Bupropion XL in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled study.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

BACKGROUND: Data remain limited on treatment strategies for adults with attention-deficit/hyperactivity disorder (ADHD). This study evaluated the efficacy and safety of an extended-release, once-daily formulation of bupropion (XL) in the treatment of adults with ADHD. METHODS: This multisite, placebo-controlled, 8-week prospective trial evaluated 162 adult patients diagnosed with ADHD (combined and inattentive types). Subjects were treated with up to 450 mg/day of bupropion XL. The primary efficacy endpoint was the proportion of ADHD responders (defined as at least a 30% reduction in the investigator-rated ADHD Rating Scale score) at week 8 (last observation carried forward [LOCF]). RESULTS: Bupropion XL responders (53%) exceeded placebo responders (31%) (p =.004 at week 8) with a significantly greater proportion of bupropion XL responders as early as week 2 (p = .01). Treatment effect size calculated for the ADHD Rating Scale total score was .6. Bupropion XL appeared to provide sustained benefit throughout the day compared with placebo (morning p =.033, afternoon p =.004, evening p = .024). Bupropion XL was safe and well tolerated, with no serious or unexpected adverse events and a low rate of drug-related study discontinuation (5%). CONCLUSIONS: The results from this multisite study indicate that bupropion XL is an effective and well-tolerated nonstimulant treatment for adult ADHD.

Full Text

Duke Authors

Cited Authors

  • Wilens, TE; Haight, BR; Horrigan, JP; Hudziak, JJ; Rosenthal, NE; Connor, DF; Hampton, KD; Richard, NE; Modell, JG

Published Date

  • April 1, 2005

Published In

Volume / Issue

  • 57 / 7

Start / End Page

  • 793 - 801

PubMed ID

  • 15820237

International Standard Serial Number (ISSN)

  • 0006-3223

Digital Object Identifier (DOI)

  • 10.1016/j.biopsych.2005.01.027


  • eng

Conference Location

  • United States