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Lucia Carol Strader

Professor of Biology
Biology
124 Science Drive, 3332 French Family Science Center, Durham, NC 27708

Selected Publications


Plants use molecular mechanisms mediated by biomolecular condensates to integrate environmental cues with development.

Journal Article The Plant Cell · September 2023 This review highlights recent literature on biomolecular condensates in plant development and discusses challenges for fully dissecting their functional roles. Plant developmental biology has been inundated with descriptive examples of biomolecular condens ... Full text Cite

Focus on biomolecular condensates.

Journal Article The Plant Cell · September 2023 Full text Cite

AUXIN RESPONSE FACTOR protein accumulation and function.

Journal Article Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology · August 2023 Auxin is a key regulator of plant developmental processes. Its effects on transcription are mediated by the AUXIN RESPONSE FACTOR (ARF) family of transcription factors. ARFs tightly control specific auxin responses necessary for proper plant growth and dev ... Full text Cite

Auxin and Abiotic Stress Responses.

Journal Article Journal of Experimental Botany · August 2023 Plants are exposed to a variety of abiotic stresses; these stresses have profound effects on plant growth, survival, and productivity. Tolerance and adaptation to stress require sophisticated stress sensing, signaling, and various regulatory mechanisms. Th ... Full text Cite

Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling.

Journal Article Journal of Genetics and Genomics = Yi Chuan Xue Bao · July 2023 The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) family of transcriptional r ... Full text Cite

Phase Separation in Biology and Disease; Current Perspectives and Open Questions.

Journal Article Journal of Molecular Biology · March 2023 In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells, now referred to as biomolecular condensates. Pioneering studi ... Full text Cite

ARF19 Condensation in the Arabidopsis Stomatal Lineage.

Journal Article Micropublication Biology · January 2023 The phytohormone auxin regulates nearly every aspect of plant development. Transcriptional responses to auxin are driven by the activities of the AUXIN RESPONSE FACTOR family of transcription factors. ARF19 (AT1G19220) is critical in the auxin signaling pa ... Full text Cite

Prediction and functional characterization of transcriptional activation domains

Conference 2023 57th Annual Conference on Information Sciences and Systems, Ciss 2023 · January 1, 2023 Gene expression is induced by transcription factors (TFs) through their activation domains (ADs). However, ADs are unconserved, intrinsically disordered sequences without a secondary structure, making it challenging to recognize and predict these regions a ... Full text Cite

Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.

Journal Article Trends in Biochemical Sciences · October 2022 The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recen ... Full text Cite

Important questions and future directions in plant biochemistry.

Journal Article Trends in Biochemical Sciences · October 2022 Full text Cite

Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning.

Journal Article Nature Communications · July 2022 Auxin critically regulates plant growth and development. Auxin-driven transcriptional responses are mediated through the AUXIN RESPONSE FACTOR (ARF) family of transcription factors. ARF protein condensation attenuates ARF activity, resulting in dramatic sh ... Full text Cite

Creativity comes from interactions: modules of protein interactions in plants.

Journal Article The Febs Journal · March 2022 Featured Publication Protein interactions are the foundation of cell biology. For robust signal transduction to occur, proteins interact selectively and modulate their behavior to direct specific biological outcomes. Frequently, modular protein interaction domains are central ... Full text Cite

Beating the heat: Phase separation in plant stress granules.

Journal Article Developmental Cell · March 2022 Plants form stress granules made of RNA binding proteins and RNA in response to various stresses. In this issue of Developmental Cell, Zhu et al. identify two RNA-binding proteins, RBGD2/4, that phase, separate, and localize stress granules to promote heat ... Full text Cite

Plant transcription factors - being in the right place with the right company.

Journal Article Current Opinion in Plant Biology · February 2022 Transcriptional regulation underlies many of the growth and developmental processes that shape plants as well as their adaptation to their environment. Key to transcriptional control are transcription factors, DNA-binding proteins that serve two essential ... Full text Cite

Structural Aspects of Auxin Signaling.

