The clinical need for clustered AChR cell-based assay testing of seronegative MG.
Publication
, Journal Article
Masi, G; Li, Y; Karatz, T; Pham, MC; Oxendine, SR; Nowak, RJ; Guptill, JT; O'Connor, KC
Published in: J Neuroimmunol
June 15, 2022
Trial eligibility in myasthenia gravis (MG) remains largely dependent on a positive autoantibody serostatus. This significantly hinders seronegative MG (SNMG) patients from receiving potentially beneficial new treatments. In a subset of SNMG patients, acetylcholine receptor (AChR) autoantibodies are detectable by a clustered AChR cell-based assay (CBA). Of 99 SNMG patients from two academic U.S. centers, 18 (18.2%) tested positive by this assay. Autoantibody positivity was further validated in 17/18 patients. In a complementary experiment, circulating AChR-specific B cells were identified in a CBA-positive SNMG patient. These findings corroborate the clinical need for clustered AChR CBA testing when evaluating SNMG patients.
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Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
June 15, 2022
Volume
367
Start / End Page
577850
Location
Netherlands
Related Subject Headings
- Receptors, Cholinergic
- Neurology & Neurosurgery
- Myasthenia Gravis
- Humans
- Biological Assay
- Autoantibodies
- 3209 Neurosciences
- 3204 Immunology
- 1109 Neurosciences
- 1107 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Masi, G., Li, Y., Karatz, T., Pham, M. C., Oxendine, S. R., Nowak, R. J., … O’Connor, K. C. (2022). The clinical need for clustered AChR cell-based assay testing of seronegative MG. J Neuroimmunol, 367, 577850. https://doi.org/10.1016/j.jneuroim.2022.577850
Masi, Gianvito, Yingkai Li, Tabitha Karatz, Minh C. Pham, Seneca R. Oxendine, Richard J. Nowak, Jeffrey T. Guptill, and Kevin C. O’Connor. “The clinical need for clustered AChR cell-based assay testing of seronegative MG.” J Neuroimmunol 367 (June 15, 2022): 577850. https://doi.org/10.1016/j.jneuroim.2022.577850.
Masi G, Li Y, Karatz T, Pham MC, Oxendine SR, Nowak RJ, et al. The clinical need for clustered AChR cell-based assay testing of seronegative MG. J Neuroimmunol. 2022 Jun 15;367:577850.
Masi, Gianvito, et al. “The clinical need for clustered AChR cell-based assay testing of seronegative MG.” J Neuroimmunol, vol. 367, June 2022, p. 577850. Pubmed, doi:10.1016/j.jneuroim.2022.577850.
Masi G, Li Y, Karatz T, Pham MC, Oxendine SR, Nowak RJ, Guptill JT, O’Connor KC. The clinical need for clustered AChR cell-based assay testing of seronegative MG. J Neuroimmunol. 2022 Jun 15;367:577850.
Published In
J Neuroimmunol
DOI
EISSN
1872-8421
Publication Date
June 15, 2022
Volume
367
Start / End Page
577850
Location
Netherlands
Related Subject Headings
- Receptors, Cholinergic
- Neurology & Neurosurgery
- Myasthenia Gravis
- Humans
- Biological Assay
- Autoantibodies
- 3209 Neurosciences
- 3204 Immunology
- 1109 Neurosciences
- 1107 Immunology