Lucia Carol Strader | Scholars@Duke

Lucia Carol Strader
Associate Professor in Biology

Normal plant morphogenesis and environmental responses require integrating multiple signals to modulate auxin responsiveness, biosynthesis, transport, and storage forms. Auxin is a critical plant hormone, controlling both cell division and cell expansion and thereby orchestrating many developmental events and environmental responses. Our research focuses on a molecular understanding of auxin signaling, auxin homeostasis, and auxin crosstalk with other hormones. Understanding these molecular details will yield insight into strategies used by plants to alter growth in response to various environmental factors.

Current Appointments & Affiliations

Associate Professor in Biology, Biology, Trinity College of Arts & Sciences 2020
Associate Professor of Cell Biology, Cell Biology, Basic Science Departments 2022

Contact Information

124 Science Drive, 3332 French Family Science Center, Durham, NC 27708
lucia.strader@duke.edu (919) 660-0335
Strader Lab Website

Background
Education, Training, & Certifications
- Ph.D., Washington State University 2004
Previous Appointments & Affiliations
- Scholar In Residence in Biology, Biology, Trinity College of Arts & Sciences 2019 - 2020
Recognition
In the News
- SEP 21, 2021 Office of Faculty Advancement
  
  Meet the Newly Tenured Faculty of 2021
- JUL 13, 2021 Trinity College of Arts and Sciences
  