Journal Article Cold Spring Harbor Perspectives in Biology · January 2022 Auxin signaling regulates growth and developmental processes in plants. The core of nuclear auxin signaling relies on just three components: TIR1/AFBs, Aux/IAAs, and ARFs. Each component is itself made up of several domains, all of which contribute to the ... Full text Cite

ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers.

Journal Article Science Advances · October 2021 The effects of abscisic acid (ABA) on plant growth, development, and response to the environment depend on local ABA concentrations. Here, we show that in Arabidopsis, ABA homeostasis is regulated by two previously unknown ABA transporters. Adenosin ... Full text Cite

Plants use molecular mechanisms mediated by biomolecular condensates to integrate environmental cues with development.

Journal Article The Plant Cell · September 2023 This review highlights recent literature on biomolecular condensates in plant development and discusses challenges for fully dissecting their functional roles. Plant developmental biology has been inundated with descriptive examples of biomolecular condens ... Full text Cite

Focus on biomolecular condensates.

Journal Article The Plant Cell · September 2023 Full text Cite

AUXIN RESPONSE FACTOR protein accumulation and function.

Journal Article Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology · August 2023 Auxin is a key regulator of plant developmental processes. Its effects on transcription are mediated by the AUXIN RESPONSE FACTOR (ARF) family of transcription factors. ARFs tightly control specific auxin responses necessary for proper plant growth and dev ... Full text Cite

Auxin and Abiotic Stress Responses.

Journal Article Journal of Experimental Botany · August 2023 Plants are exposed to a variety of abiotic stresses; these stresses have profound effects on plant growth, survival, and productivity. Tolerance and adaptation to stress require sophisticated stress sensing, signaling, and various regulatory mechanisms. Th ... Full text Cite

Nitric oxide-mediated S-nitrosylation of IAA17 protein in intrinsically disordered region represses auxin signaling.

Journal Article Journal of Genetics and Genomics = Yi Chuan Xue Bao · July 2023 The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. Auxin signaling is activated through the phytohormone-induced proteasomal degradation of the Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) family of transcriptional r ... Full text Cite

Phase Separation in Biology and Disease; Current Perspectives and Open Questions.

Journal Article Journal of Molecular Biology · March 2023 In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells, now referred to as biomolecular condensates. Pioneering studi ... Full text Cite

ARF19 Condensation in the Arabidopsis Stomatal Lineage.

Journal Article Micropublication Biology · January 2023 The phytohormone auxin regulates nearly every aspect of plant development. Transcriptional responses to auxin are driven by the activities of the AUXIN RESPONSE FACTOR family of transcription factors. ARF19 (AT1G19220) is critical in the auxin signaling pa ... Full text Cite

Prediction and functional characterization of transcriptional activation domains

Conference 2023 57th Annual Conference on Information Sciences and Systems, Ciss 2023 · January 1, 2023 Gene expression is induced by transcription factors (TFs) through their activation domains (ADs). However, ADs are unconserved, intrinsically disordered sequences without a secondary structure, making it challenging to recognize and predict these regions a ... Full text Cite

Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics.

Journal Article Trends in Biochemical Sciences · October 2022 The plant hormone auxin acts through regulated degradation of Auxin/INDOLE-3-ACETIC ACID (Aux/IAA) proteins to regulate transcriptional events. In this review, we examine the composition and function of each Aux/IAA structural motif. We then focus on recen ... Full text Cite

Important questions and future directions in plant biochemistry.

Journal Article Trends in Biochemical Sciences · October 2022 Full text Cite

Regulation of AUXIN RESPONSE FACTOR condensation and nucleo-cytoplasmic partitioning.

Journal Article Nature Communications · July 2022 Auxin critically regulates plant growth and development. Auxin-driven transcriptional responses are mediated through the AUXIN RESPONSE FACTOR (ARF) family of transcription factors. ARF protein condensation attenuates ARF activity, resulting in dramatic sh ... Full text Cite

Creativity comes from interactions: modules of protein interactions in plants.

