Operationalizing Precision Cardiovascular Medicine: Three Innovations.

Journal Article (Journal Article;Review)

For precision medicine to become a reality, we propose three changes. First, healthcare deliverables must be prioritized, enabling translation of knowledge to the clinic. Second, physicians and patients must be convinced to participate, requiring additional infrastructure in health systems. Third, discovery science must evolve to shift the preclinical landscape for innovation. We propose a change in the fundamental relationship between basic and clinical science: rather than two distinct entities between which concepts must be translated, we envision a natural hybrid of these approaches, wherein discovery science and clinical trials coincide in the same health systems and patient populations.

Full Text

Duke Authors

Cited Authors

  • Wang, JJ; Aboulhosn, JA; Hofer, IS; Mahajan, A; Wang, Y; Vondriska, TM

Published Date

  • October 14, 2016

Published In

Volume / Issue

  • 119 / 9

Start / End Page

  • 984 - 987

PubMed ID

  • 27737942

Pubmed Central ID

  • PMC5135087

Electronic International Standard Serial Number (EISSN)

  • 1524-4571

Digital Object Identifier (DOI)

  • 10.1161/CIRCRESAHA.116.309776


  • eng

Conference Location

  • United States