Skip to main content

Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols.

Publication ,  Journal Article
Sharma, S; Kapadia, A; Ria, F; Segars, WP; Samei, E
Published in: Med Phys
August 2022

PURPOSE: The gold-standard method for estimation of patient-specific organ doses in digital tomosynthesis (DT) requires protocol-specific Monte Carlo (MC) simulations of radiation transport in anatomically accurate computational phantoms. Although accurate, MC simulations are computationally expensive, leading to a turnaround time in the order of core hours for simulating a single exam. This limits their clinical utility. The purpose of this study is to overcome this limitation by utilizing patient- and protocol-specific MC simulations to develop a comprehensive database of air-kerma-normalized organ dose coefficients for a virtual population of adult and pediatric patient models over an expanded set of exam protocols in DT for retrospective and prospective estimation of radiation dose in clinical tomosynthesis. MATERIALS AND METHODS: A clinically representative virtual population of 14 patient models was used, with pediatric models (M and F) at ages 1, 5, 10, and 15 and adult patient models (M and F) with body mass index (BMIs) at 10th, 50th, and 90th percentiles of the US population. A graphics processing unit (GPU)-based MC simulation framework was used to simulate organ doses in the patient models, incorporating the scanner-specific configuration of a clinical DT system (VolumeRad, GE Healthcare, Waukesha, WI, USA) and an expanded set of exam protocols, including 21 distinct acquisition techniques for imaging a variety of anatomical regions (head and neck, thorax, spine, abdomen, and knee). Organ dose coefficients (hn ) were estimated by normalizing organ dose estimates to air kerma at 70 cm (X70cm ) from the source in the scout view. The corresponding coefficients for projection radiography were approximated using organ doses estimated for the scout view. The organ dose coefficients were further used to compute air-kerma-normalized patient-specific effective dose coefficients (Kn ) for all combinations of patients and protocols, and a comparative analysis examining the variation of radiation burden across sex, age, and exam protocols in DT, and with projection radiography was performed. RESULTS: The database of organ dose coefficients (hn ) containing 294 distinct combinations of patients and exam protocols was developed and made publicly available. The values of Kn were observed to produce estimates of effective dose in agreement with prior studies and consistent with magnitudes expected for pediatric and adult patients across the different exam protocols, with head and neck regions exhibiting relatively lower and thorax and C-spine (apsc, apcs) regions relatively higher magnitudes. The ratios (r = Kn /Kn ,rad ) quantifying the differences air-kerma-normalized patient-specific effective doses between DT and projection radiography were centered around 1.0 for all exam protocols, with the exception of protocols covering the knee region (pawk, patk). CONCLUSIONS: This study developed a database of organ dose coefficients for a virtual population of 14 adult and pediatric XCAT patient models over a set of 21 exam protocols in DT. Using empirical measurements of air kerma in the clinic, these organ dose coefficients enable practical retrospective and prospective patient-specific radiation dosimetry. The computation of air-kerma-normalized patient-specific effective doses further enables the comparison of radiation burden to the patient populations between protocols and between imaging modalities (e.g., DT and projection radiography), as presented in this study.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

August 2022

Volume

49

Issue

8

Start / End Page

5439 / 5450

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Radiometry
  • Radiation Dosage
  • Prospective Studies
  • Phantoms, Imaging
  • Pediatrics
  • Nuclear Medicine & Medical Imaging
  • Monte Carlo Method
  • Humans
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Sharma, S., Kapadia, A., Ria, F., Segars, W. P., & Samei, E. (2022). Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols. Med Phys, 49(8), 5439–5450. https://doi.org/10.1002/mp.15798
Sharma, Shobhit, Anuj Kapadia, Francesco Ria, W Paul Segars, and Ehsan Samei. “Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols.Med Phys 49, no. 8 (August 2022): 5439–50. https://doi.org/10.1002/mp.15798.
Sharma S, Kapadia A, Ria F, Segars WP, Samei E. Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols. Med Phys. 2022 Aug;49(8):5439–50.
Sharma, Shobhit, et al. “Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols.Med Phys, vol. 49, no. 8, Aug. 2022, pp. 5439–50. Pubmed, doi:10.1002/mp.15798.
Sharma S, Kapadia A, Ria F, Segars WP, Samei E. Dose coefficients for organ dosimetry in tomosynthesis imaging of adults and pediatrics across diverse protocols. Med Phys. 2022 Aug;49(8):5439–5450.

Published In

Med Phys

DOI

EISSN

2473-4209

Publication Date

August 2022

Volume

49

Issue

8

Start / End Page

5439 / 5450

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Radiometry
  • Radiation Dosage
  • Prospective Studies
  • Phantoms, Imaging
  • Pediatrics
  • Nuclear Medicine & Medical Imaging
  • Monte Carlo Method
  • Humans
  • Child