Journal Article The Febs Journal · March 2022 Featured Publication Protein interactions are the foundation of cell biology. For robust signal transduction to occur, proteins interact selectively and modulate their behavior to direct specific biological outcomes. Frequently, modular protein interaction domains are central ... Full text Cite

Beating the heat: Phase separation in plant stress granules.

Journal Article Developmental Cell · March 2022 Plants form stress granules made of RNA binding proteins and RNA in response to various stresses. In this issue of Developmental Cell, Zhu et al. identify two RNA-binding proteins, RBGD2/4, that phase, separate, and localize stress granules to promote heat ... Full text Cite

Plant transcription factors - being in the right place with the right company.

Journal Article Current Opinion in Plant Biology · February 2022 Transcriptional regulation underlies many of the growth and developmental processes that shape plants as well as their adaptation to their environment. Key to transcriptional control are transcription factors, DNA-binding proteins that serve two essential ... Full text Cite

Structural Aspects of Auxin Signaling.

Journal Article Cold Spring Harbor Perspectives in Biology · January 2022 Auxin signaling regulates growth and developmental processes in plants. The core of nuclear auxin signaling relies on just three components: TIR1/AFBs, Aux/IAAs, and ARFs. Each component is itself made up of several domains, all of which contribute to the ... Full text Cite

ABA homeostasis and long-distance translocation are redundantly regulated by ABCG ABA importers.

Journal Article Science Advances · October 2021 The effects of abscisic acid (ABA) on plant growth, development, and response to the environment depend on local ABA concentrations. Here, we show that in Arabidopsis, ABA homeostasis is regulated by two previously unknown ABA transporters. Adenosin ... Full text Cite

Direct photoresponsive inhibition of a p53-like transcription activation domain in PIF3 by Arabidopsis phytochrome B.

Journal Article Nat Commun · September 23, 2021 Photoactivated phytochrome B (PHYB) binds to antagonistically acting PHYTOCHROME-INTERACTING transcription FACTORs (PIFs) to regulate hundreds of light responsive genes in Arabidopsis by promoting PIF degradation. However, whether PHYB directly controls th ... Full text Link to item Cite

Plant promoter-proximal pausing?

Journal Article Nature Plants · July 2021 Full text Cite

Biological Phase Separation and Biomolecular Condensates in Plants.

Journal Article Annual Review of Plant Biology · June 2021 Featured Publication A surge in research focused on understanding the physical principles governing the formation, properties, and function of membraneless compartments has occurred over the past decade. Compartments such as the nucleolus, stress granules, and nuclear speckles ... Full text Cite

Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis.

Journal Article Cell Communication and Signaling : Ccs · June 2021 BackgroundBiomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the formation of biomolecular con ... Full text Cite

Nucleocytoplasmic partitioning as a mechanism to regulate Arabidopsis signaling events.

Journal Article Current Opinion in Cell Biology · April 2021 Featured Publication The nucleus is the site of transcription events - compartmentalization of transcription in eukaryotes allows for regulated access to chromatin. The nucleopore, a complex of many intrinsically disorder proteins, acts as the gatekeeper for nuclear entry and ... Full text Cite

Sequence determinants ofin cellcondensate assembly morphology, dynamics, and oligomerization as measured by number and brightness analysis

Journal Article · 2021 Background Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the formation of biomolecular co ... Full text Cite

The F-box protein AFF1 regulates ARF protein accumulation to regulate auxin response

Journal Article · 2021 ABSTRACT Auxin critically regulates nearly every aspect of plant growth and development. Auxin-driven transcriptional responses are mediated through the AUXIN RESPONSE FACTOR (ARF) family of transcription factors. Although ARF protein stability is ... Full text Cite

What is quantitative plant biology?