  Biologist Lucia Strader on Helping Plants Prepare for Environmental Challenges
Research
Selected Grants
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Collaborative Research: PlantSynBio: Identification and Design of Transcriptional Activation Domains Across Plant Species awarded by National Science Foundation 2021 - 2026
- Auxin Response Factors as a model of transcriptional control awarded by National Institutes of Health 2020 - 2025
- Using auxin to understand context-dependent hormone response awarded by National Institutes of Health 2023 - 2025
- Meeting: Auxin 2022: Cavtat, Croatia 2-7 October 2022 awarded by National Science Foundation 2022 - 2023
External Relationships
- Prose Foods
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Figueiredo, Marcelo Rodrigues Alves de, and Lucia C. Strader. “Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.” Trends in Biochemical Sciences 47, no. 10 (October 2022): 865–74. https://doi.org/10.1016/j.tibs.2022.06.004.
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  - Goloubinoff, Pierre, Jesse D. Woodson, Lucia C. Strader, and Zheng Qing Fu. “Important questions and future directions in plant biochemistry.” Trends in Biochemical Sciences 47, no. 10 (October 2022): 811–13. https://doi.org/10.1016/j.tibs.2022.07.003.
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  - Jing, Hongwei, David A. Korasick, Ryan J. Emenecker, Nicholas Morffy, Edward G. Wilkinson, Samantha K. Powers, and Lucia C. Strader. “Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning.” Nature Communications 13, no. 1 (July 2022): 4015. https://doi.org/10.1038/s41467-022-31628-2.
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  - Sageman-Furnas, Katelyn, and Lucia Strader. “Connected phytohormone biosynthesis pathways at the core of growth-stress tradeoffs.” Molecular Plant 15, no. 7 (July 2022): 1087–89. https://doi.org/10.1016/j.molp.2022.06.005.
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  - Allen, Jeffrey R., Edward G. Wilkinson, and Lucia C. Strader. “Creativity comes from interactions: modules of protein interactions in plants.” The Febs Journal 289, no. 6 (March 2022): 1492–1514. https://doi.org/10.1111/febs.15847.
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  - Allen, Jeffrey R., and Lucia C. Strader. “Beating the heat: Phase separation in plant stress granules.” Developmental Cell 57, no. 5 (March 2022): 563–65. https://doi.org/10.1016/j.devcel.2022.02.012.
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  - Strader, Lucia, Dolf Weijers, and Doris Wagner. “Plant transcription factors - being in the right place with the right company.” Current Opinion in Plant Biology 65 (February 2022): 102136. https://doi.org/10.1016/j.pbi.2021.102136.
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  - Morffy, Nicholas, and Lucia C. Strader. “Structural Aspects of Auxin Signaling.” Cold Spring Harbor Perspectives in Biology 14, no. 1 (January 2022): a039883. https://doi.org/10.1101/cshperspect.a039883.
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  - Pierik, Ronald, Christian Fankhauser, Lucia C. Strader, and Neelima Sinha. “Architecture and plasticity: optimizing plant performance in dynamic environments.” Plant Physiology 187, no. 3 (November 2021): 1029–32. https://doi.org/10.1093/plphys/kiab402.
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  - Zhang, Yuqin, Himabindu Vasuki Kilambi, Jie Liu, Hamutal Bar, Shani Lazary, Aiman Egbaria, Dagmar Ripper, et al. “ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers.” Science Advances 7, no. 43 (October 2021): eabf6069. https://doi.org/10.1126/sciadv.abf6069.
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  - Yoo, Chan Yul, Jiangman He, Qing Sang, Yongjian Qiu, Lingyun Long, Ruth Jean-Ae Kim, Emily G. Chong, et al. “Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B.” Nat Commun 12, no. 1 (September 23, 2021): 5614. https://doi.org/10.1038/s41467-021-25909-5.
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  - Morffy, Nicholas, and Lucia C. Strader. “Plant promoter-proximal pausing?” Nature Plants 7, no. 7 (July 2021): 862–63. https://doi.org/10.1038/s41477-021-00970-6.
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  - Emenecker, Ryan J., Alex S. Holehouse, and Lucia C. Strader. “Biological Phase Separation and Biomolecular Condensates in Plants.” Annual Review of Plant Biology 72 (June 2021): 17–46. https://doi.org/10.1146/annurev-arplant-081720-015238.
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  - Emenecker, Ryan J., Alex S. Holehouse, and Lucia C. Strader. “Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis.” Cell Communication and Signaling : Ccs 19, no. 1 (June 2021): 65. https://doi.org/10.1186/s12964-021-00744-9.
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  - Allen, Jeffrey R., and Lucia C. Strader. “Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events.” Current Opinion in Cell Biology 69 (April 2021): 136–41. https://doi.org/10.1016/j.ceb.2021.01.006.
