Joseph Patrick Horrigan | Scholars@Duke

Joseph Patrick Horrigan
Associate Consulting Professor in the Department of Psychiatry and Behavioral Sciences

Current Appointments & Affiliations

Associate Consulting Professor in the Department of Psychiatry and Behavioral Sciences, Psychiatry, Child & Family Mental Health & Community Psychiatry, Psychiatry & Behavioral Sciences 2015

Contact Information

2424 Erwin Road, Suite 501, Durham, NC 27705
DUMC 2737, Durham, NC 27710
joseph.p.horrigan@duke.edu (919) 681-4229

Background
Education, Training, & Certifications
- Fellowship in Pediatric Neuropsychiatry, Psychiatry, University of North Carolina, Chapel Hill, School of Medicine 1993 - 1994
- Fellowship in Child and Adolescent Psychiatry, Psychiatry, University of North Carolina, Chapel Hill, School of Medicine 1991 - 1993
- General Psychiatry Residency, Psychiatry, University of North Carolina, Chapel Hill, School of Medicine 1988 - 1992
- M.D., University of Rochester, School of Medicine and Dentistry 1988
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Algera, Hyke, Rutger van der Schrier, David Cavalla, Monique van Velzen, Margot Roozekrans, Alison McMorn, Michael Snape, et al. “Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression.” Anesthesiology 137, no. 4 (October 1, 2022): 446–58. https://doi.org/10.1097/ALN.0000000000004324.
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  - Busner, J., G. Pandina, S. Z. Domingo, A. K. Berger, M. T. Acosta, N. Fisseha, J. Horrigan, et al. “Clinician-and Patient-reported Endpoints in CNS Orphan Drug Clinical Trials: ISCTM Position Paper on Best Practices for Endpoint Selection, Validation, Training, and Standardization.” Innovations in Clinical Neuroscience 18, no. 10–12 (October 1, 2021): 15–22.
  - Horrigan, Joseph, Tiago Bernardino Gomes, Mike Snape, Nikoletta Nikolenko, Alison McMorn, Stuart Evans, Alex Yaroshinsky, Oscar Della Pasqua, Sean Oosterholt, and Hanns Lochmüller. “A Phase 2 Study of AMO-02 (Tideglusib) in Congenital and Childhood-Onset Myotonic Dystrophy Type 1 (DM1).” Pediatr Neurol 112 (November 2020): 84–93. https://doi.org/10.1016/j.pediatrneurol.2020.08.001.
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  - Berry-Kravis, Elizabeth, Joseph P. Horrigan, Nicole Tartaglia, Randi Hagerman, Alexander Kolevzon, Craig A. Erickson, Shivkumar Hatti, et al. “A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Fragile X Syndrome.” Pediatr Neurol 110 (September 2020): 30–41. https://doi.org/10.1016/j.pediatrneurol.2020.04.019.
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  - Dawson, Geraldine, Jessica M. Sun, Jennifer Baker, Kimberly Carpenter, Scott Compton, Megan Deaver, Lauren Franz, et al. “A Phase II Randomized Clinical Trial of the Safety and Efficacy of Intravenous Umbilical Cord Blood Infusion for Treatment of Children with Autism Spectrum Disorder.” J Pediatr 222 (July 2020): 164-173.e5. https://doi.org/10.1016/j.jpeds.2020.03.011.
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  - Oosterholt, Sean P., Joseph Horrigan, Nancy Jones, Larry Glass, and Oscar Della Pasqua. “Population pharmacokinetics of NNZ-2566 in healthy subjects.” Eur J Pharm Sci 109S (November 15, 2017): S98–107. https://doi.org/10.1016/j.ejps.2017.05.032.
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  - Glaze, Daniel G., Jeffrey L. Neul, Alan Percy, Tim Feyma, Arthur Beisang, Alex Yaroshinsky, George Stoms, et al. “A Double-Blind, Randomized, Placebo-Controlled Clinical Study of Trofinetide in the Treatment of Rett Syndrome.” Pediatr Neurol 76 (November 2017): 37–46. https://doi.org/10.1016/j.pediatrneurol.2017.07.002.
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  - Lane, Jane B., Amber R. Salter, Nancy E. Jones, Gary Cutter, Joseph Horrigan, Steve A. Skinner, Walter E. Kaufmann, Daniel G. Glaze, Jeffrey L. Neul, and Alan K. Percy. “Assessment of Caregiver Inventory for Rett Syndrome.” J Autism Dev Disord 47, no. 4 (April 2017): 1102–12. https://doi.org/10.1007/s10803-017-3034-3.