Journal Article Quantitative Plant Biology · January 2021 Quantitative plant biology is an interdisciplinary field that builds on a long history of biomathematics and biophysics. Today, thanks to high spatiotemporal resolution tools and computational modelling, it sets a new standard in plant science. Acquired da ... Full text Cite

Emerging Roles for Phase Separation in Plants.

Journal Article Developmental Cell · October 2020 The plant cell internal environment is a dynamic, intricate landscape composed of many intracellular compartments. Cells organize some cellular components through formation of biomolecular condensates-non-stoichiometric assemblies of protein and/or nucleic ... Full text Cite

A Prion-based Thermosensor in Plants.

Journal Article Molecular Cell · October 2020 Some prion-like domains and low-complexity regions provide the multivalency required to facilitate protein phase separation to regulate protein function. Jung et al. (2020) demonstrate how natural selection of the ELF3 prion-like domain gives rise to an in ... Full text Cite

I Will Survive: How NPR1 Condensation Promotes Plant Cell Survival.

Journal Article Cell · September 2020 The plant immune response regulator NPR1 resides in either the nucleus or in cytoplasmic puncta, depending on levels of the plant hormone salicylic acid. NPR1 nuclear roles include pathogenesis response (PR) gene regulation. In this issue of Cell, Zavaliev ... Full text Cite

A glutathione-dependent control of the indole butyric acid pathway supports Arabidopsis root system adaptation to phosphate deprivation.

Journal Article Journal of Experimental Botany · August 2020 Root system architecture results from a highly plastic developmental process to adapt to environmental conditions. In particular, the development of lateral roots and root hair growth are constantly optimized to the rhizosphere properties, including biotic ... Full text Cite

Sugar rush: Glucosylation of IPyA attenuates auxin levels.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2020 Full text Cite

Regulation of auxin transcriptional responses.

Journal Article Developmental Dynamics : an Official Publication of the American Association of Anatomists · April 2020 The plant hormone auxin acts as a signaling molecule to regulate a vast number of developmental responses throughout all stages of plant growth. Tight control and coordination of auxin signaling is required for the generation of specific auxin-response out ... Full text Cite

Auxin-Abscisic Acid Interactions in Plant Growth and Development.

Journal Article Biomolecules · February 2020 Plant hormones regulate many aspects of plant growth, development, and response to biotic and abiotic stress. Much research has gone into our understanding of individual plant hormones, focusing primarily on their mechanisms of action and the processes tha ... Full text Cite

Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana.

Journal Article Molecular Cell · October 2019 The phytohormone auxin plays crucial roles in nearly every aspect of plant growth and development. The auxin response factor (ARF) transcription factor family regulates auxin-responsive gene expression and exhibits nuclear localization in regions of high a ... Full text Cite

TRANSPORTER OF IBA1 Links Auxin and Cytokinin to Influence Root Architecture.

Journal Article Developmental Cell · September 2019 Developmental processes that control root system architecture are critical for soil exploration by plants, allowing for uptake of water and nutrients. Conversion of the auxin precursor indole-3-butyric acid (IBA) to active auxin (indole-3-acetic acid; IAA) ... Full text Cite

IBA endogenous auxin regulates Arabidopsis root system development in a glutathione-dependent way and is important for adaptation to phosphate deprivation

Journal Article · 2019 Root system architecture results from a highly plastic developmental process to perfectly adapt to environmental conditions. In particular, the development of lateral roots (LR) and root hair (RH) growth are constantly optimized to the rhizosphere properti ... Full text Cite

Interplay of Auxin and Cytokinin in Lateral Root Development.

Journal Article International Journal of Molecular Sciences · January 2019 The spacing and distribution of lateral roots are critical determinants of plant root system architecture. In addition to providing anchorage, lateral roots explore the soil to acquire water and nutrients. Over the past several decades, we have deepened ou ... Full text Cite

Indole 3-Butyric Acid Metabolism and Transport in Arabidopsis thaliana.

