Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.

Journal Article (Review;Journal Article)

The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recent characterization of Aux/IAA N-terminal disordered regions, formation of secondary structure within these disordered regions, and post-translational modifications (PTMs) that affect Aux/IAA function and stability. We propose how structural variations between Aux/IAA family members may be tuned for differential transcriptional repression and degradation dynamics.

Full Text

Duke Authors

Cited Authors

  • Figueiredo, MRAD; Strader, LC

Published Date

  • October 2022

Published In

Volume / Issue

  • 47 / 10

Start / End Page

  • 865 - 874

PubMed ID

  • 35817652

Pubmed Central ID

  • PMC9464691

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2022.06.004


  • eng