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  - Findling, Robert L., Kiki Chang, Adelaide Robb, Vicki J. Foster, Joseph Horrigan, Alok Krishen, Art Wamil, John E. Kraus, and Melissa DelBello. “Adjunctive Maintenance Lamotrigine for Pediatric Bipolar I Disorder: A Placebo-Controlled, Randomized Withdrawal Study.” J Am Acad Child Adolesc Psychiatry 54, no. 12 (December 2015): 1020-1031.e3. https://doi.org/10.1016/j.jaac.2015.09.017.
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  - Neul, Jeffrey L., Daniel G. Glaze, Alan K. Percy, Tim Feyma, Arthur Beisang, Thuy Dinh, Bernhard Suter, et al. “Improving Treatment Trial Outcomes for Rett Syndrome: The Development of Rett-specific Anchors for the Clinical Global Impression Scale.” J Child Neurol 30, no. 13 (November 2015): 1743–48. https://doi.org/10.1177/0883073815579707.
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  - Anagnostou, Evdokia, Nancy Jones, Marisela Huerta, Alycia K. Halladay, Paul Wang, Lawrence Scahill, Joseph P. Horrigan, et al. “Measuring social communication behaviors as a treatment endpoint in individuals with autism spectrum disorder.” Autism 19, no. 5 (July 2015): 622–36. https://doi.org/10.1177/1362361314542955.
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  - Jarskog, L Fredrik, Martin T. Lowy, Richard A. Grove, Richard S. E. Keefe, Joseph P. Horrigan, M Patricia Ball, Alan Breier, et al. “A Phase II study of a histamine H₃ receptor antagonist GSK239512 for cognitive impairment in stable schizophrenia subjects on antipsychotic therapy.” Schizophr Res 164, no. 1–3 (May 2015): 136–42. https://doi.org/10.1016/j.schres.2015.01.041.
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  - Scahill, Lawrence, Michael G. Aman, Luc Lecavalier, Alycia K. Halladay, Somer L. Bishop, James W. Bodfish, Sabrina Grondhuis, et al. “Measuring repetitive behaviors as a treatment endpoint in youth with autism spectrum disorder.” Autism 19, no. 1 (January 2015): 38–52. https://doi.org/10.1177/1362361313510069.
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  - Lecavalier, Luc, Jeffrey J. Wood, Alycia K. Halladay, Nancy E. Jones, Michael G. Aman, Edwin H. Cook, Benjamin L. Handen, et al. “Measuring anxiety as a treatment endpoint in youth with autism spectrum disorder.” J Autism Dev Disord 44, no. 5 (May 2014): 1128–43. https://doi.org/10.1007/s10803-013-1974-9.
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  - Grove, Richard A., Conn M. Harrington, Andreas Mahler, Isabel Beresford, Paul Maruff, Martin T. Lowy, Andrew P. Nicholls, et al. “A randomized, double-blind, placebo-controlled, 16-week study of the H3 receptor antagonist, GSK239512 as a monotherapy in subjects with mild-to-moderate Alzheimer's disease.” Curr Alzheimer Res 11, no. 1 (January 2014): 47–58. https://doi.org/10.2174/1567205010666131212110148.
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  - Grove, R. A., S. Shackelford, S. Sopper, S. Pirruccello, J. Horrigan, E. Havrdova, M. Gold, and O. Graff. “Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis.” Eur J Neurol 20, no. 7 (July 2013): 1032–42. https://doi.org/10.1111/ene.12097.
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  - Lecavalier, L., J. J. Wood, A. K. Halladay, N. E. Jones, M. G. Aman, E. H. Cook, B. L. Handen, et al. “Measuring Anxiety as a Treatment Endpoint in Youth with Autism Spectrum Disorder.” Journal of Autism and Developmental Disorders, 2013, 1–16.
  - Miller, David H., Thomas Weber, Richard Grove, Claire Wardell, Joseph Horrigan, Ole Graff, Gillian Atkinson, et al. “Firategrast for relapsing remitting multiple sclerosis: a phase 2, randomised, double-blind, placebo-controlled trial.” Lancet Neurol 11, no. 2 (February 2012): 131–39. https://doi.org/10.1016/S1474-4422(11)70299-X.
