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Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force.

Publication ,  Journal Article
Cuvelier, GDE; Schoettler, M; Buxbaum, NP; Pinal-Fernandez, I; Schmalzing, M; Distler, JHW; Penack, O; Santomasso, BD; Zeiser, R; Angstwurm, K ...
Published in: Transplant Cell Ther
August 2022

Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation can occur in nonclassical chronic graft-versus-host disease (chronic GVHD) tissues and organ systems or manifest in atypical ways in classical organs commonly affected by chronic GVHD. The National Institutes of Health (NIH) consensus projects were developed to improve understanding and classification of the clinical features and diagnostic criteria for chronic GVHD. Although still speculative whether atypical manifestations are entirely due to chronic GVHD, these manifestations remain poorly captured by the current NIH consensus project criteria. Examples include chronic GVHD impacting the hematopoietic system as immune mediated cytopenias, endothelial dysfunction, or as atypical features in the musculoskeletal system, central and peripheral nervous system, kidneys, and serous membranes. These purported chronic GVHD features may contribute significantly to patient morbidity and mortality. Most of the atypical chronic GVHD features have received little study, particularly within multi-institutional and prospective studies, limiting our understanding of their frequency, pathogenesis, and relation to chronic GVHD. This NIH consensus project task force report provides an update on what is known and not known about the atypical manifestations of chronic GVHD while outlining a research framework for future studies to be undertaken within the next 3 to 7 years. We also provide provisional diagnostic criteria for each atypical manifestation, along with practical investigation strategies for clinicians managing patients with atypical chronic GVHD features.

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Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

August 2022

Volume

28

Issue

8

Start / End Page

426 / 445

Location

United States

Related Subject Headings

  • United States
  • Prospective Studies
  • National Institutes of Health (U.S.)
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Consensus
  • Chronic Disease
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cuvelier, G. D. E., Schoettler, M., Buxbaum, N. P., Pinal-Fernandez, I., Schmalzing, M., Distler, J. H. W., … Wolff, D. (2022). Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force. Transplant Cell Ther, 28(8), 426–445. https://doi.org/10.1016/j.jtct.2022.05.038
Cuvelier, Geoffrey D. E., Michelle Schoettler, Nataliya P. Buxbaum, Iago Pinal-Fernandez, Marc Schmalzing, Jörg H. W. Distler, Olaf Penack, et al. “Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force.Transplant Cell Ther 28, no. 8 (August 2022): 426–45. https://doi.org/10.1016/j.jtct.2022.05.038.
Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, et al. Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force. Transplant Cell Ther. 2022 Aug;28(8):426–45.
Cuvelier, Geoffrey D. E., et al. “Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force.Transplant Cell Ther, vol. 28, no. 8, Aug. 2022, pp. 426–45. Pubmed, doi:10.1016/j.jtct.2022.05.038.
Cuvelier GDE, Schoettler M, Buxbaum NP, Pinal-Fernandez I, Schmalzing M, Distler JHW, Penack O, Santomasso BD, Zeiser R, Angstwurm K, MacDonald KPA, Kimberly WT, Taylor N, Bilic E, Banas B, Buettner-Herold M, Sinha N, Greinix HT, Pidala J, Schultz KR, Williams KM, Inamoto Y, Cutler C, Griffith LM, Lee SJ, Sarantopoulos S, Pavletic SZ, Wolff D. Toward a Better Understanding of the Atypical Features of Chronic Graft-Versus-Host Disease: A Report from the 2020 National Institutes of Health Consensus Project Task Force. Transplant Cell Ther. 2022 Aug;28(8):426–445.

Published In

Transplant Cell Ther

DOI

EISSN

2666-6367

Publication Date

August 2022

Volume

28

Issue

8

Start / End Page

426 / 445

Location

United States

Related Subject Headings

  • United States
  • Prospective Studies
  • National Institutes of Health (U.S.)
  • Immunology
  • Humans
  • Graft vs Host Disease
  • Consensus
  • Chronic Disease
  • 3201 Cardiovascular medicine and haematology
  • 1103 Clinical Sciences