Systems-based approaches to cardiovascular disease.

Journal Article (Journal Article;Review)

Common cardiovascular diseases, such as atherosclerosis and congestive heart failure, are exceptionally complex, involving a multitude of environmental and genetic factors that often show nonlinear interactions as well as being highly dependent on sex, age, and even the maternal environment. Although focused, reductionistic approaches have led to progress in elucidating the pathophysiology of cardiovascular diseases, such approaches are poorly powered to address complex interactions. Over the past decade, technological advances have made it possible to interrogate biological systems on a global level, raising hopes that, in combination with computational approaches, it may be possible to more fully address the complexities of cardiovascular diseases. In this Review, we provide an overview of such systems-based approaches to cardiovascular disease and discuss their translational implications.

Full Text

Duke Authors

Cited Authors

  • MacLellan, WR; Wang, Y; Lusis, AJ

Published Date

  • January 10, 2012

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • 172 - 184

PubMed ID

  • 22231714

Pubmed Central ID

  • PMC3823242

Electronic International Standard Serial Number (EISSN)

  • 1759-5010

Digital Object Identifier (DOI)

  • 10.1038/nrcardio.2011.208

Language

  • eng

Conference Location

  • England