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  - Kraus, John E., Joseph P. Horrigan, David J. Carpenter, Regan Fong, Pamela S. Barrett, and John T. Davies. “Clinical features of patients with treatment-emergent suicidal behavior following initiation of paroxetine therapy.” J Affect Disord 120, no. 1–3 (January 2010): 40–47. https://doi.org/10.1016/j.jad.2009.04.004.
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  - Santen, G., J. Horrigan, M. Danhof, and O. Della Pasqua. “From trial and error to trial simulation. Part 2: an appraisal of current beliefs in the design and analysis of clinical trials for antidepressant drugs.” Clin Pharmacol Ther 86, no. 3 (September 2009): 255–62. https://doi.org/10.1038/clpt.2009.107.
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  - Bielski, Robert J., Lynn Cunningham, Joseph P. Horrigan, Peter D. Londborg, Ward T. Smith, and Kenneth Weiss. “Gepirone extended-release in the treatment of adult outpatients with major depressive disorder: a double-blind, randomized, placebo-controlled, parallel-group study.” J Clin Psychiatry 69, no. 4 (April 2008): 571–77. https://doi.org/10.4088/jcp.v69n0408.
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  - Moore, Heidi K., Carroll W. Hughes, James C. Mundt, A John Rush, Laurie Macleod, Graham J. Emslie, Shailesh Jain, et al. “A pilot study of an electronic, adolescent version of the quick inventory of depressive symptomatology.” J Clin Psychiatry 68, no. 9 (September 2007): 1436–40. https://doi.org/10.4088/jcp.v68n0917.
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  - Krulewicz, Stan, David J. Carpenter, Regan Fong, Joseph P. Horrigan, Alan Lipschitz, Philip Perera, and Karen Dineen Wagner. “Analysis of electrocardiographic data following use of paroxetine in pediatric depression and obsessive-compulsive disorder.” J Am Acad Child Adolesc Psychiatry 45, no. 4 (April 2006): 422–30. https://doi.org/10.1097/01.chi.0000198593.30702.48.
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  - Clayton, A. H., H. A. Croft, J. P. Horrigan, D. S. Wightman, A. Krishen, N. E. Richard, and J. G. Modell. “Bupropion extended release compared with escitalopram: Effects on sexual functioning and antidepressant efficacy in 2 randomized, double-blind, placebo-controlled studies.” Journal of Clinical Psychiatry 67, no. 5 (January 1, 2006): 736–46. https://doi.org/10.4088/JCP.v67n0507.
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  - Wilens, Timothy E., Barbara R. Haight, Joseph P. Horrigan, James J. Hudziak, Norman E. Rosenthal, Daniel F. Connor, Kenneth D. Hampton, Nathalie E. Richard, and Jack G. Modell. “Bupropion XL in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled study.” Biol Psychiatry 57, no. 7 (April 1, 2005): 793–801. https://doi.org/10.1016/j.biopsych.2005.01.027.
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  - Mehta, Satwant Kaur. “Oral flower essences for ADHD.” J Am Acad Child Adolesc Psychiatry 41, no. 8 (August 2002): 895. https://doi.org/10.1097/00004583-200208000-00005.
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  - Barnhill, J., and J. P. Horrigan. “Tourette's syndrome and autism: A search for common ground.” Mental Health Aspects of Developmental Disabilities 5, no. 1 (March 14, 2002): 7–15.
  - Horrigan, J. P., L. J. Barnhill, and R. R. Kohli. “Adderall, the atypicals, and weight gain.” J Am Acad Child Adolesc Psychiatry 40, no. 6 (June 2001): 620. https://doi.org/10.1097/00004583-200106000-00004.
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  - Horrigan, J. P. “Present and future pharmacotherapeutic options for adult attention deficit/hyperactivity disorder.” Expert Opin Pharmacother 2, no. 4 (April 2001): 573–86. https://doi.org/10.1517/14656566.2.4.573.