Journal Article Frontiers in Plant Science · January 2019 Auxin is a crucial phytohormone involved in multiple plant developmental processes. Spatiotemporal regulation of auxin levels is necessary to achieve development of organs in the proper place and at the proper time. These levels can be regulated by convers ... Full text Cite

Locally Sourced: Auxin Biosynthesis and Transport in the Root Meristem.

Journal Article Developmental Cell · November 2018 Localized maxima of the plant hormone auxin are crucial to root development and meristem maintenance. In this issue of Developmental Cell, Brumos et al. used elegant genetic and grafting experiments to distinguish between the contributions of local and dis ... Full text Cite

Kinase MPK17 and the Peroxisome Division Factor PMD1 Influence Salt-induced Peroxisome Proliferation.

Journal Article Plant Physiology · January 2018 Peroxisomes are small organelles that house many oxidative reactions. Peroxisome proliferation is induced under multiple stress conditions, including salt stress; however, factors regulating this process are not well defined. We have identified a role for ... Full text Cite

Roles for IBA-derived auxin in plant development.

Journal Article Journal of Experimental Botany · January 2018 The plant hormone auxin is a central regulator of plant growth and development. Because auxin plays critical roles in cell division and cell expansion, plants use a number of cellular mechanisms to regulate auxin levels and response. Among these mechanisms ... Full text Cite

An Arabidopsis kinase cascade influences auxin-responsive cell expansion.

Journal Article The Plant Journal : for Cell and Molecular Biology · October 2017 Mitogen-activated protein kinase (MPK) cascades are conserved mechanisms of signal transduction across eukaryotes. Despite the importance of MPK proteins in signaling events, specific roles for many Arabidopsis MPK proteins remain unknown. Multiple studies ... Full text Cite

The Roles of β-Oxidation and Cofactor Homeostasis in Peroxisome Distribution and Function in Arabidopsis thaliana.

Journal Article Genetics · November 2016 Key steps of essential metabolic pathways are housed in plant peroxisomes. We conducted a microscopy-based screen for anomalous distribution of peroxisomally targeted fluorescence in Arabidopsis thaliana This screen uncovered 34 novel alleles in 15 genes a ... Full text Cite

Auxin perception and downstream events.

Journal Article Current Opinion in Plant Biology · October 2016 Auxin responses have been arbitrarily divided into two categories: genomic and non-genomic effects. Genomic effects are largely mediated by SCFTIR1/AFB-Aux/IAA auxin receptor complexes whereas it has been postulated that AUXIN BINDING PROTEIN 1 ... Full text Cite

Up in the air: Untethered Factors of Auxin Response.

Journal Article F1000research · January 2016 As a prominent regulator of plant growth and development, the hormone auxin plays an essential role in controlling cell division and expansion. Auxin-responsive gene transcription is mediated through the TRANSPORT INHIBITOR RESPONSE1/AUXIN SIGNALING F-BOX ... Full text Cite

The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana.

Journal Article Plos One · January 2016 Peroxisomes are single-membrane bound organelles that are essential for normal development in plants and animals. In mammals and yeast, the peroxin (PEX) proteins PEX3 and PEX19 facilitate the early steps of peroxisome membrane protein (PMP) insertion and ... Full text Cite

Refining the nuclear auxin response pathway through structural biology.

Journal Article Current Opinion in Plant Biology · October 2015 Auxin is a key regulator of plant growth and development. Classical molecular and genetic techniques employed over the past 20 years identified the major players in auxin-mediated gene expression and suggest a canonical auxin response pathway. In recent ye ... Full text Cite

Genome Sequencing of Arabidopsis abp1-5 Reveals Second-Site Mutations That May Affect Phenotypes.

Journal Article The Plant Cell · July 2015 Auxin regulates numerous aspects of plant growth and development. For many years, investigating roles for AUXIN BINDING PROTEIN1 (ABP1) in auxin response was impeded by the reported embryo lethality of mutants defective in ABP1. However, identification of ... Full text Cite

Defining a two-pronged structural model for PB1 (Phox/Bem1p) domain interaction in plant auxin responses.

