Research Interests
My current research interests include the following:
1. Discovering new therapies for immune mediated diseases such as Sjogren's syndrome and WHIM; we are actively enrolling patients in clinical trials
2. Investigating the pathogenesis of Adenosine Deaminase Deficiency (ADA) disorders
3. Characterizing novel genetic variants of WHIM syndrome and ADA deficiency disorders
1. Discovering new therapies for immune mediated diseases such as Sjogren's syndrome and WHIM; we are actively enrolling patients in clinical trials
2. Investigating the pathogenesis of Adenosine Deaminase Deficiency (ADA) disorders
3. Characterizing novel genetic variants of WHIM syndrome and ADA deficiency disorders
Selected Grants
A Phase 3, randomized, double-blind, placebo-controlled, multicenter study of mavorixafor in participants with congenital and acquired primary autoimmune and idiopathic chronic neutropenic disorders who are experiencing recurrent and/or serious infec
Clinical TrialPrincipal Investigator · Awarded by X4 Pharmaceuticals · 2025 - 2029HZNP-DAZ-303: A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Dazodalibep in participants with Sjogren's syndrome with moderate-to-severe symptom state.
Clinical TrialPrincipal Investigator · Awarded by Horizon Therapeutics Ireland DAC · 2024 - 2026HZNP-DAZ-301: A phase 3 randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of Dazodalibep in participants with Sjogren's syndrome with moderate-to-severe systemic disease activity.
Clinical TrialPrincipal Investigator · Awarded by Horizon Therapeutics Ireland DAC · 2024 - 2026Non-Registry Agreement Clinical Trial
Clinical TrialCo Investigator · Awarded by Chiesi USA, Inc · 2022 - 2025A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of Mavorixafor in Patients with WHIM Syndrome with Open-Label Extension
Clinical TrialPrincipal Investigator · Awarded by X4 Pharmaceuticals · 2020 - 2022Reprogramming Inflammatory Cells with Mesenchymal Stromal Cell RNA Granules
ResearchMentor · Awarded by Cord Blood Association Foundation · 2019 - 2022Rheumatoid Arthritis ABBV-3373
Clinical TrialPrincipal Investigator · Awarded by AbbVie Inc. · 2019 - 2020Medical and Graduate Student Preceptorship
FellowshipPrincipal Investigator · Awarded by Rheumatology Research Foundation · 2019 - 2020Light-mediated delivery of therapeutics for Rheumatoid Arthritis
ResearchPrincipal Investigator · Awarded by Rheumatology Research Foundation · 2016 - 2018External Relationships
- American College of Rheumatology
- Amgen, Inc.
- Chiesi USA
- Current Allergy and Asthma Reports
- Department of Justice
- National Institute of Health
- North Carolina Rheumatology Association
- US Department of Defense
- X4 Pharmaceuticals
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.