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  - Emenecker, Ryan, Alex Holehouse, and Lucia Strader. “Sequence determinants ofin cellcondensate assembly morphology, dynamics, and oligomerization as measured by number and brightness analysis,” 2021. https://doi.org/10.1101/2021.04.18.440340.
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  - Jing, Hongwei, David Korasick, Ryan Emenecker, Nicholas Morffy, Edward Wilkinson, Samantha Powers, and Lucia Strader. “The F-box protein AFF1 regulates ARF protein accumulation to regulate auxin response,” 2021. https://doi.org/10.1101/2021.04.25.441346.
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  - Emenecker, Ryan J., Alex S. Holehouse, and Lucia C. Strader. “Emerging Roles for Phase Separation in Plants.” Developmental Cell 55, no. 1 (October 2020): 69–83. https://doi.org/10.1016/j.devcel.2020.09.010.
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  - Van Norman, Jaimie M., Lucia C. Strader, and Rosangela Sozzani. “Editorial overview: Directionality and precision - how signaling and gene regulation drive plant development and growth.” Current Opinion in Plant Biology 57 (October 2020): A1–3. https://doi.org/10.1016/j.pbi.2020.11.001.
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  - Wilkinson, Edward G., and Lucia C. Strader. “A Prion-based Thermosensor in Plants.” Molecular Cell 80, no. 2 (October 2020): 181–82. https://doi.org/10.1016/j.molcel.2020.09.026.
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  - Mittag, Tanja, and Lucia C. Strader. “I Will Survive: How NPR1 Condensation Promotes Plant Cell Survival.” Cell 182, no. 5 (September 2020): 1072–74. https://doi.org/10.1016/j.cell.2020.08.011.
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  - Trujillo-Hernandez, José A., Laetitia Bariat, Tara A. Enders, Lucia C. Strader, Jean-Philippe Reichheld, and Christophe Belin. “A glutathione-dependent control of the indole butyric acid pathway supports Arabidopsis root system adaptation to phosphate deprivation.” Journal of Experimental Botany 71, no. 16 (August 2020): 4843–57. https://doi.org/10.1093/jxb/eraa195.
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  - Homayouni, Arielle L., and Lucia C. Strader. “Sugar rush: Glucosylation of IPyA attenuates auxin levels.” Proceedings of the National Academy of Sciences of the United States of America 117, no. 14 (April 2020): 7558–60. https://doi.org/10.1073/pnas.2003305117.
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  - Powers, Samantha K., and Lucia C. Strader. “Regulation of auxin transcriptional responses.” Developmental Dynamics : An Official Publication of the American Association of Anatomists 249, no. 4 (April 2020): 483–95. https://doi.org/10.1002/dvdy.139.
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  - Emenecker, Ryan J., and Lucia C. Strader. “Auxin-Abscisic Acid Interactions in Plant Growth and Development.” Biomolecules 10, no. 2 (February 2020): E281. https://doi.org/10.3390/biom10020281.
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  - Powers, Samantha K., Alex S. Holehouse, David A. Korasick, Katherine H. Schreiber, Natalie M. Clark, Hongwei Jing, Ryan Emenecker, et al. “Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana.” Molecular Cell 76, no. 1 (October 2019): 177-190.e5. https://doi.org/10.1016/j.molcel.2019.06.044.
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  - Michniewicz, Marta, Cheng-Hsun Ho, Tara A. Enders, Eric Floro, Suresh Damodaran, Lauren K. Gunther, Samantha K. Powers, et al. “TRANSPORTER OF IBA1 Links Auxin and Cytokinin to Influence Root Architecture.” Developmental Cell 50, no. 5 (September 2019): 599-609.e4. https://doi.org/10.1016/j.devcel.2019.06.010.
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  - Damodaran, Suresh, and Lucia C. Strader. “Indole 3-Butyric Acid Metabolism and Transport in Arabidopsis thaliana.” Frontiers in Plant Science 10 (January 2019): 851. https://doi.org/10.3389/fpls.2019.00851.
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  - Jing, Hongwei, and Lucia C. Strader. “Interplay of Auxin and Cytokinin in Lateral Root Development.” International Journal of Molecular Sciences 20, no. 3 (January 2019): E486. https://doi.org/10.3390/ijms20030486.
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  - Trujillo-Hernandez, José, Laetitia Bariat, Lucia Strader, Jean-Philippe Reichheld, and Christophe Belin. “IBA endogenous auxin regulates Arabidopsis root system development in a glutathione-dependent way and is important for adaptation to phosphate deprivation,” 2019. https://doi.org/10.1101/818344.
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  - Morffy, Nicholas J., and Lucia C. Strader. “Locally Sourced: Auxin Biosynthesis and Transport in the Root Meristem.” Developmental Cell 47, no. 3 (November 2018): 262–64. https://doi.org/10.1016/j.devcel.2018.10.018.