Journal Article The Journal of Biological Chemistry · May 2015 Phox/Bem1p (PB1) domains are universal structural modules that use surfaces of different charge for protein-protein association. In plants, PB1-mediated interactions of auxin response factors (ARF) and auxin/indole 3-acetic acid inducible proteins regulate ... Full text Cite

Gateway-compatible tissue-specific vectors for plant transformation.

Journal Article Bmc Research Notes · March 2015 BackgroundUnderstanding regulation of developmental events has increasingly required the use of tissue-specific expression of diverse genes affecting plant growth and environmental responses.FindingsTo allow for cloning of presumptive pro ... Full text Cite

Auxin activity: Past, present, and future.

Journal Article American Journal of Botany · February 2015 Long before its chemical identity was known, the phytohormone auxin was postulated to regulate plant growth. In the late 1800s, Sachs hypothesized that plant growth regulators, present in small amounts, move differentially throughout the plant to regulate ... Full text Cite

Abscisic acid regulates root elongation through the activities of auxin and ethylene in Arabidopsis thaliana.

Journal Article G3 (Bethesda, Md.) · May 2014 Abscisic acid (ABA) regulates many aspects of plant growth and development, including inhibition of root elongation and seed germination. We performed an ABA resistance screen to identify factors required for ABA response in root elongation inhibition. We ... Full text Cite

Molecular basis for AUXIN RESPONSE FACTOR protein interaction and the control of auxin response repression.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2014 In plants, the AUXIN RESPONSE FACTOR (ARF) transcription factor family regulates gene expression in response to auxin. In the absence of auxin, ARF transcription factors are repressed by interaction with AUXIN/INDOLE 3-ACETIC ACID (Aux/IAA) proteins. Altho ... Full text Cite

Auxin biosynthesis and storage forms.

Journal Article Journal of Experimental Botany · June 2013 The plant hormone auxin drives plant growth and morphogenesis. The levels and distribution of the active auxin indole-3-acetic acid (IAA) are tightly controlled through synthesis, inactivation, and transport. Many auxin precursors and modified auxin forms, ... Full text Cite

Auxin 2012: a rich mea ho'oulu.

Journal Article Development (Cambridge, England) · March 2013 In December 2012, scientists from around the world gathered in Waikoloa, Hawaii for 'Auxin 2012', a meeting organized by Paula McSteen (University of Missouri, USA), Ben Scheres (Utrecht University, The Netherlands) and Yunde Zhao (University of California ... Full text Cite

A role for the root cap in root branching revealed by the non-auxin probe naxillin.

Journal Article Nature Chemical Biology · September 2012 The acquisition of water and nutrients by plant roots is a fundamental aspect of agriculture and strongly depends on root architecture. Root branching and expansion of the root system is achieved through the development of lateral roots and is to a large e ... Full text Cite

A gain-of-function mutation in IAA16 confers reduced responses to auxin and abscisic acid and impedes plant growth and fertility.

Journal Article Plant Molecular Biology · July 2012 Auxin regulates many aspects of plant development, in part, through degradation of the Aux/IAA family of transcriptional repressors. Consequently, stabilizing mutations in several Aux/IAA proteins confer reduced auxin responsiveness. However, of the 29 app ... Full text Cite

Transport and metabolism of the endogenous auxin precursor indole-3-butyric acid.

Journal Article Molecular Plant · May 2011 Plant growth and morphogenesis depend on the levels and distribution of the plant hormone auxin. Plants tightly regulate cellular levels of the active auxin indole-3-acetic acid (IAA) through synthesis, inactivation, and transport. Although the transporter ... Full text Cite

Multiple facets of Arabidopsis seedling development require indole-3-butyric acid-derived auxin.

Journal Article The Plant Cell · March 2011 Levels of auxin, which regulates both cell division and cell elongation in plant development, are controlled by synthesis, inactivation, transport, and the use of storage forms. However, the specific contributions of various inputs to the active auxin pool ... Full text Cite

Ethylene directs auxin to control root cell expansion.

