shaheen, and Teresa K. Tarrant. “Sclerosing mesenteritis successfully treated with a TNF antagonist.” Bmj Case Rep 2010 (December 20, 2010). https://doi.org/10.1136/bcr.07.2010.3145.
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  - Tarrant, Teresa K., Rishi R. Rampersad, Denise Esserman, Lisa R. Rothlein, Peng Liu, Richard T. Premont, Robert J. Lefkowitz, David M. Lee, and Dhavalkumar D. Patel. “Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN).” Clin Immunol 129, no. 1 (October 2008): 115–22. https://doi.org/10.1016/j.clim.2008.06.008.
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  - Graziewicz, Maria A., Teresa K. Tarrant, Brian Buckley, Jennifer Roberts, LeShara Fulton, Henrik Hansen, Henrik Ørum, Ryszard Kole, and Peter Sazani. “An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models.” Mol Ther 16, no. 7 (July 2008): 1316–22. https://doi.org/10.1038/mt.2008.85.
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  - Xu, Hui, Phyllis B. Silver, Teresa K. Tarrant, Chi-Chao Chan, and Rachel R. Caspi. “Tgf-beta inhibits activation and uveitogenicity of primary but not of fully polarized retinal antigen-specific memory-effector T cells.” Invest Ophthalmol Vis Sci 44, no. 11 (November 2003): 4805–12. https://doi.org/10.1167/iovs.02-0843.
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  - Tarrant, Teresa K., D Hugh Frazer, James P. Aya-Ay, and Dhavalkumar D. Patel. “B cell loss leading to remission in severe systemic lupus erythematosus.” J Rheumatol 30, no. 2 (February 2003): 412–14.
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- Conference Papers
  - Malcolm, Elizabeth, Zachary Brandon, John Paul Shoup, Lauren Wilson, Heather King, Allison Lewinski, Melissa Greiner, et al. “IMPLEMENTATION AND EFFECTIVENESS OF RHEUMATOLOGY E-CONSULTS INTERVENTION TO REDUCE SPECIALIST WAIT TIMES.” In Journal of General Internal Medicine, 35:S167–S167, 2020.
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  - Min, H., L. Xu, R. Parrott, E. M. Rabjohns, R. R. Rampersad, T. K. Tarrant, C. Overall, et al. “Reprogramming inflammatory macrophages with mesenchymal stromal cells.” In Cytotherapy, 22:S83–84, 2020.
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  - Wickenheisser, V., E. M. Zywot, E. Rabjohns, N. Orlova, C. M. Marvin, S. Ding, D. S. Lawrence, and T. R. Tarrant. “Photo-released drugs: A targeted treatment approach for arthritis.” In Progress in Biomedical Optics and Imaging Proceedings of Spie, Vol. 11223, 2020. https://doi.org/10.1117/12.2546949.
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  - Tarrant, Teresa K., Christina Marvin, Qunzhao Wang, Stephen Serafin, and David Lawrence. “Light-Mediated Delivery of Therapeutics.” In Journal of Allergy and Clinical Immunology, 141:AB197–AB197. MOSBY-ELSEVIER, 2018.
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  - Brozowski, Jaime M., Roman G. Timoshchenko, D Stephen Serafin, Jessica Koontz, Brittney Allyn, Amanda M. Eudy, Taylor Harris, et al. “G Protein-Coupled Receptor Kinase 3 Modulates Mesenchymal Stem Cell Proliferation and Differentiation through Sphingosine-1-Phosphate Receptor Regulation.” In Arthritis & Rheumatology, Vol. 69. WILEY, 2017.
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  - Yang, Luanna, Shaili N. Shah, D Stephen Serafin, Roman G. Timoshchenko, Paula Scotland, Kristy Richards, Matthew J. Billard, Patricia L. Lugar, and Teresa K. Tarrant. “Interrogating Genetic Susceptibility Loci in CVID and Autoimmunity.” In Journal of Allergy and Clinical Immunology, 137:AB179–AB179. Elsevier BV, 2016. https://doi.org/10.1016/j.jaci.2015.12.720.
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  - Tarrant, T. K., R. R. Rampersad, C. G. Moore, L. R. Rothlein, R. M. Lefkowitz, D. M. Lee, and D. D. Patel. “G-Protein Receptor Kinases (grKs) Play an Important Regulatory Role in the K/BxN Serum Transfer Model of Inflammatory Arthritis.” In Journal of Allergy and Clinical Immunology, 119:S234–35. Elsevier BV, 2007. https://doi.org/10.1016/j.jaci.2006.12.288.
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  - Tarrant, T. K., R. R. Rampersad, R. K. Lefkowitz, D. M. Lee, and D. D. Patel. “Beta-arrestin2 and G-protein receptor kinases play an important regulatory role in the K/BxN serum transfer model of inflammatory arthritis.” In Arthritis and Rheumatism, 52:S270–S270. WILEY-BLACKWELL, 2005.
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Teaching & Mentoring
Advising & Mentoring
- I enjoy working with students and fellows at all levels of training from the Department of Medicine as well as those from different disciplinary backgrounds on collaborative projects. My philosophy of teaching is to allow learners to question and to pursue investigations within a structured mentored environment. Students and fellows who work for me receive verbal and written feedback, and I similarly have found feedback from them to be invaluable to my professional growth as a researcher and educator. I have previously mentored trainees from the Departments of Medicine, Microbiology/Immunology, Pharmacy, Pharmacology, Chemistry, and Cell Biology and Physiology. I’ve also had the opportunity to directly mentor postdoctoral research fellows, undergraduates, and master’s candidates, including students who have successfully competed for K and F level federal funding. I have served on thesis committees for MD/PhD and PhD students as well as played an integral role in the Fellowship Training Programs of Allergy Immunology and Rheumatology by supervising these trainees in the clinic, participating in their education at academic conferences and journal clubs, and by serving as the dedicated supervisor of several of them in the research portions of their training.
Available to mentor:
- Post-Doc
Scholarly, Clinical, & Service Activities
Service to the Profession

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Awards & Honors

Selected Grants

External Relationships

Selected Publications

Academic Articles

Conference Papers

Advising & Mentoring

Available to mentor:

Service to the Profession