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  - Frick, Elizabeth M., and Lucia C. Strader. “Kinase MPK17 and the Peroxisome Division Factor PMD1 Influence Salt-induced Peroxisome Proliferation.” Plant Physiology 176, no. 1 (January 2018): 340–51. https://doi.org/10.1104/pp.17.01019.
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  - Frick, Elizabeth M., and Lucia C. Strader. “Roles for IBA-derived auxin in plant development.” Journal of Experimental Botany 69, no. 2 (January 2018): 169–77. https://doi.org/10.1093/jxb/erx298.
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  - Enders, Tara A., Elizabeth M. Frick, and Lucia C. Strader. “An Arabidopsis kinase cascade influences auxin-responsive cell expansion.” The Plant Journal : For Cell and Molecular Biology 92, no. 1 (October 2017): 68–81. https://doi.org/10.1111/tpj.13635.
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  - Rinaldi, Mauro A., Ashish B. Patel, Jaeseok Park, Koeun Lee, Lucia C. Strader, and Bonnie Bartel. “The Roles of β-Oxidation and Cofactor Homeostasis in Peroxisome Distribution and Function in Arabidopsis thaliana.” Genetics 204, no. 3 (November 2016): 1089–1115. https://doi.org/10.1534/genetics.116.193169.
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  - Strader, Lucia C., and Yunde Zhao. “Auxin perception and downstream events.” Current Opinion in Plant Biology 33 (October 2016): 8–14. https://doi.org/10.1016/j.pbi.2016.04.004.
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  - McDonnell, Margaret M., Sarah E. Burkhart, Jerrad M. Stoddard, Zachary J. Wright, Lucia C. Strader, and Bonnie Bartel. “The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.” Plos One 11, no. 1 (January 2016): e0148335. https://doi.org/10.1371/journal.pone.0148335.
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  - Powers, Samantha K., and Lucia C. Strader. “Up in the air: Untethered Factors of Auxin Response.” F1000research 5 (January 2016): F1000FacultyRev-133. https://doi.org/10.12688/f1000research.7492.1.
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  - Korasick, David A., Joseph M. Jez, and Lucia C. Strader. “Refining the nuclear auxin response pathway through structural biology.” Current Opinion in Plant Biology 27 (October 2015): 22–28. https://doi.org/10.1016/j.pbi.2015.05.007.
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  - Enders, Tara A., Sookyung Oh, Zhenbiao Yang, Beronda L. Montgomery, and Lucia C. Strader. “Genome Sequencing of Arabidopsis abp1-5 Reveals Second-Site Mutations That May Affect Phenotypes.” The Plant Cell 27, no. 7 (July 2015): 1820–26. https://doi.org/10.1105/tpc.15.00214.
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  - Korasick, David A., Srirupa Chatterjee, Marco Tonelli, Hesam Dashti, Soon Goo Lee, Corey S. Westfall, D Bruce Fulton, et al. “Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses.” The Journal of Biological Chemistry 290, no. 20 (May 2015): 12868–78. https://doi.org/10.1074/jbc.m115.648253.
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  - Michniewicz, Marta, Elizabeth M. Frick, and Lucia C. Strader. “Gateway-compatible tissue-specific vectors for plant transformation.” Bmc Research Notes 8 (March 2015): 63. https://doi.org/10.1186/s13104-015-1010-6.
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  - Enders, Tara A., and Lucia C. Strader. “Auxin activity: Past, present, and future.” American Journal of Botany 102, no. 2 (February 2015): 180–96. https://doi.org/10.3732/ajb.1400285.
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  - Thole, Julie M., Erin R. Beisner, James Liu, Savina V. Venkova, and Lucia C. Strader. “Abscisic acid regulates root elongation through the activities of auxin and ethylene in Arabidopsis thaliana.” G3 (Bethesda, Md.) 4, no. 7 (May 2014): 1259–74. https://doi.org/10.1534/g3.114.011080.
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  - Korasick, David A., Corey S. Westfall, Soon Goo Lee, Max H. Nanao, Renaud Dumas, Gretchen Hagen, Thomas J. Guilfoyle, Joseph M. Jez, and Lucia C. Strader. “Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression.” Proceedings of the National Academy of Sciences of the United States of America 111, no. 14 (April 2014): 5427–32. https://doi.org/10.1073/pnas.1400074111.
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  - Korasick, David A., Tara A. Enders, and Lucia C. Strader. “Auxin biosynthesis and storage forms.” Journal of Experimental Botany 64, no. 9 (June 2013): 2541–55. https://doi.org/10.1093/jxb/ert080.
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  - Strader, Lucia C., and Jennifer L. Nemhauser. “Auxin 2012: a rich mea ho'oulu.” Development (Cambridge, England) 140, no. 6 (March 2013): 1153–57. https://doi.org/10.1242/dev.090530.