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  - Kano, K., and O. Arisaka. “Fluvoxamine and enuresis.” J Am Acad Child Adolesc Psychiatry 39, no. 12 (December 2000): 1464–66. https://doi.org/10.1097/00004583-200012000-00003.
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  - Godart, N. T., G. Agman, F. Perdereau, and P. Jeammet. “Naltrexone treatment of self-injurious behavior.” J Am Acad Child Adolesc Psychiatry 39, no. 9 (September 2000): 1076–78. https://doi.org/10.1097/00004583-200009000-00005.
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  - Horrigan, J. P., and L. J. Barnhill. “Low-dose amphetamine salts and adult attention-deficit/hyperactivity disorder.” J Clin Psychiatry 61, no. 6 (June 2000): 414–17. https://doi.org/10.4088/jcp.v61n0604.
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  - Horrigan, J. P., and L. J. Barnhill. “Naltrexone treatment of self-injurious behavior.” Journal of the American Academy of Child and Adolescent Psychiatry 39, no. 9 (January 1, 2000): 1077–78. https://doi.org/10.1097/00004583-200009000-00006.
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  - Horrigan, J. P., and L. J. Barnhill. “Fluvoxamine and enuresis.” Journal of the American Academy of Child and Adolescent Psychiatry 39, no. 12 (January 1, 2000): 1465–66. https://doi.org/10.1097/00004583-200012000-00004.
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  - Samuel, R. Z. “Priapism associated with venlafaxine use.” J Am Acad Child Adolesc Psychiatry 39, no. 1 (January 2000): 16–17. https://doi.org/10.1097/00004583-200001000-00010.
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  - Greenblatt, J. “Nutritional supplements in ADHD.” J Am Acad Child Adolesc Psychiatry 38, no. 10 (October 1999): 1209–11. https://doi.org/10.1097/00004583-199910000-00005.
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  - Horrigan, J. P., and L. J. Barnhill. “Guanfacine and secondary mania in children.” J Affect Disord 54, no. 3 (August 1999): 309–14. https://doi.org/10.1016/s0165-0327(98)00183-9.
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  - Callaghan, R. S. “Appetite and weight in children treated for ADHD.” J Am Acad Child Adolesc Psychiatry 38, no. 7 (July 1999): 792–93. https://doi.org/10.1097/00004583-199907000-00002.
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  - Chong, Y., R. Harris, and W. J. Kim. “Dystonia as a side effect of nonneuroleptics.” J Am Acad Child Adolesc Psychiatry 38, no. 7 (July 1999): 793–95. https://doi.org/10.1097/00004583-199907000-00005.
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  - Horrigan, J. P. “Dr. Horrigttn replies.” Journal of the American Academy of Child and Adolescent Psychiatry 38, no. 1 (January 1, 1999): 3. https://doi.org/10.1097/00004583-199901000-00005.
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  - Horrigan, J. P. “Comment by Dr. Horrigan, at the invitation of the editor.” Journal of the American Academy of Child and Adolescent Psychiatry 38, no. 10 (January 1, 1999): 1210–11. https://doi.org/10.1097/00004583-199910000-00006.
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  - Horrigan, J. P., and L. J. Barnhill. “Dystonia as a side effect of nonneuroleptics.” Journal of the American Academy of Child and Adolescent Psychiatry 38, no. 7 (January 1, 1999): 794–95. https://doi.org/10.1097/00004583-199907000-00006.
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  - Namerow, L. B. “Seizure associated with bupropion and guanfacine.” J Am Acad Child Adolesc Psychiatry 38, no. 1 (January 1999): 2–3. https://doi.org/10.1097/00004583-199901000-00003.
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  - Horrigan, J. P., and L. Sikich. “Diet and the atypical neuroleptics.” J Am Acad Child Adolesc Psychiatry 37, no. 11 (November 1998): 1126–27. https://doi.org/10.1097/00004583-199811000-00003.
