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The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.

Publication ,  Journal Article
Lusis, AJ; Seldin, MM; Allayee, H; Bennett, BJ; Civelek, M; Davis, RC; Eskin, E; Farber, CR; Hui, S; Mehrabian, M; Norheim, F; Pan, C ...
Published in: J Lipid Res
June 2016

The Hybrid Mouse Diversity Panel (HMDP) is a collection of approximately 100 well-characterized inbred strains of mice that can be used to analyze the genetic and environmental factors underlying complex traits. While not nearly as powerful for mapping genetic loci contributing to the traits as human genome-wide association studies, it has some important advantages. First, environmental factors can be controlled. Second, relevant tissues are accessible for global molecular phenotyping. Finally, because inbred strains are renewable, results from separate studies can be integrated. Thus far, the HMDP has been studied for traits relevant to obesity, diabetes, atherosclerosis, osteoporosis, heart failure, immune regulation, fatty liver disease, and host-gut microbiota interactions. High-throughput technologies have been used to examine the genomes, epigenomes, transcriptomes, proteomes, metabolomes, and microbiomes of the mice under various environmental conditions. All of the published data are available and can be readily used to formulate hypotheses about genes, pathways and interactions.

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Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

June 2016

Volume

57

Issue

6

Start / End Page

925 / 942

Location

United States

Related Subject Headings

  • Transcriptome
  • Quantitative Trait Loci
  • Osteoporosis
  • Obesity
  • Microbiota
  • Mice
  • Metabolic Diseases
  • Insulin Resistance
  • Hybridization, Genetic
  • Humans
 

Citation

APA
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ICMJE
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Lusis, A. J., Seldin, M. M., Allayee, H., Bennett, B. J., Civelek, M., Davis, R. C., … Wang, J. (2016). The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res, 57(6), 925–942. https://doi.org/10.1194/jlr.R066944
Lusis, Aldons J., Marcus M. Seldin, Hooman Allayee, Brian J. Bennett, Mete Civelek, Richard C. Davis, Eleazar Eskin, et al. “The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.J Lipid Res 57, no. 6 (June 2016): 925–42. https://doi.org/10.1194/jlr.R066944.
Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, et al. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 Jun;57(6):925–42.
Lusis, Aldons J., et al. “The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.J Lipid Res, vol. 57, no. 6, June 2016, pp. 925–42. Pubmed, doi:10.1194/jlr.R066944.
Lusis AJ, Seldin MM, Allayee H, Bennett BJ, Civelek M, Davis RC, Eskin E, Farber CR, Hui S, Mehrabian M, Norheim F, Pan C, Parks B, Rau CD, Smith DJ, Vallim T, Wang Y, Wang J. The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits. J Lipid Res. 2016 Jun;57(6):925–942.

Published In

J Lipid Res

DOI

EISSN

1539-7262

Publication Date

June 2016

Volume

57

Issue

6

Start / End Page

925 / 942

Location

United States

Related Subject Headings

  • Transcriptome
  • Quantitative Trait Loci
  • Osteoporosis
  • Obesity
  • Microbiota
  • Mice
  • Metabolic Diseases
  • Insulin Resistance
  • Hybridization, Genetic
  • Humans