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Jeffrey Guptill

Adjunct Associate Professor in the Department of Neurology
Neurology, Neuromuscular Disease
Duke Box 3403, Duke South Clinic, 1L, Durham, NC 27710
Box 3403 DUMC, Duke South Clinic, 1L, Durham, NC 27710

Current Appointments & Affiliations


Adjunct Associate Professor in the Department of Neurology · 2022 - Present Neurology, Neuromuscular Disease, Neurology

Recent Publications


Immune dysregulation in chronic inflammatory demyelinating polyneuropathy.

Journal Article J Neuroimmunol · June 15, 2024 OBJECTIVE: Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoimmune disorder of the peripheral nerves with an incompletely understood underlying pathophysiology. This investigation focused on defining B and T cell frequencies, T cell funct ... Full text Link to item Cite

Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.

Journal Article Psychiatry Res · March 2024 The Patient Health Questionnaire 9 (PHQ-9) is the current standard outpatient screening tool for measuring and tracking the nine symptoms of major depressive disorder (MDD). While the PHQ-9 was originally conceptualized as a unidimensional measure, it has ... Full text Link to item Cite

Intravenous Ganaxolone: Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability in Healthy Adults.

Journal Article Clin Pharmacol Drug Dev · March 2024 Ganaxolone, a neuroactive steroid anticonvulsant that modulates both synaptic and extrasynaptic γ-aminobutyric acid type A (GABAA ) receptors, is in development for treatment of status epilepticus (SE) and rare epileptic disorders, and has been approved in ... Full text Link to item Cite
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Recent Grants


COMBINE - ARLG 2.0 - DEPRU Site Budget (Yr8 of ARLG/Yr1 of ARLG 2.0)

Clinical TrialPrincipal Investigator · Awarded by DCRI-Duke-Site · 2019 - 2026

A Long-Term, Single-Arm, Open-label, Multicenter Phase 3 Study to Evaluate the Safety

Clinical TrialPrincipal Investigator · Awarded by Argenx BVBA · 2023 - 2026

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Education, Training & Certifications


Virginia Commonwealth University · 2005 M.D.