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  - De Rybel, Bert, Dominique Audenaert, Wei Xuan, Paul Overvoorde, Lucia C. Strader, Stefan Kepinski, Rebecca Hoye, et al. “A role for the root cap in root branching revealed by the non-auxin probe naxillin.” Nature Chemical Biology 8, no. 9 (September 2012): 798–805. https://doi.org/10.1038/nchembio.1044.
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  - Rinaldi, Mauro A., James Liu, Tara A. Enders, Bonnie Bartel, and Lucia C. Strader. “A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility.” Plant Molecular Biology 79, no. 4–5 (July 2012): 359–73. https://doi.org/10.1007/s11103-012-9917-y.
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  - Strader, Lucia C., and Bonnie Bartel. “Transport and metabolism of the endogenous auxin precursor indole-3-butyric acid.” Molecular Plant 4, no. 3 (May 2011): 477–86. https://doi.org/10.1093/mp/ssr006.
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  - Strader, Lucia C., Dorthea L. Wheeler, Sarah E. Christensen, John C. Berens, Jerry D. Cohen, Rebekah A. Rampey, and Bonnie Bartel. “Multiple facets of Arabidopsis seedling development require indole-3-butyric acid-derived auxin.” The Plant Cell 23, no. 3 (March 2011): 984–99. https://doi.org/10.1105/tpc.111.083071.
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  - Strader, Lucia C., Grace L. Chen, and Bonnie Bartel. “Ethylene directs auxin to control root cell expansion.” The Plant Journal : For Cell and Molecular Biology 64, no. 5 (December 2010): 874–84. https://doi.org/10.1111/j.1365-313x.2010.04373.x.
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  - Strader, Lucia C., Angela Hendrickson Culler, Jerry D. Cohen, and Bonnie Bartel. “Conversion of endogenous indole-3-butyric acid to indole-3-acetic acid drives cell expansion in Arabidopsis seedlings.” Plant Physiology 153, no. 4 (August 2010): 1577–86. https://doi.org/10.1104/pp.110.157461.
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  - Ruzicka, Kamil, Lucia C. Strader, Aurélien Bailly, Haibing Yang, Joshua Blakeslee, Lukasz Langowski, Eliska Nejedlá, et al. “Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.” Proceedings of the National Academy of Sciences of the United States of America 107, no. 23 (June 2010): 10749–53. https://doi.org/10.1073/pnas.1005878107.
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  - Strader, Lucia C., Erin R. Beisner, and Bonnie Bartel. “Silver ions increase auxin efflux independently of effects on ethylene response.” The Plant Cell 21, no. 11 (November 2009): 3585–90. https://doi.org/10.1105/tpc.108.065185.
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  - Strader, Lucia C., and Bonnie Bartel. “The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid.” The Plant Cell 21, no. 7 (July 2009): 1992–2007. https://doi.org/10.1105/tpc.109.065821.
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  - Strader, Lucia C., Melanie Monroe-Augustus, Kristen C. Rogers, Grace L. Lin, and Bonnie Bartel. “Arabidopsis iba response5 suppressors separate responses to various hormones.” Genetics 180, no. 4 (December 2008): 2019–31. https://doi.org/10.1534/genetics.108.091512.
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  - Strader, Lucia C., and Bonnie Bartel. “A new path to auxin.” Nature Chemical Biology 4, no. 6 (June 2008): 337–39. https://doi.org/10.1038/nchembio0608-337.
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  - Strader, Lucia C., Melanie Monroe-Augustus, and Bonnie Bartel. “The IBR5 phosphatase promotes Arabidopsis auxin responses through a novel mechanism distinct from TIR1-mediated repressor degradation.” Bmc Plant Biology 8 (April 2008): 41. https://doi.org/10.1186/1471-2229-8-41.
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  - Strader, Lucia C., Siân Ritchie, Jonathan D. Soule, Karen M. McGinnis, and Camille M. Steber. “Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY.” Proceedings of the National Academy of Sciences of the United States of America 101, no. 34 (August 2004): 12771–76. https://doi.org/10.1073/pnas.0404287101.
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  - McGinnis, Karen M., Stephen G. Thomas, Jonathan D. Soule, Lucia C. Strader, Janice M. Zale, Tai-ping Sun, and Camille M. Steber. “The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase.” The Plant Cell 15, no. 5 (May 2003): 1120–30. https://doi.org/10.1105/tpc.010827.
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- Preprints
  - Jing, Hongwei, Xiaolu Yang, Jian Feng, Jian Zhang, Lucia Strader, and Jianru Zuo. “S-nitrosylation of Aux/IAA protein represses auxin signaling.” BioRxiv, 2022. https://doi.org/10.1101/2022.10.07.511298.
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Teaching & Mentoring
Recent Courses

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Education, Training, & Certifications

Previous Appointments & Affiliations

In the News

Selected Grants

External Relationships

Selected Publications

Academic Articles

Preprints

Recent Courses