Journal Article The Plant Journal : for Cell and Molecular Biology · December 2010 Root morphogenesis is controlled by the regulation of cell division and expansion. We isolated an allele of the eto1 ethylene overproducer as a suppressor of the auxin-resistant mutant ibr5, prompting an examination of crosstalk between the phytohormones a ... Full text Cite

Conversion of endogenous indole-3-butyric acid to indole-3-acetic acid drives cell expansion in Arabidopsis seedlings.

Journal Article Plant Physiology · August 2010 Genetic evidence in Arabidopsis (Arabidopsis thaliana) suggests that the auxin precursor indole-3-butyric acid (IBA) is converted into active indole-3-acetic acid (IAA) by peroxisomal beta-oxidation; however, direct evidence that Arabidopsis converts IBA t ... Full text Cite

Arabidopsis PIS1 encodes the ABCG37 transporter of auxinic compounds including the auxin precursor indole-3-butyric acid.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · June 2010 Differential distribution of the plant hormone auxin within tissues mediates a variety of developmental processes. Cellular auxin levels are determined by metabolic processes including synthesis, degradation, and (de)conjugation, as well as by auxin transp ... Full text Cite

Silver ions increase auxin efflux independently of effects on ethylene response.

Journal Article The Plant Cell · November 2009 Silver nitrate and aminoethoxyvinylglycine (AVG) are often used to inhibit perception and biosynthesis, respectively, of the phytohormone ethylene. In the course of exploring the genetic basis of the extensive interactions between ethylene and auxin, we co ... Full text Cite

The Arabidopsis PLEIOTROPIC DRUG RESISTANCE8/ABCG36 ATP binding cassette transporter modulates sensitivity to the auxin precursor indole-3-butyric acid.

Journal Article The Plant Cell · July 2009 Plants have developed numerous mechanisms to store hormones in inactive but readily available states, enabling rapid responses to environmental changes. The phytohormone auxin has a number of storage precursors, including indole-3-butyric acid (IBA), which ... Full text Cite

Arabidopsis iba response5 suppressors separate responses to various hormones.

Journal Article Genetics · December 2008 Auxin controls numerous plant growth processes by directing cell division and expansion. Auxin-response mutants, including iba response5 (ibr5), exhibit a long root and decreased lateral root production in response to exogenous auxins. ibr5 also displays r ... Full text Cite

A new path to auxin.

Journal Article Nature Chemical Biology · June 2008 Full text Cite

The IBR5 phosphatase promotes Arabidopsis auxin responses through a novel mechanism distinct from TIR1-mediated repressor degradation.

Journal Article Bmc Plant Biology · April 2008 BackgroundIn Arabidopsis, INDOLE-3-BUTYRIC ACID RESPONSE5 (IBR5), a putative dual-specificity protein phosphatase, is a positive regulator of auxin response. Mutations in IBR5 result in decreased plant height, defective vascular development, incre ... Full text Cite

Recessive-interfering mutations in the gibberellin signaling gene SLEEPY1 are rescued by overexpression of its homologue, SNEEZY.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · August 2004 This article reports the genetic interaction of two F-box genes, SLEEPY1 (SLY1) and SNEEZY (SNE), in Arabidopsis thaliana gibberellin (GA) signaling. The SLY1 gene encodes an F-box subunit of a Skp1-cullin-F-box (SCF) E3 ubiquitin ligase complex that posit ... Full text Cite

The Arabidopsis SLEEPY1 gene encodes a putative F-box subunit of an SCF E3 ubiquitin ligase.

Journal Article The Plant Cell · May 2003 The Arabidopsis SLY1 (SLEEPY1) gene positively regulates gibberellin (GA) signaling. Positional cloning of SLY1 revealed that it encodes a putative F-box protein. This result suggests that SLY1 is the F-box subunit of an SCF E3 ubiquitin ligase that regula ... Full text Cite