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IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.

Publication ,  Journal Article
Ren, S; Lu, G; Ota, A; Zhou, ZH; Vondriska, TM; Lane, TF; Wang, Y
Published in: PLoS One
2014

We recently reported that the PPM1l gene encodes an endoplasmic reticulum (ER) membrane targeted protein phosphatase (named PP2Ce) with highly specific activity towards Inositol-requiring protein-1 (IRE1) and regulates the functional outcome of ER stress. In the present report, we found that the PP2Ce protein is highly expressed in lactating epithelium of the mammary gland. Loss of PP2Ce in vivo impairs physiological unfolded protein response (UPR) and induces stress kinase activation, resulting in loss of milk production and induction of epithelial apoptosis in the lactating mammary gland. This study provides the first in vivo evidence that PP2Ce is an essential regulator of normal lactation, possibly involving IRE1 signaling and ER stress regulation in mammary epithelium.

Duke Scholars

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Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

11

Start / End Page

e111606

Location

United States

Related Subject Headings

  • Unfolded Protein Response
  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Protein Phosphatase 2C
  • Postpartum Period
  • Phosphoprotein Phosphatases
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Membrane Proteins
  • Mammary Glands, Animal
 

Citation

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Ren, S., Lu, G., Ota, A., Zhou, Z. H., Vondriska, T. M., Lane, T. F., & Wang, Y. (2014). IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. PLoS One, 9(11), e111606. https://doi.org/10.1371/journal.pone.0111606
Ren, Shuxun, Gang Lu, Asuka Ota, Z Hong Zhou, Thomas M. Vondriska, Timothy F. Lane, and Yibin Wang. “IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.PLoS One 9, no. 11 (2014): e111606. https://doi.org/10.1371/journal.pone.0111606.
Ren S, Lu G, Ota A, Zhou ZH, Vondriska TM, Lane TF, et al. IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. PLoS One. 2014;9(11):e111606.
Ren, Shuxun, et al. “IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland.PLoS One, vol. 9, no. 11, 2014, p. e111606. Pubmed, doi:10.1371/journal.pone.0111606.
Ren S, Lu G, Ota A, Zhou ZH, Vondriska TM, Lane TF, Wang Y. IRE1 phosphatase PP2Ce regulates adaptive ER stress response in the postpartum mammary gland. PLoS One. 2014;9(11):e111606.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2014

Volume

9

Issue

11

Start / End Page

e111606

Location

United States

Related Subject Headings

  • Unfolded Protein Response
  • Signal Transduction
  • Protein Serine-Threonine Kinases
  • Protein Phosphatase 2C
  • Postpartum Period
  • Phosphoprotein Phosphatases
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Membrane Proteins
  • Mammary Glands, Animal