Current Duke Appointments & Affiliations
Medical Associate Professor in the Department of Psychiatry and Behavioral Sciences
·
2025 - Present
Psychiatry, Child & Family Mental Health & Community Psychiatry,
Psychiatry & Behavioral Sciences
Recent Scholarly Works
Population Pharmacokinetics of Tideglusib in Congenital and Childhood Myotonic Dystrophy Type 1: Influence of Demographic and Clinical Factors on Systemic Exposure
Journal article Pharmaceutics · August 1, 2025 Background: GSK3β is an intracellular regulatory kinase that is dysregulated in multiple tissues in Type 1 myotonic dystrophy (DM-1). Tideglusib inhibits GSK3β activity in preclinical models of DM-1 and promotes cellular maturation, normalising aberrant mo ... Full text CiteAn open-label study evaluating the safety and efficacy of AMO-01 for the treatment of seizures in Phelan-McDermid syndrome.
Journal article HGG Adv · April 10, 2025 Phelan-McDermid syndrome (PMS) is a neurodevelopmental disorder caused by haploinsufficiency of the SHANK3 gene. Approximately 25% of individuals with PMS have epilepsy. Treatment of epilepsy in PMS may require multiple anticonvulsants, and in a minority o ... Full text Link to item CiteInternational workshop: what is needed to ensure outcome measures for Rett syndrome are fit-for-purpose for clinical trials? June 7, 2023, Nashville, USA.
Journal article Trials · December 21, 2024 INTRODUCTION: The clinical, research and advocacy communities for Rett syndrome are striving to achieve clinical trial readiness, including having fit-for-purpose clinical outcome assessments. This study aimed to (1) describe psychometric properties of cli ... Full text Link to item CiteEducation
University of Rochester, School of Medicine and Dentistry ·
1988
M.D.