p38 MAP kinases in the heart.

Journal Article (Journal Article;Review)

p38 kinases are members of the mitogen-activated protein kinases (MAPK) with established contribution to a wide range of signaling pathways and different biological processes. The prototypic p38 MAPK, p38α was originally identified as an essential signaling kinase for inflammatory cytokine production Extensive studies have now revealed that p38s have critical roles in many different tissues far beyond immune regulation and inflammatory responses. In this review, we will focus on the structure and molecular biology of p38s, and their specific roles in heart, especially regarding myocyte proliferation, apoptosis, and hypertrophic responses.

Full Text

Duke Authors

Cited Authors

  • Yokota, T; Wang, Y

Published Date

  • January 10, 2016

Published In

Volume / Issue

  • 575 / 2 Pt 2

Start / End Page

  • 369 - 376

PubMed ID

  • 26390817

Pubmed Central ID

  • PMC4860190

Electronic International Standard Serial Number (EISSN)

  • 1879-0038

Digital Object Identifier (DOI)

  • 10.1016/j.gene.2015.09.030


  • eng

Conference Location

  • Netherlands