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  - Tilton, P. “Bupropion and guanfacine.” J Am Acad Child Adolesc Psychiatry 37, no. 7 (July 1998): 682–83. https://doi.org/10.1097/00004583-199807000-00002.
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  - Horrigan, J. P., L. Sikich, H. E. Courvoisie, and L. J. Barnhill. “Alternative therapies in the child psychiatric clinic.” J Child Adolesc Psychopharmacol 8, no. 4 (1998): 249–50. https://doi.org/10.1089/cap.1998.8.249.
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  - Horrigan, J. P., and L. J. Barnhill. “Does guanfacine trigger mania in children?” J Child Adolesc Psychopharmacol 8, no. 2 (1998): 149–50. https://doi.org/10.1089/cap.1998.8.149.
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  - Horrigan, J. P., L. J. Barnhill, and H. E. Courvoisie. “Olanzapine in PDD.” J Am Acad Child Adolesc Psychiatry 36, no. 9 (September 1997): 1166–67. https://doi.org/10.1097/00004583-199709000-00007.
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  - Balentine, J., and J. Hagman. “More on melatonin.” J Am Acad Child Adolesc Psychiatry 36, no. 8 (August 1997): 1013. https://doi.org/10.1097/00004583-199708000-00001.
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  - Horrigan, J. P., and L. J. Barnhill. “More on melatonin.” J Am Acad Child Adolesc Psychiatry 36, no. 8 (August 1997): 1014. https://doi.org/10.1097/00004583-199708000-00002.
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  - Horrigan, J. P., and L. J. Barnhill. “Risperidone and explosive aggressive autism.” J Autism Dev Disord 27, no. 3 (June 1997): 313–23. https://doi.org/10.1023/a:1025854532079.
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  - Horrigan, J. P., and L. Jarrett Barnhill. “Letter to editor.” Journal of the American Academy of Child and Adolescent Psychiatry 36, no. 8 (January 1, 1997): 1014.
  - Horrigan, J. P. “Guanfacine for PTSD nightmares.” J Am Acad Child Adolesc Psychiatry 35, no. 8 (August 1996): 975–76. https://doi.org/10.1097/00004583-199608000-00006.
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  - Horrigan, J. P., and L. J. Barnhill. “The suppression of nightmares with guanfacine.” J Clin Psychiatry 57, no. 8 (August 1996): 371.
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  - Horrigan, J. P., and L. J. Barnhill. “Guanfacine for Treatment of Attention-Deficit Hyperactivity Disorder in Boys.” Journal of Child and Adolescent Psychopharmacology 5, no. 3 (January 1, 1995): 215–23. https://doi.org/10.1089/cap.1995.5.215.
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  - Horrigan, J. P., and L. J. Barnhill. “Paroxetine-pimozide drug interaction.” J Am Acad Child Adolesc Psychiatry 33, no. 7 (September 1994): 1060–61. https://doi.org/10.1097/00004583-199409000-00022.
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- Conference Papers
  - Snape, Michael F., Joseph P. Horrigan, Robert M. J. Deacon, Michael J. Hurley, and Patricia Cogram. “5.16 AMO-01 in the SHANK3 Knockout Transgenic Mouse Model of Phelan Mcdermid Syndrome.” In Journal of the American Academy of Child &Amp; Adolescent Psychiatry, 56:S258–59. Elsevier BV, 2017. https://doi.org/10.1016/j.jaac.2017.09.299.
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  - Jarskog, F Fredrik, Richard A. Grove, Joseph P. McEvoy, Richard S. E. Keefe, Martin T. Lowy, Joseph P. Horrigan, and Margaret A. Peykamian. “Randomized, Double-Blind, Placebo Controlled, Parallel Group Exploratory Study of GSK239512 for Cognitive Impairment in Stable Schizophrenia Subjects on Background Antipsychotic Therapy.” In Biological Psychiatry, 71:63S-64S. ELSEVIER SCIENCE INC, 2012.
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Education, Training, & Certifications

Selected Publications

Academic Articles

Conference Papers